International Journal of Medicine and Health Development最新文献

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A case report of intracholecystic papillary neoplasm presenting as gallbladder polyp 胆囊内乳头状肿瘤表现为胆囊息肉1例
International Journal of Medicine and Health Development Pub Date : 2023-04-01 DOI: 10.4103/ijmh.ijmh_70_22
J. Thiek, Lachit Kalita, Kiran Kamalasanan
{"title":"A case report of intracholecystic papillary neoplasm presenting as gallbladder polyp","authors":"J. Thiek, Lachit Kalita, Kiran Kamalasanan","doi":"10.4103/ijmh.ijmh_70_22","DOIUrl":"https://doi.org/10.4103/ijmh.ijmh_70_22","url":null,"abstract":"Intracholecystic papillary neoplasm was a newly proposed term in the 2019 World Health Organization classification of tumors of the digestive system, as a preinvasive neoplasm of the gallbladder. We report a case of intra-cholecystic papillary neoplasm, biliary type with high-grade dysplasia presenting as a polypoidal mass in the fundus of the gallbladder, in a 47-year-old man with a history of periodic abdominal pain and dyspepsia of 6-month duration. As the term for the pathological classification in itself is new, we wish to report this case for record storing purposes that may be imperative if any further study on the said topic is planned in the future.","PeriodicalId":14106,"journal":{"name":"International Journal of Medicine and Health Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79923778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical profile and short-term outcomes of patients admitted with acute pulmonary embolism in a tertiary care centre 三级护理中心收治的急性肺栓塞患者的临床概况和短期预后
International Journal of Medicine and Health Development Pub Date : 2023-04-01 DOI: 10.4103/ijmh.ijmh_1_23
Vinayak Pai, Suyash Ambekar, M. Nadkar, Alhad Mulkalwar, Priyadarshi Prajjwal
{"title":"Clinical profile and short-term outcomes of patients admitted with acute pulmonary embolism in a tertiary care centre","authors":"Vinayak Pai, Suyash Ambekar, M. Nadkar, Alhad Mulkalwar, Priyadarshi Prajjwal","doi":"10.4103/ijmh.ijmh_1_23","DOIUrl":"https://doi.org/10.4103/ijmh.ijmh_1_23","url":null,"abstract":"Background: Venous thromboembolism is a major contributor to the global disease burden, with an incidence of around 10 million cases per year and substantially associated morbidity and mortality. Objectives: The study aimed to assess the clinical, laboratory, and radiological profile along with electrocardiogram and echocardiogram changes and the treatment and outcomes in patients admitted with acute pulmonary embolism (PE) in a tertiary care centre. The etiologies and risk factors of the same were also evaluated. Materials and Methods: This was a hospital-based prospective observational study conducted among 31 patients over a period of 18 months. The study was conducted at a tertiary care centre in the Department of General Medicine. Patients of age more than 12 years, admitted with a confirmed diagnosis of acute PE based on computed tomography pulmonary angiography (CTPA), were included in the study. Results: Thrombolysis was done in 12.9% cases, while anticoagulants were given in 87.1% cases. Oxygen therapy was required in 74.2% cases on day 1 while in 9.7% on day 30. Secondary pulmonary hypertension was the commonest complication observed in the study, in 54.8% cases. Severe hypoxia was seen in 35.4% cases. No complications were seen in 6.4% cases. Mortality was recorded in 9.6% of the cases. Conclusion: Since PE is among the leading causes of death and disability, there should be a high degree of suspicion in all clinical settings. And since prolonged immobilisation is a strong risk factor for PE patients at risk, they should be offered prophylactic anticoagulation.","PeriodicalId":14106,"journal":{"name":"International Journal of Medicine and Health Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86715331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Analysis of burden and outcomes of anticoagulant induced adverse drug effects at a tertiary care centre 某三级医疗中心抗凝药物不良反应负担及结果分析
International Journal of Medicine and Health Development Pub Date : 2023-04-01 DOI: 10.4103/ijmh.ijmh_76_22
Arnav Tongaonkar, K. Joshi, Alhad Mulkalwar, Shweta Gajare
