International Journal of Medical Toxicology and Forensic Medicine最新文献

{"title":"Forensica Application as Learning Media on Forensic","authors":"Idha Arfianti Wiraagni, Beta Ahlam Gizela, Firdaus, A. B. Auvaq, Budiatri Retno Noormaningrum, Busyra, Wendi Wiradinata, Nurholis Majid","doi":"10.32598/ijmtfm.v13i2.40171","DOIUrl":"https://doi.org/10.32598/ijmtfm.v13i2.40171","url":null,"abstract":"Background: Time of death estimation is crucial to help investigators to solve a case. In this study, Forensica application, version 4, an android-based mobile phone application was developed as a tool to educate and calculate the time of death estimation. This study aimed to compare the level of knowledge between medical students that studied using the application and textbook. Methods: Both groups had the same study duration and answered the same questions. Participants had then filled out a questionnaire about the Forensica. Results: Statistical analysis shows that gender differences do not result in significant differences. The mean of the post-test result shows significant improvement (P=0.00) in both groups when compared to the pre-test result. Conclusion: The result shows that generally, the respondents feel that learning with Forensica was easier, faster, more fun, more practical, and more exciting than learning compared with textbooks. Thus, Forensica application can be a better learning method alternative to textbooks that is easier, faster, more fun, more practical, and more exciting.","PeriodicalId":14168,"journal":{"name":"International Journal of Medical Toxicology and Forensic Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43667124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality due to H1N1 Influenza in Cases Registered at the Autopsy Halls of Kahrizak, Tehran","authors":"M. Forouzesh, Ramin Talaie, Nahid Dadashzadehasl, Seyed Shahram Mousavi, Abdolrazagh Barzegar, eyed Amirhosein Mahdavi, M. Ghadipasha, Roya Kordrostami, R. Valizadeh","doi":"10.32598/ijmtfm.v13i2.41490","DOIUrl":"https://doi.org/10.32598/ijmtfm.v13i2.41490","url":null,"abstract":"H1N1 swine flu is an acute disease that infects the upper respiratory tract and can cause inflammation of the upper respiratory tract, trachea, and possibly the lower respiratory tract. The known course for H1N1 swine flu is varied from one to four days, on average for most people about two days, but in some cases, it can be up to seven days.","PeriodicalId":14168,"journal":{"name":"International Journal of Medical Toxicology and Forensic Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47214206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Formalin Versus Bouin Solution for Rat Testicular Tissue Fixation: A Histochemical and Immunohistochemical Evaluation","authors":"Zainab Waleed Aziz, Mohammed Ghassan Saeed, Karam Turath Tawfeeq","doi":"10.32598/ijmtfm.v13i2.40267","DOIUrl":"https://doi.org/10.32598/ijmtfm.v13i2.40267","url":null,"abstract":"Background: An accurate histopathological assessment and reporting of testicular biopsies require an appropriate tissue fixative. We assessed the histological, histochemical, and immunohistochemical quality of testicular biopsies, comparing 10% formalin versus Bouin solution as tissue fixatives. Methods: This experimental study utilized 20 adult male albino rats equally divided into five cages for 30 days. By the end of the experiment, all animals were anesthetized, and both testes were removed and weighted; one testicle was fixed in 10% formalin and the other testicle in Bouin solution, offering 40 specimens and then subjected to histological, morphometric, histochemical, and immunohistochemical assessments. Results: Formalin revealed high-quality cytological details and better nuclear chromatin detail (P=0.03). At the architectural level, the Bouin solution showed better quality details with less cytoplasmic shrinkage of seminiferous tubule germ cells (P=0.001). Bouin’s fixed tissues were more suitable for staining by trichrome methods but unsuitable when subsequent immunohistochemistry was requested. The diagnostic concordance between the Bouin solution versus formalin-fixed biopsies was 91.7%. Conclusion: This study supports that the morphology of testicular tissue fixed with Bouin solution was nearly comparable to those fixed with 10% neutral buffered formalin. However, the Bouin solution cannot substitute formalin when subsequent immunohistochemistry is considered.","PeriodicalId":14168,"journal":{"name":"International Journal of Medical Toxicology and Forensic Medicine","volume":"1 1","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41411161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autopsy