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Anti-Inflammatory and Antimicrobial Activities of Essential Oil of Urochloa distachya (L.) 尿藻挥发油的抗炎抑菌活性研究
International Journal of Pharmaceutical Investigation Pub Date : 2025-04-23 DOI: 10.5530/ijpi.20250283
Smrutiranjan Dash, Rajasekaran Sidhan
{"title":"Anti-Inflammatory and Antimicrobial Activities of Essential Oil of Urochloa distachya (L.)","authors":"Smrutiranjan Dash, Rajasekaran Sidhan","doi":"10.5530/ijpi.20250283","DOIUrl":"https://doi.org/10.5530/ijpi.20250283","url":null,"abstract":"Background Herbal medicines have been valued for centuries as potent treatments for various conditions, including inflammatory and microbial infections. Urochloa distachya (Signal grass), an annual grass belonging to the Poaceae family, is characterized by lance-shaped leaves and 2-3 racemes. This plant is native to tropical regions of Asia and Africa but has also spread to other regions. It thrives in hot, humid climates, particularly during monsoon seasons. Materials and methods: The anti-inflammatory activity was evaluated using the carrageenan-induced paw edema model in experimental animals. Paw edema was induced by injecting carrageenan into the hind paw, and the extent of inflammation was measured at specific time intervals. The antimicrobial activity was assessed using the disk diffusion method. The zone of inhibition around the discs was measured to determine antimicrobial efficacy.Results GC-MS analysis of the essential oil of Urochloa distachya identified eight phytoconstituents, Phytol (59.91%) is identified as the highest peak compound. The anti-inflammatory properties of the plant were evaluated using a carrageenan-induced paw edema model in rats. At a dose of 400 mg/kg, the essential oil significantly (p<0.05) reduced paw edema, achieving a notable inhibition rate of 56.5% at the 4th hr. The antibacterial activity was evaluated against S. typhi and S. aureus. Molecular docking study was performed using protein COX-2, IL-1β, NF-κB, Phospholipase and TNF-α. β-Carotene showed the highest docking scores of -9.0, -7.8, -7.6, -7.3 and -7.7 against COX-2, IL-1β, NF-κB, Phospholipase and TNF-α, respectively. Similarly, docking scores of -7.7, -7.8 and -7.7 were observed against Dihydropteroate synthase, Transpeptidase and Type I dehydroquinase.Conclusion Urochloa distachya exhibits substantial potential as a natural source of essential oils with potent anti-inflammatory and antimicrobial properties, underscoring its potential for future therapeutic applications.","PeriodicalId":14218,"journal":{"name":"International Journal of Pharmaceutical Investigation","volume":"15 3","pages":"1017-1038"},"PeriodicalIF":0.0,"publicationDate":"2025-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147893909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Finerenone as a New Potent Resistant Hypertension Agent: A Review 菲尼酮作为一种新型强效抗高血压药：综述
IF 0.5
International Journal of Pharmaceutical Investigation Pub Date : 2023-12-27 DOI: 10.5530/ijpi.14.1.2
S. Nyamagoud, AgadiHiremath Viswanatha Swamy, Jayasheela S Hiremath, Abhishek BJ Abhishek, Saurav Raj, Megha Hegde, Dhananjay Tikadar, Raviteja Somashekhar Kanavi, Rohith Javali Veeresh
