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2011 International Workshop on Biophotonics最新文献

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Silicon micromachined photonic crystal integrated in an opto-fluidic microsystem 集成于光流微系统中的硅微机械光子晶体
2011 International Workshop on Biophotonics Pub Date : 2011-06-08 DOI: 10.1109/IWBP.2011.5954862
S. Surdo, L. Strambini, G. Barillaro, F. Carpignano, S. Merlo
{"title":"Silicon micromachined photonic crystal integrated in an opto-fluidic microsystem","authors":"S. Surdo, L. Strambini, G. Barillaro, F. Carpignano, S. Merlo","doi":"10.1109/IWBP.2011.5954862","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954862","url":null,"abstract":"In this work, fabrication and testing of closed-loop opto-fluidic microsystems integrating both optical and fluidic functionalities on the same chip are reported. The microsystems consisted of an electrochemically micromachined silicon substrate, on which high-order vertical silicon/air one dimensional photonic crystals (1D PhCs) were integrated together with fluidic microchannels, bonded to a glass cover, the latter provided with inlet/outlet holes for liquid injection/extraction in/out the PhCs air gaps. An experimental characterization was performed by pumping different liquids (water, ethanol, isopropanol) through the opto-fluidic microsystem and by measuring the reflectivity spectrum in the wavelength range 1.0 – 1.7 µm (at normal incidence) with an inplane fiber optic setup. Experimental results, which well agreed with theoretical predictions, demonstrated the high sensitivity of the opto-fluidic microsystem in measuring small refractive index changes, which was estimated to be 1049 nm/RIU.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129369542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Automated sample processing for flow cytometry 用于流式细胞术的自动样品处理
2011 International Workshop on Biophotonics Pub Date : 2011-06-08 DOI: 10.1109/IWBP.2011.5954859
Jasenka Memisevic, L. Shriver-Lake, P. Howell, J. Golden, N. Hashemi, Kirsten B. Jackson, F. Ligler
{"title":"Automated sample processing for flow cytometry","authors":"Jasenka Memisevic, L. Shriver-Lake, P. Howell, J. Golden, N. Hashemi, Kirsten B. Jackson, F. Ligler","doi":"10.1109/IWBP.2011.5954859","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954859","url":null,"abstract":"The utility of pathogen and toxin detection systems depends not only upon sensitivity, specificity and capability for multiplexed recognition, but also on access at the point of need, ease of use, and response time. Combining microfluidics and optical biosensors facilitates miniaturization and automation, while careful design makes it possible to test variable quantities of complex matrices such as food (mL) and clinical samples (µL). We report on progress towards an optofluidic system that combines a rotating magnet trap for automated sample processing and a microflow cytometer capable of 4-color analysis to achieve multi-analyte diagnostics. Sample and antibody-coated magnetic beads are introduced into a moving magnetic field created by magnets rotating in the opposite direction of the flow. The color-coded magnetic beads with captured target remain in suspension while fluorescent tracer reagents are introduced to the flow, thus optimizing the binding kinetics and minimizing aggregation. Magnetic beads with bound target and tracer reagents are released for multiplexed analysis by reversing the direction of spinning magnets.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122781479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Raman spectroscopy - An essential tool for biophotonics 拉曼光谱-生物光子学的重要工具
2011 International Workshop on Biophotonics Pub Date : 2011-06-08 DOI: 10.1109/IWBP.2011.5954844
J. Popp, B. Dietzek, M. Schmitt, P. Rosch, R. Moller, C. Krafft
{"title":"Raman spectroscopy - An essential tool for biophotonics","authors":"J. Popp, B. Dietzek, M. Schmitt, P. Rosch, R. Moller, C. Krafft","doi":"10.1109/IWBP.2011.5954844","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954844","url":null,"abstract":"We will present modern trends in Raman microspectroscopy spanning a multitude of different Raman based technologies from e.g. Raman-microspectroscopy, UV resonance Raman, SERS, towards nonlinear Raman microscopy (CARS) for biomedical diagnosis.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117099677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Studying mammalian development with optical coherence tomography 用光学相干断层扫描研究哺乳动物的发育
2011 International Workshop on Biophotonics Pub Date : 2011-06-08 DOI: 10.1109/IWBP.2011.5954819
I. Larina, M. Dickinson, K. Larin
{"title":"Studying mammalian development with optical coherence tomography","authors":"I. Larina, M. Dickinson, K. Larin","doi":"10.1109/IWBP.2011.5954819","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954819","url":null,"abstract":"The mouse provides an excellent model for studying mammalian development and disease because of the resemblance to humans, potential for genetic manipulation, and rapid generation time. However, mammalian embryos develop in utero, which limits the ability to observe development with high-resolution. In this study, we adopted Swept Source Optical Coherence Tomography (SS-OCT) for live visualization of mouse embryos during different stages of the development. We demonstrate capability of OCT as a novel methodology for live imaging of mouse embryos both in culture and through the uterine wall.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133642936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Femtosecond laser micromachining for the realization of fully integrated optofluidic devices 飞秒激光微加工实现全集成光流器件
2011 International Workshop on Biophotonics Pub Date : 2011-06-08 DOI: 10.1109/IWBP.2011.5954858
R. Osellame, R. Martínez Vázquez, A. Crespi, G. Cerullo, R. Ramponi
{"title":"Femtosecond laser micromachining for the realization of fully integrated optofluidic devices","authors":"R. Osellame, R. Martínez Vázquez, A. Crespi, G. Cerullo, R. Ramponi","doi":"10.1109/IWBP.2011.5954858","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954858","url":null,"abstract":"Femtosecond laser micromachining is a powerful tool for the fabrication of both optical waveguides and, when followed by chemical etching, of microchannels, with unprecedented intrinsic 3D capabilities. Basics of the technique and examples of fully integrated optofluidic devices are presented.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127380819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication of three-dimensional conducting nanostructures by nonlinear lithography 非线性光刻技术制备三维导电纳米结构
