Jong-Chan Youn, Darae Kim, Jae Yeong Cho, Dong-Hyuk Cho, Sang Min Park, Mi-Hyang Jung, Junho Hyun, Hyun-Jai Cho, Seong-Mi Park, Jin-Oh Choi, Wook-Jin Chung, Byung-Su Yoo, Seok-Min Kang
{"title":"Korean Society of Heart Failure Guidelines for the Management of Heart Failure: Treatment.","authors":"Jong-Chan Youn, Darae Kim, Jae Yeong Cho, Dong-Hyuk Cho, Sang Min Park, Mi-Hyang Jung, Junho Hyun, Hyun-Jai Cho, Seong-Mi Park, Jin-Oh Choi, Wook-Jin Chung, Byung-Su Yoo, Seok-Min Kang","doi":"10.36628/ijhf.2023.0011","DOIUrl":"10.36628/ijhf.2023.0011","url":null,"abstract":"<p><p>The Korean Society of Heart Failure (KSHF) guidelines aim to provide physicians with evidence-based recommendations for the management of patients with heart failure (HF). After the first introduction of the KSHF guidelines in 2016, newer therapies for HF with reduced ejection fraction, HF with mildly reduced ejection fraction, and HF with preserved ejection fraction have since emerged. The current version has been updated based on international guidelines and research data on Korean patients with HF. Herein, we present Part II of these guidelines, which comprises treatment strategies to improve the outcomes of patients with HF.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"5 2","pages":"66-81"},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/36/ce/ijhf-5-66.PMC10172080.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9461422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bong-Joon Kim, Soo-Jin Kim, Sung-Il Im, Hyunsu Kim, Jung-Ho Heo, Tae-Won Jang
{"title":"Pulmonary Hypertension With Unilateral Pulmonary Vein Atresia.","authors":"Bong-Joon Kim, Soo-Jin Kim, Sung-Il Im, Hyunsu Kim, Jung-Ho Heo, Tae-Won Jang","doi":"10.36628/ijhf.2023.0003","DOIUrl":"https://doi.org/10.36628/ijhf.2023.0003","url":null,"abstract":"The recently revised European Society of Cardiology/European Respiratory Society guidelines changed the diagnostic criteria for pulmonary hypertension from a mean pulmonary arterial pressure (PAP) of 25 mmHg or greater to more than 20 mmHg, emphasizing early diagnosis.1) Patients with cardiac malformations with shunts may develop pulmonary arterial hypertension (PAH) due to right ventricle (RV) volume/pressure overload due to the shunts. However, in patients who underwent cardiac surgery for congenital cardiac anomaly at birth, the state of the vascular structure and hemodynamic changes may vary, complicating the diagnosis and classification of pulmonary hypertension.","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"5 2","pages":"102-105"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/e7/35/ijhf-5-102.PMC10172077.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9472968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Mortality Benefit of Milrinone as a Continuous Outpatient Intravenous Inotrope Therapy in Advanced Heart Failure: A Systemic Review and Meta-Analysis.","authors":"Gaspar Del Rio-Pertuz, Juthipong Benjanuwattra, Phichayut Phinyo, Natnicha Leelaviwat, Poemlarp Mekraksakit, Nandini Nair","doi":"10.36628/ijhf.2022.0034","DOIUrl":"https://doi.org/10.36628/ijhf.2022.0034","url":null,"abstract":"https://e-heartfailure.org Advanced (stage D) heart failure (AHF) is defined by severe and refractory symptoms, not responding to maximum guideline-directed medical therapy, that markedly interfere with daily life and lead to recurrent hospitalizations.1) According to the AHA/ACC/ESFA 2022 guideline, continuous outpatient intravenous inotrope therapy is a strategy used as in interim treatment to those with AHF awaiting for mechanical circulatory support or cardiac transplantation (class IIa recommendation) and palliative treatment to improve symptom and functional status (class IIb recommendation).1) Milrinone and dobutamine are the most frequently used intravenous inotropes.2) Despite the aforementioned recommendation, there’s a sparsity of data comparing the benefit between those inotropic agents. Recent randomized-controlled trial and meta-analyses did not show an advantage of milrinone over dobutamine with regards to in-hospital mortality in patients with acute cardiogenic shock3-5); however, there was an increasing mortality benefit of milrinone over time, suggesting the possibility of time-dependent effect.4) A systemic review and meta-analysis was, therefore, performed to compare the mortality benefit between continuous outpatient intravenous therapy with milrinone and dobutamine.","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"5 2","pages":"106-110"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/30/e4/ijhf-5-106.PMC10172078.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9472972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ji Hoon Lim, Soo Yong Lee, Min Ho Ju, Seok Hyun Kim, Jin Hee Choi, Min Ku Chon, Sang Hyun Lee, Ki Won Hwang, Jeong Su Kim, Yong Hyun Park, Junehong Kim, Kook Jin Chun, Mi Hee Lim, Chee-Hoon Lee, Hyung Gon Je