{"title":"Analysis of burden and outcomes of anticoagulant induced adverse drug effects at a tertiary care centre","authors":"Arnav Tongaonkar, K. Joshi, Alhad Mulkalwar, Shweta Gajare","doi":"10.4103/ijmh.ijmh_76_22","DOIUrl":"https://doi.org/10.4103/ijmh.ijmh_76_22","url":null,"abstract":"Background: Anticoagulants are among the most commonly used drugs in hospitalized patients known to cause adverse drug reactions (ADRs). They have commonly been used as standard therapy in venous thromboembolism, stroke prevention, etc. Objectives: The authors aimed to assess the incidence of ADRs, clinical profile, severity and causality among the admitted patients taking anticoagulants in a tertiary care hospital. Materials and Methods: This was a hospital-based, prospective, observational, non-interventional cohort study undertaken in the General Medicine Wards of King Edward Memorial Hospital, Mumbai from June 2017 to December 2018. Every patient’s data was recorded using a structured ADR reporting form. The baseline parameters, medical history and underlying diseases, clinical data, characteristics of ADRs, and details of medication responsible for ADRs, as well as details of the drugs used for treatment of ADRs were recorded. The data was analyzed using descriptive statistics with the Statistical Packages for the Social Sciences (SPSS) version 26.0 software. Results: Out of the 164 patients admitted due to ADRs within the study period, 32 (19.5%) had developed ADRs due to anticoagulant treatment. Most anticoagulant-related ADRs involved the vascular system (n = 32). The severity of ADR was found to be mild in one patient (3.1%), moderate in 22 patients (68.8%), and severe in nine patients (28.1%). Twenty (62.5%) patients completely recovered, nine (28.1%) patients were still recovering (at the time of the analysis of the data), and three (9.4%) patients had a fatal outcome. Presence of systemic comorbidities and polypharmacy were found to be significant risk factors associated with anticoagulant-associated ADRs. Conclusion: Anticoagulants commonly cause ADRs in the study population. Patient education at the time of prescription can prevent many ADRs due to medication error or poor compliance. In addition, installing a better surveillance system in hospitals could alleviate the prevalence of ADRs.","PeriodicalId":14106,"journal":{"name":"International Journal of Medicine and Health Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86844221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Healthcare workers’ willingness to report to work during a pandemic in southeastern Nigeria: A hypothetical case using Ebola virus disease 尼日利亚东南部大流行期间卫生保健工作者报告工作的意愿:一个使用埃博拉病毒病的假设病例
International Journal of Medicine and Health Development Pub Date : 2023-01-01 DOI: 10.4103/ijmh.ijmh_63_22
N. Ibiok, C. Onyedinma, Olanike Agwu-Umahi, C. Kassy, I. Obionu, O. Chime, I. Ogugua, C. Ochie, S. Arinze-onyia, A. Ndu, E. Aguwa, AdaezeTheodore Okeke
{"title":"Healthcare workers’ willingness to report to work during a pandemic in southeastern Nigeria: A hypothetical case using Ebola virus disease","authors":"N. Ibiok, C. Onyedinma, Olanike Agwu-Umahi, C. Kassy, I. Obionu, O. Chime, I. Ogugua, C. Ochie, S. Arinze-onyia, A. Ndu, E. Aguwa, AdaezeTheodore Okeke","doi":"10.4103/ijmh.ijmh_63_22","DOIUrl":"https://doi.org/10.4103/ijmh.ijmh_63_22","url":null,"abstract":"Background: The Ebola virus disease (EVD) outbreak of 2014–2016 in West Africa was the world’s deadliest to date, and the World Health Organization declared it an international health emergency. It adversely affected the health system with many healthcare workers (HCWs) being worried about going to work. Objective: This study therefore aimed at determining the willingness of HCWs to report to work in an outbreak of EVD. Materials and Methods: A semi-structured, self-administered, questionnaire-based cross-sectional study was conducted among 360 doctors, nurses, and medical laboratory workers in public and private health facilities in Enugu Metropolis. Results: Seventy-three percent (73%) of our respondents were willing to report to work during an outbreak of EVD. Nurses were about five times more likely to be willing to work than other categories of staff [odd ratio (OR) = 4.999; confidence interval (CI)= 2.15–11.597; P < 0.001] and female HCWs were about 1.3 times more likely to be willing to work than males during an EVD outbreak (OR =1.275; CI=0.743–2.815; P = 0.049). Availability of vaccination for healthcare staff (88.6%) and family members (79.2%) were the greatest personal and family-related motivating factors for willingness to work, whereas the provision of antiviral treatment for staff with unprotected exposure to an ill patient (78.1%) was the greatest work motivating factor. However, passion for work surpassed increased remuneration (61.4%) as a personal motivating factor for HCWs willingness to report to work during an EVD outbreak. Conclusion: Our study showed that HCWs were largely willing to work during an EVD outbreak. Personal vaccination for staff and family members and provision of antivirals were the major motivating factors.","PeriodicalId":14106,"journal":{"name":"International Journal of Medicine and Health Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78143336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Renal biomarkers in pre-eclampsia and their associations with severity of pre-eclampsia 子痫前期肾脏生物标志物及其与子痫前期严重程度的关系
International Journal of Medicine and Health Development Pub Date : 2023-01-01 DOI: 10.4103/ijmh.ijmh_11_22
P. Ezechukwu, E. Ugwu, S. Obi, G. Eleje, P. Agu, E. Iloghalu, K. Obioha, C. Onwuka, A. Ugwu, O. Onodugo, B. Ozumba
{"title":"Renal biomarkers in pre-eclampsia and their associations with severity of pre-eclampsia","authors":"P. Ezechukwu, E. Ugwu, S. Obi, G. Eleje, P. Agu, E. Iloghalu, K. Obioha, C. Onwuka, A. Ugwu, O. Onodugo, B. Ozumba","doi":"10.4103/ijmh.ijmh_11_22","DOIUrl":"https://doi.org/10.4103/ijmh.ijmh_11_22","url":null,"abstract":"Background: Preeclampsia is one of the leading causes of maternal and perinatal morbidity and mortality in Nigeria and worldwide. It is not yet concluded as to whether or not elevated levels of serum creatinine and/or uric acid could be regarded as a predictive indicator for the severity of the disease. Objectives: To compare the mean serum levels of uric acid and creatinine in preeclamptic and normotensive pregnant women and assess for any associations between these renal biomarkers and the severity of preeclampsia in Nigeria. Materials and Methods: It was a cross-sectional analytical study of 132 women with preeclampsia (n = 61) and normotensive pregnant women (n = 61). The study group comprised eligible consecutive women diagnosed with preeclampsia, whereas the control group comprised appropriately matched normotensive pregnant women. Main outcome measures included the mean serum levels of uric acid and creatinine in both groups, and their levels in cases with mild and severe degrees of preeclampsia. Results: The mean serum levels of uric acid and creatinine were significantly higher in women with preeclampsia than in normotensive pregnant women (7.67 ± 2.9 versus 4.56 ± 1.1; P < 0.001, and 0.76 ± 0.3 versus 0.53 ± 0.1; P < 0.001, respectively). There was no significant difference in the mean serum levels of uric acid and creatinine in women with mild and severe degrees of preeclampsia (6.66 ± 2.3 versus 7.77 ± 2.9; P = 0.37, and 0.56 ± 0.2 versus 0.79 ± 0.4; P = 0.12, respectively). Conclusions: This study has demonstrated that serum uric acid and serum creatinine levels are elevated in pregnancies complicated by preeclampsia. However, there is no significant association between serum levels of these renal biomarkers and the severity of preeclampsia. The studied renal biomarkers are therefore important in the diagnostic workup of preeclampsia but of limited value in the disease prognostication.","PeriodicalId":14106,"journal":{"name":"International Journal of Medicine and Health Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76356935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adenomatoid odontogenic tumors: Rare cases in Enugu, Eastern Nigeria 腺瘤样牙源性肿瘤:尼日利亚东部埃努古的罕见病例
International Journal of Medicine and Health Development Pub Date : 2023-01-01 DOI: 10.4103/ijmh.ijmh_32_22
M. Nwoga
