International journal of occupational medicine and environmental health最新文献

{"title":"Prevalence of burnout among healthcare professionals during the COVID-19 pandemic and associated factors - a scoping review.","authors":"Agata Stodolska,&nbsp;Grzegorz Wójcik,&nbsp;Ilona Barańska,&nbsp;Violetta Kijowska,&nbsp;Katarzyna Szczerbińska","doi":"10.13075/ijomeh.1896.02007","DOIUrl":"https://doi.org/10.13075/ijomeh.1896.02007","url":null,"abstract":"<p><p>The outbreak of the COVID-19 pandemic exerted significant mental burden on healthcare workers (HCWs) operating in the frontline of the COVID-19 care as they experienced high levels of stress and burnout. The aim of this scoping review was to identify prevalence and factors associated with burnout among HCWs during the first year of the COVID-19 pandemic. A literature search was performed in PubMed, Web of Science, and CINAHL. Studies were selected based on the following inclusion criteria: cross-sectional, longitudinal, case-control, or qualitative analyses, published in peer-reviewed journals, between January 1, 2020 and February 28, 2021. Studies carried out on other occupations than healthcare workers or related to other pandemics than COVID-19 were excluded. Following the abstract screen, from 141 original papers identified, 69 articles were eventually selected. A large variation in the reported burnout prevalence among HCWs (4.3-90.4%) was observed. The main factors associated with increase/ decrease of burnout included: demographic characteristics (age, gender, education level, financial situation, family status, occupation), psychological condition (psychiatric diseases, stress, anxiety, depression, coping style), social factors (stigmatisation, family life), work organization (workload, working conditions, availability of staff and materials, support at work), and factors related with COVID-19 (fear of COVID-19, traumatic events, contact with patients with COVID-19, having been infected with COVID-19, infection of a colleague or a relative with COVID-19, higher number of deaths observed by nurses during the COVID-19 pandemic). The findings should be useful for policy makers and healthcare managers in developing programs preventing burnout during the current and future pandemics. Int J Occup Med Environ Health. Int J Occup Med Environ Health. 2023;36(1):21-58.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/f2/ad/ijomeh-36-21.PMC10464746.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10095193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Professional challenges of nurses working during the SARS-CoV-2 virus pandemic.","authors":"Grażyna Puto,&nbsp;Lena Serafin,&nbsp;Zofia Musiał,&nbsp;Patrycja Zurzycka,&nbsp;Alicja Kamińska,&nbsp;Agnieszka Gniadek","doi":"10.13075/ijomeh.1896.02028","DOIUrl":"https://doi.org/10.13075/ijomeh.1896.02028","url":null,"abstract":"<p><strong>Objectives: </strong>The diverse list of tasks and needs related to the SARS-CoV-2 pandemic may lead to different professional experiences in nurses working with patients infected with and not infected with SARS-CoV-2. The aim of the study was to measure the professional challenges of nurses working during the SARS-CoV-2 pandemic in Poland.</p><p><strong>Material and methods: </strong>The study was conducted in 2021 in a group of 151 nurses. The following scales were used: the<i> Perceived Stress Scale</i> (PSS-10), the <i>General Self-Efficacy Scale</i> (GSES), the<i> Impact of Event Scale - Revised</i> (IES-R), the <i>Minnesota Satisfaction Questionnaire</i> (MSQ-SF), the <i>Areas of Worklife Survey</i> (AWS) and the <i>Maslach Burnout Inventory - Human Services Survey</i> (MBIHSS).</p><p><strong>Results: </strong>Nurses working with patients infected with SARS-CoV-2 showed a positive correlation between workload and emotional exhaustion (ρ = 0.26, p = 0.02), as well as positive correlations among control, community and depersonalization (ρ = 0.25, p = 0.02; ρ = 0.23, p = 0.04). Among nurses working with uninfected patients, positive correlations were found among control, community, fairness and emotional exhaustion (ρ = 0.40, p = 0.000; ρ = 0.41, p = 0.000; ρ = 0.25, p = 0.03), as well as correlations between control and depersonalization (ρ = 0.33, p = 0.01), and among control, community and personal accomplishment (ρ = 0.23, p = 0.05; ρ = 0.27, p = 0.02).</p><p><strong>Conclusions: </strong>Nurses working during the SARS-CoV-2 pandemic with infected and uninfected patients both experienced a variety of psychosocial challenges in coping with the demands of their work, social relationships and personal life. Int J Occup Med Environ Health. 2023;36(1):112-24.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/01/ijomeh-36-112.PMC10464736.