International journal of occupational medicine and environmental health最新文献

{"title":"Immunoaging - the effect of age on serum levels of NET biomarkers in men: a pilot study.","authors":"Marzena Garley, Wioleta Justyna Omeljaniuk, Radosław Motkowski, Wioletta Ratajczak-Wrona, Ewa Jabłońska, Daniel Filipkowski, Angelika Edyta Charkiewicz","doi":"10.13075/ijomeh.1896.02125","DOIUrl":"10.13075/ijomeh.1896.02125","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to evaluate the impact of aging on the formation of neutrophil extracellular traps (NETs). The impaired formation of NETs is the cause of an abnormal innate immune response.</p><p><strong>Material and methods: </strong>The study included a total of 45 healthy male subjects of different age groups. Whole blood was collected from the subjects, and the concentration of myeloperoxidase (MPO), the main biocidal protein in NETs, was determined in serum using ELISA. The serum levels of circulating free DNA (cfDNA), which are the structural basis of NETs, were also measured by fluorescence. In addition, the white blood cell count was determined, whole blood smear was evaluated, and the neutrophillymphocyte ratio was calculated. The variations in the levels of NET biomarkers were analyzed in different age groups.</p><p><strong>Results: </strong>The low levels of MPO (243.70 ng/ml) and cfDNA (6.24 ng/100 μl) in boys indicated neutrophil insufficiency for NETosis in children. A progressive increase in the levels of MPO and cfDNA with age was observed among adolescents (420.91, p = 0.04; 13.55, p = 0.03, respectively), with the highest level noted in the healthy adult group (466.58, p = 0.01; 14.07, p = 0.01, respectively). The levels of the studied parameters were comparable in adolescents and young adults, which proved that the NETosis process was appropriate and suggested the attainment of neutrophil maturity for the release of NETs in adolescence. The levels of MPO and cfDNA were low in older men (225.46, p < 0.01; 5.19, p < 0.01, respectively) indicating impaired NET formation.</p><p><strong>Conclusions: </strong>Data on the generation of NETs in different age groups obtained in this study can allow a better understanding of the ontogenesis of the immune system in terms of the course of NETosis, and also indicate the need to support nonspecific responses in children and adults. Further research should be performed to determine the possibility of regulating the NETosis process. Int J Occup Med Environ Health. 2023;36(3):333-48.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":"36 3","pages":"333-348"},"PeriodicalIF":2.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10664002/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10567291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term healthcare professionals' experiences of burnout and correlation between burnout and fatigue: a cross-sectional study.","authors":"Karmen Erjavec, Ljiljana Leskovic","doi":"10.13075/ijomeh.1896.02182","DOIUrl":"10.13075/ijomeh.1896.02182","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the study was to analyze the long-term burnout levels of healthcare professionals (HCPs) working in Slovenian nursing homes during the fifth wave of the pandemic; to compare the results of similar facilities in 2020 and 2013; and to examine the correlation between demographics and burnout and fatigue among HCPs.</p><p><strong>Material and methods: </strong>The study used a descriptive, correlational cross-sectional method.</p><p><strong>Results: </strong>In the fifth wave, HCPs suffered more from emotional exhaustion, depersonalization and lack of personal accomplishment than in the first wave of the pandemic and in the spring of 2013. The HCPs caring for COVID-19 patients and younger women had higher rates of burnout and fatigue than other occupational groups. There is a strong positive correlation between burnout and fatigue.</p><p><strong>Conclusions: </strong>There is an urgent need to address the problem of fatigue and burnout with administrative measures. Int J Occup Med Environ Health. 2023;36(3):396-405.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":"36 3","pages":"396-405"},"PeriodicalIF":2.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10567293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prenatal polyunsaturated fatty acids and atopic dermatitis and food allergy in children from Polish Mother and Child Cohort study.","authors":"Alexandra Jerzyńska, Alicja Polańska, Elżbieta Trafalska, Agnieszka Jankowska, Daniela Podlecka, Agnieszka Brzozowska","doi":"10.13075/ijomeh.1896.02222","DOIUrl":"10.13075/ijomeh.1896.02222","url":null,"abstract":"<p><strong>Objectives: </strong>Polyunsaturated fatty acids (PUFAs) are involved both in immune system regulation and inflammation. The aim of this prospective study was to evaluate the association between maternal dietary intake of PUFAs during pregnancy and atopic dermatitis (AD) and food allergy (FA) in their children up to 7-9 years of age.