International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association最新文献_第8页

Detection of IL-13, IL-10, and IL-6 in the leprosy skin lesions of patients during prednisolone treatment for type 1 (T1R) reactions. 强的松龙治疗1型(T1R)反应患者麻风皮损中IL-13、IL-10和IL-6的检测

International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2004-03-01 DOI: 10.1489/1544-581X(2004)072<0027:DOIIAI>2.0.CO;2

Sara E Atkinson, Saroj Khanolkar-Young, Sharon Marlowe, Suman Jain, Raj Gopal Reddy, Sujai Suneetha, Diana N J Lockwood

{"title":"Detection of IL-13, IL-10, and IL-6 in the leprosy skin lesions of patients during prednisolone treatment for type 1 (T1R) reactions.","authors":"Sara E Atkinson, Saroj Khanolkar-Young, Sharon Marlowe, Suman Jain, Raj Gopal Reddy, Sujai Suneetha, Diana N J Lockwood","doi":"10.1489/1544-581X(2004)072<0027:DOIIAI>2.0.CO;2","DOIUrl":"https://doi.org/10.1489/1544-581X(2004)072<0027:DOIIAI>2.0.CO;2","url":null,"abstract":"This study demonstrates the presence of IL-10 and IL-6, by immunohistochemistry, in the skin lesions of patients with Type 1 reactions. Fifteen patients with Type 1 reaction from Hyderabad, India were included in this study. They were all receiving standardized treatment for Type 1 reactions: a reducing course of daily oral prednisolone for 6 months. Biopsies were taken before treatment and during treatment at weeks 1, 4, and 6 months. IL-13 was observed in the lesions of most patients. By week 4 of treatment, the presence of IL-13, IL-10, and IL-6 in the lesions had decreased significantly. Although some patients showed significant clinical skin sign improvement within one week of therapy, no concomitant decrease or increase in any of the cytokines was observed at this time point. Interestingly, some cytokine activity within the lesions was observed after 6 months of treatment.","PeriodicalId":14078,"journal":{"name":"International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association","volume":"72 1","pages":"27-34"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24582641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

What is the best way to use BCG to protect against leprosy: when, for whom, and how often? 使用卡介苗预防麻风病的最佳方法是什么:何时、对谁、以及多久接种一次?

International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2004-03-01 DOI: 10.1489/1544-581X(2004)072<0048:WITBWT>2.0.CO;2

W Cairns S Smith

引用次数: 7

Design of the leprosy component of the Brazilian BCG revaccination trial for assessing BCG effectiveness against leprosy in school children. 设计巴西卡介苗再接种试验的麻风病部分，以评估卡介苗对学龄儿童麻风病的有效性。

International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2004-03-01 DOI: 10.1489/1544-581X(2004)072<0008:DOTLCO>2.0.CO;2

Sérgio S Cunha, Inês Dourado, Mauricio L Barreto, Neal Alexander, Susan M Pereira, Yury Ichihara, Emilia S Pereira, Valderiza Pedrosa, Fatima Maroja, Carla Ribas, Laura C Rodrigues

{"title":"Design of the leprosy component of the Brazilian BCG revaccination trial for assessing BCG effectiveness against leprosy in school children.","authors":"Sérgio S Cunha, Inês Dourado, Mauricio L Barreto, Neal Alexander, Susan M Pereira, Yury Ichihara, Emilia S Pereira, Valderiza Pedrosa, Fatima Maroja, Carla Ribas, Laura C Rodrigues","doi":"10.1489/1544-581X(2004)072<0008:DOTLCO>2.0.CO;2","DOIUrl":"https://doi.org/10.1489/1544-581X(2004)072<0008:DOTLCO>2.0.CO;2","url":null,"abstract":"Background: BCG vaccination confers protection against leprosy, and vaccination among household contacts has been recommended in Brazil. Nevertheless, vaccination of the entire community against leprosy is not advocated as leprosy has low incidence in most populations. Despite that, in Brazil, BCG vaccination is recommended among school children to prevent tuberculosis and this large scale vaccination may also affect the occurrence of leprosy, which led to investigations of its impact on leprosy in endemic areas of Brazil.Objectives: To estimate the effectiveness against leprosy of a dose of BCG vaccine given to school children in a population with a high coverage of neonatal BCG. Long term objectives are to compare the impact of vaccination among schoolchildren with the existing recommendation to vaccinate household contacts of leprosy.Study design: Cluster randomized controlled field trial with no placebo.Study population: Children aged 7 to 14 years attending state schools with high coverage of neonatal BCG.Methods: 286 state schools in the city of Manaus, Brazil, were randomized to receive BCG or not. Identifying information was collected for 152,438 school children, of whom 72,980 are in intervention schools. BCG vaccination was given intradermically to children in schools allocated to vaccination. Follow-up relies on ascertainement of cases diagnosed at the health services and notified to the reference center for leprosy.","PeriodicalId":14078,"journal":{"name":"International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association","volume":"72 1","pages":"8-15"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24582643","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Active surveillance of leprosy contacts in country with low prevalence rate. 在低流行率国家积极监测麻风接触者。