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10471385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Remote and on-site work stress severity during the COVID-19 pandemic: comparison and selected conditions.","authors":"Agata Chudzicka-Czupała,&nbsp;Marta Żywiołek-Szeja,&nbsp;Mateusz Paliga,&nbsp;Damian Grabowski,&nbsp;Noemi Krauze","doi":"10.13075/ijomeh.1896.02001","DOIUrl":"https://doi.org/10.13075/ijomeh.1896.02001","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the present study was to explore whether remote and on-site work stress during the COVID-19 pandemic was experienced with different severity. The second goal was to investigate stress conditions at both working modes.</p><p><strong>Material and methods: </strong>The study involved 946 individuals working in the education system and BSS sector in different Polish organizations. The following tools were used: the <i>Brief Scale of Vocational Stress</i> by Dudek and Hauk, the Polish version of the scales to measure work-family conflicts by Grzywacz, Frone, Brewer and Kovner, Meyer and <i>Allen's Affective, Continuance, and Normative Commitment Scales</i> in the Polish adaptation by Bańka, Wołowska and Bazińska, the<i> Satisfaction with Job Scale</i> by Zalewska.</p><p><strong>Results: </strong>The analysis of intergroup differences revealed that remote work stress severity was significantly lower than on-site work stress severity. The regression analyses proved that work-family conflict and job satisfaction were significant predictors of remote and on-site work stress. Continuance commitment positively predicted on-site work stress. Both models turned out to be statistically significant. The variables included in the models explained 39% and 35% of the variability of the remote work and on-site work stress, respectively.</p><p><strong>Conclusions: </strong>Remote work is associated with lower stress severity than on-site work. For both types of work, the higher the level of work-family conflict, the higher the level of stress severity, but the higher the job satisfaction, the lower the stress severity. Continuance commitment is positively related to on-site stress, which means that people who work for an organization and see no alternative feel more stressed. Such an effect was observed only in the case of on-site work. The study findings are discussed in light of previous research, and implications for organizational practice are considered. Int J Occup Med Environ Health. 2023;36(1):96-111.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/00/1f/ijomeh-36-96.PMC10464780.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10471386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lithium batteries safety, wider perspective.","authors":"Bartłomiej Łukasz,&nbsp;Iwona Rybakowska,&nbsp;Anna Krakowiak,&nbsp;Magdalena Gregorczyk,&nbsp;Wojciech Waldman","doi":"10.13075/ijomeh.1896.01995","DOIUrl":"https://doi.org/10.13075/ijomeh.1896.01995","url":null,"abstract":"<p><p>Energy production and storage has become a pressing issue in recent decades and its solutions bring new problems. This paper reviews the literature on the human and environmental risks associated with the production, use, and disposal of increasingly common lithium-ion batteries. Popular electronic databases were used for this purpose focused on the period since 2000. Assessment of the toxicological and environmental impact of batteries should then have a holistic scope to precede and guide the introduction of appropriate safety measures. In this short review the authors will try to touch upon this complex subject and point out some important issues related to an unprecedented development of lithium ion batteries-powered world. Given the multi-billion dollar business with the risks associated with the development of new technologies requires careful consideration of whether the balance of profits and losses is beneficial to humans and the planet. Int J Occup Med Environ Health. 2023;36(1):3-20.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1e/e2/ijomeh-36-3.PMC10464770.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10100382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Developing a work well-being questionnaire for social- and health-care managers.","authors":"Niina Herttuala,&nbsp;Anne Konu,&nbsp;Lauri Kokkinen","doi":"10.13075/ijomeh.1896.01910","DOIUrl":"https://doi.org/10.13075/ijomeh.1896.01910","url":null,"abstract":"<p><strong>Objectives: </strong>There is a need for up-to-date research on health-care and social managers' work well-being. The purpose was to develop a questionnaire for measuring health-care and social managers' subjective work well-being and to determine whether their background factors are connected to their work well-being.