Finding of Fatal Child Physical Abuse by Stepfather: Case Report","authors":"Galih Endradita M, Muhammad Kholil Ikhsan, William Daniel Napitupulu, A. Yudianto","doi":"10.32598/ijmtfm.v13i2.40881","DOIUrl":"https://doi.org/10.32598/ijmtfm.v13i2.40881","url":null,"abstract":"Child physical abuse (CPA) is prone to occur in developing areas. Aside from stressors in the home, the presence of a stepfather is another cause of CPA. The case reported here is of a 3-year-old girl who experienced fatal physical abuse by her stepfather. On external examination, bruises were found on the forehead, right and left cheeks, chin, chest, back, upper and lower left arms, pubic lips, upper and lower right legs, and lower left legs, and blisters on the lips. On internal examination, severe damage was found to internal organs. This paper also discussed how this case was viewed from the Indonesian legal framework.","PeriodicalId":14168,"journal":{"name":"International Journal of Medical Toxicology and Forensic Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49030228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceptions and experiences of Forensic Medicine Department service recipients and providers during male sexual dysfunction assessment following filing for divorce: a qualitative study in Iran","authors":"M. Safaei, Raziyeh Maasoumi, S. Mahdavi, Laleh Ghadirian","doi":"10.32598/ijmtfm.v13i1.39138","DOIUrl":"https://doi.org/10.32598/ijmtfm.v13i1.39138","url":null,"abstract":"Background: In the current era, divorce has become quite commonplace. One of the significant reasons for divorce is sexual dysfunction. the aim of this study was to explore the perceptions and experience of Forensic Medicine Department service recipients and providers during male sexual dysfunction assessment following filing for divorce. Methods: This study was a qualitative study that was analyzed through a content analysis approach. Individual interviews were used for data collection. The data were collected through in-depth semi-structured interviews with Twenty service recipients and nine service providers of Forensic Medicine Department in Tehran from Jan 2022 and ended in March 2022. Results: The analysis of the data led to the extraction of two main categories, including: existing challenges of the forensic medical system in the sexual assessment process with 3 sub-categories (Absence of the plaintiff during the assessment process, sharing a common room with other clients, The psychosocial pressure associated with a Rigi Scan test) and features of desirable evaluation services with 5 Sub-categories (Service delivery to couples, Service delivery by observing ethical principles, confidentiality and human dignity, Comprehensive physical-psychological-communicative assessment, Service delivery that emphasizes informing couples about the road ahead, Provision of services if the authenticity of the sexual problem is proven). Conclusion: Based on the results of the present study, Service recipients expected the claimant to be present throughout the evaluation process and to cover the expenses too. Moreover, they expected a better atmosphere to be available for these individuals and that human dignity and ethical principles be safeguarded. Furthermore, based on their opinions, a comprehensive physical-psychological-communicative assessment was necessary and couples should be informed and aware of the process when they enter it –particularly when the complaint is proven to be unreal, and all evaluations should be performed on both spouses, not just one.","PeriodicalId":14168,"journal":{"name":"International Journal of Medical Toxicology and Forensic Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44804572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of Gender and Age Based on Three-dimensional Computed Tomography Scan Indices of the Twelfth Thoracic Vertebrae and the First and Fifth Lumbar Vertebrae in Iranian Adults","authors":"S. H. S. Mostafavi, Ramin Emami, A. Memarian, S. Soltani, O. Motamedi, Mohammadreza Khaleghi, Shirin Habibi","doi":"10.32598/ijmtfm.v13i1.39171","DOIUrl":"https://doi.org/10.32598/ijmtfm.v13i1.39171","url":null,"abstract":"Background: Gender identification is a crucial starting point in creating a biological profile for human skeletal remains because it reduces the number of possible matches by 50%. The vertebrae (especially the chest and back) can also be some of the best-preserved skeletal elements in some areas of forensics and archeology. In the present study, gender and age were assessed based on the