International Journal of Pharmacological Research最新文献_第3页

Casuarinin effects on cancer chemoprevention: Progress, potential and promise 木麻黄素对癌症化学预防的作用:进展、潜力和前景

International Journal of Pharmacological Research Pub Date : 2017-10-07 DOI: 10.7439/IJPR.V7I9.4352

J. Khan, M. Qadir

引用次数: 0

Cross-cytotoxicity study of antimalarial drugs and traditional medicinal plants on Renal Cells 抗疟药物与传统药用植物对肾细胞的交叉细胞毒性研究

International Journal of Pharmacological Research Pub Date : 2017-10-01 DOI: 10.7439/ijpr.v7i9.4413

T. Daubrey-Potey, S. Aoussi, V. Adjogoua, Gisele Kouakou-sirensy, M. Kamagat, M. Dosso, H. Dié-Kacou

{"title":"Cross-cytotoxicity study of antimalarial drugs and traditional medicinal plants on Renal Cells","authors":"T. Daubrey-Potey, S. Aoussi, V. Adjogoua, Gisele Kouakou-sirensy, M. Kamagat, M. Dosso, H. Dié-Kacou","doi":"10.7439/ijpr.v7i9.4413","DOIUrl":"https://doi.org/10.7439/ijpr.v7i9.4413","url":null,"abstract":"Objective: The association of Artemisinin based combination therapy with herbal medicine seems to be a factor favouring the occurrence of serious adverse effects, hepatitis disorders and acute renal failure in particular. The aim of this study was to evaluate the cross- toxicity of these associations on renal cells. Methods: African green monkey kidney cells (VERO) were incubated with anti-malarial drugs and plant preparations. The products used were: Artesunate 100mg / amodiaquine 270mg (ASAQ) and artemether 80mg / lumefantrine 480mg (AL) , and Sida acuta and Enantia polycarpa at a concentration of 10 ?g / ml. After 5 days of incubation, a cell count was performed using a haemocytometer. Results: ASAQ resulted in significant cell destruction compared to the control between Day2 (p 30% in the tubes treated with ASAQ and Sida acuta . Finally, cell destruction was statistically significant in tubes treated with the combination of antimalarial drugs and traditional plants compared to the control tube from Day2 (p <0.001). Conclusion: The renal toxicity observed with ASAQ, Sida acuta and combination of antimalarial drugs and herbs, appears dose-dependent or cumulative. The mechanism of this renal toxicity should be better analysed in further studies.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"17 1","pages":"181-186"},"PeriodicalIF":0.0,"publicationDate":"2017-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81758408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Review on Argemone Mexicana 墨西哥凤尾草综述

International Journal of Pharmacological Research Pub Date : 2017-10-01 DOI: 10.7439/IJPR.V7I9.4386

S. Husna, V. Reddy

引用次数: 3

Effects of crude aqueous extracts of Heliotropium indicum Linn (Boraginaceae) on blood pressure in Wistar rats 淫羊藿粗水提物对Wistar大鼠血压的影响

International Journal of Pharmacological Research Pub Date : 2017-08-30 DOI: 10.7439/ijpr.v7i8.4295

A. Marius, B. Awèdé, R. Osseni, Godfried Dougnon, Wallis Dosseh, L. Lagnika, R. Darboux, A. Laleye

{"title":"Effects of crude aqueous extracts of Heliotropium indicum Linn (Boraginaceae) on blood pressure in Wistar rats","authors":"A. Marius, B. Awèdé, R. Osseni, Godfried Dougnon, Wallis Dosseh, L. Lagnika, R. Darboux, A. Laleye","doi":"10.7439/ijpr.v7i8.4295","DOIUrl":"https://doi.org/10.7439/ijpr.v7i8.4295","url":null,"abstract":"The present work was carried out to investigate the effects of crude aqueous extracts of the stem with leaves and roots of Heliotropium indicum Linn on blood pressure in Wistar rats. Crude aqueous extracts were obtained by decoction of Heliotropium indicum stem with leaves and roots. A phytochemical screening of extracts has been made by thin layer chromatography. The pharmacological effect of the extracts was assessed by administration to L-NAME-induced hypertensive Wistar rats. Blood pressures were measured by carotid catheterization. The chemical screening revealed the presence of many secondary metabolites such as coumarins, flavonoids, anthocyanics, lignans, saponins, tannins, terpenes and triterpenes in both extract. Alkaloid were detected only in the root extract. 7-days administration of L-NAME induced an increasis of rat mean arterial pressure (MAP) from 1063 mmHg to 1342 mmHg. Administration of both extracts significantly decreased the MAP from 1342 mmHg to respectively to 108 1 mmHg for the stem with leaf extract and to 1212 mmHg for the root extract . These results provide a support for the use of this plant in traditional medicine.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"1 1","pages":"165-169"},"PeriodicalIF":0.0,"publicationDate":"2017-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89372891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Monoclonal antibodies and its impact on modern health services A review 单克隆抗体及其对现代卫生服务的影响

