International Journal of Phytomedicine最新文献_第2页

Immune stimulating and galectin-3 inhibitory effects of a hydrophilic polysaccharide nutraceutical from Tinospora cordifolia 堇青花亲水性多糖营养品的免疫刺激和半乳糖凝集素-3抑制作用

International Journal of Phytomedicine Pub Date : 2021-01-17 DOI: 10.5138/09750185.2449

C. Ramachandran, K. Quirin, E. Escalon, S. Melnick

{"title":"Immune stimulating and galectin-3 inhibitory effects of a hydrophilic polysaccharide nutraceutical from Tinospora cordifolia","authors":"C. Ramachandran, K. Quirin, E. Escalon, S. Melnick","doi":"10.5138/09750185.2449","DOIUrl":"https://doi.org/10.5138/09750185.2449","url":null,"abstract":"Tinospora cordifolia is an important ayurvedic herb known for its immune stimulating effect. In this investigation, we describe the galectin-3 inhibitory and immune stimulating properties of a novel water-soluble nutraceutical made from Tinospora cordifolia stem. This proprietary extract (T2CA) had a total yield of 6% and contained 86.9% carbohydrates with a high proportion of patented (1,4)-α-D-glucan in it. The T2CA activated T-cytotoxic and NK cells significantly contributing to its immune stimulating effect. Moreover, T2CA induced the activation of functional NK cells in human lymphocyte cultures that in turn contributed to the death of K562 leukemic cells in a dose-dependent manner in co-culture experiments. T2CA inhibited the expression of phosphorylated galectin-3 expression in human glioblastoma cell line which in turn inhibits the activity of MMP2 and MMP9 proteins in zymography investigations and inhibits migration of cancer cells in in vitro scratch assay. Western blot hybridization studies showed that T2CA downregulates the expression of total gal 3 proteins and extended the survival of AKR/J mice injected with Ehrlich ascites tumor cells in the Kepler-Meier survival curve analysis. The inhibitory effect of T2CA on phopho-galectin-3 expression and the activation of T-cytotoxic and NK cells suggested its protective effects against pathogenic infections and human malignancies via its immune stimulating mechanisms.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"362 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79589232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevention of β-amyloid-induced toxicity in a differentiated neuronal (IMR32) cell line by Khaya grandifololia (Welw) C. DC. 大叶茶对分化神经元(IMR32)细胞系β-淀粉样蛋白诱导的毒性的预防作用。

International Journal of Phytomedicine Pub Date : 2021-01-17 DOI: 10.5138/09750185.2443

E. Armand, M. Shantaram, S. N. Fewou, F. N. Njayou, Sayali Chandrashekhar Deolankar, P. K. Modi, P. Moundipa

{"title":"Prevention of β-amyloid-induced toxicity in a differentiated neuronal (IMR32) cell line by Khaya grandifololia (Welw) C. DC.","authors":"E. Armand, M. Shantaram, S. N. Fewou, F. N. Njayou, Sayali Chandrashekhar Deolankar, P. K. Modi, P. Moundipa","doi":"10.5138/09750185.2443","DOIUrl":"https://doi.org/10.5138/09750185.2443","url":null,"abstract":"Alzheimer’s disease (AD) belongs to the class of neurodegenerative disorder and is biochemically characterized by amyloid-β (Aβ) plaques deposition, accumulation of neurofibrillary tangles (NFTs) accumulation and ultimately neuronal loss. Even though, the progress made in developing efficient AD therapy, there is no effective drug capable to stop and/or slow down AD progression. In the current article, we investigated the neuroprotective effect of Khaya grandifololia crude extract and fraction 2 against Aβ 42 -induced cytotoxicity and hyperphosphorylation of tau protein in differentiated neuronal cells (IMR32). Reactive oxygen species production, apoptosis and mitochondrial dynamics and function, synaptic protein, and tau phosphorylation were evaluated using fluorescence microscopy and immunoblotting. Cell viability was assessed using the MTT assay. Findings revealed that exposure of differentiated IMR32 cells to Aβ 42 alone induced the impairment of mitochondrial dynamics, decrease synaptic protein expression and increase hyperphosphorylation of tau protein (phospho tau181). In contrast, the presence of crude extract and KGf2 significantly inhibited the cleavage of Caspase-3 activation. In addition, the levels of synaptic proteins (Symptosomal associated protein 25 and Synaptosin) and superoxide dismutase were restored upon treatment with crude extract and fraction 2. Hyperphosphorylation of tau protein (Thr181) and ERK (Thr202/Tyr205) activities were also significantly reduced after treatment with crude extract and fraction 2. Our findings suggest that KG extract is a potential source for candidate drug against AD and may contribute to the development of efficient therapeutic strategy against AD.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"58 34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82356083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Isolation of biologically active metabolites from Bougainvillea spectabilis Willd. cultivated in Egypt 九重葛生物活性代谢物的分离。埃及栽培