{"title":"Direct Extracorporeal Membrane Oxygenation Bridged Heart Transplantation: The Importance of Multi-Organ Failure.","authors":"Ji Hoon Lim, Soo Yong Lee, Min Ho Ju, Seok Hyun Kim, Jin Hee Choi, Min Ku Chon, Sang Hyun Lee, Ki Won Hwang, Jeong Su Kim, Yong Hyun Park, Junehong Kim, Kook Jin Chun, Mi Hee Lim, Chee-Hoon Lee, Hyung Gon Je","doi":"10.36628/ijhf.2023.0013","DOIUrl":"https://doi.org/10.36628/ijhf.2023.0013","url":null,"abstract":"<p><strong>Background and objectives: </strong>Recently, approximately 40% of all heart transplantation (HTx) in South Korea are performed using the direct extracorporeal membrane oxygenation (ECMO) bridging method. We conducted a study to examine the clinical outcome of direct ECMO-bridged HTx and to investigate the impact of multi-organ failure (MOF).</p><p><strong>Methods: </strong>From June 2014 to September 2022, a total of 96 adult patients who underwent isolated HTx at a single tertiary hospital were included in the study. The patients were sub-grouped into ECMO (n=48) and non-ECMO group (n=48), and the ECMO group was subdivided into awake (n=22) and non-awake (n=26) groups based on mechanical ventilator (MV) dependency. Baseline characteristics, 30-day, and 1-year mortality were analyzed retrospectively.</p><p><strong>Results: </strong>The 1-year survival rate was significantly lower in the ECMO group (72.9% vs. 95.8%, p=0.002). There was a significant difference in the 30-day survival rate between the awake and non-awake ECMO groups (81.8% vs. 65.4%, p=0.032). In the univariate analysis of logistic regression for 1-year mortality, the odds ratio was 8.5 for ECMO bridged HTx compared to the non-ECMO group, 12.3 in patients who required MV (p=0.003), and 23 with additional hemodialysis (p<0.001).</p><p><strong>Conclusions: </strong>Patients who required MV in ECMO bridged HTx showed higher preoperative MOF rates and early mortality than those extubated. When considering ECMO bridged HTx, the severity of MOF should be thoroughly investigated, and careful patient selection is necessary.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"5 2","pages":"91-99"},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/c6/de/ijhf-5-91.PMC10172075.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9461420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SGLT-2 Inhibitors in Heart Failure: A Review of Current Evidence.","authors":"Khawaja M Talha, Stefan D Anker, Javed Butler","doi":"10.36628/ijhf.2022.0030","DOIUrl":"10.36628/ijhf.2022.0030","url":null,"abstract":"<p><p>Sodium-glucose co-transporter 2 (SGLT-2) inhibitors are the latest addition to guideline-directed medical therapy in heart failure (HF) with reduced ejection fraction with recent trials suggesting a significant reduction in adverse cardiovascular outcomes in patients with HF with mildly reduced and preserved ejection fraction. SGLT-2 inhibitors have evolved as metabolic drugs due to their multi-system effects and are indicated for the management of HF across the ejection fraction spectrum, type 2 diabetes, and chronic kidney disease. There is ongoing research to explore the mechanistic effects of SGLT-2 inhibitors in HF and to evaluate their use in worsening HF and after myocardial infarction. This review focuses on the evidence for SGLT-2 inhibitors from type 2 diabetes cardiovascular outcome and primary HF trials and discusses ongoing research related to their use in cardiovascular disease.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"5 2","pages":"82-90"},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/19/f2/ijhf-5-82.PMC10172076.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9467656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kyu-Sun Lee, Junghyun Noh, Seong-Mi Park, Kyung Mook Choi, Seok-Min Kang, Kyu-Chang Won, Hyun-Jai Cho, Min Kyong Moon
{"title":"Evaluation and Management of Patients With Diabetes and Heart Failure: A Korean Diabetes Association and Korean Society of Heart Failure Consensus Statement.","authors":"Kyu-Sun Lee, Junghyun Noh, Seong-Mi Park, Kyung Mook Choi, Seok-Min Kang, Kyu-Chang Won, Hyun-Jai Cho, Min Kyong Moon","doi":"10.36628/ijhf.2022.0028","DOIUrl":"10.36628/ijhf.2022.0028","url":null,"abstract":"<p><p>Diabetes mellitus is a major risk factor for the development of heart failure. Furthermore, the prognosis of heart failure is worse in patients with diabetes mellitus than in those without it. Therefore, early diagnosis and proper management of heart failure in patients with diabetes mellitus are important. This review discusses the current criteria for diagnosis and screening tools for heart failure and the currently recommended pharmacological therapies for heart failure. We also highlight the effects of anti-diabetic medications on heart failure.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"5 1","pages":"1-20"},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/a3/8d/ijhf-5-1.PMC9902644.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10768290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Perirenal Fat and Renal Congestion: A Double Burden on Kidney Function in Acute Decompensated Heart Failure.","authors":"Dong-Hyuk Cho","doi":"10.36628/ijhf.2023.0005","DOIUrl":"10.36628/ijhf.2023.0005","url":null,"abstract":"","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"5 1","pages":"34-35"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/8f/a3/ijhf-5-34.PMC9902642.