Güneş ÇAKMAK GENÇ, Sevim KARAKAŞ ÇELİK, Mürsel Hazaloğlu, M. Harma, Ahmet Dursun
{"title":"Gestasyonel Diyabet ile IL8/CXCL8 rs4073 Gen Polimorfizmi Arasındaki İlişkinin Araştırılması","authors":"Güneş ÇAKMAK GENÇ, Sevim KARAKAŞ ÇELİK, Mürsel Hazaloğlu, M. Harma, Ahmet Dursun","doi":"10.25048/tudod.1198053","DOIUrl":"https://doi.org/10.25048/tudod.1198053","url":null,"abstract":"Amaç: Gestasyonel Diyabet (GDM) ilk defa gebelikte tanı konulan glukoz intoleransıdır. Hem anne hem de bebekte komplikasyon \u0000riskini artıran GDM için ileri gebelik yaşı, çok sayıda parite, önceki gebelikte GDM öyküsü, genetik faktörler gibi birçok risk faktörü \u0000tanımlanmıştır. Ayrıca bazı inflamatuar mediatörler, kemokinler ve onları kodlayan genlerin polimorfizmlerinin GDM ile ilişkisi \u0000gösterilmiştir. Biz bu çalışmada GDM tanısı konulan gebelerle sağlıklı gebelerdeki genotip ve allel frekans dağılımlarını karşılaştırarak, \u0000GDM yatkınlığı ile IL8/CXCL8 rs4073 (251A/T) gen polimorfizminin ilişkisini belirlemeyi amaçladık. \u0000Gereç ve Yöntemler: Çalışmamıza GDM tanılı 100 gebe ve kontrol grubu olarak 100 sağlıklı gebe dahil edilmiştir. Tüm katılımcılar \u0000Zonguldak Bülent Ecevit Üniversitesi Tıp Fakültesi Hastanesi Kadın Hastalıkları ve Doğum Anabilim Dalı’nda takip edilmiştir. IL8/ \u0000CXCL8 rs4073 gen polimorfizminin genotiplenmesi, polimeraz zincir reaksiyonu bazlı restriksiyon fragman uzunluk polimorfizmi \u0000(PCR-RFLP) yöntemi kullanılarak belirlenmiştir. GDM hastalarında ve kontrollerde her bir gen polimorfizminin genotip sıklığını \u0000karşılaştırmak için χ2 testi kullanıldı. \u0000Bulgular: Gestasyonel diyabetli gebelerle sağlıklı gebeler arasında rs4073 polimorfizmi genotip ve allel frekans dağılımları açısından \u0000istatistiksel olarak anlamlı bir farklılık saptanmamıştır (sırasıyla; p=0,260, p=1,000). \u0000Sonuç: Bulgularımız IL8/CXCL8 rs4073 gen polimorfizminin GDM’ye yatkınlıkla ilişkili olmadığını göstermekle birlikte bulgularımızın \u0000doğrulanması için farklı etnik grupları içeren geniş örneklem büyüklükleriyle, katılımcıların vücut kütle indeksleri, gebelik öncesi \u0000kiloları gibi klinik parametreler de dahil edilerek yapılacak ileri çalışmalara ihtiyaç vardır","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122232853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
E. A. Cimbek, Semiha Bekfi̇lavi̇oğlu, G. Karagüzel
{"title":"The Relationship Between Long-Term Glycemic Control and Partial Remission in Type 1 Diabetes: A Retrospective Study","authors":"E. A. Cimbek, Semiha Bekfi̇lavi̇oğlu, G. Karagüzel","doi":"10.25048/tudod.1170939","DOIUrl":"https://doi.org/10.25048/tudod.1170939","url":null,"abstract":"Aim: Partial remission (PR) is a significant period in the early course of type 1 diabetes (T1D) with implications for diabetes management. We aimed to investigate whether long-term hemoglobin A1c (HbA1c) outcomes in T1D differed as a result of experiencing PR. We also analyzed the demographic and clinical factors that may influence long-term glycemic control. \u0000Material and methods: We retrospectively tracked the HbA1c values of 131 children and adolescents with T1D over a 5-year period. Patients were stratified into low (","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124619806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Comparison of Food Addiction Rates and Characteristics Between Obese and Non-Obese Individuals: A Cross-Sectional Study","authors":"H. H. Mutlu, Hasan Huseyin Mutlu","doi":"10.25048/tudod.1159245","DOIUrl":"https://doi.org/10.25048/tudod.1159245","url":null,"abstract":"Aim: Even though obesity and food addiction have been linked, only a small number of obese individuals fulfill the diagnostic criteria for food addiction, on the other hand some normal and underweight people also meet these criteria. To investigate the difference between the prevalence of food addiction between obese and non-obese persons using Yale Food Addiction Scale. \u0000Material and