International Journal of Phytomedicine Pub Date : 2020-11-29 DOI: 10.5138/09750185.2405

K. Deeb, H. Eid, A. Sleem, Ghada F Metwally, M. A. Halim

{"title":"Isolation of biologically active metabolites from Bougainvillea spectabilis Willd. cultivated in Egypt","authors":"K. Deeb, H. Eid, A. Sleem, Ghada F Metwally, M. A. Halim","doi":"10.5138/09750185.2405","DOIUrl":"https://doi.org/10.5138/09750185.2405","url":null,"abstract":"Bougainvillea spectabilis Willd. is an ornamental plant cultivated in tropical, subtropical regions and other places as Egypt. The present study aimed to perform bioassay guided fractionation and isolation of some of the bioactive compounds from the Egyptian cultivate. The total ethanol extracts of the leaves (T.ET.L.), stems (T.ET.S.) and flowers (T.ET.F.) were screened for some pharmacological activities viz. in vivo anti-oxidant and anti-hepatotoxic, in addition to in vitro cytotoxic activities. The anti-oxidant effect was assessed by measuring serum glutathione level (GSH) in alloxan-induced diabetic rats. The anti-hepatotoxic activity was evaluated via measuring serum markers level viz . alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) in CCl4-induced hepatotoxicity in rats. In vitro cytotoxicity of the different extracts was estimated for liver cancer cell line (HEPG2) adopting Sulforhodamine B stain assay. T.ET.L. exhibited significantly potent anti-oxidant and anti-hepatotoxic activities, while T.ET.S. showed the highest cytotoxic activity. Through biological guided fractionation, leaves and stems were subjected to successive solvent extraction, whereas the leaves ethyl acetate (Et.Ac.L.) and the stems ethanol 70% (Et.70%S.) extracts showed highly potent activities. Thus, different chromatographic techniques were performed on Et.Ac.L. and Et.70%S. extracts leading to the isolation of five bioactive metabolites. Three flavonoids were isolated from Et.Ac.L.; genistein-7-O-rutinoside (1) , formononetin-7-O-rutinoside (2) and myricetin (3) , while orobol-7-O-glucoside (4) and hesperidin (5) were isolated from Et.70%S. This work demonstrated the importance of the plant as a promising anti-oxidant, anti-hepatotoxic and cytotoxic product for nutraceutical use.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"77 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77303349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hepatoprotective activity of aqueous extract of Balanites aegyptiaca L. Delile (Balanitaceae) roots bark 巴兰科埃及巴兰根皮水提物的保肝活性

International Journal of Phytomedicine Pub Date : 2020-11-29 DOI: 10.5138/09750185.2433

Traoré Tata Kadiatou, N. Ouedraogo, G. Ouédraogo, Gilchrist A. L. Boly, Leïla M. E. W. Kabré, Ernest Nogma Sombié, J. N’do, S. Ouedraogo, M. Lompo, S. Ouédraogo, A. Tibiri, I. Guissou

{"title":"Hepatoprotective activity of aqueous extract of Balanites aegyptiaca L. Delile (Balanitaceae) roots bark","authors":"Traoré Tata Kadiatou, N. Ouedraogo, G. Ouédraogo, Gilchrist A. L. Boly, Leïla M. E. W. Kabré, Ernest Nogma Sombié, J. N’do, S. Ouedraogo, M. Lompo, S. Ouédraogo, A. Tibiri, I. Guissou","doi":"10.5138/09750185.2433","DOIUrl":"https://doi.org/10.5138/09750185.2433","url":null,"abstract":"Balanites aegyptiaca (L.) Del (Balanitaceae) is traditionally used for the treatment of various ailments such as syphilis, jaundice and liver disorders, epilepsy, ... This study was designed to evaluate acute toxicity and hepatoprotective effect of aqueous extract of Balanites aegyptiaca on CCl 4 induced hepatotoxicity in rats. Methods: Acute toxicity was assessed with the extract at a dose of 2000 mg / kg bw. The extract at doses of 25, 50 and 100 mg / kg b.w. was orally administered respectively to CC1 4 -induced hepatotoxicity (0.5 ml / kg) animals. Silymarin (100 mg / kg) was given as a reference. Biochemical parameters such as ALT, AST, PT, ALB and ALP were assayed as well as enzymatic antioxidant activities SOD, CAT and MDA. Nitrogen monoxide (NO) involved in inflammation was also measured. Results: Activities of liver marker enzymes, ALT, AST and ALP, total protein, albumin and showed a significant hepatoprotective effect. Regarding antioxidant enzymatic activities in vivo (SOD, CAT and MDA) of aqueous extract exhibited a significant effect showing increasing levels of SOD, CAT and reducing malondialdehyde (MDA) levels. The production of NO is significantly reduced compared to the batch intoxicated by CCl 4 . Conclusion: Balanites aegyptiaca is endowed with hepatoprotective properties that can be attributed to antioxidant potential which could justify its use in traditional medicine in liver disorders.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78694127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In vitro Hepatoprotective potential of the whole plant of Fumaria indica (Haussk.) Pugsley and an isolated alkaloid Protopine 印度富氏菌(Fumaria indica, Haussk.)全株体外肝保护作用的研究帕格斯利和一种分离生物碱原碱