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10768287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Stable Severe Reduction in Ejection Fraction Following COVID-19 mRNA Vaccine: Are They Related?","authors":"Bistees George, Maya Guglin","doi":"10.36628/ijhf.2022.0027","DOIUrl":"https://doi.org/10.36628/ijhf.2022.0027","url":null,"abstract":"severe cardiomyopathy following vaccine administration. Vaccine correlation and potential mechanisms remain to be an enigma","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"5 1","pages":"48-50"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/23/9e/ijhf-5-48.PMC9902643.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10768288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
In-Jeong Cho, Jin Wi, Sang-Eun Lee, Dong-Hyeok Kim, Wook Bum Pyun
{"title":"Perirenal Fat and Kidney Function Deterioration in Patients With Acute Decompensated Heart Failure.","authors":"In-Jeong Cho, Jin Wi, Sang-Eun Lee, Dong-Hyeok Kim, Wook Bum Pyun","doi":"10.36628/ijhf.2022.0029","DOIUrl":"https://doi.org/10.36628/ijhf.2022.0029","url":null,"abstract":"<p><strong>Background and objectives: </strong>The thick perirenal fat pad can induce high intracapsular pressure and cause compression of the renal vasculature and resultant congestive nephropathy. The current study investigated the association of perirenal fat thickness with kidney dysfunction in patients with acute decompensated heart failure (ADHF).</p><p><strong>Methods: </strong>Data from 266 patients hospitalized with ADHF were analyzed. Patients were divided into two groups according to the glomerular filtration rate (GFR) at admission (preserved kidney function [GFR ≥60 mL/min/1.73 m<sup>2</sup>] and reduced kidney function [GFR <60 mL/min/1.73 m<sup>2</sup>] groups). Right and left posterior perirenal fat thicknesses were measured using computed tomography, and their average values were calculated. Associated factors with reduced kidney function was assessed by logistic regression model, presenting with odds ratio (OR) and confidence interval (CI).</p><p><strong>Results: </strong>Increasing age (OR, 1.08; 95% CI, 1.04-1.12; p<0.001), diabetes mellitus (OR, 2.46; 95% CI, 1.18-5.12; p<0.017), increased log N-terminal pro-B-type natriuretic peptide (NT-proBNP) (OR, 1.82; 95% CI, 1.32-2.52; p<0.001), and increased average perirenal fat thickness (OR, 1.11; 95% CI, 1.06-1.16; p<0.001) were independently associated with reduced kidney function. In the subgroup analyses, patients over 70 years old, the ratio of mitral-to-mitral annular velocity >15, elevated log NT-proBNP had a significantly higher association with increased perirenal fat thickness with reduced kidney function.</p><p><strong>Conclusions: </strong>Thick perirenal fat pads were independently associated with kidney function deterioration in patients hospitalized with ADHF.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"5 1","pages":"36-47"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/53/92/ijhf-5-36.PMC9902646.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10768285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Lifestyle Modification in Heart Failure Management: Are We Using Evidence-Based Recommendations in Real World Practice?","authors":"Miguel Camafort, Seong-Mi Park, Seok-Min Kang","doi":"10.36628/ijhf.2022.0032","DOIUrl":"https://doi.org/10.36628/ijhf.2022.0032","url":null,"abstract":"<p><p>The heart failure (HF) guideline's purpose is to assist medical professionals while treating patients with HF in accordance with the best current research. Many cases of HF are both, avoidable and treatable thanks to scientific trials. Management is, therefore, based on lifestyle changes, also called non-pharmacological treatment. These, based on lifestyle changes, should be recommended in every patient at risk for HF or with diagnosed of HF, but evidence in itself is scarce. DASH Diet could be clearly beneficial while Mediterranean diet doesn't have enough evidence at the present moment. Smoking should be stopped, and excessive amounts of alcohol drinking avoided, but there is no clinical trial nor registry performed on these aspects. A moderate salt restriction is better than a strict reduction. Exercise and cardiac rehabilitation are beneficial but there are no clear recommendations about type, duration, etc. Most of the evidence that we have in HF patients with obesity is contradictory. Finally, due to the high number of aged frail patients in HF lifestyle changes should be individualized, but again available data is scant. Therefore, due to the lack of current evidence, these gaps need to be considered and need new efforts on investigation in the next future.</p>","PeriodicalId":14058,"journal":{"name":"International Journal of Heart Failure","volume":"5 1","pages":"21-33"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/3e/de/ijhf-5-21.PMC9902645.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10768284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}