</p><p><strong>Material and methods: </strong>The authors developed a questionnaire based on their previous health-care and social managers' work well-being framework. It covers 5 separate categories: 1) individual factors, 2) social factors, 3) professional support from one's own manager, 4) organizational factors, and 5) work-related factors. Using statistical methods, the authors examined the questionnaire's internal validity, its fit with the framework, and the connections between several background factors and work well-being. The survey data (N = 281) were collected from South Osthrobothnia and Central Osthrobothnia in Finland.</p><p><strong>Results: </strong>The questionnaire's internal validity was good, and it fit rather well with the authors' previous framework. Managers' work well-being was highest for the category of \"professional support from one's own manager\" and lowest for \"organizational factors.\" The authors found connections between different categories of work well-being and a) years of managerial experience, b) level of management, and c) occupational group.</p><p><strong>Conclusions: </strong>The questionnaire gives a holistic view of managers' work well-being and is suit- able for measuring work well-being in the social- and health-care context. An examination showed that there is a need to improve the individual situations of the social- and health-care managers. The questionnaire can be used to assess managers' work well-being and to build a knowledge base for developing organizational policies. Int J Occup Med Environ Health. 2022;35(6):665-78.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/18/8d/ijomeh-35-665.PMC10464797.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10452405","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The prevalence of dyspnea in the adult Polish population.","authors":"Aleksandra Undrunas, Piotr Bandosz, Marcin Rutkowski, Aleksandra Puch-Walczak, Krzysztof Kuziemski, Tomasz Zdrojewski","doi":"10.13075/ijomeh.1896.01959","DOIUrl":"10.13075/ijomeh.1896.01959","url":null,"abstract":"<p><strong>Objectives: </strong>Dyspnea is one of the most predominant symptom in clinical practice. There is a lack of data about incidents of dyspnea among Polish adults therefore it would be important to establish prevalence of this symptom before COVID-19 pandemic to assess the impact of this infection on the functioning of the adult Polish population in the future. The aim of the study was to establish prevalence of dyspnea in adult Polish population.</p><p><strong>Material and methods: </strong>It was an observational-cross-sectional study, with representative sample of adult Poles aged 18-79 years. The 2413 participants were surveyed. Responders were asked if and when dyspnea occurs and what is its severity in relation to 1 of 4 categories (A, B, C, and D) describing the impact of dyspnea on reduced exercise tolerance and daily activities.</p><p><strong>Results: </strong>The 67.1% of the respondents answered negatively to all question about experiencing dyspnea (females (F) 61% vs. males (M) 74%, p < 0.05). Dyspnea only during intense physical exertion (A), was reported by 22.8% (F 26.2% vs. M 19.2%, p = 0.07). Dyspnea limiting daily activities (B, C and D) was reported by 10.1% (F 13.1% vs. M 7%, p < 0.05). Significant differences in the severity of dyspnea were found between the age groups. People diagnosed with chronic heart failure or lung diseases significantly more often reported dyspnea than people without these conditions.</p><p><strong>Conclusions: </strong>Every tenth Pole reported dyspnea limiting performing activities of daily living. Additionally, about 20% of Poles experienced dyspnea considered as \"gray area,\" only during intense physical exertion, that requires deepening and clarifying the medical history. Int J Occup Med Environ Health. 2022;35(6):747-52.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/44/ijomeh-35-747.PMC10464792.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10094656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of empathy and cognitive trauma processing in the occurrence of professional posttraumatic growth among women working with victims of violence.","authors":"Nina Ogińska-Bulik,&nbsp;Paulina Michalska","doi":"10.13075/ijomeh.1896.01945","DOIUrl":"https://doi.org/10.13075/ijomeh.1896.01945","url":null,"abstract":"<p><strong>Objectives: </strong>Professionals helping victims of violence trauma, in addition to a number of negative effects, may also experience positive changes in the form of vicarious posttraumatic growth (VPTG). Cognitive trauma processing and empathy seem to be important to VPTG. The aim was to determine the relationship between empathy, cognitive trauma processing and VPTG in female professionals helping violence victims.