International Journal of Precision Engineering and Manufacturing-Green Technology最新文献

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Large-Sized Segmented-in-Series SOFC on Flat-Tubular Substrates: Performance and Preliminary Redox Cycling Study 平板基板上的大型分段串联SOFC:性能和初步氧化还原循环研究
3区 工程技术
International Journal of Precision Engineering and Manufacturing-Green Technology Pub Date : 2025-12-18 DOI: 10.1007/s40684-025-00825-x
Yanan Li, Jiu-Tao Gao, Huiyu Zhang, Wanming Li, Changqing Liu, Cheng‐Xin Li
{"title":"Large-Sized Segmented-in-Series SOFC on Flat-Tubular Substrates: Performance and Preliminary Redox Cycling Study","authors":"Yanan Li, Jiu-Tao Gao, Huiyu Zhang, Wanming Li, Changqing Liu, Cheng‐Xin Li","doi":"10.1007/s40684-025-00825-x","DOIUrl":"https://doi.org/10.1007/s40684-025-00825-x","url":null,"abstract":"","PeriodicalId":14238,"journal":{"name":"International Journal of Precision Engineering and Manufacturing-Green Technology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147899532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cholesterol-paclitaxel conjugate nanoparticles for in vivo hitchhiking of serum albumin to enhance antitumor efficacy 胆固醇-紫杉醇结合纳米颗粒体内搭便车血清白蛋白增强抗肿瘤疗效
3区 工程技术
International Journal of Precision Engineering and Manufacturing-Green Technology Pub Date : 2025-08-08 DOI: 10.1016/j.preme.2025.100036
Xiumin Yao, Zhengyuan Xu, Biyou Zhang, Tao Zhang, Chong Ma, Shaojin Lu, Qing Pei, Zhigang Xie
{"title":"Cholesterol-paclitaxel conjugate nanoparticles for in vivo hitchhiking of serum albumin to enhance antitumor efficacy","authors":"Xiumin Yao, Zhengyuan Xu, Biyou Zhang, Tao Zhang, Chong Ma, Shaojin Lu, Qing Pei, Zhigang Xie","doi":"10.1016/j.preme.2025.100036","DOIUrl":"https://doi.org/10.1016/j.preme.2025.100036","url":null,"abstract":"Self-delivery systems are considered to be a promising strategy to optimize drug formulation and improve treatment outcomes. Herein a paclitaxel (PTX) prodrug was designed by modifying PTX with cholesterol molecule with the disulfide bond as the bridging group. The self-delivery PSSch NPs with high content of PTX up to 61.6 ​wt% were obtained by the self-assembly of as-synthesized PTX prodrug in the absence of any adjuvants. PSSch NPs had good colloidal stability and strong interaction with serum albumin. The non-covalent binding to albumin not only accelerated drug release in a reductive environment, but also enhanced cellular endocytosis by tumor cells. After intravenous injection, PSSch NPs exhibited preferential tumor accumulation and superior tumor inhibition effects with the help of serum albumin. This study provides a vital guide for the construction of self-delivery nanoformulations for potentiated chemotherapy. • Modification with cholesterol endows the paclitaxel prodrug with good self-assembly ability. • Binding of PSSch NPs to albumin promoted reductive-responsive drug release. • PSSch NPs had enhanced cellular internalization after interaction with HSA.","PeriodicalId":14238,"journal":{"name":"International Journal of Precision Engineering and Manufacturing-Green Technology","volume":"2 3","pages":"100036-100036"},"PeriodicalIF":0.0,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147880398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A broad−spectrum supramolecular host based on cucurbit[8]uril encapsulation for the reversal of neuromuscular blockade 一种基于瓜bbbbil包封的广谱超分子宿主,用于逆转神经肌肉阻滞
3区 工程技术
International Journal of Precision Engineering and Manufacturing-Green Technology Pub Date : 2025-07-15 DOI: 10.1016/j.preme.2025.100034
Mengyao Li, Meiru Zhang, Rui Fei, Yundong Zhang, Danyu Xia, Shaolong Qi, Jianshi Du