International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2004-03-01 DOI: 10.1489/1544-581X(2004)072<0050:ASOLCI>2.0.CO;2

Masanori Kai, Yumi Maeda, Shinji Maeda, Yasuo Fukutomi, Kazuo Kobayashi, Yoshiko Kashiwabara, Masahiko Makino, Mohammad Ali Abbasi, Muhammad Zubair Khan, Pervez Ali Shah

{"title":"Active surveillance of leprosy contacts in country with low prevalence rate.","authors":"Masanori Kai, Yumi Maeda, Shinji Maeda, Yasuo Fukutomi, Kazuo Kobayashi, Yoshiko Kashiwabara, Masahiko Makino, Mohammad Ali Abbasi, Muhammad Zubair Khan, Pervez Ali Shah","doi":"10.1489/1544-581X(2004)072<0050:ASOLCI>2.0.CO;2","DOIUrl":"https://doi.org/10.1489/1544-581X(2004)072<0050:ASOLCI>2.0.CO;2","url":null,"abstract":"For advanced control of leprosy in Pakistan where the World Health Organization leprosy elimination goal was achieved in 1996, we conducted surveillance of Mycobacterium leprae-seropositive patients and their contacts and drug resistant strains of M. leprae. We measured anti-PGL-I antibody level in sera from leprosy patients and their contacts for early detection of M. leprae infection. Out of 34 leprosy patients undergoing treatment, 4 lepromatous leprosy patients were antibody positive, and 6.8 to 23.7 percent of occupational or household contacts were seropositive. Furthermore, three cases (1.2%) had a high antibody titer. For surveillance of drug resistant strains of M. leprae, dapsone and rifampin were targeted. Four out of 18 polymerase chain reaction (PCR) positive samples had mutation in folP gene, and among 10 PCR positive samples, one had a mutation in the rpoB gene. These results indicate that serological analysis of patient contacts might be useful to find out high risk individuals, and there are M. leprae strains resistant to chemotherapeutic agents in Pakistan.","PeriodicalId":14078,"journal":{"name":"International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association","volume":"72 1","pages":"50-3"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24582637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Lepromatous leprosy with extensive unusual ulcerations and cachexia. Is it the first case of Lucio's phenomenon from Iran? 具有广泛的异常溃疡和恶病质的麻风病。这是卢西奥现象在伊朗的第一个案例吗?

International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2004-03-01 DOI: 10.1489/1544-581X(2004)072<0056:LLWEUU>2.0.CO;2

Javad Golchai, Omid Zargari, Arash Maboodi, Aptin Maboodi, Siamak Granmayeh

引用次数: 10

Leprosy patients with lepromatous disease have an up-regulated IL-8 response that is unlinked to TNF-alpha responses. 患有麻风病的麻风患者IL-8反应上调，与tnf - α反应无关。

International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2004-03-01 DOI: 10.1489/1544-581X(2004)072<0035:LPWLDH>2.0.CO;2