</p><p><strong>Material and methods: </strong>The study included 154 women representing 3 professional groups (therapists, social workers, probation officers). The subjects' age ranged 26-67 years (M±SD 43.98±10.83). The study used 3 standard measurement tools, i.e. the <i>Secondary Posttraumatic Growth Inventory</i>, the <i>Empathic Sensitiveness Scale</i>, measuring 3 aspects of empathy, i.e. empathic concern, personal distress and perspective taking, the <i>Cognitive Processing of Trauma Scale</i>, allowing assessment of 5 remedial strategies (positive cognitive restructuring, downward comparison, resolution/acceptance, denial, regret) and a survey developed for the use of the research.</p><p><strong>Results: </strong>Positive correlations were found between empathy, cognitive coping strategies and VPTG. Positive cognitive restructuring and resolution/acceptance strategies were found to mediate the relationship between empathy and VPTG.</p><p><strong>Conclusions: </strong>Professionals helping trauma victims may experience positive effects in the form of VPTG. The occurrence of VPTG in female professionals is enhanced by the use of empathy and positive coping strategies. Int J Occup Med Environ Health. 2022;35(6):679-92.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/15/5b/ijomeh-35-679.PMC10464719.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10470412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of worklife areas, trust in supervisor and interpersonal trust as conditions of severity of stress at work.","authors":"Agata Chudzicka-Czupała,&nbsp;Damian Grabowski,&nbsp;Agnieszka Czerw,&nbsp;Marta Stasiła-Sieradzka","doi":"10.13075/ijomeh.1896.01990","DOIUrl":"https://doi.org/10.13075/ijomeh.1896.01990","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the paper is to present the findings from a study of the relationships between perception of worklife areas and trust in supervisor and interpersonal trust on the one hand, and assessment of the severity of stress at work on the other hand.</p><p><strong>Material and methods: </strong>The study involved 1113 individuals working in different Polish organizations. The <i>Perceived Stress Scale</i> (PSS-10) was used to measure stress severity. Assessments of worklife areas were measured using the <i>Areas of Worklife Survey</i>, while trust was measured using the <i>Trust in Supervisor Scale</i> and the <i>Interpersonal Trust Measures</i>, a tool for measuring trust in co-workers.</p><p><strong>Results: </strong>The regression analysis results prove that stress severity depends to the largest extent on the assessment of worklife areas (workload, reward, and values), as well as trust in the skills and competencies of the supervisor and trust in co-workers, based on cognitive factors. The role of trust in the supervisor, emphasizing the latter's benevolence and the belief in their integrity and of trust in co-workers, based on emotions, and the relationships of these variables with stress require clarification. The model turned out to be statistically significant, the variables included in the model explain 45% of the variability of the dependent variable.</p><p><strong>Conclusions: </strong>Assessment of worklife areas is more significant for stress level prediction than the trust dimensions studied. Conclusions concerning the relationships between trust and stress must be cautious, and the matter should be studied further. Int J Occup Med Environ Health. 2022;35(6):719-30.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c4/f5/ijomeh-35-719.PMC10464817.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10451923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of calorie restriction on the anthropometric parameters, HOMA-IR index, and lipid profile of female office workers with overweight and obesity: a preliminary study.","authors":"Ewa Sadowska-Krępa,&nbsp;Agnieszka Gdańska,&nbsp;Miroslava Přidalová,&nbsp;Michał Rozpara,&nbsp;Małgorzata Grabara","doi":"10.13075/ijomeh.1896.01963","DOIUrl":"https://doi.org/10.13075/ijomeh.1896.01963","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluates the effect of a 3-month calorie restriction (CR) without snacking on the anthropometric parameters, Homeostatic Model Assesment of Insulin Resistance (HOMA-IR), and lipid profiles of female office workers with overweight or obesity, whose physical activity was limited during the COVID-19 pandemic lockdown.