</p><p><strong>Material and methods: </strong>The study population consists of 557 mother-child pairs from the Polish Mother and Child Cohort (REPRO_PL). Based on the <i>Food Frequency Questionnaire</i> completed between the 20-24th weeks of pregnancy, n-3 and n-6 PUFAs as well as n-6:n-3 fatty acid ratio were estimated using food composition tables. Children's health examinations at the age of 1, 2, and 7-9 years were performed by an allergist. Generalized estimating equations were performed in order to assess the prevalence of AD and FA at 3 time points. Independent variables in the equation were n-3, n-6 PUFAs and n-6:n-3 PUFAs ratio. In addition multivariate models were performed to assess the association of PUFAs with AD and FA.</p><p><strong>Results: </strong>The prevalence of AD was 37%, 26% and 21% and FA 26%, 22% and 22% at age of 1, 2 and 7-9 years, respectively. Higher n-6:n-3 fatty acid ratio correlated with higher prevalence of AD at age of 7-9 years (p < 0.07). In multivariate model n-6 PUFAs were significantly associated with increased risk of persistent FA (OR = 1.5, 95% CI: 1.1-2.1).</p><p><strong>Conclusions: </strong>These results may contribute to the existing knowledge on the impact of maternal diet during pregnancy on children's optimal health, however further studies are needed before drawing conclusions and creating clinical practice guidelines. Int J Occup Med Environ Health. 2023;36(3):428-36.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":"36 3","pages":"428-436"},"PeriodicalIF":2.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10567295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hospital medical care and the COVID-19 mortality in METEOR partner countries (the Netherlands, Belgium, Italy, And Poland).","authors":"Małgorzata Kowalska, Peter de Winter, Lode Godderis, Anke Boone, Szymon Szemik","doi":"10.13075/ijomeh.1896.02187","DOIUrl":"10.13075/ijomeh.1896.02187","url":null,"abstract":"<p><strong>Objectives: </strong>Healthcare systems in European countries, including METEOR partner countries, are faced with the aging population, an increase in costs for innovative technologies and medication, a shortage of health professionals, and inequality in access to healthcare. Presented paper aimed to recognize and compare the functioning of healthcare systems between METEOR partner countries and simultaneously check if the current epidemiological situation of COVID-19 has some relationship with the number of medical staff, yearly gross domestic product, or documented percentage of fully vaccinated people.</p><p><strong>Material and methods: </strong>In the model of descriptive epidemiological study, available demographic, socioeconomic, and healthcare organizational data in the Netherlands, Belgium, Italy, and Poland were compared to the epidemiological situation of the COVID-19 pandemic (percentage of fully vaccinated people, incidence, and mortality) in all mentioned countries.</p><p><strong>Results: </strong>Obtained data confirmed that the lowest number of physicians, as well as the life expectancy and gross domestic product per capita, is in Poland. Simultaneously, the lower number of medical staff and lower gross domestic product (GDP) correspond to higher mortality due to COVID-19. The percentage of fully vaccinated with the last dose of the primary series was also the lowest in Poland.</p><p><strong>Conclusions: </strong>Obtained results confirmed that higher mortality due to COVID-19 in METEOR participants' countries is related to a lower number of medical staff and weaker GDP. The worse situation was noted in Poland, a country with problems in the functioning healthcare system, including hospital care and a serious shortage of practicing medical staff. Int J Occup Med Environ Health. 2023;36(3):417-27.