Methods: A demographic information form and Yale Food Addiction Scale was applied to obese and non-obese individiuals admitted to family medicine and obesity outpatient clinic. Significant differences of normally distributed data were assessed using a t-test, and significant differences of not normally distributed data were analyzed using the Mann-Whitney U test. Categorical data were expressed as percentages. The associations between food addiction and age, BMI, gender, and smoking status and the associationsbetween gender, smoking, food addiction, and obesity were determined by using the established a binary logistic regression models. P","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129357828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Bozdemir, Züleyha ŞİMŞEK YABAN, S. Güler, Z. Utkan
{"title":"Learning Needs of Bariatric Surgery Patients: A Qualitative Study","authors":"H. Bozdemir, Züleyha ŞİMŞEK YABAN, S. Güler, Z. Utkan","doi":"10.25048/tudod.1116507","DOIUrl":"https://doi.org/10.25048/tudod.1116507","url":null,"abstract":"Aim: This study was planned to determine the training needs that patients who experienced bariatric surgery patients should receive from health professionals. \u0000Material and Methods: The research was planned using a qualitative research methods. The study was conducted with 13 patients in a university hospital between April 2020 and July 2020. Research data was collected using a Semi-Structured Interview form and patient socio-demographic form. The data analysis method was used with MAXQDA 2020-Qualitative data Analyses program, Colaizzi's 7-step analysis process. \u0000Results: We five main themes related to the learning needs of patients who have undergone bariatric surgery were determined as; “Physiological Requirements, Psychological Requirements, Social requirements, Consulting requirements and Learning methods”. \u0000Conclusion: It was determined that the patients had the highest learning needs on postoperative nutrition, complications, surgical procedure, symptoms, daily life activities, mobilization, adapting to the social life, learning materials, to come together with the people experiencing the process of bariatric surgery, etc. in the codes and sub-codes created from the patient expressions. Patients undergoing bariatric surgery need continuous, easily accessible, applicable, and emotional support to prevent complications before and after the surgery, to make behavioral changes and prevent weight gain.","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125205864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of First Trimester Fasting Blood Glucose, HOMA-IR and HbA1c in Prediction of Gestational Diabetes Mellitus in Non-Obese Pregnant Women: A Retrospective Study","authors":"M. Kırlangıç, B. N. Arıcı Halıcı","doi":"10.25048/tudod.1198697","DOIUrl":"https://doi.org/10.25048/tudod.1198697","url":null,"abstract":"Aim: Gestational Diabetes Mellitus (GDM) is the most common endocrine complication in pregnancy with fetomaternal comorbidities. It is aimed to evaluate fasting blood glucose (FBG), homeostasis model assessment of insulin resistance (HOMA-IR), and hemoglobin A1c (HbA1c) values in the first trimester in non-obese pregnant women for early detection of GDM. \u0000Material and Methods: Pregnant women with first-trimester FBG, HOMA-IR, HbA1c values, and second-trimester OGTT results were scanned from the hospital database. First-trimester height, weight, age and gestational weeks were also recorded. The presence of Body Mass Index (BMI) over 30 kg/m2, chronic and systemic disease and history of G(DM) were not included in the study. ROC analysis was performed on FBG, HOMA-IR, and HbA1c. \u0000Results: This retrospective study was conducted between 01/01/2021, and 01/01/2022 in Tuzla State Hospital Gynecology and Obstetrics Clinic. 