International journal of neurology最新文献

{"title":"Normal Pressure Hydrocephalus Secondary to Intracranial Mass: A Case Series","authors":"Noman Lateef, A. Ansari, Abubakar Tauseef, A. Darbar, Ommega Internationals","doi":"10.15436/2377-1348.17.1668","DOIUrl":"https://doi.org/10.15436/2377-1348.17.1668","url":null,"abstract":"","PeriodicalId":14163,"journal":{"name":"International journal of neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73353054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kappa Opioid System Involvement in Mood and Anxiety Disorders","authors":"G. Taylor, Jacob N. Huffman","doi":"10.17554/J.ISSN.2313-5611.2017.03.70","DOIUrl":"https://doi.org/10.17554/J.ISSN.2313-5611.2017.03.70","url":null,"abstract":"Current interest in opioid drugs is directed mostly on morphine-like drugs that activate the μ opioid peptide (MOP) system and induce euphoria and, potentially, addiction. Less attention has been paid to the κ opioid peptide (KOP) system, likely because drugs that activate the KOP system have low abuse potential. Indeed, activation of the KOP system often is reported to have effects on brain and behavior that are opposite to MOP activation. The literature suggests that dynorphin and its κ receptor are, indeed, unique among the opioids. That uniqueness has generated interest in our laboratory. We have taken a different approach to understanding the KOP system. Rather than focusing on drug abuse, we have adopted mood and anxiety as a model for investigation of the KOP system. The assumption is that clarification of the underlying mechanisms and behavioral outcomes of κ agonists and antagonists will help inform the KOP system for other situations, including drug use and abuse. This review will highlight the basis for our fascination with KOP and the κ receptor.","PeriodicalId":14163,"journal":{"name":"International journal of neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89232036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sildenafil Associated Threatened Ischemic Stroke Reversed with Alteplase","authors":"S. Simons, A. Rosengart, K. Schlick, S. Torbati, P. Lyden, Ommega Internationals","doi":"10.15436/2377-1348.17.1371","DOIUrl":"https://doi.org/10.15436/2377-1348.17.1371","url":null,"abstract":"","PeriodicalId":14163,"journal":{"name":"International journal of neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74433808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NEUROLETCTINS: BIOCHEMICAL CHARACTERISATION AND FUNCTIONS","authors":"Nugzar Georg Aleksidza","doi":"10.17554/J.ISSN.2313-5611.2017.03.64","DOIUrl":"https://doi.org/10.17554/J.ISSN.2313-5611.2017.03.64","url":null,"abstract":"The presented work deals with the recent achievements in the field of research of neurolectins, their quantitative and qualitative distribution in cerebral cells of different animals, subcellular structures and synaptosomes in relation to embryonic development. Distribution of neurolectin-binding receptors glycoproteins and glycolipids in the same structures, their role in the processes of migration of neurons and other mechanisms are studied as well. Two membrane neurolectins VL-1 and VL-NAGA have been revealed in synaptosomes, which according to our hypothesis are actively involved in absorption and secretion of neurotransmitters. It was established that VL-1, located on the outer membrane of synaptosomes participates in absorption and metabolism of biologically active substances, though VL-NAGA, which is located in the inner side of the membrane is also involved in their metabolism. It is considered that negative effects of wheat germ agglutinin (WGA) lectins, among them neurotoxic, cardiotoxic and immunotoxic, can be avoided by means of well toasted bread, because in the process of toasting lectins undergo denaturation and lose their toxic activity. Food should be chewed well, until it becomes saturated with glycoprotein mucine, which is component of saliva, as N-acetyl-D-glucosamine binding and inactivating WGA is presented in its active centre. In conclusion it is said that uptake of food additives offered by D’Adamo, with the ability of binding WGA and other neurolectins, is not recommended for teenagers and pregnant women, as they may cause