{"title":"Finerenone as a New Potent Resistant Hypertension Agent: A Review","authors":"S. Nyamagoud, AgadiHiremath Viswanatha Swamy, Jayasheela S Hiremath, Abhishek BJ Abhishek, Saurav Raj, Megha Hegde, Dhananjay Tikadar, Raviteja Somashekhar Kanavi, Rohith Javali Veeresh","doi":"10.5530/ijpi.14.1.2","DOIUrl":"https://doi.org/10.5530/ijpi.14.1.2","url":null,"abstract":"","PeriodicalId":14218,"journal":{"name":"International Journal of Pharmaceutical Investigation","volume":"70 2","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Challenges and Future Prospects: A Benefaction of Phytoconstituents on Molecular Targets Pertaining to Alzheimer’s Disease 挑战与前景：植物成分对阿尔茨海默病分子靶点的益处
IF 0.5
International Journal of Pharmaceutical Investigation Pub Date : 2023-12-27 DOI: 10.5530/ijpi.14.1.15
Himanshu Sharma, Phool Chandra
{"title":"Challenges and Future Prospects: A Benefaction of Phytoconstituents on Molecular Targets Pertaining to Alzheimer’s Disease","authors":"Himanshu Sharma, Phool Chandra","doi":"10.5530/ijpi.14.1.15","DOIUrl":"https://doi.org/10.5530/ijpi.14.1.15","url":null,"abstract":"","PeriodicalId":14218,"journal":{"name":"International Journal of Pharmaceutical Investigation","volume":"48 207","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Effect of the Mixture of Natural and Cellulose-Based Polymers on the Physicochemical Properties of Sumatriptan Succinate Mucoadhesive Buccal Patches 天然聚合物和纤维素基聚合物混合物对琥珀酸舒马曲普坦黏胶颊黏贴剂理化性质的影响
IF 0.5
International Journal of Pharmaceutical Investigation Pub Date : 2023-12-27 DOI: 10.5530/ijpi.14.1.25
Sandhya Murali, Prasanth Viswanadhan Vasantha
{"title":"The Effect of the Mixture of Natural and Cellulose-Based Polymers on the Physicochemical Properties of Sumatriptan Succinate Mucoadhesive Buccal Patches","authors":"Sandhya Murali, Prasanth Viswanadhan Vasantha","doi":"10.5530/ijpi.14.1.25","DOIUrl":"https://doi.org/10.5530/ijpi.14.1.25","url":null,"abstract":"","PeriodicalId":14218,"journal":{"name":"International Journal of Pharmaceutical Investigation","volume":"50 2","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Socio-economic Status and Depressive Symptoms in Diabetes Patients: A Cross-Sectional Study 糖尿病患者的社会经济地位与抑郁症状：一项横断面研究
IF 0.5
International Journal of Pharmaceutical Investigation Pub Date : 2023-12-27 DOI: 10.5530/ijpi.14.1.28
Pravalika Mupparapu, Afra Azeenath, Tahsina Firdous, Tamanna Yeasmin, Mohd Azharuddin
{"title":"Socio-economic Status and Depressive Symptoms in Diabetes Patients: A Cross-Sectional Study","authors":"Pravalika Mupparapu, Afra Azeenath, Tahsina Firdous, Tamanna Yeasmin, Mohd Azharuddin","doi":"10.5530/ijpi.14.1.28","DOIUrl":"https://doi.org/10.5530/ijpi.14.1.28","url":null,"abstract":"","PeriodicalId":14218,"journal":{"name":"International Journal of Pharmaceutical Investigation","volume":"8 2","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of Medication Adherence in Cardiovascular Patients in Tertiary Care Hospital: A Prospective Observational Study 评估三级医院心血管病患者的用药依从性：前瞻性观察研究
IF 0.5
International Journal of Pharmaceutical Investigation Pub Date : 2023-12-27 DOI: 10.5530/ijpi.14.1.20
S. Nyamagoud, AgadiHiremath Viswanatha Swamy, Abhishek B J Abhishek, Amisha Netalakar, Bhoomika SK Bhoomika, Namratha D Namratha, Tahameen K Kurabanavar
{"title":"Assessment of Medication Adherence in Cardiovascular Patients in Tertiary Care Hospital: A Prospective Observational Study","authors":"S. Nyamagoud, AgadiHiremath Viswanatha Swamy, Abhishek B J Abhishek, Amisha Netalakar, Bhoomika SK Bhoomika, Namratha D Namratha, Tahameen K Kurabanavar","doi":"10.5530/ijpi.14.1.20","DOIUrl":"https://doi.org/10.5530/ijpi.14.1.20","url":null,"abstract":"","PeriodicalId":14218,"journal":{"name":"International Journal of Pharmaceutical Investigation","volume":"3 5","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preparation and Characterization of Hydroxyapatite- Chitosan Biocomposites of Cissus quadrangularis Linn. for Bone Regeneration in Osteoporosis 制备和表征用于骨质疏松症患者骨再生的羟基磷灰石壳聚糖林木生物复合材料