International Journal of Pharmacological Research Pub Date : 2017-08-30 DOI: 10.7439/IJPR.V7I8.4296

S. Das, V. Sehgal

引用次数: 1

Influence of Pharmacology on Knowledge, Attitude and Practice of Self Medication in 2nd year Medical Students -Observational Questionnaire Based Study 药理学对二年级医学生自我药疗知识、态度和行为的影响——基于观察性问卷的研究

International Journal of Pharmacological Research Pub Date : 2017-08-28 DOI: 10.7439/ijpr.v7i8.4326

C. Manasa, L. Kalpana, Veena Rm, D. BharathKumarV

{"title":"Influence of Pharmacology on Knowledge, Attitude and Practice of Self Medication in 2nd year Medical Students -Observational Questionnaire Based Study","authors":"C. Manasa, L. Kalpana, Veena Rm, D. BharathKumarV","doi":"10.7439/ijpr.v7i8.4326","DOIUrl":"https://doi.org/10.7439/ijpr.v7i8.4326","url":null,"abstract":"Background: Self medication has been misused by use of non-prescription drugs amongst students which has become a serious problem. The youth is especially exposed to the media and the increased advertising of pharmaceuticals poses a larger threat to the young population. Aims & Objectives: To determine the influence of Pharmacology on Knowledge, Attitude and Practice of Self Medication in 2 nd year Medical Students Materials and Methods: Self administered, semi structured validated questionnaires as pretest will be given at the beginning of 2 nd year (3 rd term) followed by post test at the end of 2 nd year (5 th term). Study was done among 105 and 109 in 3 rd and 5 th term 2 nd year medical students. Results: Out of 118 second year medical students, 105 were of 3 rd term and 109 were of 5 th term. In 3 rd term 58 were males and 47 were females, while in 5 th term, 61 were males and 47 were females. In 5 th term students knowledge regarding use of drugs for self medication were 106(97.2%), 104(95.4%), 108(99%), 86(78.8%), 69(63.3%) and 94(86.2%) compared to 3 rd term students which were 45(42.8%), 36(43.2%), 56(53.3%), 63(60%), 24(22.8%) and 53(50.4%) respectively. Attitude wise 98(89.9%) in 5 th term and 82(78%) believe that drug should not be taken which has expired date. 103(94.5%) of 5 th term students and 101(96.1%) of 3 rd term students had felt the necessity of medical knowledge towards self-medication. Among the participants participating self-medication, majority 96(88%) in 5 th term and 91(86.6%) 3 rd term followed allopathic system of medicine. Conclusion: In our study 5 th term students were more confident and well versed with pharmacology and hence better knowledge, attitude and practice was observed compared to 3 rd term students.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"183 1","pages":"160-164"},"PeriodicalIF":0.0,"publicationDate":"2017-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77542932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Usage pattern of Proton pump inhibitor among resident doctors in a tertiary-care hospital of Manipur 曼尼普尔邦某三级医院住院医师质子泵抑制剂的使用模式

International Journal of Pharmacological Research Pub Date : 2017-07-28 DOI: 10.7439/IJPR.V7I7.4108

Omkar Prasad Baidya, S. Chaudhuri, Mukut Debnath, T. G. Singh

{"title":"Usage pattern of Proton pump inhibitor among resident doctors in a tertiary-care hospital of Manipur","authors":"Omkar Prasad Baidya, S. Chaudhuri, Mukut Debnath, T. G. Singh","doi":"10.7439/IJPR.V7I7.4108","DOIUrl":"https://doi.org/10.7439/IJPR.V7I7.4108","url":null,"abstract":"Objectives: To determine the prevalence of proton pump inhibitor use among the junior doctors in a tertiary health care centre of Manipur & to assess the practice of proton pump inhibitor use among them.Materials & Methodology: A cross-sectional study was conducted among the junior doctors i.e. internees, house officers and post graduate students in a tertiary health care centre of Manipur during November to January 2012. Respondents were purposively selected and data were collected using structured interview schedule which consists of socio-demographic variables, questions on use of PPI. Those who refused to participate and who could not be contacted even after 3 successive visits were excluded from the study. Data were analysed using SPSS 20 & was presented in mean, percentages etc.Results: Prevalence of PPI use was 66.6%. All the doctors used PPI only on selective patients. Majority of them use for gastrointestinal diseases (84%). Little more than 9 in 10 participants used PPI for the patients aged 20-30 years. Majority of them used PPI for 2-4 wks in Acid Peptic Disorder (30.5%) and less than 1week in Non Acid Peptic Disorder. More than 8 in 10 participants told that PPI was the best drug for acid peptic disorder and majority opined that PPI should not be used randomly for all gastro-intestinal disorder.Conclusion: Inappropriate use of PPI remains rampant in hospital practice. Increased awareness should be created among the clinicians so that appropriate prescription of PPIs could improve the patient care.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"197 1","pages":"144-147"},"PeriodicalIF":0.0,"publicationDate":"2017-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79914989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