{"title":"A broad−spectrum supramolecular host based on cucurbit[8]uril encapsulation for the reversal of neuromuscular blockade","authors":"Mengyao Li, Meiru Zhang, Rui Fei, Yundong Zhang, Danyu Xia, Shaolong Qi, Jianshi Du","doi":"10.1016/j.preme.2025.100034","DOIUrl":"https://doi.org/10.1016/j.preme.2025.100034","url":null,"abstract":"Reversal agents are crucial for eliminating residual neuromuscular blockade after anesthesia to ensure patient safety. Sugammadex, a supramolecular reversal agent, specifically reverses neuromuscular blockade induced by rocuronium (Roc) and vecuronium (Vec), but it may cause life−threatening adverse reactions. Here, we introduce a PEG−modified, water−soluble cucurbit[8]uril derivative ( CB [8] −PEG ), designed as a broad−spectrum reversal agent to aminosteroid neuromuscular blocking agents (NMBAs) post−anesthesia, via supramolecular encapsulation. CB [8] −PEG is distinguished by its lack of severe adverse effects on electrocardiograms (ECG), renal function, and blood coagulation, offering better biosafety compared with sugammadex. NMR and isothermal titration calorimetry (ITC) studies confirmed its exceptional binding affinities to Vec, Roc, and pancuronium (Pan), which were in the range of 10 5 ∼10 6 ​M −1 , indicating robust host−guest interactions with NMBAs. The in vivo application of CB [8] −PEG significantly hastens neuromuscular recovery and spontaneous breathing, as reflected by a 93.7 ​% reduction in the recovery time of the mice to normal movement, a 98.1 ​% decrease in the spontaneous respiration resumption time of the rabbits, and an 89.8 ​% reduction in the neuromuscular function recovery time of the rabbits. Moreover, biosafety assays imply that CB [8] −PEG performs superior biocompatibility. These findings suggest that CB[8] −PEG is a promising candidate as a clinical broad−spectrum reversal agent for neuromuscular blockade. • The PEG−modified CB[8] derivative CB[8]−PEG enhances water solubility, facilitating its application in vivo. • CB[8] and CB[8]−PEG tightly encapsulate aminosteroid neuromuscular blocking agents via non−covalent interactions. • CB[8]−PEG shows fewer adverse effects on ECG, renal function, and coagulation than the γ−cyclodextrin derivative sugammadex. • CB[8]−PEG rapidly reverses vecuronium, rocuronium, and pancuronium−induced neuromuscular blockade in animals with high biocompatibility.","PeriodicalId":14238,"journal":{"name":"International Journal of Precision Engineering and Manufacturing-Green Technology","volume":"2 3","pages":"100034-100034"},"PeriodicalIF":0.0,"publicationDate":"2025-07-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147886155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Gadolinium coordination nanoparticle-based contrast agent for T1-Weighted magnetic resonance imaging of tumors 钆配位纳米颗粒造影剂在肿瘤t1加权磁共振成像中的应用
3区 工程技术
International Journal of Precision Engineering and Manufacturing-Green Technology Pub Date : 2025-06-01 DOI: 10.1016/j.preme.2025.100033
Guochao Wu, Jie Feng, Ruilong Zhou, Qingdeng Fan, Bin Ren, Ya Huang, Zehui Wang, Lin Huang, Jing Yang, Jiaoyang Zhu, Xiang Qin, Chenggong Yan, Xiangrong Yu, Zheyu Shen
{"title":"Gadolinium coordination nanoparticle-based contrast agent for T1-Weighted magnetic resonance imaging of tumors","authors":"Guochao Wu, Jie Feng, Ruilong Zhou, Qingdeng Fan, Bin Ren, Ya Huang, Zehui Wang, Lin Huang, Jing Yang, Jiaoyang Zhu, Xiang Qin, Chenggong Yan, Xiangrong Yu, Zheyu Shen","doi":"10.1016/j.preme.2025.100033","DOIUrl":"https://doi.org/10.1016/j.preme.2025.100033","url":null,"abstract":"To overcome the problems associated with commercial Gd chelates ( i.e. , low longitudinal relaxivity r 1 , nephrotoxicity, short half-lives in blood circulation, and brain deposition), a type of Gd-based contrast agent (GBCA), i.e. , Gd-coordinated nanoparticles (GCNs), was synthesized and developed as a CA for T 1 -weighted magnetic resonance imaging (MRI). Typically, soybean peptide (SP) was used to coordinate with Gd 3+, forming SP-based GCN nanoparticles (SP-GCNs). The robust coordination between Gd 3+ and SP prevents Gd 3+ release from SP-GCN in vivo , even in acidic environments. The high tumbling time of SP-GCN contributes to high r 1 values (16.20 ± 0.08 mM -1 s -1 at 3.0 T, 10.58 ± 0.12 mM -1 s -1 at 7.0 T), resulting in a reduced Gd dosage and nephrotoxicity risk. The very low r 2 / r 1 ratios (1.23 ± 0.03 at 3.0 T and 1.52 ± 0.01 at 7.0 T) make the SP-GCN highly suitable for T 1 -weighted MRI. Furthermore, SP-GCN is water dispersible and stable, and has a small particle size of 6.91 nm and a relatively long blood circulation half-life (1.48 h). In