IF 0.5
International Journal of Pharmaceutical Investigation Pub Date : 2023-12-27 DOI: 10.5530/ijpi.14.1.27
Tejas B Patel, Shantilal Padhiyar, Vipul T Prajapati, Vashisith P Bhavsar, Nishit D Patel, Dharmik A Shah
{"title":"Preparation and Characterization of Hydroxyapatite- Chitosan Biocomposites of Cissus quadrangularis Linn. for Bone Regeneration in Osteoporosis","authors":"Tejas B Patel, Shantilal Padhiyar, Vipul T Prajapati, Vashisith P Bhavsar, Nishit D Patel, Dharmik A Shah","doi":"10.5530/ijpi.14.1.27","DOIUrl":"https://doi.org/10.5530/ijpi.14.1.27","url":null,"abstract":"","PeriodicalId":14218,"journal":{"name":"International Journal of Pharmaceutical Investigation","volume":"9 2","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing Permeability of Acyclovir from Mucoadhesive Buccal films Utilizing Herbal Bioenhancers: An in vitro Investigation 利用草本生物增强剂提高阿昔洛韦从黏附性颊黏膜中的渗透性：体外研究
IF 0.5
International Journal of Pharmaceutical Investigation Pub Date : 2023-12-27 DOI: 10.5530/ijpi.14.1.16
Anjana Chandran, M. Koland, Sindhoor Shridharan Mulleria
{"title":"Enhancing Permeability of Acyclovir from Mucoadhesive Buccal films Utilizing Herbal Bioenhancers: An in vitro Investigation","authors":"Anjana Chandran, M. Koland, Sindhoor Shridharan Mulleria","doi":"10.5530/ijpi.14.1.16","DOIUrl":"https://doi.org/10.5530/ijpi.14.1.16","url":null,"abstract":"","PeriodicalId":14218,"journal":{"name":"International Journal of Pharmaceutical Investigation","volume":"81 3","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139153946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Novel Approaches in Glycogen Storage Disease Type I Management: Harnessing the Potential of Micronutrients and Macro Molecules 治疗 I 型糖原贮积症的新方法：利用微量营养素和大分子的潜力
IF 0.5
International Journal of Pharmaceutical Investigation Pub Date : 2023-12-27 DOI: 10.5530/ijpi.14.1.18
Santosh B Patil, Pramod C Gadad
{"title":"Novel Approaches in Glycogen Storage Disease Type I Management: Harnessing the Potential of Micronutrients and Macro Molecules","authors":"Santosh B Patil, Pramod C Gadad","doi":"10.5530/ijpi.14.1.18","DOIUrl":"https://doi.org/10.5530/ijpi.14.1.18","url":null,"abstract":"","PeriodicalId":14218,"journal":{"name":"International Journal of Pharmaceutical Investigation","volume":"49 1","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Systematic Approach to Vildagliptin-Eudragit RL 100 Coated Nanoparticles by Combined Techniques of Solvent Evaporation and Nano-precipitation Using Quality by Design Concept 利用 "质量源于设计 "理念，采用溶剂蒸发和纳米沉淀相结合的技术，系统地制备维达列汀-Eudragit RL 100 涂层纳米粒子
IF 0.5
International Journal of Pharmaceutical Investigation Pub Date : 2023-12-27 DOI: 10.5530/ijpi.14.1.31
A. Ammanage, V. Mastiholimath
{"title":"A Systematic Approach to Vildagliptin-Eudragit RL 100 Coated Nanoparticles by Combined Techniques of Solvent Evaporation and Nano-precipitation Using Quality by Design Concept","authors":"A. Ammanage, V. Mastiholimath","doi":"10.5530/ijpi.14.1.31","DOIUrl":"https://doi.org/10.5530/ijpi.14.1.31","url":null,"abstract":"","PeriodicalId":14218,"journal":{"name":"International Journal of Pharmaceutical Investigation","volume":"64 11","pages":""},"PeriodicalIF":0.5,"publicationDate":"2023-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139154416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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