International Journal of Phytomedicine Pub Date : 2020-11-29 DOI: 10.5138/09750185.2402

A. Rajopadhye, A. Upadhye

{"title":"In vitro Hepatoprotective potential of the whole plant of Fumaria indica (Haussk.) Pugsley and an isolated alkaloid Protopine","authors":"A. Rajopadhye, A. Upadhye","doi":"10.5138/09750185.2402","DOIUrl":"https://doi.org/10.5138/09750185.2402","url":null,"abstract":"Fumaria indica (Haussk.) Pugsley, Fumariaceae [syn. F. vaillantii Loisel.] is an important medicinal plant known as ‘Fumitory’. Ethnobotanical and ayurvedic literature reports that the plant is used in treatment of liver diseases as well as diverse pharmacological activities. In present work, in vitro hepatoprotective effects of ethanol extract of F. indica (FUP) and alkaloid, protopine (PRT) on carbon tetrachloride induced oxidative stress has been demonstrated. An isoquinoline alkaloid, protopine was isolated from ethanol extract of F. indica and characterized by spectral data. Carbon tetrachloride (CCl 4 ) and ethanol has been used as a hepatotoxin. Cytotoxicity was estimated by quantitating the release of lactate dehydrogenase (LDH) in culture medium along with antioxidant enzymes namely superoxide dismutase, catalase and glutathione reductase. HPLC profile of FUP and PRT was developed using water: methanol (7:3) as a mobile phase. CCl 4 and ethanol induces 5.5 and 4 times more release of LDH from the liver cells and twice the amount of lipid peroxidation as compared to the cells from untreated liver tissue. These LDH and lipid perioxidation activities were reduced significantly in dose dependent manner after addition of FUP and PRT (at doses 0.5 % FUP and at does 0.025, 0.05 % PRT; p < 0.001). The activity of antioxidant enzymes was found to be elevated in CCl 4 /ethanol treated cells. However, after addition of FUP/PRT along with cytotoxicant the activities were lowered significantly. The peak of PRT has been detected in FUP at retention times 1.670. sBased on these studies it may be precluded that protopine from F. indica , as a possible therapeutic for preventing oxidative stress in vitro by boosting the antioxidant capacity of the liver.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78846678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In-vitro Anti-cercarial activity of extracts and steroidal alkaloids from the stem bark of Holarrhena floribunda (G. Don) Dur. & Schinz 花楸茎皮提取物及甾体生物碱体外抗子宫颈炎活性研究。& Schinz

International Journal of Phytomedicine Pub Date : 2020-10-21 DOI: 10.5138/09750185.2415

I. Amponsah, F. A. Armah, J. Alake, B. Harley, E. Ampofo, Evelyn Asante-Kwatia, Aglomasa Bill Clinton, Benjamin Amoani, I. T. Henneh