Z Hasan, A Mahmood, S Zafar, A A Khan, R Hussain

{"title":"Leprosy patients with lepromatous disease have an up-regulated IL-8 response that is unlinked to TNF-alpha responses.","authors":"Z Hasan, A Mahmood, S Zafar, A A Khan, R Hussain","doi":"10.1489/1544-581X(2004)072<0035:LPWLDH>2.0.CO;2","DOIUrl":"https://doi.org/10.1489/1544-581X(2004)072<0035:LPWLDH>2.0.CO;2","url":null,"abstract":"Tumor necrosis factor (TNF-alpha) in conjunction with interferon-gamma (IFN-gamma) plays an important role in lymphocyte recruitment and granuloma formation in mycobacterial diseases. Lepromatous leprosy infections are typically associated with low to absent T cell responses and the absence of INF-gamma secretion. Chemokines such as IL-8, MCP-1, and MIP-1beta, have also been shown to recruit neutrophils and lymphocytes to the site of mycobacterial infections. We have studied IL-8 expression in relation to TNF-alpha and TGF-beta in monocytes from lepromatous patients (LL) as compared with healthy endemic controls. In endemic controls, no spontaneous expression of IL-8, TNF-alpha, and TGF-beta was observed, but BCG and M. leprae induced activation of all three cytokines. Lepromatous leprosy monocytes spontaneously expressed high levels of IL-8 and TGF-beta but negligible levels of TNF-alpha. A further increase in IL-8 secretion or gene expression by BCG or M. leprae was not significant. BCG, but not M. leprae, was able to stimulate TNF-alpha activation in lepromatous leprosy subjects. TGF-beta responses in LL were parallel to those of IL-8. This suggests a vigorous and active ongoing IL-8 response in lepromatous disease that is independent of TNF-alpha activation. Therefore, in the absence of IFN-gamma and TNF-alpha activation, IL-8 may assume a pivotal role in cell recruitment in leprosy patients with disseminated mycobacterial infections.","PeriodicalId":14078,"journal":{"name":"International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association","volume":"72 1","pages":"35-44"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24582640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 25

Relapses in multibacillary patients treated with multi-drug therapy until smear negativity: findings after twenty years. 接受多种药物治疗的多细菌患者复发至涂片阴性:20年后的发现。

International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2004-03-01 DOI: 10.1489/1544-581X(2004)072<0001:RIMPTW>2.0.CO;2

Gift Norman, Geetha Joseph, Joseph Richard

{"title":"Relapses in multibacillary patients treated with multi-drug therapy until smear negativity: findings after twenty years.","authors":"Gift Norman, Geetha Joseph, Joseph Richard","doi":"10.1489/1544-581X(2004)072<0001:RIMPTW>2.0.CO;2","DOIUrl":"https://doi.org/10.1489/1544-581X(2004)072<0001:RIMPTW>2.0.CO;2","url":null,"abstract":"The Schieffelin Leprosy Research and Training Center at Karigiri, India participated in several of the World Health Organization (WHO) trials. The first trial on combined therapy in multi-bacillary leprosy was initiated in 1981. The main objectives of this field trial were to evaluate the efficacy of WHO recommended regimens in preventing relapses, especially drug resistance relapses. This paper reports on the relapses twenty years after patients were inducted into the WHO field trial. Between 1981 and 1982, 1067 borderline lepromatous and lepromatous patients were inducted into the WHO field trial for combined therapy in multi-bacillary leprosy trial. Among them, 357 patients were skin smear positive. During the follow-up in 2002, only 173 of them could be traced and assessed. The mean duration of follow-up was 16.4 +/- 1.83 years. Two patients relapsed 14 and 15 years after being released from treatment, the relapse rate being 0.07 per 100 person years follow-up. Drug susceptibility tests done on one of the relapsed patients revealed drug sensitive organisms to all multi-drug therapy drugs.","PeriodicalId":14078,"journal":{"name":"International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association","volume":"72 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2004-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24581829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 32

Phimosis as a presenting manifestation of genital involvement in leprosy. 包茎是麻风病中生殖器受累的一种表现。

International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2004-03-01 DOI: 10.1489/1544-581X(2004)072<0054:PAAPMO>2.0.CO;2

Sunil Dogra, Inderjeet Kaur, Bhushan Kumar

引用次数: 2

IL-10 treatment of macrophages bolsters intracellular survival of Mycobacterium leprae. 巨噬细胞IL-10治疗可促进麻风分枝杆菌的细胞内存活。

International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2004-03-01 DOI: 10.1489/1544-581X(2004)072<0016:ITOMBI>2.0.CO;2

Yasuo Fukutomi, Masanori Matsuoka, Fumishige Minagawa, Satoshi Toratani, Gregory McCormick, James Krahenbuhl

引用次数: 17

Leprosy in Greece at the end of the 20th century (1988-2000). 20世纪末希腊的麻风病(1988-2000)。

International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2003-12-01 DOI: 10.1489/1544-581X(2003)071<0357:LIGATE>2.0.CO;2

Kyriakos Kyriakis

引用次数: 1