</p><p><strong>Material and methods: </strong>Forty-eight women aged 20-38 years (28.9±5.24) with low physical activity levels were divided into a non-snacking (NS) group (N = 21) and a snacking (S) group (N = 27) prior to the dietary intervention. Their daily energy intake during the intervention was lowered by 30% compared with the baseline level, and the proportion of polyunsaturated fatty acids and fiber in their diet was increased (to >30 g/day). The proportion of saturated fatty acids and simple carbohydrates was also reduced. The study participants were assessed at the baseline and post-intervention for anthropometric variables (body weight, body fat percentage BMI, waist circumference, hip circumference, waist-to-hip ratio) and the concentrations of insulin, total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C). Moreover, the values for HOMA-IR, the atherogenic index of plasma (AIP), and the ratios of TC/HDL-C, TG/HDL-C, and LDL-C/HDL-C were calculated.</p><p><strong>Results: </strong>All anthropometric parameter values obtained post-intervention were lower than the baseline in both groups. The serum insulin concentration and HOMA-IR decreased respectively by an average of 6% and 25% in the NS group and 37% and 45% in the S group. The lipid profiles of all participants improved significantly, with the LDL-C concentration showing a more promising trend in the S group (decrease by 27%) than in the NS group (17%).</p><p><strong>Conclusions: </strong>The study showed that CR improved the anthropometric parameters, HOMA-IR index, and lipid profiles of all participants. Int J Occup Med Environ Health. 2022;35(6):693-706.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/68/f3/ijomeh-35-693.PMC10464818.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10151133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exposure to particulate matter 2.5 leading to lung microbiome disorder and the alleviation effect of <i>Auricularia auricular-judae</i> polysaccharide.","authors":"Yanshu Zhang,&nbsp;Bin He,&nbsp;Lei Wu,&nbsp;Xiaoyi Mi,&nbsp;Lijin Zhang,&nbsp;Shuang Li,&nbsp;Jian Wang,&nbsp;Xiaoyu Yu","doi":"10.13075/ijomeh.1896.01742","DOIUrl":"https://doi.org/10.13075/ijomeh.1896.01742","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the paper is to explore the role of lung microbiome disorder in lung tissue injury induced by exposure to particulate matter with a maximum diameter of 2.5 μm (PM2.5) and the alleviation effect of <i>Auricularia auricular-judae</i> polysaccharide (AAP).</p><p><strong>Material and methods: </strong>Sprague Dawley rats were given PM_2.5 suspension at a dose of 20 mg/l twice a week for 8 weeks. Then, 100 mg/kg or 200 mg/kg of AAP was administered to the rats after PM_2.5 exposure. The bronchoalveolar lavage fluid (BALF) and lung tissue samples were collected at the end of the experiment. The BALF was meant to detect changes in lung microbiome by 16S sequences and cluster analysis, with the application of the principal component analysis and the partial least squares discriminant analysis. The levels of interferon-γ (IFN-γ), and interleukin (IL)-4, IL-8, and IL-10 in lung tissue were detected by the enzyme-linked immunosorbent assay method. The pathological changes in lung tissue were observed by hematoxylin and eosin staining.</p><p><strong>Results: </strong>After PM_2.5 exposure, the alveolar septum was widened, and the structures of alveolar walls were destroyed. There was inflammatory cells infiltration in the alveolar space and the interstitial space. Alpha diversity in BALF showed that the Chao1, ACE, Simpson, and Shannon values were increased, and the lung microbiome analysis revealed that the relative abundance of <i>Firmicutes</i> and <i>Clostridium</i> increased, while the relative abundance of <i>Bacteroidetes</i> and <i>Akkermansia</i> decreased. The contents of IFN-γ and IL-8 in lung tissue increased while the content of IL-10 decreased. After the administration of AAP, the alveolar structure damage was alleviated, and the interstitial hemorrhage, edema, and inflammatory cells infiltration were reduced. The Chao1 and ACE values decreased, and the taxonomic abundance values of <i>Akkermansia</i> were much higher. Simultaneously, the contents of IFN-γ, IL-4, and IL-8 decreased, and the content of IL-10 increased.</p><p><strong>Conclusions: </strong>It was found that PM_2.5 resulted in lung microbiome disorder, which might lead to the inflammation of lung tissue. It was also revealed that AAP could alleviate the inflammatory damage of lung tissue induced by PM_2.5. Int J Occup Med Environ Health. 2022;35(6):651-64.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":null,"pages":null},"PeriodicalIF":2.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/56/7d/ijomeh-35-651.PMC10464723.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10099422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}