{"title":"In-vitro Anti-cercarial activity of extracts and steroidal alkaloids from the stem bark of Holarrhena floribunda (G. Don) Dur. & Schinz","authors":"I. Amponsah, F. A. Armah, J. Alake, B. Harley, E. Ampofo, Evelyn Asante-Kwatia, Aglomasa Bill Clinton, Benjamin Amoani, I. T. Henneh","doi":"10.5138/09750185.2415","DOIUrl":"https://doi.org/10.5138/09750185.2415","url":null,"abstract":"Context: Schistosomiasis continues to be the leading cause of morbidity and mortality among the neglected tropical diseases. Apart from the high cost of chemotherapy, concerns over drug resistance and tolerance have been raised in the past decade . Objective : The aim of the study was to evaluate the anticercarial activity of extracts and compounds from the stem bark of Holarrhena floribunda on cercaria of Schistosoma haematobium . Methods : Hydroethanolic and alkaloidal extracts from the stem bark of H. floribunda were tested on cercaria at concentrations between 500.00 and 15.625 μg/mL for 180 minutes and assessing the percentage viability at time intervals of 0, 15, 30, 60, 120 and 180 minutes. Praziquantel, used as reference drug, and the isolated compounds were tested at similar concentrations. The cercaria mortalities and IC 50 of extracts and compounds were estimated after 30 minutes of incubation. Results : The 70 %v/v ethanol extract showed the highest activity (IC 50 =20.09±1.11 μg/mL) with praziquantel giving IC 50 of 695.50±1.12. The alkaloids holonamine, holadienine and conessine, isolated from the stem bark, showed considerable cercaricidal activity with the latter recording an IC 50 of 33.28±1.04. Conclusion : The study gives first-hand knowledge of the anti-cercarial activity of H. floribunda and its steroidal alkaloids. This gives credence to the traditional uses of the plant as an anti-parasitic agent.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"9 1","pages":"69-78"},"PeriodicalIF":0.0,"publicationDate":"2020-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86635970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Antitumoral properties of butanolic fraction from leaves extract of Chrysobalanus icaco L. in breast and lung cancer cell lines. 金盏花叶提取物丁醇醇组分对乳腺癌和肺癌细胞株的抗肿瘤作用。

International Journal of Phytomedicine Pub Date : 2020-07-21 DOI: 10.5138/09750185.2377

L. O. Cruz, B. Fróes, Luana Brito do Nascimento Araújo, Ísis Salviano, José Luiz Mazzei, B. O. Soares, R. Araujo, F. Dantas, A. Mencalha

{"title":"Antitumoral properties of butanolic fraction from leaves extract of Chrysobalanus icaco L. in breast and lung cancer cell lines.","authors":"L. O. Cruz, B. Fróes, Luana Brito do Nascimento Araújo, Ísis Salviano, José Luiz Mazzei, B. O. Soares, R. Araujo, F. Dantas, A. Mencalha","doi":"10.5138/09750185.2377","DOIUrl":"https://doi.org/10.5138/09750185.2377","url":null,"abstract":"Infusion of leaves from Chrysobalanus icaco L., known as Icaco or Abajeru, is widely consumed in Brazil due to its therapeutic effects, such as hyperglycemia regulation, anti-inflammatory, analgesic and against chronic diarrhea. The aqueous and hydroalcoholic extract from Icaco also present anti-cancer properties, including colon cancer and leukemia. However, the antitumoral activity of the butanolic fraction still unknown. This study aimed to investigate the antitumoral properties of butanolic fraction against breast and lung cancer cell lines. Breast and lung cancer cell lines were incubated with the butanolic fraction (0.5, 1 and 5 µg.mL-1) for 24h. WST-1 and Trypan blue exclusion assays evaluated cell viability. The reactive oxygen species generation was measured, and the cell death pathway was analyzed by flow cytometry. The phytochemical profile was determined by thin-layer chromatography (TLC) analysis. The butanolic fraction presents triterpenes, flavonoids, and phenolic compounds as its major constituents. Cell proliferation of MDA-MB-231 and A549 were decreased by butanolic fraction (0.5, 1.0, and 5.0 µg.mL -1 ) treatment. Butanolic fraction (5.0 µg.mL -1 ) increase intracellular reactive oxygen species levels in MDA-MB-231, 118%, and in A549, 20%, cell lines. The loss of viability and reactive oxygen species increase was accompanied by apoptosis induction. The cellular migration of both cell lines was decreased by 13% in MDA-MB-231 and by 58% in A549 with the butanolic fraction of C. icaco . These results suggest that the butanolic fraction from Chrysobalanus icaco has anti-cancer properties against MDA-MB-231 and A549 cancer cells.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"27 1","pages":"01-06"},"PeriodicalIF":0.0,"publicationDate":"2020-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84131315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Abengourou forastero cocoa against doxorubicin-induced cardiotoxicity in experimental rats 阿本古罗可可豆对阿霉素诱导的大鼠心脏毒性的影响

International Journal of Phytomedicine Pub Date : 2020-07-21 DOI: 10.5138/09750185.2392