inhibition of key processes, involved in mechanisms of structural-functional organization of brain.","PeriodicalId":14163,"journal":{"name":"International journal of neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82874250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuroprotective Efficacy of A Combination of Fish Oil and Bacopa Monnieri Against 3-Nitropropionic Acid Induced Oxidative Stress in Rats","authors":"Denny Joseph Manual Kollareth, M. Muralidhara","doi":"10.17554/J.ISSN.2313-5611.2017.03.67","DOIUrl":"https://doi.org/10.17554/J.ISSN.2313-5611.2017.03.67","url":null,"abstract":"AIM: Despite the evidence on the beneficial effects of n-3 polyunsaturated fatty acids (n-3 PUFA) on neurodegenerative conditions, several concerns have been raised since PUFA may increase oxidative stress resulting in the formation of lipid peroxides. Hence addition of antioxidants/phytochemicals is recommended. In the present study, we have used fish oil (FO) in combination with Bacopa monnieri (BM) and examined the neuroprotective propensity of the combination (FO+BM) employing chronic 3-nitropropionic acid (NPA) model of neurotoxicity in rats. MATERIALS AND METHODS: Growing male rats administered NPA (10 mg/kg bw, 14d) were supplemented with FO (2 mL/kg bw), BM (100 mg/kg bw) or combination (FO+BM) for 14 days. RESULTS: Higher degree of protection was discernible among FO+BM rats against NPA induced behavioral alterations. Further, NPA administration resulted in significantly elevated oxidative markers in brain regions (striatum- St, cerebellum- Cb) while robust protection was evident among rats supplemented with FO+BM. Depleted GSH levels in St were restored among all the supplemented groups. The combination also predominantly normalized the activity of antioxidant enzymes in brain regions. Further, significantly depleted dopamine levels in St were partially restored only among FO+BM rats. However, the combination did not offer protection against NPA induced mitochondrial dysfunction. CONCLUSION: The present data clearly suggests that it is possible to enhance the degree of neuroprotection by a combination of FO with phytochemicals (such as BM) and thus provides an improved strategy for the treatment/ management of oxidative stress mediated neurodegenerative conditions.","PeriodicalId":14163,"journal":{"name":"International journal of neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75435232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination of Tanacethum Partenium, 5-Hydrossitriptophan (5-Http) and Magnesium in the Prophylaxis of Episodic Migraine without Aura (AURASTOP®) An Observational Study","authors":"V. Dalla, P. Zavarize, G. Ngonga, A. Pezzini, G. Volta, Ommega Internationals","doi":"10.15436/2377-1348.17.1630","DOIUrl":"https://doi.org/10.15436/2377-1348.17.1630","url":null,"abstract":"Objective: The study aim is to verify whether treatment with a new combination of tanacethum partenium, 5-hydrossitriptophan (5-http) and magnesium (Aurastop®) reduces headache frequency and intensity in patients suffering from episodic migraine without aura when used in migraine prevention. Methods: Forty patients, suffering from migraine without aura for at least 6 months with monthly frequency of 3 to 8 crises and presence of headache of 4 to12 days, were enrolled in this open study and treated orally with Aurastop twice daily for 3 months. The primary endpoint was reduction of migraine frequency (headache days per month) over an observation period of 3 months. The secondary endpoint was a composite of monthly frequency and intensity of pain crises, analgesics use (number of medications) and subjective change of pain intensity. Results: All the parameters significantly improved at the end of treatment with Aurastop. We observed a significant reduction of the number of headache days (from 8.8 ± 2.0 before treatment to 2.7 ± 1.7 post treatment, p < 0.001), as well as of the number of attacks (from 5.0 ± 1.2 per month to 2.1 ± 0.9 per month, p < 0.001), of pain intensity (from Visual Analogic Scale [VAS] 6.9 ± 1.0 to 3.3 ± 1.5, p < 0.001), and of the number of analgesics assumed by each subject (from 8.5 ± 1.6 per month to 2.4 ± 1.5 per month, p < 0.001). No serious adverse events