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International Journal of Pancreatology最新文献

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Oxidative stress 氧化应激
International Journal of Pancreatology Pub Date : 2022-01-07 DOI: 10.1007/BF02924357
A. Dabrowski, A. Gabryelewicz
{"title":"Oxidative stress","authors":"A. Dabrowski, A. Gabryelewicz","doi":"10.1007/BF02924357","DOIUrl":"https://doi.org/10.1007/BF02924357","url":null,"abstract":"","PeriodicalId":14226,"journal":{"name":"International Journal of Pancreatology","volume":"28 1","pages":"193-199"},"PeriodicalIF":0.0,"publicationDate":"2022-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88216293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgery in acute pancreatitis 急性胰腺炎的外科治疗
International Journal of Pancreatology Pub Date : 2007-10-01 DOI: 10.1007/BF02925580
E. Bradley, E. Steinhaus
{"title":"Surgery in acute pancreatitis","authors":"E. Bradley, E. Steinhaus","doi":"10.1007/BF02925580","DOIUrl":"https://doi.org/10.1007/BF02925580","url":null,"abstract":"","PeriodicalId":14226,"journal":{"name":"International Journal of Pancreatology","volume":"6 1","pages":"67-73"},"PeriodicalIF":0.0,"publicationDate":"2007-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87358138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
In vivo effect of pancreatic phospholipase A2 on the arachidonic acid cascade 胰腺磷脂酶A2对花生四烯酸级联反应的体内影响
International Journal of Pancreatology Pub Date : 2001-01-01 DOI: 10.1385/IJGC:29:2:069
Makoto Motoyoshi, M. Sugiyama, Y. Atomi, W. Kimura, H. Nagawa
{"title":"In vivo effect of pancreatic phospholipase A2 on the arachidonic acid cascade","authors":"Makoto Motoyoshi, M. Sugiyama, Y. Atomi, W. Kimura, H. Nagawa","doi":"10.1385/IJGC:29:2:069","DOIUrl":"https://doi.org/10.1385/IJGC:29:2:069","url":null,"abstract":"","PeriodicalId":14226,"journal":{"name":"International Journal of Pancreatology","volume":"212 1","pages":"69-76"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76174675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
A novel, clinically relevant animal model of metastatic pancreatic adenocarcinoma biology and therapy. 一种新的、临床相关的转移性胰腺腺癌动物模型的生物学和治疗。
International Journal of Pancreatology Pub Date : 2001-01-01 DOI: 10.1385/IJGC:29:1:37
B Wang, Q Shi, J L Abbruzzese, Q Xiong, X Le, K Xie
{"title":"A novel, clinically relevant animal model of metastatic pancreatic adenocarcinoma biology and therapy.","authors":"B Wang, Q Shi, J L Abbruzzese, Q Xiong, X Le, K Xie","doi":"10.1385/IJGC:29:1:37","DOIUrl":"10.1385/IJGC:29:1:37","url":null,"abstract":"<p><p>In this study, we report a metastatic model of Panc02 murine pancreatic adenocarcinoma. Parental Panc02 cells were orthotopically implanted into the pancreas of syngeneic C57BL/6 mice. Tumor cells were isolated from liver micrometastases 90 d after tumor implantation and established as a culture (Panc02-H1). The Panc02-H1 cells were then implanted into the pancreas of mice. Liver metastases were then collected and established as Panc02-H2 cells. This process was repeated until the Panc02-H7 cell line was established. These cells were extremely aggressive after implantation as manifested by progressive growth in the pancreas, peritoneal dissemination, and distant metastasis to multiple organs, including the liver and lungs. Moreover, Panc02-H7 cells expressed the inducible nitric oxide synthase gene at a very low level in culture and produced highly vascularized tumors having a large number of infiltrating macrophages. Collectively, this model system should be a valuable tool for investigating the molecular mechanisms governing pancreatic cancer growth and metastasis and exploring potential treatment modalities for this disease.</p>","PeriodicalId":14226,"journal":{"name":"International Journal of Pancreatology","volume":"65 1","pages":"37-46"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76504927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Portal vein thrombosis and pancreatic failure 门静脉血栓和胰腺衰竭
International Journal of Pancreatology Pub Date : 2001-01-01 DOI: 10.1385/IJGC:29:2:107
N. Afzal, M. Brueton, J. Fell, A. Baker
{"title":"Portal vein thrombosis and pancreatic failure","authors":"N. Afzal, M. Brueton, J. Fell, A. Baker","doi":"10.1385/IJGC:29:2:107","DOIUrl":"https://doi.org/10.1385/IJGC:29:2:107","url":null,"abstract":"","PeriodicalId":14226,"journal":{"name":"International Journal of Pancreatology","volume":"9 1","pages":"107-111"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74385743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Pancreatic arteriovenous malformation associated with duodenal ulcer and H.Pylori infection 胰动静脉畸形与十二指肠溃疡和幽门螺杆菌感染有关
International Journal of Pancreatology Pub Date : 2001-01-01 DOI: 10.1385/IJGC:29:2:113
N. Régenet, J. Tuech, P. Pessaux, C. Aubé, M. Rousselet, J. Arnaud
{"title":"Pancreatic arteriovenous malformation associated with duodenal ulcer and H.Pylori infection","authors":"N. Régenet, J. Tuech, P. Pessaux, C. Aubé, M. Rousselet, J. Arnaud","doi":"10.1385/IJGC:29:2:113","DOIUrl":"https://doi.org/10.1385/IJGC:29:2:113","url":null,"abstract":"","PeriodicalId":14226,"journal":{"name":"International Journal of Pancreatology","volume":"29 1","pages":"113-116"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79057673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