A. Dembele, A. Okon, B. N. Djyh, P. Kambou, J. Djaman, Mireille Treyavo, J. N’Guessan

{"title":"Effect of Abengourou forastero cocoa against doxorubicin-induced cardiotoxicity in experimental rats","authors":"A. Dembele, A. Okon, B. N. Djyh, P. Kambou, J. Djaman, Mireille Treyavo, J. N’Guessan","doi":"10.5138/09750185.2392","DOIUrl":"https://doi.org/10.5138/09750185.2392","url":null,"abstract":"Oxidative stress is a determining factor in the pathophysiology of heart disease. This study aimed at evaluating the protective activity of Abengourou Forastero cocoa in doxorubicin-induced cardiotoxicity in rats. Thirty (30) wistar rats divided into 5 groups were orally pretreated with distilled water, resveratrol (25 mg/kg/day) or defatted Abengourou Forastero cocoa powder (1000 and 1500 mg/kg/day) for sixty (60) consecutive days. A single dose of doxorubicin (15 mg/kg/day) was administered on day 59 by intraperitoneal route. The biochemical parameters were assessed and a histological examination of the heart was performed. This study showed that doxorubicin treated animals exhibited a significant increase of alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, phosphocreatine kinases, creatine kinases, total cholesterol, triglycerides, and LDL-cholesterol levels in serum. However, a decrease of HDL-cholesterol and an alteration of cardiac tissue were noticed. Preventive treatment with Abengourou Forastero cocoa at doses of 1000 and 1500 mg/kg significantly reduced the biochemical and histological alterations induced by doxorubicin. Results showed that Abengourou Forastero cocoa protects and prevents against doxorubicin-induced cardiac damage.","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"60 1","pages":"13-18"},"PeriodicalIF":0.0,"publicationDate":"2020-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81109358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Medicinal Properties of P aullinia pinnata Linn. Leaves 山茱萸的药用特性研究。叶子

International Journal of Phytomedicine Pub Date : 2020-06-24 DOI: 10.5138/09750185.2376

O. Adeyemo-Salami

引用次数: 0

Ayurveda and Siddha systems polyherbal formulations to treat COVID-19 caused by SARS-CoV-2 and brief insight on application of Molecular Docking and SWISS Target prediction tools to study efficacy of active molecules 阿育吠陀和悉达体系多草药制剂治疗SARS-CoV-2引起的COVID-19，并简要介绍分子对接和SWISS靶标预测工具在活性分子疗效研究中的应用

International Journal of Phytomedicine Pub Date : 2020-06-24 DOI: 10.5138/09750185.2409

H. K. Manikyam, S. Joshi, M. Malinidevi, Afeefa Noor

{"title":"Ayurveda and Siddha systems polyherbal formulations to treat COVID-19 caused by SARS-CoV-2 and brief insight on application of Molecular Docking and SWISS Target prediction tools to study efficacy of active molecules","authors":"H. K. Manikyam, S. Joshi, M. Malinidevi, Afeefa Noor","doi":"10.5138/09750185.2409","DOIUrl":"https://doi.org/10.5138/09750185.2409","url":null,"abstract":"Ayurveda and Siddha systems are the two ancient medical systems originated in India more than 4000 years ago had given many formulary and treatment methods against influenza like infections. Kabasura churan from Siddha system and Maha sudharshan churan from the Ayurvedic system are the two major formulations along with many other individual herbs mentioned in the texts to treat Influenza like infections. Kabasura churan and Maha Sudarshan churan both have antipyretic, analgesic and anti-inflammatory effects. Both formulations were prepared according to Siddha and Ayurvedic texts. Herbs mentioned in both formulations like Turmeric, Tulsi (Basil), Kalmegh (Andrographis), Black Pepper, Liquorice (Mulethi), and Dronapushpi (Leucas) etc., had direct antiviral effect. Herbs like Aswagandha, Ginger, Guduchi (Tinospora), Kulanjan (Galangal) etc., had immunomodulatory and anti-inflammatory effect. Active compounds from different herbs were selected to study their antiviral activity through molecular docking algorithm. Application of modern of tools like Bioinformatics and Highthroughput screening methods can predict the efficacy of the ancient documented formulations and can be compared as per their literature. Compounds like curcumin, Glycyrrhizin, Ursolic acid, Quercetin, Andrographolide, Coumarins etc. were showed polyspecific activity like inhibition of Spike protein, Furin, Main Protease (Mpro) and Papain like Proteases (PLpro). Thus we propose use of Kabasura churan and Maha Sudharshan churan as alternative complementary medicine as a palliative treatment against COVID-19 caused by SARS-CoV-2 by conducting proper Randomized Clinical Trials","PeriodicalId":14199,"journal":{"name":"International Journal of Phytomedicine","volume":"29 1","pages":"35-41"},"PeriodicalIF":0.0,"publicationDate":"2020-06-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84067022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0