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":"36 3","pages":"417-427"},"PeriodicalIF":2.0,"publicationDate":"2023-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10663996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10567297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Not so good hybrid work model? Resource losses and gains since the outbreak of the COVID-19 pandemic and job burnout among non-remote, hybrid, and remote employees.","authors":"Marta Stasiła-Sieradzka, Elżbieta Sanecka, Elżbieta Turska","doi":"10.13075/ijomeh.1896.02026","DOIUrl":"10.13075/ijomeh.1896.02026","url":null,"abstract":"<p><strong>Objectives: </strong>The COVID-19 pandemic contributing to the dissemination of alternative work models such as fully remote or hybrid work models. The present study focused on these 2 types of unplanned changes in the working environment. The conservation of resources theory, the first aim of this study was to examine the predictive role of resource losses and gains since the outbreak of the COVID-19 pandemic in job burnout. Moreover, the authors investigated how non-remote, remote, and hybrid employees differ in resource losses and gains and job burnout.</p><p><strong>Material and methods: </strong>A cross-sectional online comparative study was conducted a year after the outbreak of the COVID-19 pandemic. The respondents provided sociodemographic data, reported their current work model, and completed validated measures of resource losses and gains and job burnout: the <i>Conservation of Resources Evaluation</i> and the <i>Oldenburg Burnout Inventory</i>. Based on the data collected from 1000 working adults from the Polish population, the authors tested the differences in losses and gains of different categories of resources and job burnout components between the 3 groups of employees representing distinct working models, i.e., non-remote, hybrid, and remote.</p><p><strong>Results: </strong>In general, the associations of losses and gains with job burnout subscales have been confirmed, regardless of the level of analysis of losses and gains. The authors' findings indicated that hybrid workers experienced significantly higher resource losses and gains (both in general and in different domains) in comparison to non-remote and remote workers. In turn, non-remote employees scored significantly higher on disengagement, which is one of the job burnout components.</p><p><strong>Conclusions: </strong>Hybrid workers experienced the highest levels of both resource losses and gains during the COVID-19 pandemic, compared to non-remote and remote workers, suggesting that this form of working arrangement involves the greatest changes in different life domains, bringing both positive and negative consequences for the employee. Int J Occup Med Environ Health. 2023;36(2):229-49.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":"36 2","pages":"229-249"},"PeriodicalIF":1.4,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0d/4f/ijomeh-36-229.PMC10464789.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10153792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mental condition and physical activity of individuals working during the COVID-19 pandemic in Poland.","authors":"Jolanta Zwolińska,&nbsp;Paweł Walski,&nbsp;Kamil Zajdel","doi":"10.13075/ijomeh.1896.01984","DOIUrl":"https://doi.org/10.13075/ijomeh.1896.01984","url":null,"abstract":"<p><strong>Objectives: </strong>The study assessed quality of life and depression in working people during COVID-19 pandemic, relative to their physical activity.</p><p><strong>Material and methods: </strong>The study involved 1194 people living in south-eastern Poland, and assessed life satisfaction (<i>Life Satisfaction Questionnaire - 9</i> [LISAT-9]), quality of life (<i>World Health Organization Quality of Life - BREF</i> [WHOQoL-BREF]), depression (<i>Beck Depression Inventory</i> [BDI]) and physical activity.</p><p><strong>Results: </strong>The respondents on average scored 4.32 in LISAT-9; respectively 66.2, 68.3, 69.6 and 63.5 in physical, psychological, social and environment domains of WHOQoL-BREF and 9.2 in BDI. Regularly performed physical activity positively affected the scores in all the psychometric tests in women with higher and secondary education and in men with vocational education. Women presented lower life satisfaction, poorer quality of life and higher level of depression than men. The psychometric scores were also differentiated by type of employment and job. Depression was identified in 44% of all the respondents.</p><p><strong>Conclusions: </strong>Individuals who are economically active during the pandemic report good quality of life and no or only mild signs of depression. Working people with higher education cope more effectively with adversities of the pandemic, compared to those with lower education. Int J Occup Med Environ Health. 2023;36(2):274-90.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":"36 2","pages":"274-290"},"PeriodicalIF":2.0,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a9/fb/ijomeh-36-274.PMC10464786.