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International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association最新文献

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Leprosy bacillus triggers the wrong cells. 麻风病杆菌触发了错误的细胞。
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2005-09-01
Tom H M Ottenhoff, Michèl R Klein
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引用次数: 0
Quantitative measurement of sensory impairment in referral centers. 转诊中心感觉障碍的定量测量。
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2005-09-01
Ramaswamy Premkumar, Pichaimuthu Rajan, Ebenezer Daniel
{"title":"Quantitative measurement of sensory impairment in referral centers.","authors":"Ramaswamy Premkumar, Pichaimuthu Rajan, Ebenezer Daniel","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14078,"journal":{"name":"International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association","volume":"73 3","pages":"219-22"},"PeriodicalIF":0.0,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26135787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Erythema nodosum leprosum and HIV infection: A therapeutic experience. 麻风结节性红斑与HIV感染:治疗经验。
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2005-09-01
Nand Lal Sharma, Vikram K Mahajan, Vikas C Sharma, Sandip Sarin, Ramesh Chander Sharma
{"title":"Erythema nodosum leprosum and HIV infection: A therapeutic experience.","authors":"Nand Lal Sharma,&nbsp;Vikram K Mahajan,&nbsp;Vikas C Sharma,&nbsp;Sandip Sarin,&nbsp;Ramesh Chander Sharma","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The relationship between leprosy and HIV infection is not yet fully understood, as not much is known about the natural history of the co-infected patients. The matter has become more confusing because of conflicting reports. Type-1 lepra reactions and neuritis appear to be severe and more frequent among them. But erythema nodosum leprosum too is not as uncommon among these patients as it was once thought. Management of these co-infected patients is often difficult for want of clear-cut guidelines on clinical care. We report here our experience of treating recurrent, severe erythema nodosum leprosum in a patient concurrently having leprosy and HIV infection. Early institution of antiretroviral therapy appears to provide an edge in improving the therapeutic outcome for him. It also suggests a direct and more complex interplay of HIV and Mycobacterium leprae infection.</p>","PeriodicalId":14078,"journal":{"name":"International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association","volume":"73 3","pages":"189-93"},"PeriodicalIF":0.0,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26135358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Borderline tuberculoid leprosy with type 1 reaction in an HIV patient--a phenomenon of immune reconstitution. HIV患者伴有1型反应的边缘性结核样麻风病——免疫重建现象。
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2005-09-01
Tarun Narang, Sunil Dogra, Inderjeet Kaur
{"title":"Borderline tuberculoid leprosy with type 1 reaction in an HIV patient--a phenomenon of immune reconstitution.","authors":"Tarun Narang,&nbsp;Sunil Dogra,&nbsp;Inderjeet Kaur","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14078,"journal":{"name":"International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association","volume":"73 3","pages":"203-5"},"PeriodicalIF":0.0,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26135360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Co-localization of Pityriasis versicolor and BT Hansen's disease. 花斑糠疹与BT汉森病的共定位。
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2005-09-01
Tarun Narang, Sunil Dogra, Inderjeet Kaur
{"title":"Co-localization of Pityriasis versicolor and BT Hansen's disease.","authors":"Tarun Narang,&nbsp;Sunil Dogra,&nbsp;Inderjeet Kaur","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14078,"journal":{"name":"International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association","volume":"73 3","pages":"206-7"},"PeriodicalIF":0.0,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26135783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Paucibacillary treatment for large tuberculoid lesions of leprosy? 麻风病大结核样病变的少菌治疗?
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2005-09-01
Mônica Nunes Souza Santos, Luis Carlos Lima de Ferreira, Sinésio Talhari
{"title":"Paucibacillary treatment for large tuberculoid lesions of leprosy?","authors":"Mônica Nunes Souza Santos,&nbsp;Luis Carlos Lima de Ferreira,&nbsp;Sinésio Talhari","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14078,"journal":{"name":"International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association","volume":"73 3","pages":"225-7; author reply 227-8"},"PeriodicalIF":0.0,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26135789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Has the term "elimination" outlived its utility? “淘汰”一词已经过时了吗?