New simplex Type 1 lytic infection pyridine system derivative as a novel goal against Herpes 新的单纯型1型溶性感染吡啶体系衍生物作为抗疱疹的新靶点

International Journal of Pharmacological Research Pub Date : 2017-07-28 DOI: 10.7439/IJPR.V7I7.3932

M. Costa, Viveca A Giongo, C. Cirne-Santos, Caroline Barros, Valéria Garrido, T. M. Souza, J. L. Abrantes, Luiz C. S. Pinheiro, Sergio Pinheiro, A. Bernardino, I. Paixão

{"title":"New simplex Type 1 lytic infection pyridine system derivative as a novel goal against Herpes","authors":"M. Costa, Viveca A Giongo, C. Cirne-Santos, Caroline Barros, Valéria Garrido, T. M. Souza, J. L. Abrantes, Luiz C. S. Pinheiro, Sergio Pinheiro, A. Bernardino, I. Paixão","doi":"10.7439/IJPR.V7I7.3932","DOIUrl":"https://doi.org/10.7439/IJPR.V7I7.3932","url":null,"abstract":"The pyridine system derivatives have been studied as antiviral drug new models against HIV infection using bioisosterism as a powerful tool. In the last decades, the number of this work, thienopyridine derivatives were evaluated as an HSV-1 inhibitor to since the elevated number of acyclovir resistance in immunocompromised patients could promote a continuous viral pool increase and disease recurrence. In these substances, thienopyridine derivative with radical nitrate in para position (109) was able to inhibit 99% of HSV-1 replication in Vero cells with EC 50 value of 100 pM, and SI value three times higher than acyclovir. In kinetic enzymatic assay this substance was also able to inhibit about 50% of HSV-1 DNA polymerase but in a non-competitive mechanism a new synergic system to control herpes infections. Preliminary in vivo model studies revealed that substance 109 is toxic when administered in 300 g/mL concentrations. In this work, we concluded that thienopyridine derivatives can be considered a promising new anti-HSV-1 drug and can be used for clinical testing.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"43 1","pages":"148-153"},"PeriodicalIF":0.0,"publicationDate":"2017-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80422054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Efficacy and safety of oral vitamin D (cholecalciferol) supplement therapy in Stage I primary hypertension; a prospective, randomized, double-blind, placebo controlled, clinical trial in a tertiary care hospital in central India. 口服维生素D(胆钙化醇)补充治疗I期原发性高血压的疗效和安全性在印度中部一家三级医院进行的一项前瞻性、随机、双盲、安慰剂对照的临床试验。

International Journal of Pharmacological Research Pub Date : 2017-06-28 DOI: 10.7439/IJPR.V7I6.4206

M. Mahajan, S. Deshmukh, Sujata Dudhgaonkar

{"title":"Efficacy and safety of oral vitamin D (cholecalciferol) supplement therapy in Stage I primary hypertension; a prospective, randomized, double-blind, placebo controlled, clinical trial in a tertiary care hospital in central India.","authors":"M. Mahajan, S. Deshmukh, Sujata Dudhgaonkar","doi":"10.7439/IJPR.V7I6.4206","DOIUrl":"https://doi.org/10.7439/IJPR.V7I6.4206","url":null,"abstract":"Introduction : Hypertension is one of the most common cardiovascular disorders. Almost all targets in its therapy are exploited and there is a growing need to search for newer targets. Vitamin D is gaining increasing attention in treatment of primary hypertension. Objectives : To study the efficacy and safety of Vitamin D supplementation on systolic and diastolic BP in patients of primary hypertension (JNC 7 stage I) receiving conventional antihypertensive medications (namely Tab atenolol 50mg or Tab amlodipine 5mg). Methods : It was a prospective, randomized, double blind, parallel, placebo controlled clinical trial with 2 groups of 33 patients each. Both groups had patients receiving conventional antihypertensives (Tab atenolol50mg or Tab amlodipine 5mg). Group A patients were given placebo (lactose tablets) and Group B were given oral Vitamin D 3 (60,000 IU) once weekly at bedtime after meals, repeated every fortnightly for 12 weeks. Results : Patients belonging to Group B showed a statistically significant (p < 0.0001) decline in both systolic blood pressure after 12 weeks of receiving vitamin D supplementation. There was no significant change in the safety parameters. Conclusions : Thus, our study shows that Vitamin D supplementation has some role in safely reducing systolic blood pressure after 12 weeks of supplementation and hence it should be supplemented with antihypertensive drugs to the patients with hypertension.","PeriodicalId":14194,"journal":{"name":"International Journal of Pharmacological Research","volume":"24 1","pages":"135-137"},"PeriodicalIF":0.0,"publicationDate":"2017-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86480683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An investigation on conformation of antimicrobial and superfluous ecological role of Acacia nilotica indica 尼罗卡刺槐抗菌构象及超生态作用的研究

International Journal of Pharmacological Research Pub Date : 2017-06-28 DOI: 10.7439/ijpr.v7i6.4199

M. Saravanaraja, K. Nagarajan

引用次数: 0