measurement of three-dimensional computed tomography (CT) scan indices of the Twelfth thoracic (T12) vertebrae and the first and fifth lumbar (L1 and L5) vertebrae in Iranian adults. Methods: The present study was a descriptive study carried out on 200 participants over 18 years of age in 2020. Individuals measuring thoracic and lumbar vertebrae diameters (T12 and first and fifth lumbar vertebrae) by three-dimensional computed tomography (CT) scan (Toshiba, Japan, 16-Slice) with multiplanar reconstruction (MPR) and volume rendering were placed in two sagittal and horizontal sections. Results: The mean age of male and female participants was 34.62±9.63 years and 34.10±9.70 years, respectively, which were not significantly different (P=0.789). The present study showed that the mean indices for T12, L1 and L5 vertebrae were significantly higher in males (P>0.05). The results also showed that T12, L1, and L5 indices of nuts are not good predictors for age estimation. Conclusion: Based on the results, the indices of the T12 vertebrae and the L1, and L5 vertebrae can be used to determine gender, but these indices are not a good criterion to estimate age and do not have the necessary accuracy to predict the age variable.","PeriodicalId":14168,"journal":{"name":"International Journal of Medical Toxicology and Forensic Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49045017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Crocin Supplementation on Sleep Quality, General Health, and Happiness in Elderly Population: A Randomized, Double-blind, Placebo-controlled Trial","authors":"H. Sadeghi-Gandomani, H. Banafshe, Z. Sadat, Ghaderi Amir, Shirvanizadeh Fatemeh, M. Afshar, Narges Naseri-Borujeni","doi":"10.32598/ijmtfm.v12i4.38718","DOIUrl":"https://doi.org/10.32598/ijmtfm.v12i4.38718","url":null,"abstract":"Background: Aging is a period of human life in which general health, especially happiness, and hope, may be impaired. Also, sleep quality, general health, and happiness of the elderly begin o decline at this stage of life. The present study aimed to determine the effect of crocin of saffron on sleep quality, general health, and happiness in the elderly population Methods: In this triple-blind randomized trial, 70 elderly people referred to Kashan health center in 2020 were selected. The study samples were divided into intervention and control groups using computer-generated random numbers to receive 30 mg/d of crocin (2 plus crocin tablet, 15 mg Beck depression inventory [BID]) (n=35) or placebo (2 tablets per day, 15 mg Beck depression inventory [BID]) (n=35), one hour after taking food, for 4 weeks. The sleep quality, general health, and happiness were evaluated at the beginning of the study, 4 and 8 weeks after the intervention. Data were analyzed using Chi-square, independent t-test, and repeated measures analysis of variance (ANOVA). Results: The two groups were matched in terms of demographic characteristics (P>0.05). The independent t-test showed no significant difference between the two groups in the baseline (sleep quality P=0.55, general health P=0.060, and happiness P=0.83) while a statistically significant difference was observed between the two groups on the post-test (P=0.001) and follow-up for three variables. Conclusion: The consumption of crocin by elderly individuals had useful outcomes on sleep quality, well-being, and happiness. Given that the efficacy of the psychological drugs is vital, nurses can use natural medications, such as crocin to improve the psychological disorders of elderly people.","PeriodicalId":14168,"journal":{"name":"International Journal of Medical Toxicology and Forensic Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43939124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Autopsy Case of Drowning Under the Influence of Etizolam: A Case Report","authors":"Sella Takei, H. Kinoshita, M. Jamal, Tadayoshi Yamashita, Etsuko Tanaka, Sachiko Kawahara, Hiroko Abe, S. Kimura","doi":"10.32598/ijmtfm.v13i1.40000","DOIUrl":"https://doi.org/10.32598/ijmtfm.v13i1.40000","url":null,"abstract":"A fatal case of drowning under the influence of etizolam is presented. Quantitative toxicological analysis revealed etizolam concentrations of 0.50 µg/mL and 0.068 µg/mL in femoral venous blood and urine, respectively. According to the autopsy findings, the results of toxicological examinations, and the investigation by the authorities, it is concluded that the cause of death is drowning under the influence of etizolam.","PeriodicalId":14168,"journal":{"name":"International Journal of Medical Toxicology and