vitro and in vivo MRI efficacy studies and biocompatibility assessments indicate that the SP-GCN is an outstanding T 1 -weighted MRI CA. • A type of Gd-based contrast agent (GBCA), i.e. , Gd-coordinated nanoparticles (GCNs), was synthesized and developed as a CA for T 1 -weighted magnetic resonance imaging (MRI). • GCNs can overcome the problems of conventional GBCAs, i.e. , Gd chelates and Gd oxide nanoparticles (GONs). • Soybean peptide (SP) was used to coordinate with Gd 3+ to form SP-based GCN nanoparticles (SP-GCNs). • The high tumbling time of SP-GCN contributes to high r 1 values (16.20 ± 0.08 mM -1 s -1 at 3.0 T, 10.58 ± 0.12 mM -1 s -1 at 7.0 T), resulting in a reduced Gd dosage and nephrotoxicity risk.","PeriodicalId":14238,"journal":{"name":"International Journal of Precision Engineering and Manufacturing-Green Technology","volume":"2 2","pages":"100033-100033"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147331031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
NIR-II-responsive photothermal microneedle patch loaded with myricetin nanodrugs for the treatment of drug-resistant bacteria-infected wounds 负载杨梅素纳米药物的nir - ii响应性光热微针贴片治疗耐药细菌感染创面
3区 工程技术
International Journal of Precision Engineering and Manufacturing-Green Technology Pub Date : 2025-04-15 DOI: 10.1016/j.preme.2025.100028
Chuanlan Xia, Xinwei Fu, Xin Luo, Bo Wang, Bo Wang, Shan Yi Du, Zhensen Pan, Yunlong Yu, Zhong Li, Yuejun Kang, Bin Wang, Bin Wang
{"title":"NIR-II-responsive photothermal microneedle patch loaded with myricetin nanodrugs for the treatment of drug-resistant bacteria-infected wounds","authors":"Chuanlan Xia, Xinwei Fu, Xin Luo, Bo Wang, Bo Wang, Shan Yi Du, Zhensen Pan, Yunlong Yu, Zhong Li, Yuejun Kang, Bin Wang, Bin Wang","doi":"10.1016/j.preme.2025.100028","DOIUrl":"https://doi.org/10.1016/j.preme.2025.100028","url":null,"abstract":"Drug-resistant bacterium-infected wounds pose a serious threat to human health and constitute one of the major causes of death in the clinic. It is necessary to develop a novel treatment platform with remarkable anti-infective properties and wound-healing ability. Herein, a myricetin nanodrug-loaded microneedle patch (HMY-HA@SF-MNs) with a photothermal therapeutic effect and wound healing capacity was designed and fabricated for the treatment of drug-resistant bacterium-infected wounds. The nanodrug is synthesized by self-assembly of myricetin, Mg 2+ and humic acid, which results in outstanding anti-inflammatory and antioxidant effects and thus further promotes cell proliferation. In addition, the nanodrug-loaded microneedle patch shows strong photothermic conversion efficiency, and its temperature can increase to 60.3 ​°C under irradiation with a 1064 ​nm near-infrared (NIR) laser. The microneedle patch had high biological safety, demonstrated remarkable reactive oxygen species (ROS) scavenging activity and had a significant therapeutic effect on Methicillin-resistant Staphylococcus aureus -infected wounds under NIR irradiation. The myricetin nanodrug-based microneedle patch may serve as an efficient route for clinical application in the treatment of drug-resistant bacterium-infected wounds. • A NIR-II-responsive photothermal platform has been designed for treating drug-resistant bacterial infections in wounds, integrating anti-inflammatory, antibacterial, and enhanced cell proliferation properties. • This approach overcomes the limitations of the low solubility and poor permeability of myricetin in its application.","PeriodicalId":14238,"journal":{"name":"International Journal of Precision Engineering and Manufacturing-Green Technology","volume":"2 2","pages":"100028-100028"},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147879911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Zwitterionic polymers improve the therapeutic effect of silk fibroin-based nanomedicines against ulcerative colitis via the oral route 两性离子聚合物通过口服途径改善丝素纳米药物对溃疡性结肠炎的治疗效果
3区 工程技术
International Journal of Precision Engineering and Manufacturing-Green Technology Pub Date : 2025-03-28 DOI: 10.1016/j.preme.2025.100027
Cheng Xu, Xue Xia, Ga Liu, Yajun Wang, Bo Xiao