{"title":"Adenomatoid odontogenic tumors: Rare cases in Enugu, Eastern Nigeria","authors":"M. Nwoga","doi":"10.4103/ijmh.ijmh_32_22","DOIUrl":"https://doi.org/10.4103/ijmh.ijmh_32_22","url":null,"abstract":"Adenomatoid odontogenic tumors (AOTs) are very rare. We present a case series of eight AOTs seen and managed at University of Nigeria Teaching Hospital (UNTH), Ituku-Ozalla, Enugu State, Nigeria over a 10-year period, from 2012 to 2021. Their epidemiological data and clinic-pathological information were obtained from the biopsy forms, histopathology reports, and case files archived in the Records Department of the hospital. The AOTs were diagnosed in 8 patients out of the 225 odontogenic tumors seen during the period giving a prevalence of 3.6%. Five patients (62.5%) were males, whereas three (37.5%) were females giving a male-to-female ratio of 1.7:1. The mean (SD) age at onset of lesion was 12.4 (5.4) years with a range of 5–21 years. The location of the tumors was anterior in 62.5% of the jaw cases. A maxillary location was observed in 62.5% of the cases. Pain complaint was reported in 25% of the subjects. Tumor fluid was aspirated in 75.0% (n = 6) of the lesions: straw aspirate (83.3%),and dark-brown aspirate (16.7%). A tooth was associated with the tumor in 87.5% (n = 7) of the cases, with the canine impacted in 85.7% (n = 6) of these. Only one case (12.5%) was extrafollicular. The AOTs are uncommon and differed from other Nigerian studies by exhibiting a male gender prevalence, lower mean age, and frequent straw aspirates.","PeriodicalId":14106,"journal":{"name":"International Journal of Medicine and Health Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86516114","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Successful pregnancies after vaginal reconstruction following acquired gynatresia with pudendal thigh (Singapore) flaps 阴部大腿(新加坡)皮瓣获得性阴道置换术后阴道重建成功妊娠
International Journal of Medicine and Health Development Pub Date : 2023-01-01 DOI: 10.4103/ijmh.ijmh_57_22
Johnson Achebe, Obinna Remigius Okwesili, C. Adiri, E. Asimadu
{"title":"Successful pregnancies after vaginal reconstruction following acquired gynatresia with pudendal thigh (Singapore) flaps","authors":"Johnson Achebe, Obinna Remigius Okwesili, C. Adiri, E. Asimadu","doi":"10.4103/ijmh.ijmh_57_22","DOIUrl":"https://doi.org/10.4103/ijmh.ijmh_57_22","url":null,"abstract":"Acquired gynatresia resulting from traumatic vaginal delivery is rare. The use of bilateral pudendal flaps for reconstruction provides sensate tissue for a functional neovagina. Reconstruction of the vagina after complete stenosis from birth trauma has not widely been reported. We present a 29-year-old woman who developed vaginal stenosis within 2 months after vaginal delivery of a stillbirth baby. There was a failure of coitus for approximately 5 months before presentation. She had successful vaginal reconstruction with pudendal flaps and became pregnant twice through coitus after surgery. Her baby was delivered via Caesarean section. We have reported a case where the vagina was successfully reconstructed with bilateral pudendal thigh flaps which resulted in subsequent spontaneous (unassisted) pregnancies.","PeriodicalId":14106,"journal":{"name":"International Journal of Medicine and Health Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81496896","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of relationship between anthropometric measurements and reproductive hormonal profiles, among females of childbearing age at a tertiary health facility in Nigeria 评估尼日利亚某三级保健机构育龄妇女的人体测量值与生殖激素状况之间的关系
International Journal of Medicine and Health Development Pub Date : 2023-01-01 DOI: 10.4103/ijmh.ijmh_47_22
Waliu Oladosu, AdewaleMukaila Alayo, A. Ahmed, O. Jimoh, Sekinat Olarinoye-Raji, Basirat Egbeyemi, Taofeek Ajadi
{"title":"Assessment of relationship between anthropometric measurements and reproductive hormonal profiles, among females of childbearing age at a tertiary health facility in Nigeria","authors":"Waliu Oladosu, AdewaleMukaila Alayo, A. Ahmed, O. Jimoh, Sekinat Olarinoye-Raji, Basirat Egbeyemi, Taofeek Ajadi","doi":"10.4103/ijmh.ijmh_47_22","DOIUrl":"https://doi.org/10.4103/ijmh.ijmh_47_22","url":null,"abstract":"Background: Increasing prevalence of overweight and obesity has profound impacts on health generally, including the reproductive system. Traditionally, pear body shapes, from narrow waist and wide hip circumferences, have been associated with high fecundability among females. Although this has been scientifically demonstrated by a number of researches only a few of these investigations were conducted with black women in Africa who were of reproductive age. Objectives: The