2011 International Workshop on Biophotonics Pub Date : 2011-06-08 DOI: 10.1109/IWBP.2011.5954827
K. Terzaki, A. Gaidukevičiūtė, C. Reinhardt, C. Fotakis, M. Vamvakaki, M. Farsari
{"title":"Fabrication of three-dimensional conducting nanostructures by nonlinear lithography","authors":"K. Terzaki, A. Gaidukevičiūtė, C. Reinhardt, C. Fotakis, M. Vamvakaki, M. Farsari","doi":"10.1109/IWBP.2011.5954827","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954827","url":null,"abstract":"The structuring and metallization of a zirconium-containing organic-inorganic photosensitive material doped with a metal-binding monomer was reported. The silver seeding and reduction parameters were examined and two different metallization techniques, metal bath and silver plating were examined on visual results and ohmic conductivity.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"54 47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123355897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Digital holographic self-referencing quantitative phase microscopy 数字全息自参考定量相位显微镜
2011 International Workshop on Biophotonics Pub Date : 2011-06-08 DOI: 10.1109/IWBP.2011.5954823
M. Paturzo, L. Miccio, S. Grilli, A. Finizio, P. Ferraro, G. Coppola, G. Di Caprio, M. Gioffré, R. Puglisi, D. Balduzzi, A. Galli
{"title":"Digital holographic self-referencing quantitative phase microscopy","authors":"M. Paturzo, L. Miccio, S. Grilli, A. Finizio, P. Ferraro, G. Coppola, G. Di Caprio, M. Gioffré, R. Puglisi, D. Balduzzi, A. Galli","doi":"10.1109/IWBP.2011.5954823","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954823","url":null,"abstract":"A numerical method to easily obtain a quantitative phase map of objects flowing in micro-fluidic devices using a digital holographic microscope is shown. The presented technique is called digital self-referencing because the retrieved wavefront is folded in order to subtract the area outside the micro-fluidic channel from the area where the sample is.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121047150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanobiophotonics: Using the nanophotonics toolbox to manipulate biological fluorophores 纳米光子学:使用纳米光子学工具箱来操纵生物荧光团
2011 International Workshop on Biophotonics Pub Date : 2011-06-08 DOI: 10.1109/IWBP.2011.5954845
C. Blum, N. Zijlstra, Y. Cesa, V. Subramaniam, J. M. van den Broek, A. Mosk, W. Vos
{"title":"Nanobiophotonics: Using the nanophotonics toolbox to manipulate biological fluorophores","authors":"C. Blum, N. Zijlstra, Y. Cesa, V. Subramaniam, J. M. van den Broek, A. Mosk, W. Vos","doi":"10.1109/IWBP.2011.5954845","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954845","url":null,"abstract":"We show that nanophotonic manipulation of biological fluorophores can alter the spectral characteristics of visible fluorescent proteins (VFP), and that the changed spectral properties quantitatively reflect the sub surface quality of photonic crystals. Nanophotonic manipulation of VFP fluorescence lifetimes gives access to the quantum efficiency of emitting states without biasing from dark states, a parameter inaccessible to conventional methods.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"118 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126230544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Optical sensor for extracorporeal blood flow measurement 用于体外血流测量的光学传感器
2011 International Workshop on Biophotonics Pub Date : 2011-06-08 DOI: 10.1109/IWBP.2011.5954834
M. Norgia, A. Pesatori, L. Rovati
{"title":"Optical sensor for extracorporeal blood flow measurement","authors":"M. Norgia, A. Pesatori, L. Rovati","doi":"10.1109/IWBP.2011.5954834","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954834","url":null,"abstract":"This work describes the design and realization of an optical sensor for measuring extracorporeal blood flow. The instrument is realized by means of a self-mixing interferometer and a dedicated data elaboration system, developed by means of a numerical simulator of the blood optical scattering.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121839636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of optical tissue phantom in verification and validation of medical imaging devices 光学组织幻影在医学成像设备验证中的作用
2011 International Workshop on Biophotonics Pub Date : 2011-06-08 DOI: 10.1109/IWBP.2011.5954806
J. Bouchard, I. Noiseux, I. Veilleux, O. Mermut
{"title":"The role of optical tissue phantom in verification and validation of medical imaging devices","authors":"J. Bouchard, I. Noiseux, I. Veilleux, O. Mermut","doi":"10.1109/IWBP.2011.5954806","DOIUrl":"https://doi.org/10.1109/IWBP.2011.5954806","url":null,"abstract":"Optical tissue phantoms are very important tools for the development of biomedical imaging applications. They play an important role from proof of concept to clinical trials. Optical phantoms are often used as reference materials against which instruments results can be compared. It is therefore important that the optical properties of reference phantoms be measured in a manner that is traceable to the international system of units. SI traceability insures long term consistency of results and will therefore improve the effectiveness of diffuse optics research effort more effective by reducing unwanted variability in the data produced and shared by the community. The ultimate benefit of SI traceability is the reduction of variability in the data produced by novel diagnostic devices, which will in turn increase the statistical power of clinical trials aiming at validating their clinical usefulness. SI traceability, which implies uncertainty analysis, is also relevant to traceability aspects mandated by FDA's Good Manufacturing Practices.","PeriodicalId":142421,"journal":{"name":"2011 International Workshop on Biophotonics","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128645800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
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