Forensic Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44938782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of COVID-19 on Intoxication Pattern by Drugs of Abuse in Egypt","authors":"H. Aboubakr, Nadia Abd El Monem Kotb, F. Shaban, Hanaa Mohamed Samir Elattar, E. Shalaby","doi":"10.32598/ijmtfm.v13i1.39497","DOIUrl":"https://doi.org/10.32598/ijmtfm.v13i1.39497","url":null,"abstract":"Background: Drug abuse is considered a global and growing problem worldwide. Emergency medical care is required for acute intoxication, which adds to the threat of COVID-19. This study aims to evaluate the effect of the COVID-19 pandemic on the pattern of acute toxicity in drug abuse patients admitted to National Environmental and Clinical Toxicology and Research Center (NECTR), Cairo University. Methods: This comparative study included 978 cases admitted to NECTR during 12 months before the COVID-19 pandemic (2018-2019) and 12 months during the pandemic (2020-2021). Results: The number of cases during the pandemic was lower than before; adults and men predominate in both periods. During the pandemic, cannabis, heroin, opium, and alcohol showed a mild increase, while the new synthetic drugs, tramadol, and pregabalin, showed a mild decrease. A significant increase in discharges and a decrease in intensive care unit (ICU) admissions were observed during the pandemic. Besides, more oxygen (O2) therapy was required, and more cases died on mechanical ventilation. The worst outcome was associated with old age, male gender, heroin and opium toxicity, and the highest score of poisoning severity. Conclusion: The COVID-19 pandemic had a definite reforming effect on the pattern of intoxication by drugs of abuse in NECTR, Egypt.","PeriodicalId":14168,"journal":{"name":"International Journal of Medical Toxicology and Forensic Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46796590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Systematic Review of the Possibility of Determining Age Based on DNA Methylation of the ELOVL2 Gene in Human Samples","authors":"Foroozan Faress, M. Ameri, Marzieh Mojbafan, M. Aminifard, S. Marashi","doi":"10.32598/ijmtfm.v13i1.39298","DOIUrl":"https://doi.org/10.32598/ijmtfm.v13i1.39298","url":null,"abstract":"Background: In forensic medicine, predicting the age of a victim or suspect can be a clue to solving a crime. Epigenetics has recently played a vital role in age prediction in forensic medicine. Cytosine methylation at cytosine and guanine separated by phosphate (CpG) sites is well recognized as a novel epigenetic marker for age estimation. This study aimed to summarize the information obtained from previous studies to determine age by evaluating DNA methylation in the ELOVL2 gene. Methods: In this systematic review, all related articles published between 2012 and 2022 were extracted by searching reputable scientific databases, such as ISI Web of Science, Science Direct, PubMed, and Scopus. After selecting the appropriate articles, the full text of the articles was prepared and fully evaluated by the researchers. The protocol of this study was carried out based on the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement. Results: Out of 307 articles, 5 articles were eligible for review according to the study protocol. The strongest correlation between DNA methylation and age was observed at sites 11044644 and 11044634 on chromosome 6 in the living cases. The relationship between the chronological age and the age calculated through DNA methylation was above 90% with an approximate error ranging from 7.5 to 10.4. However, the relationship between the chronological age and the age calculated through DNA methylation was above 90% in the multivariate analysis of sites 11044624 and 11044634 on chromosome 6. In this case, the calculation error reached approximately 6.9 years. Hence, considering a combination of multiple cytosine and guanine separated by phosphate (CpG) sites improves the calculation accuracy and reduces the error percentage. The relationships between DNA methylation and the age at sites 11044880 and 11044640 on chromosome 6 were significantly less reported in the blood samples taken from the dead and in those taken from the living (nearly 64%–78.5%). Conclusion: The results of this study indicated that DNA methylation in the ELOVL2 gene could help predict a person’s biological age.","PeriodicalId":14168,"journal":{"name":"International Journal of Medical Toxicology and Forensic Medicine","volume":" ","pages":""},"PeriodicalIF":0.3,"publicationDate":"2023-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46458438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}