{"title":"Zwitterionic polymers improve the therapeutic effect of silk fibroin-based nanomedicines against ulcerative colitis via the oral route","authors":"Cheng Xu, Xue Xia, Ga Liu, Yajun Wang, Bo Xiao","doi":"10.1016/j.preme.2025.100027","DOIUrl":"https://doi.org/10.1016/j.preme.2025.100027","url":null,"abstract":"The efficiency of oral drug delivery for treating ulcerative colitis (UC) is often limited by poor mucus-penetrating capability and inadequate drug accumulation in the colitis tissues. To address these issues, we developed zwitterionic polymer-modified silk fibroin-based nanoparticles (NPs). These NPs exhibited a nanoscale size of approximately 200 ​nm with a highly uniform size distribution and a slight negative surface charge (−10 ​mV). Notably, the zwitterionic NPs demonstrated enhanced mucus-penetrating ability and increased uptake efficiency by macrophages compared with the control NPs, resulting in significant anti-inflammatory and antioxidant activities. In vivo studies further revealed that orally administered zwitterionic NPs preferentially accumulated in colitis tissues and outperformed the clinical drug dexamethasone in terms of anti-inflammatory and mucosal repair effects in both acute and chronic colitis models. These findings suggest that zwitterionic polymer-modified NPs represent a promising oral drug delivery platform for the effective treatment of UC. • Zwitterionic pluronic polymers were synthesized and used to functionalize the silk fibroin-based nanoparticles (SFNPs). • Zwitterionic polymers enhanced the motion of SFNPs in the mucus layer. • Zwitterionic polymers counteracted the negative effects of polyethylene glycol on the cellular uptake of SFNPs. • Zwitterionic functionalization improved the therapeutic effect of SFNPs in the treatment of ulcerative colitis.","PeriodicalId":14238,"journal":{"name":"International Journal of Precision Engineering and Manufacturing-Green Technology","volume":"2 2","pages":"100027-100027"},"PeriodicalIF":0.0,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147908378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Nanodrug delivery system for precision treatment of pulmonary fibrosis 纳米给药系统用于肺纤维化的精准治疗
3区 工程技术
International Journal of Precision Engineering and Manufacturing-Green Technology Pub Date : 2025-03-21 DOI: 10.1016/j.preme.2025.100025
Xianhao Yi, Xinru Zhang, Yuanye Guan, Yun Sha, Xiaoliang Cheng, Yong Chul Lee, Wei‐En Yuan
{"title":"Nanodrug delivery system for precision treatment of pulmonary fibrosis","authors":"Xianhao Yi, Xinru Zhang, Yuanye Guan, Yun Sha, Xiaoliang Cheng, Yong Chul Lee, Wei‐En Yuan","doi":"10.1016/j.preme.2025.100025","DOIUrl":"https://doi.org/10.1016/j.preme.2025.100025","url":null,"abstract":"Pulmonary fibrosis (PF) is a chronic lung disease with high morbidity and mortality, complex pathological mechanisms and limited available treatments. Recently, the rapid development of nanotechnology has brought new hope for treating PF. Owing to their unique advantages in drug delivery, oxidative stress modulation, and gene protection, nanomaterials are capable of optimizing therapeutic efficacy and reversing side effects. In this review, the basic pathological mechanisms of PF are first introduced. Second, the application potential of various nanomaterials for treating PF is summarized. Finally, their advantages and challenges are discussed in detail, providing references for developing more promising and precise therapeutic strategies in the future. • This article summarizes the pathogenesis of pulmonary fibrosis (PF) and key therapeutic targets. • Recent advancements in nanotechnology applications for PF treatment are discussed. • This review highlights the advantages and challenges of nanotherapies and provides prospects for future developments.","PeriodicalId":14238,"journal":{"name":"International Journal of Precision Engineering and Manufacturing-Green Technology","volume":"2 2","pages":"100025-100025"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147877491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Chitosan hydrogels loaded with pH-responsive nanozymes for precision treatment of wound infection 负载ph反应纳米酶的壳聚糖水凝胶用于伤口感染的精确治疗