131 pregnant women who met the inclusion criteria were reached. Twenty of pregnant women were evaluated as GDM positive(+). Age, height, weight, BMI, gestational week, and nulliparity were observed to be similar between the groups. FBG, insulin, HOMA-IR, and HbA1c values were higher in the group with GDM. As a result of ROC analysis, those with an FBG value of 88,5 mg/dl (sensitivity 68.2%, specificity 68.2%), a HOMA-IR value of 2.24 (sensitivity 63.6%, specificity 64.5%), and a HbA1c (sensitivity 68.2%, specificity 66.7%) value of over 5.25% were observed to be at risk for GDM. \u0000Conclusion: It has shown that pregnant women with high first trimester FBG, HOMA-IR and HbA1c have a high risk for GDM and can be used as a predictor of GDM.","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131091992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Veli Akkurt, Mehmet Fatih Deveci, Osman Başpınar, Mehmet Keskin
{"title":"Tip 1 Diyabetli Çocuklarda Kardiyak Fonksiyonlar ile Karotis İntima Media Kalınlığının Değerlendirilmesi","authors":"Veli Akkurt, Mehmet Fatih Deveci, Osman Başpınar, Mehmet Keskin","doi":"10.25048/tudod.1152686","DOIUrl":"https://doi.org/10.25048/tudod.1152686","url":null,"abstract":"Amaç: Tip 1 Diyabetes Mellitus (DM) tanısı ile izlenen çocuklarda, karotis intima media kalınlığı (KİMK), sol kardiyak sistolik ve diyastolik fonksiyonları ekokardiyografik yöntem ile değerlendirmek. \u0000Gereç ve Yöntemler: Üniversitemizde en az 4 yıldır tip 1 DM tanısı ile izlenen 31 hasta ve kontrol grubu olarak 19 sağlıklı çocuk çalışmaya alınmıştır. Hastalar; glisemik kontrol düzeyleri, hastalık süreleri ve cinsiyetlerine göre gruplandırılarak, kontrol grubuyla karşılaştırıldı. SPSS for Windows version 17.0 paket programı kullanılarak istatistiksel analizler yapıldı. \u0000Bulgular: Hasta ve kontrol grubu; yaş, boy, cinsiyet, ağırlık, vücut kütle indeksi, sistolik ve diyastolik kan basıncı bakımından benzerdi (p>0.05). Diyabetli hastalar ve kontrol grubu, kardiyak sistolik ve diyastolik fonksiyonlar, KİMK değerleri arasında anlamlı bir fark yoktu (p>0.05). Hastalar diyabet sürelerine göre ve glisemik kontrole göre alt gruplara ayrıldığında KİMK düzeyleri arasında anlamlı bir fark bulunamadı (sırasıyla, p=0.084 ve p=0.410). DM süresi ≥8 yıl olan hastalarda KİMK 0.54 mm olarak istatistiksel anlamlı olmasa da belirgin artmış olarak bulundu. Alt grup analizinde diyabetik erkeklerde, kontrol grubu erkeklere ve diyabetik kızlara göre sol KİMK anlamlı olarak artmış olarak bulundu (sırasıyla, p=0.026 ve p=0.022). Diyabetik erkeklerde ortalama KİMK kız grubuna göre anlamlı fark saptandı (p=0.042). \u0000Sonuç: Diyabetik erkeklerde artış gösteren ortalama ve sol KİMK, ateroskleroz açısından cinsiyetin bağımsız bir risk faktörü olabileceğini düşündürdü. Yoğun diyabet tedavisi ve glisemik kontrolüne rağmen Tip 1 DM özellikle erkek cinsiyette çocukluk çağında dahi kardiyovasküler sistemi etkileyen önemli bir risk faktörüdür.","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"175 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115177212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Emerging Roles of MicroRNAs as Biomarkers in Diabetic Nephropathy","authors":"Destan Kalacay, A. Hacışevki","doi":"10.25048/tudod.1111845","DOIUrl":"https://doi.org/10.25048/tudod.1111845","url":null,"abstract":"Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus (DM), as well as the most common health issue among End Stage Renal Diseases (ESRD). Recent studies have shown that this concern will likely to become a global phenomenon in the future. Early diagnosis of DN is vital for its treatment. MicroRNAs (miRNAs or miRs) are the most promising for new biomarker candidates proposed for DN. MiRNAs, known as non protein-coding short-chain RNA sequences, have a regulatory role in many cellular events. Advances in molecular genetics and successful genomic techniques allow miRNAs to be used in the diagnosis of several diseases. As the DN diagnostic markers used today are insufficient for some cases, identifying new diagnostic markers is the basis of recent studies. Successful use of miRNAs in the areas of cancer, immunity and diabetes indicates that the DN perspective should be based on miRNA. In this review, miRNAs and their role in DN will be reviewed.","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122324263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ahmet Sakallioğlu, İrfan Akaray, Sultan Kaya, Ö. Kaya, Gizem Köse, Rüveyde Gari̇p, Hande Guclu