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10153793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensitivity and specificity of using exercise heart rate in a thermoneutral environment to predict heat tolerance status.","authors":"Sarah Northway,&nbsp;Douglas Jones,&nbsp;Michael Buono","doi":"10.13075/ijomeh.1896.02065","DOIUrl":"https://doi.org/10.13075/ijomeh.1896.02065","url":null,"abstract":"<p><strong>Objectives: </strong>Following heat illness, a return to activity may require passing a heat tolerance test (HTT). However, there are several logistical limitations to the widespread use of the HTT. Thus, it would be advantageous to develop a test that could be conducted in a thermoneutral (~22°C) environment to predict heat tolerance status. The purpose of the current study was to determine the sensitivity and specificity of using the criteria of a heart rate (HR) ≥130 bpm following 30 min of thermoneutral exercise in detecting heat-intolerant and heat-tolerant individuals.</p><p><strong>Material and methods: </strong>Sixty-five subjects visited the lab on 3 separate days. The first visit consisted of completing a maximal oxygen uptake (VO2 max) test to assess cardiovascular fitness. For lab visits 2 and 3, subjects randomly completed a 2-hour walking treadmill test in either a hot (40°C, 40% relative humidity [RH]) or thermoneutral (22°C, 40% RH) environment.</p><p><strong>Results: </strong>Forty-eight subjects were classified as heat-intolerant and 17 subjects as heat-tolerant. Using the criterion of a HR ≥130 bpm at 30 min of exercise in the thermoneutral environment, specificity (54%) and sensitivity (100%) of passing the HTT was calculated. Secondary analysis using multiple regression revealed 3 significant variables for predicting ending HR during the HTT. They were: 1) absolute VO2 max (l/min), 2) age, and 3) HR at 30 min of exercise during thermoneutral exercise.</p><p><strong>Conclusions: </strong>Exercise in a thermoneutral environment had a positive predictive value of 100%, thus, if a subject has a HR ≥130 bpm at 30 min of exercise in a thermoneutral environment, they are very likely to fail a subsequent 2-hour HTT in the heat and be classified as heat-intolerant. Therefore, prior screening has the potential to save time and money, along with providing safety to a heat-intolerant subject. Int J Occup Med Environ Health. 2023;36(2):192-200.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":"36 2","pages":"192-200"},"PeriodicalIF":2.0,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/1a/0d/ijomeh-36-192.PMC10464765.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10454504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors related to personal quality of life in prison inmates.","authors":"Bartłomiej Skowroński,&nbsp;Elżbieta Barbara Talik","doi":"10.13075/ijomeh.1896.01961","DOIUrl":"https://doi.org/10.13075/ijomeh.1896.01961","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the study was to analyze the determinants of prison inmates' personal quality of life (PQoL).</p><p><strong>Material and methods: </strong>Three hundred ninety men imprisoned in penitentiary institutions were assessed. Data were collected by means of the the <i>Sense of Quality of Life Questionnaire</i>, the <i>General Self-Esteem Scale, the Social Support Scale</i>, the <i>Resiliency Assessment Scale</i>, the <i>Trait Personality Inventory</i>, which have high validity and reliability. All models were specified in structural equations modeling using Mplus v. 8.2.</p><p><strong>Results: </strong>The positive correlates of PQoL are: self-efficacy, social support, and ego-resiliency. The negative correlate of PQoL is trait depression. The study confirmed that 2 factors affected ego-resiliency: self-efficacy and trait depression.</p><p><strong>Conclusions: </strong>All significant factors, such as self-efficacy, social support, ego-resiliency, or trait depression, should be taken into account in rehabilitation programs. Int J Occup Med Environ Health. 2023;36(2):291-302.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":"36 2","pages":"291-302"},"PeriodicalIF":2.0,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/91/ed/ijomeh-36-291.PMC10464816.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10472931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Occupational health: the role of demographic factors in the condition of increased risk.","authors":"Aleksandra Sitarevic,&nbsp;Ana Nesic-Tomasevic,&nbsp;Dragan Nikolic,&nbsp;Aleksandar Sofic","doi":"10.13075/ijomeh.1896.01943","DOIUrl":"https://doi.org/10.13075/ijomeh.1896.01943","url":null,"abstract":"<p><strong>Objectives: </strong>The paper analyses the impact of socio-demographic characteristics of the employees in conditions of uncertainty in the organizations.