3区 工程技术
International Journal of Precision Engineering and Manufacturing-Green Technology Pub Date : 2024-11-28 DOI: 10.1016/j.preme.2024.100014
Binglin Ye, Xiaojiong Bao, Danfeng Jian, Huang Yang, Lulu Jin, Zongrui Tong
{"title":"Chitosan hydrogels loaded with pH-responsive nanozymes for precision treatment of wound infection","authors":"Binglin Ye, Xiaojiong Bao, Danfeng Jian, Huang Yang, Lulu Jin, Zongrui Tong","doi":"10.1016/j.preme.2024.100014","DOIUrl":"https://doi.org/10.1016/j.preme.2024.100014","url":null,"abstract":"Chronic wounds often exhibit protracted healing processes, predominantly attributed to the pervasive presence of bacterial pathogens. Nanozymes with reactive oxygen species (ROS) generation capabilities have become a burgeoning strategy within the realm of antibacterial intervention. However, an overabundance of toxic ROS can cause damage to healthy tissues surrounding the wound or during the tissue regeneration phase. Thus, there is a need for an accurate antibacterial dressing that can be applied directly to wounds. In this study, we fabricated chitosan hydrogels loaded with pH-responsive palladium (Pd) nanozymes (Pd@QCS/OD) for precision treatment of wound infection. The peroxidase-like activity of Pd enzymes can be triggered by the acidic microenvironment of infected wounds and then generate many poisonous hydroxyl radicals to achieve precise antibacterial behavior. Moreover, chitosan hydrogels synthesized via a Schiff base reaction are conducive to subsequent tissue regeneration. Both in vitro and in vivo experiments demonstrated that the Pd@QCS/OD hydrogels had effective antibacterial effects and accelerated wound recovery. This research offers some insight into the precise treatment of bacterial infections. • Development of a hydrogel dressing for precise treatment of wound infection. • The dressing was prepared from chitosan hydrogels loaded with palladium nanozymes. • The dressing can generate hydroxyl radicals in an acidic environment to kill bacteria precisely.","PeriodicalId":14238,"journal":{"name":"International Journal of Precision Engineering and Manufacturing-Green Technology","volume":"1 2","pages":"100014-100014"},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147889998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Research on enzymatic co-assembly nanomedicine in oral squamous cell carcinoma 酶促共组装纳米药物治疗口腔鳞状细胞癌的研究
3区 工程技术
International Journal of Precision Engineering and Manufacturing-Green Technology Pub Date : 2024-09-13 DOI: 10.1016/j.preme.2024.100008
Zhijun Xue, Yaxuan Guo, Yuanzhu Zhou, Lin Qiu, Jingrui Xin, Dan Ding, Jing Shen
{"title":"Research on enzymatic co-assembly nanomedicine in oral squamous cell carcinoma","authors":"Zhijun Xue, Yaxuan Guo, Yuanzhu Zhou, Lin Qiu, Jingrui Xin, Dan Ding, Jing Shen","doi":"10.1016/j.preme.2024.100008","DOIUrl":"https://doi.org/10.1016/j.preme.2024.100008","url":null,"abstract":"Oral squamous cell carcinoma (OSCC) represents the predominant form of malignancy within the head and neck region, accounting for more than 90 ​% of all oral cavity tumors. OSC cells commonly overexpress epidermal growth factor receptor (EGFR), which is closely associated with the development, progression, and differentiation of tumors. Despite surgery and chemotherapy being the primary therapeutic interventions for OSCC, their efficacy is suboptimal compared with that of other oral malignancies. We engineered a polypeptide molecule (HCPT-G D F D F D pYERGD, designated HP), which features the chemotherapeutic agent 10-hydroxycamptothecin (HCPT) at its N-terminus and the tumor-homing ligand Arginine-Glycine-Aspartic acid (RGD) at its C-terminus. The RGD moiety confers upon the polypeptide the ability to co-target cancer cells synergistically. The EGFR inhibitor cetuximab was co-assembled with HP via an enzymatic catalysis co-assembly technique to create a nanofibrillar structure, resulting in antibody‒polypeptide coassembly. In vitro assays have demonstrated that the co-assembled nanomedicine exhibits high affinity for OSCC cells, is efficiently internalized, and elicits potent