were observed. Conclusion: Though obtained in the setting of an open-trial, our findings suggest that the new combination of tanacethum partenium, 5-hydrossitriptophan (5-http) and magnesium (AURASTOP®) is a promising approach for migraine prevention and warrant further investigation to confirm the safety and efficacy of this treatment. *Corresponding author: Giorgio Dalla Volta, Neurology Department, Istituto Clinico Città Di Brescia,Via Gualla, 25123 Brescia, Italy, E-mail: dalla@numerica.it Received Date: August 02, 2017 Accepted Date: August 10, 2017 Published Date: August 11, 2017 Citation: Dalla Volta, G., et al. Combination of Tanacethum Partenium, 5-Hydrossitriptophan (5-Http) and Magnesium in the Prophylaxis of Episodic Migraine without Aura (AURASTOP®)-An Observational Study. (2017) Int J Neuro Brain Dis 4(3): 14. Int J Neurol Brain Disord | Volume 4: Issue 3 www.ommegaonline.org","PeriodicalId":14163,"journal":{"name":"International journal of neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79897810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra and Extracranial Suppurative Complications of Sinusitis, Management with Limited Resources-: A Report of Two Cases with a Review of the Literature","authors":"S. Sharma, Ommega Internationals","doi":"10.15436/2377-1348.17.1045","DOIUrl":"https://doi.org/10.15436/2377-1348.17.1045","url":null,"abstract":"","PeriodicalId":14163,"journal":{"name":"International journal of neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90861052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delay in Pusher Syndrome Recovery is Related to Frontal White Matter Lesions","authors":"Hiroaki Abe","doi":"10.23937/2378-3001/1410065","DOIUrl":"https://doi.org/10.23937/2378-3001/1410065","url":null,"abstract":"","PeriodicalId":14163,"journal":{"name":"International journal of neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91063109","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal White Matter Alteration in Prolonged Disorders of Consciousness due to Traffic Accidents","authors":"Hiroaki Abe","doi":"10.23937/2378-3001/1410064","DOIUrl":"https://doi.org/10.23937/2378-3001/1410064","url":null,"abstract":"Objectives: We analyzed longitudinal white matter alterations by diffusion tensor imaging (DTI) in patients with prolonged disorders of consciousness (PDC). Participants: Seventeen patients with PDC having an average of 328.8 days post-injury and eleven control participants. Main measures: All participants underwent two DTI studies. Fractional anisotropy (FA) values were analyzed using whole-brain analysis (WBA) of 7 patients with no marked brain deformities; mean FA values of forceps minor (mFAFM) were subsequently measured by regional-brain analysis (RBA). Relationships between WB and regional FA values and recovery from PDC were evaluated. Results: WBA in the PDC group showed that FA values were significantly lower in multiple white matter regions (P < 0.05), particularly in part of the forceps minor, in the second scan than they were in the first scan. RBA showed that mFAFM significantly decreased (P < 0.01). Further, WBA revealed that a significant positive correlation was observed between the degree of recovery from PDC and the difference in the number of voxels with FA values > 0.2 (r = 0.65, P < 0.01) between the first and second scans. Conclusion: Our results showed microstructural white matter changes in patients with PDC, suggesting recovery from PDC with long-term treatment.","PeriodicalId":14163,"journal":{"name":"International journal of neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90146637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant Intra-Ventricular Calcified Meningioma in Childhood Manifest as Movement Disorders : A Extremely Rare Presentation","authors":"S. A. Ali, A. Jagetia, R. K. Saran, Daljit Singh, Ommega Internationals","doi":"10.15436/2377-1348.17.1529","DOIUrl":"https://doi.org/10.15436/2377-1348.17.1529","url":null,"abstract":"","PeriodicalId":14163,"journal":{"name":"International journal of neurology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2017-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74498218","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}