{"title":"Diyabetik Retinopatili Hastalarda Sağlıkla İlişkili Yaşam Kalitesini Etkileyen Faktörlerin Değerlendirilmesi","authors":"Ahmet Sakallioğlu, İrfan Akaray, Sultan Kaya, Ö. Kaya, Gizem Köse, Rüveyde Gari̇p, Hande Guclu","doi":"10.25048/tudod.1127641","DOIUrl":"https://doi.org/10.25048/tudod.1127641","url":null,"abstract":"Amaç: Diyabetik retinopati (DRP) hastalarında sağlıkla ilişkili yaşam kalitesini (SİYK) etkileyen faktörlerin araştırılması. \u0000Gereç ve Yöntemler: Çalışmaya tip 2 diyabet nedeniyle DRP açısından takipli 400 hastanın 800 gözü katılmıştır. Hastalar oftalmolojik muayene sonrasında Kısa Form-36 (SF-36) anketini doldurmuştur. SF-36’ya göre fiziksel işlev, fiziksel rol, bedensel ağrı, genel sağlık, canlılık, sosyal işlevsellik, duygusal rol ve ruh sağlığı, fiziksel ve zihinsel bileşen özet ölçümleri hesaplandı. Hastaların demografik özellikleri hasta dosyalarından not edilmiştir. İki bağımsız grubu karşılaştırmak için normal dağılım varsayıldığında bağımsız örneklemlerde T-testi, verilerin normalliği reddedildiğinde Mann-Whitney U testi kullanıldı. İkiden fazla olan bağımsız grupların karşılaştırılmasında Bonferroni veya Tamhane’s T2 düzeltmeli ANOVA testi, sayısal değişkenler arasındaki ilişki Pearson korelasyon testi ile değerlendirildi. Anlamlılık düzeyi p","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127183865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Given According to Knowledge, Motivation and Behavioral Skills (IMB Model) The Effect of Diabetes Education on Self-Care","authors":"B. Inkaya, Tuba Yılmazer, Hilal Tüzer, E. Erbil","doi":"10.25048/tudod.1149785","DOIUrl":"https://doi.org/10.25048/tudod.1149785","url":null,"abstract":"Aim: It has been determined that the education given according to the information, motivation, and behaviour model is effective in AIDS, chronic diseases, glucose control in diabetes, and self-care behaviours such as diet and exercise. The aim of this study, which is planned from this point of view, is to evaluate the effect of education given according to the information, motivation, and behaviour model on diabetic self-care management. \u0000Material and Methods: This study was conducted as an experimental study with a nonrandomized control group that included 90 diabetes mellitus individuals, with 45 in the intervention group and 45 in the control group. The control group were given formal diabetes mellitus education. In contrast, the intervention group received an education based on the information, motivation, and behaviour model and diabetes mellitus cases were followed for six months. Data were collected with a questionnaire on the essential characteristics of the patients, an evaluation form on the level of knowledge about diabetes, an evaluation form on their motivation about diabetes, and a diabetes self-care activities questionnaire. An Independent Sample-t test was used to analyze the data, and Paired Sample-test statistics were used to compare two dependent groups. Mann-Whitney U test was used to compare the measurement values of two independent groups that did not have a normal distribution. Wilcoxon test statistics were used to compare two dependent groups. \u0000Results: At the end of the study, it was determined that while HbA1c in the intervention group decreased for 6 months, knowledge scores, motivation levels and self-care skill scores increased (t=7.067, p","PeriodicalId":141643,"journal":{"name":"Turkish Journal of Diabetes and Obesity","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128833165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}