objectives of the study were to compare the mean reproductive hormone levels between the different waist-to-hip ratio (WHR) and body mass index (BMI) categories and also to determine the correlations between the two anthropometric measurements and the reproductive hormones in a black African population. Materials and Methods: It was an analytical cross-sectional study of 180 females of a childbearing age. The WHR and BMI were measured as per standard recommendations. Serum levels of follicle stimulating hormone (FSH), luteinizing hormone (LH), prolactin, estradiol, day-21 progesterone, and testosterone were assayed. Results: A majority of the research participants were within the age group 21–30 years. Thirty three percent (33%) and 28.9% of participants were overweight and obese, respectively, using BMI compared with 26.7% and 20%, respectively, using WHR. Seventy six point nine percent (76.9%) of participants with an optimal BMI range ovulated with 61.5% having adequate luteal phase support compared with 75% and 54.2%, respectively, using WHR. Day-21 serum progesterone and serum estradiol were significantly negatively correlated with WHR and BMI (P < 0.05). BMI, however, showed a better correlation than WHR (r = -0.535 vs. -0.397; P = 0.001 vs. 0.008, respectively). Gonadotropins were significantly lower among overweight and obese groups for both BMI and WHR (P < 0.05), but only WHR showed moderately positive significant correlation with gonadotropins (LH: r = 0.050 vs. r = 0.215, P = 0.003, respectively; FSH: r = 0.159 vs. r = 0.431, P = 0.001, respectively), same as serum testosterone (r = 0.580 vs. r = 0.611, P = 0.002, respectively). Conclusions: Anthropometric measurements can serve as objective clues to functionality and optimal concentrations of reproductive hormones. Weight control should therefore aid the optimization of reproductive hormones and fertility among females of reproductive age.","PeriodicalId":14106,"journal":{"name":"International Journal of Medicine and Health Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81148179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness and safety of vaginal versus sublingual misoprostol for cervical ripening and induction of labor: A randomized controlled trial 阴道与舌下米索前列醇用于宫颈成熟和引产的有效性和安全性:一项随机对照试验
International Journal of Medicine and Health Development Pub Date : 2023-01-01 DOI: 10.4103/ijmh.ijmh_59_22
R. Okonkwo, A. Onyeabochukwu, E. Izuka, O. Onyegbule, C. Duke-Onyeabo, C. Obiora-Izuka, U. Nwagha
{"title":"Effectiveness and safety of vaginal versus sublingual misoprostol for cervical ripening and induction of labor: A randomized controlled trial","authors":"R. Okonkwo, A. Onyeabochukwu, E. Izuka, O. Onyegbule, C. Duke-Onyeabo, C. Obiora-Izuka, U. Nwagha","doi":"10.4103/ijmh.ijmh_59_22","DOIUrl":"https://doi.org/10.4103/ijmh.ijmh_59_22","url":null,"abstract":"Background: Vaginal misoprostol is a highly effective method of cervical ripening and induction of labor; however, it is associated with some complications. Therefore, there is need to explore other routes of administration that may be safer, acceptable, and also effective. Objective: The aim of this study was to compare the effectiveness and safety of vaginal versus sublingual misoprostol for cervical ripening and induction of labor. Materials and Methods: This was a randomized controlled trial conducted among booked antenatal women in Owerri, South-East Nigeria. The eligible participants were randomized to receive either 25 μg of misoprostol vaginally (n = 90) or 25 μg sublingually (n = 90). Outcome measures included delivery within 24 h, induction to delivery interval, cesarean section rate, side effects of misoprostol, Apgar Score at birth, and admission into the Neonatal Intensive Care Unit. Results: There was no significant difference in the effectiveness and side effects of both routes of administration (p > 0.05). The results were comparable in both groups, except for the time to reach the active phase of labor (vaginal route 16.64 ± 9.12 vs. sublingual route 13.78 ± 7.47, P = 0.023) and the number of doses of misoprostol used (vaginal route 2.81 ± 1.53 vs. sublingual route 2.34 ± 1.49, P = 0.040). Conclusion: The effectiveness of cervical ripening and induction of labor is comparable in both groups and the side effect profile is also similar. Hence, the sublingual route is as effective and as safe as the vaginal route but with added advantage of shortening the duration of active phase of labor and requiring less doses for induction of labor.","PeriodicalId":14106,"journal":{"name":"International Journal of Medicine and Health Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79454743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histopathological evaluation of benign soft tissue lesions at Nnamdi Azikiwe University teaching hospital, Nnewi, south-east Nigeria: A 9-year review 尼日利亚东南部Nnewi Nnamdi Azikiwe大学教学医院良性软组织病变的组织病理学评估:9年回顾