WR-2721 reduces intestinal toxicity from concurrent gemcitabine and radiation treatment WR-2721减少吉西他滨和放疗同时引起的肠道毒性
International Journal of Pancreatology Pub Date : 2001-01-01 DOI: 10.1385/IJGC:29:1:19
T. Phan, C. Crane, N. Janjan, E. Vrdoljak, L. Milas, K. Mason
{"title":"WR-2721 reduces intestinal toxicity from concurrent gemcitabine and radiation treatment","authors":"T. Phan, C. Crane, N. Janjan, E. Vrdoljak, L. Milas, K. Mason","doi":"10.1385/IJGC:29:1:19","DOIUrl":"https://doi.org/10.1385/IJGC:29:1:19","url":null,"abstract":"","PeriodicalId":14226,"journal":{"name":"International Journal of Pancreatology","volume":"26 1","pages":"19-23"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91282979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Expression of the IIIc variant of FGF receptor-1 confers mitogenic responsiveness to heparin and FGF-5 in TAKA-1 pancreatic ductal cells. 在TAKA-1胰腺导管细胞中，FGF受体-1的IIIc变体的表达赋予了肝素和FGF-5的有丝分裂反应性。
International Journal of Pancreatology Pub Date : 2001-01-01 DOI: 10.1385/IJGC:29:2:085
M Kornmann, M E Lopez, H G Beger, M Korc
{"title":"Expression of the IIIc variant of FGF receptor-1 confers mitogenic responsiveness to heparin and FGF-5 in TAKA-1 pancreatic ductal cells.","authors":"M Kornmann, M E Lopez, H G Beger, M Korc","doi":"10.1385/IJGC:29:2:085","DOIUrl":"10.1385/IJGC:29:2:085","url":null,"abstract":"<p><strong>Background: </strong>Fibroblast growth factors (FGFs) contribute to angiogenesis and mitogenesis by binding to tyrosine kinase receptors termed FGF receptors (FGFRs). FGF-5 is a secreted FGF that is believed to preferentially act via the IIIc splice variant of FGFR-1. Human pancreatic ductal carcinoma cells express FGF-5 and FGFR-1IIIc, implying a potential for autocrine growth modulation.</p><p><strong>Aim: </strong>In this study we investigated the importance of FGFR-1 IIIc expression for FGF-5 mitogenic signaling in a pancreatic ductal cell line.</p><p><strong>Methods: </strong>A cDNA encoding FGFR-1 IIIc was expressed in the well-differentiated TAKA-1 Syrian hamster pancreatic ductal cell line.</p><p><strong>Results: </strong>TAKA-1 cells secrete FGF-5, but were found not to express FGFR-1 and to be unresponsive to exogenous FGF-5. In contrast, TAKA-1 clones expressing FGFR-1 IIIc were growth stimulated in the presence of FGF-5 and displayed enhanced mitogen-activated protein kinase (MAPK) activity in the presence of FGF-5. PD98059, an inhibitor of this pathway, inhibited FGF-5-induced growth in these clones.</p><p><strong>Conclusion: </strong>Our data demonstrate that FGFR-1 IIIc can mediate FGF-5-induced mitogenesis via the MAPK pathway in pancreatic ductal cells, and suggest that expression of FGFR-1 IIIc in conjunction with FGF-5 may contribute to the pathobiology of human pancreatic cancer.</p>","PeriodicalId":14226,"journal":{"name":"International Journal of Pancreatology","volume":"96 1","pages":"85-92"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88043709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mouse models of metastatic pancreatic adenocarcinoma. 转移性胰腺腺癌小鼠模型。
International Journal of Pancreatology Pub Date : 2001-01-01 DOI: 10.1385/IJGC:29:1:25
K Xie, B Wang, Q Shi, J L Abbruzzese, Q Xiong, X Le
{"title":"Mouse models of metastatic pancreatic adenocarcinoma.","authors":"K Xie, B Wang, Q Shi, J L Abbruzzese, Q Xiong, X Le","doi":"10.1385/IJGC:29:1:25","DOIUrl":"10.1385/IJGC:29:1:25","url":null,"abstract":"<p><p>Pancreatic adenocarcinoma is a deadly disease. Its etiology is unknown, and metastatic disease kills the majority of patients who have it. Effective prevention is clearly the ultimate goal for eradicating this disease provided that the effects of environmental and genetic elements on pancreatic cancer development are fully understood. Currently, it appears that the control of pancreatic cancer metastasis is of immediate urgency. Fulfillment of this difficult task relies on knowledge of the cellular and molecular biology of metastasis. The use of relevant animal models will help define each aspect of this complicated process.</p>","PeriodicalId":14226,"journal":{"name":"International Journal of Pancreatology","volume":"28 1","pages":"25-35"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79124588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fourth annual scientific conference of the lustgarten foundation for pancreatic cancer research June 19–20, 2002 第四届胰腺癌研究基金会年度科学会议于2002年6月19-20日举行
International Journal of Pancreatology Pub Date : 2001-01-01 DOI: 10.1007/s12029-001-0003-y
{"title":"Fourth annual scientific conference of the lustgarten foundation for pancreatic cancer research June 19–20, 2002","authors":"","doi":"10.1007/s12029-001-0003-y","DOIUrl":"https://doi.org/10.1007/s12029-001-0003-y","url":null,"abstract":"","PeriodicalId":14226,"journal":{"name":"International Journal of Pancreatology","volume":"6 1","pages":"181"},"PeriodicalIF":0.0,"publicationDate":"2001-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78193357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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