</p><p><strong>Material and methods: </strong>The study was conducted on a sample of 210 employees using the <i>Mental Health Inventory</i> - 38 (MHI-38), <i>Satisfaction with life scale</i> (SWLS), and the <i>Center for Epidemiological Studies - Depression</i> (CES-D).</p><p><strong>Results: </strong>The results showed that female respondents had significantly higher scores on ANX (t = 2,278, p < 0.05), while male employees had higher scores on life satisfaction (t = 2.103, p < 0.05). Older employees have a higher tendency for loss of emotional-behavioral control (F = 4.427, p < 0.05). Respondents who have satisfying living standards have also higher scores on SWLS (t = 2.257, p < 0.05). Respondents who have dissatisfying living standard have higher scores on generally positive affect (t = 3.152, p < 0.01), life satisfaction (t = 3.571, p < 0.01), psychological distress (t = 2.929, p < 0.01) and loss of emotional- behavioral control (t = 2.361, p < 0.05). Employees with different levels of educational background have similar tendencies in life satisfaction, mental health, and depressive symptoms (p > 0.05).</p><p><strong>Conclusions: </strong>The study showed that the specific socio-demographic profile of the employees is related to higher levels of mental health issues. Specifically, the mental health of female and older employees have been especially affected and disturbed by uncertain conditions. The results can be potentially used both in the terms of designing activities that support the mental health of the population, as well as in relation to the mental health of employees. Int J Occup Med Environ Health. 2023;36(2):250-62.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":"36 2","pages":"250-262"},"PeriodicalIF":2.0,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/b3/8c/ijomeh-36-250.PMC10464728.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10153797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of air quality on sleep and cognitive performance in school children aged 10-12 years: a double-blinded, placebo-controlled, crossover trial.","authors":"Frida Bejder Klausen,&nbsp;Ali Amidi,&nbsp;Søren K Kjærgaard,&nbsp;Vivi Schlünssen,&nbsp;Peter Ravn,&nbsp;Kirsten Østergaard,&nbsp;Vibeke Heitmann Gutzke,&nbsp;Marianne Glasius,&nbsp;Therese Koops Grønborg,&nbsp;Stefan Nygaard Hansen,&nbsp;Robert Zachariae,&nbsp;Pawel Wargocki,&nbsp;Torben Sigsgaard","doi":"10.13075/ijomeh.1896.02032","DOIUrl":"https://doi.org/10.13075/ijomeh.1896.02032","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effect of CO₂ during sleep on next-morning cognitive performance in young schoolchildren, the authors performed a double-blind fully balanced crossover placebo-controlled study.</p><p><strong>Material and methods: </strong>The authors included 36 children aged 10-12 years in the climate chamber. The children slept at 21°C in 6 groups each at 3 different conditions separated by 7 days in a random order. Conditions were as follows: high ventilation with CO₂ at 700 ppm, high ventilation with added pure CO₂ at 2000-3000 ppm, and reduced ventilation with CO₂ at 2-3000 ppm and bioeffluents. Children were subjected to a digital cognitive test battery (CANTAB) in the evening prior to sleep and on the next morning after breakfast. Sleep quality was monitored with wrist actigraphs.</p><p><strong>Results: </strong>There were no significant exposure effects on cognitive performance. Sleep efficiency was significantly lower at high ventilation with CO₂ at 700 ppm which is considered to be a chance effect. No other effects were seen, and no relation between air quality during sleep and next-morning cognitive performance was observed in the children emitting an estimated 10 l_CO₂/h per child.</p><p><strong>Conclusions: </strong>No effect of CO₂ during sleep was found on next day cognition. The children were awakened in the morning, and spent from 45-70 min in well-ventilated rooms before they were tested. Hence, it cannot be precluded that the children have benefitted from the good indoor air quality conditions before and during the testing period. The slightly better sleep efficiency during high CO₂ concentrations might be a chance finding. Hence, replication is needed in actual bedrooms controlling for other external factors before any generalizations can be made. Int J Occup Med Environ Health. 2023;36(2):177-91.</p>","PeriodicalId":14173,"journal":{"name":"International journal of occupational medicine and environmental health","volume":"36 2","pages":"177-191"},"PeriodicalIF":2.0,"publicationDate":"2023-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0e/d7/ijomeh-36-177.PMC10464806.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10100922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}