inhibitory effects. Furthermore, bioinformatics analysis suggested that the co-assembled nanomedicine downregulated genes enriched in the PI3K-Akt signaling cascade. The co-assembled nanomedicine dramatically reduces cancer while sparing negative effects, as shown by in vivo animal models. This research endeavors to develop a new nanomedicine delivery platform that integrates molecular targeting with efficient intracellular drug delivery. This system not only markedly augments the therapeutic efficacy of the chemotherapeutic agent HCPT but also substantially mitigates patient adverse effects, thus offering a more secure and efficacious therapeutic strategy for the management of OSCC. • Oral squamous cell carcinoma (OSCC) can exhibit heightened levels of epidermal growth factor receptor expression. • The overexpression of EGFR is connected to the occurrence, development, and diversity of tumors. • Enzyme-Mediated Co-assembly Nanodrugs with Molecular Targeting Capabilities. • Co-assembled nanomedicine exhibits significant anticancer efficacy. • Co-assembled nanomedicine can induce enrichment of genes related to tumors.","PeriodicalId":14238,"journal":{"name":"International Journal of Precision Engineering and Manufacturing-Green Technology","volume":"1 2","pages":"100008-100008"},"PeriodicalIF":0.0,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147878573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Online Vibration Detection in High-Speed Robotic Milling Process Based on Wavelet Energy Entropy of Acoustic Emission 基于声发射小波能量熵的高速机器人铣削过程在线振动检测
IF 4.2 3区 工程技术
International Journal of Precision Engineering and Manufacturing-Green Technology Pub Date : 2024-09-11 DOI: 10.1007/s40684-024-00660-6
Maojun Li, Yajie Chen, Guanbo Wang, Zilei Wen, Xujing Yang
{"title":"Online Vibration Detection in High-Speed Robotic Milling Process Based on Wavelet Energy Entropy of Acoustic Emission","authors":"Maojun Li, Yajie Chen, Guanbo Wang, Zilei Wen, Xujing Yang","doi":"10.1007/s40684-024-00660-6","DOIUrl":"https://doi.org/10.1007/s40684-024-00660-6","url":null,"abstract":"<p>This work used acoustic emission (AE) technique to detect machining vibrations during robotic milling process, and elaborated the impact mechanism of milling vibrations on surface roughness and residual stress. The findings indicated that the features relating to machining vibration included a sudden increase of amplitude in the time domain, and variations of frequency distribution in the frequency domain. The duration of machining vibration was exceedingly brief, and the changes of frequency distribution were mainly concentrated in 150–730 kHz. For the processing of AE signals, wavelet energy entroy (WEE) was selected as a detection indicator to monitor machining vibration. A laser vibrometer was also used to collect radial vibration signals for verification, which have similar characteristics with AE signals, confirming the effectiveness of vibration detecting based on AE method. At low spindle speeds, machining vibration is prone to occur at the cut-in and cut-out positions, and tends to become more frequent with the increase of feed speed. High spindle speed and low feed speed can effectively avoid the occurrence of machining vibration. The severe machining vibration occurred when the milling speed was set at 10,000 rpm with feed speed of 1440 mm/min. The influence of robotic milling vibration on surface integrity was also evaluated in details. The amplitude and frequency of machining vibrations during the robotic milling process are random, making the impact mechanism on surface integrity highly complex. Depending on specific conditions, these vibrations could result in deteriorated milling surfaces.</p>","PeriodicalId":14238,"journal":{"name":"International Journal of Precision Engineering and Manufacturing-Green Technology","volume":"171 1","pages":""},"PeriodicalIF":4.2,"publicationDate":"2024-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142197619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"工程技术","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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