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2005-09-01
R Ganapati, V V Pai
{"title":"Has the term \"elimination\" outlived its utility?","authors":"R Ganapati,&nbsp;V V Pai","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14078,"journal":{"name":"International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association","volume":"73 3","pages":"229"},"PeriodicalIF":0.0,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26135790","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effects of purification and fluorescent staining on viability of Mycobacterium leprae. 纯化及荧光染色对麻风分枝杆菌生存力的影响。
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2005-09-01
Ramanuj Lahiri, Baljit Randhawa, James L Krahenbuhl
{"title":"Effects of purification and fluorescent staining on viability of Mycobacterium leprae.","authors":"Ramanuj Lahiri,&nbsp;Baljit Randhawa,&nbsp;James L Krahenbuhl","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Over the years, researchers have carried out experiments with Mycobacterium leprae obtained from either human multibacillary lesions, or infected armadillo tissues, or infected footpad tissues of conventional mice as well as athymic nu/nu mice. In general, these sources of leprosy bacilli are satisfactory for most biochemical and mouse footpad studies, but less than satisfactory for studies in cell biology and immunology where contaminating host tissues pose a serious problem. We examined the utility of a procedure for eliminating mouse footpad tissue from M. leprae suspension using sodium hydroxide solution and its subsequent effect on the viability of the organism by determining the rate of palmitic acid oxidation, bacterial membrane integrity, and growth in the mouse footpad. We found that treating M. leprae suspension, obtained from infected nu/nu mouse footpad, with 0.1N NaOH for 3 min was sufficient to remove the majority of mouse tissue without adversely affecting the viability of the organism. This is a simple and rapid method to get suspensions of nu/nu footpad-derived viable M. leprae essentially free of host tissues, which can be a research reagent for studying the host-pathogen relationship in leprosy. We also report here a method for labeling M. leprae with the fluorescent dye PKH26, without compromising on the viability of the organism. This method may be useful in intracellular trafficking studies of M. leprae or in other cell biology studies that require tracking of the bacteria using fluorescent tag. We observed the staining to be stable in vitro over considerable lengths of time and did not affect the viability of the bacteria.</p>","PeriodicalId":14078,"journal":{"name":"International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association","volume":"73 3","pages":"194-202"},"PeriodicalIF":0.0,"publicationDate":"2005-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26135359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leprosy susceptibility-a matter of protein degradation? The role of proteasomes in infection and disease. 麻风病易感性——蛋白质降解的问题?蛋白酶体在感染和疾病中的作用。
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2005-06-01
Ulrich Steinhoff, Alexander Visekruna
{"title":"Leprosy susceptibility-a matter of protein degradation? The role of proteasomes in infection and disease.","authors":"Ulrich Steinhoff,&nbsp;Alexander Visekruna","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":14078,"journal":{"name":"International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association","volume":"73 2","pages":"135-7"},"PeriodicalIF":0.0,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26135799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Persister studies in leprosy patients after multi-drug treatment. 麻风病患者多药治疗后的持续研究。
International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association Pub Date : 2005-06-01
U D Gupta, K Katoch, H B Singh, M Natrajan, V M Katoch
{"title":"Persister studies in leprosy patients after multi-drug treatment.","authors":"U D Gupta,&nbsp;K Katoch,&nbsp;H B Singh,&nbsp;M Natrajan,&nbsp;V M Katoch","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Cutaneous biopsies were collected from leprosy patients who attended the out-patient department of the Institute for treatment at different intervals, i.e., 12 months, 18 months, 24 months, 36 months, and more after beginning the multi-drug treatment therapy (M.D.T.). The patients belonged to the two drug regimens; (i) standard multibacillary (MB) M.D.T. after 12, 24, and 36 months; or (ii) standard M.D.T. + Minocycline 100 mg once a month (supervised) + Ofloxacin 400 mg once a month supervised for 12 months Biopsies were processed for mouse footpad inoculation and for estimating ATP levels by bioluminescence assay as per established methods. Viable bacilli were observed in 23.5% up to 1 year, 7.1% at 2 years, and in 3.84% at 3 years of M.D.T. by MFP and 29.4%, 10.7%, and 3.84% by ATP assay in the M.D.T. group at the same time period, respectively, but not in M.D.T. + Minocycline + Ofloxacin group after one year. The overall percentage of persisters was 5.55% by MFP and 7.14% by ATP assay up to 3 years of treatment.</p>","PeriodicalId":14078,"journal":{"name":"International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association","volume":"73 2","pages":"100-4"},"PeriodicalIF":0.0,"publicationDate":"2005-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"26135792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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