International Journal of Pharmaceutical Research最新文献_第4页

Action of Ultra-low Dose Medicine on Oxidative Stress and Cell Stiffness of Microglial Cells In Vitro with Actin Filaments Reorganization 超低剂量药物对体外肌动蛋白丝重组小胶质细胞氧化应激和细胞硬度的影响

International Journal of Pharmaceutical Research Pub Date : 2022-01-01 DOI: 10.31838/ijpr/2022.14.01.016

引用次数: 0

Recent Progress And Biomedical Applications Of Metal Oxide Based Biodegradable Polymer Nanocomposites –An Overview 金属氧化物基可生物降解聚合物纳米复合材料的研究进展及生物医学应用综述

International Journal of Pharmaceutical Research Pub Date : 2022-01-01 DOI: 10.31838/ijpr/2022.14.01.007

引用次数: 0

Enhancing and improvement of plant growth by using Bacillus isolate GK15 from rhizosphere soil 根际土壤分离芽孢杆菌GK15促进和改善植物生长

International Journal of Pharmaceutical Research Pub Date : 2022-01-01 DOI: 10.31838/ijpr/2022.14.01.006

引用次数: 0

Novel nano-metal complexes of modified aspirin as future antimicrobial agents 新型纳米金属配合物改性阿司匹林作为未来抗菌剂

International Journal of Pharmaceutical Research Pub Date : 2022-01-01 DOI: 10.31838/ijpr/2022.14.01.015

引用次数: 1

A Review on Metformin: Clinical Significance and Side Effects 二甲双胍的临床意义及不良反应综述

International Journal of Pharmaceutical Research Pub Date : 2021-11-30 DOI: 10.31838/ijpr/2021.13.03.020

M. Avijit, Singh Ashini

{"title":"A Review on Metformin: Clinical Significance and Side Effects","authors":"M. Avijit, Singh Ashini","doi":"10.31838/ijpr/2021.13.03.020","DOIUrl":"https://doi.org/10.31838/ijpr/2021.13.03.020","url":null,"abstract":"Metformin is a biguanide that has been used extensively worldwide for the treatment of type II diabetes mellitus. It improves glycaemic control by enhancing insulin sensitivity in liver and muscle. An advantage of metformin treatment is the tendency of weight reduction and the absence of significant hypoglycaemia; blood glucose levels are reduced only to normal as it does not stimulate insulin secretion. Metformin also has a beneficial effect on several cardiovascular risk factors including dyslipidemia, elevated plasminogen activator inhibitor 1 levels, other fibrinolytic abnormalities, hyperinsulinemia, and insulin resistance. Metformin enhances muscle and adipocyte insulin receptor number and/or affinity, increases insulin receptor tyrosine kinase activity, stimulates glucose transport and glycogen synthesis, and reduces both hepatic gluconeogenesis and glycogenolysis. The disadvantages are confined to the gastro-intestinal side effects and the potential risk of vitamin B 12 and folic acid deficiency during long-term use. These side effects can be minimized by slow titration and consumption with meals. The under lying mechanism for gastrointestinal intolerance are proposed to be stimulation of intestinal secretion of serotonin, alteration in incretin and metabolism of glucose, and malabsorption of bile salts. Lactic acidosis is rare contraindication associated with metformin. Most reported cases of lactic acidosis occur in patients with contraindications, particularly impaired renal function. Metformin has a good safety profile, efficacy and comparatively reduced cost. Its ability to improve insulin sensitivity and the cardiovascular risk profile of type II diabetic patients has enhanced its clinical use as first-line therapy.","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75198821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Ayurvedic Management Of Knee Joint Pain Associated With Sthaulya- Single Case Study. 阿育吠陀治疗与水草相关的膝关节疼痛-单例研究。

International Journal of Pharmaceutical Research Pub Date : 2021-08-02 DOI: 10.31838/ijpr/2021.13.03.192

引用次数: 0

COVID-19 vaccine hesitancy assessment among the educated Indian population: An online survey 印度受教育人群COVID-19疫苗犹豫评估:一项在线调查

International Journal of Pharmaceutical Research Pub Date : 2021-08-02 DOI: 10.31838/ijpr/2021.13.03.196

K. Choudhary, P. Garapati, S. Prasad, K. Murti, S. Singh, N. Kumar

{"title":"COVID-19 vaccine hesitancy assessment among the educated Indian population: An online survey","authors":"K. Choudhary, P. Garapati, S. Prasad, K. Murti, S. Singh, N. Kumar","doi":"10.31838/ijpr/2021.13.03.196","DOIUrl":"https://doi.org/10.31838/ijpr/2021.13.03.196","url":null,"abstract":"The COVID-19 (SARS-Cov-2) pandemic has emerged in Wuhan city, China and spread globally. Despite Government lockdown process in India the number of infected people increases day by day. The only way to curb this pandemic is vaccination but still people are reluctant to receive COVID-19 vaccine. Hence online survey-based study was conducted to know Indians perception towards vaccination and reason behind their hesitancy. The online questionnaire in Google form has been circulated among people through Email and WhatsApp. 272 responses were included for analysis. The collected data were analysed by SPSS version 26 using t test and ANOVA by considering p value of less than 0.05 as significant. The study reveals that among participants 60% have good knowledge about COVID-19 and major source of information received from News (n=140), Social media (n=131) and Government website (n=101). The 58.8% among participants are willing to take vaccine and major reason behind hesitancy towards vaccine is side effect and safety concern. Focused intervention programmes and awareness campaign development will be essential by utilising social media and news channels. Govt. official needed to release newsletter through their website about safety and efficacy of vaccine to remove hesitancy among people.","PeriodicalId":14220,"journal":{"name":"International Journal of Pharmaceutical Research","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79236929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Anti-Helicobacter pylori activity of aqueous extracts from Achyrocline species and Pseudognaphalium gaudichaudianum Achyrocline和Pseudognaphalium gaudichadidianum水提物抗幽门螺杆菌活性研究

International Journal of Pharmaceutical Research Pub Date : 2021-08-02 DOI: 10.31838/ijpr/2021.13.03.198

引用次数: 0

Formulation and Evaluation of Lercanidipine Loaded Solid Lipid Nanoparticles By Design Of Experiment 利卡尼地平负载固体脂质纳米颗粒的制备及实验设计评价

International Journal of Pharmaceutical Research Pub Date : 2021-08-02 DOI: 10.31838/ijpr/2021.13.03.200

引用次数: 0

Some parasites that might be related to the occurrence of cancer 一些寄生虫可能与癌症的发生有关

International Journal of Pharmaceutical Research Pub Date : 2021-08-02 DOI: 10.31838/ijpr/2021.13.03.190

引用次数: 0