International Journal of Medicine and Health Development Pub Date : 2023-01-01 DOI: 10.4103/ijmh.ijmh_49_22
I. Ezejiofor, Olaniyi Olaofe, O. Ezejiofor, N. Ozor, Nonyelum Osonwa
{"title":"Histopathological evaluation of benign soft tissue lesions at Nnamdi Azikiwe University teaching hospital, Nnewi, south-east Nigeria: A 9-year review","authors":"I. Ezejiofor, Olaniyi Olaofe, O. Ezejiofor, N. Ozor, Nonyelum Osonwa","doi":"10.4103/ijmh.ijmh_49_22","DOIUrl":"https://doi.org/10.4103/ijmh.ijmh_49_22","url":null,"abstract":"Background: Soft tissue lesions are remarkably diverse and range from inflammatory, self-limited lesions to neoplasm. The diversity of these lesions frequently poses a diagnostic challenge to pathologists and remains a subject of interests. Lack of research on soft tissues in our setting has prompted the need to study them. Objectives: The aim of this study was to determine the benign lesions of soft tissues with respect to age, sex, anatomic site, and histologic types. It also aimed to determine the baseline data of benign soft tissue lesions in Nnewi, Nigeria. Materials and Methods: This study reviewed all histologically diagnosed benign soft tissue lesions at the Histopathology Department of Nnamdi Azikiwe University Teaching Hospital (NAUTH), Nnewi, Nigeria from 2011 to 2019 and classified the tumors using the 2020 WHO Classification of Soft Tissue Tumours. Results: A total of 351 cases of soft tissue lesions were diagnosed during the study period, out of which 251 were benign lesions and accounted for 71.5% (251/351) of all soft tissue lesions, whereas 28.5% (100/351) of the cases were malignant. The benign lesions included inflammatory and benign neoplasm, of which neoplasm accounted for the majority of the cases with a frequency of 94.0% (236/251), whereas inflammatory lesions accounted for 5.9% (15/251). The 236 benign soft tissue tumors diagnosed had a male-to-female ratio of 1: 1.4 with a mean age (SD) of 37.5 (19.5) years. The most frequent occurrence of benign tumors was seen in the fourth decade with 52 cases (21.0%), followed by fifth decade with 42 cases (16.7%). Adipocytic tumors were the commonest with a frequency of 54.0% (135/251), followed by peripheral nerve sheath tumors (PNSTs) with 12.4% (31/251) and then vascular and fibroblastic/myofibroblastic tumors with 10.8% (27/251) and 5.6% (14/251), respectively. Lipoma is the most common histologic type of benign soft tissue tumor and the only benign adipocytic tumor. This is followed by hemangioma 9.6% (24/251) and then neurofibroma 7.6% (19/251). Lipoma accounted for 37.09% (135/351) of all soft tissue lesions and the majority of them were seen in the fourth decade, whereas hemagioma and neurofibroma occurred more at the first decade. The most common anatomic distributions of these benign tumors were lower extremities with 23.5% (n = 59/251), followed by trunk 21.1% (n = 53). The major inflammatory lesions were tuberculoid granulomatous inflammation and panniculitis with 2.3% (6/251) of cases each. Others were necrotizing fasciitis (n = 2) and eosinophilic myositis (n = 1). Conclusion: Benign soft tissue tumors had a slight female preponderance. Lipoma is the single most common benign soft tissue neoplasm, whereas tuberculosis and panniculitis were the two most common inflammatory soft tissue lesions. Histopathological evaluation of these lesions still stands as a gold standard in their diagnosis.","PeriodicalId":14106,"journal":{"name":"International Journal of Medicine and Health Development","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85514738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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