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A Case Report on Early Diagnosis of Brain Tuberculoma in an Adolescent 1例青少年脑结核瘤早期诊断报告
International Journal of Advances in Pharmacy and Biotechnology Pub Date : 2019-06-15 DOI: 10.38111/ijapb.20190502002
G. Rachana, B. Subrahmanyam, N. Prashanthi, B. Sharvanabhava
{"title":"A Case Report on Early Diagnosis of Brain Tuberculoma in an Adolescent","authors":"G. Rachana, B. Subrahmanyam, N. Prashanthi, B. Sharvanabhava","doi":"10.38111/ijapb.20190502002","DOIUrl":"https://doi.org/10.38111/ijapb.20190502002","url":null,"abstract":"","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78104601","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RP-HPLC Method Development and Validation of Rofecoxib in Bulk and Dosage Form 罗非昔布原料药和剂型的反相高效液相色谱法开发与验证
International Journal of Advances in Pharmacy and Biotechnology Pub Date : 2019-06-15 DOI: 10.38111/ijapb.20190502001
Yamini Kumara Tadikonda, M. Dhanalakshmi
{"title":"RP-HPLC Method Development and Validation of Rofecoxib in Bulk and Dosage Form","authors":"Yamini Kumara Tadikonda, M. Dhanalakshmi","doi":"10.38111/ijapb.20190502001","DOIUrl":"https://doi.org/10.38111/ijapb.20190502001","url":null,"abstract":"","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77292475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
RP-HPLC Method for Determination of Zinostatin in Bulk and Pharmaceutical Formulation 反相高效液相色谱法测定原料药和制剂中唑他汀的含量
International Journal of Advances in Pharmacy and Biotechnology Pub Date : 2019-03-15 DOI: 10.38111/ijapb.20190501002
Md. Asra Farheen, M. Dhanalakshmi, Yamini Kumara Tadikonda
{"title":"RP-HPLC Method for Determination of Zinostatin in Bulk and Pharmaceutical Formulation","authors":"Md. Asra Farheen, M. Dhanalakshmi, Yamini Kumara Tadikonda","doi":"10.38111/ijapb.20190501002","DOIUrl":"https://doi.org/10.38111/ijapb.20190501002","url":null,"abstract":"","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85037277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Review on Tracer Technique and Its Applications in Synthesis of Secondary Metabolites in Pharmacognosy 示踪技术及其在生药学次生代谢物合成中的应用综述
International Journal of Advances in Pharmacy and Biotechnology Pub Date : 2019-03-15 DOI: 10.38111/ijapb.20190501001
D. Girija, Basu Venkateswara Reddy, K. Kamalakar, C. Manasa, B. Pavani
{"title":"A Review on Tracer Technique and Its Applications in Synthesis of Secondary Metabolites in Pharmacognosy","authors":"D. Girija, Basu Venkateswara Reddy, K. Kamalakar, C. Manasa, B. Pavani","doi":"10.38111/ijapb.20190501001","DOIUrl":"https://doi.org/10.38111/ijapb.20190501001","url":null,"abstract":"","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"2015 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87797661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Prospective Observational Study: Phenytoin Pharmacokinetic Pattern in Cerebrovascular Accident and Head Trauma Patients in Warangal Population 一项前瞻性观察研究:瓦朗加尔地区脑血管意外和头部创伤患者苯妥英药代动力学模式
International Journal of Advances in Pharmacy and Biotechnology Pub Date : 2019-01-27 DOI: 10.38111/ijapb.20190501003
Yashwanth Kumar K, M. K, V. E, Sharavanabhava B.S
{"title":"A Prospective Observational Study: Phenytoin Pharmacokinetic Pattern in Cerebrovascular Accident and Head Trauma Patients in Warangal Population","authors":"Yashwanth Kumar K, M. K, V. E, Sharavanabhava B.S","doi":"10.38111/ijapb.20190501003","DOIUrl":"https://doi.org/10.38111/ijapb.20190501003","url":null,"abstract":"An phenytoin is commonly administered as prophylactic or treatment of epileptic episodes in acute brain injury due to head injury. The aim of the study is to evaluate PK pattern of phenytoin in patients with traumatic and non-traumatic brain injuries. This study was carried out in 30 adult head injury patients and who were administered with phenytoin for prophylaxis of post trauma seizures or treatment. Serum Phenytoin concentrations (Cp) were determined and were compared between CVA and HT patients. The Km and Vmax were significantly higher in HT patients. The Cp and the Cp/dose ratio were higher in the CVA patients significantly (P<0.05). APACHE П score was significantly lower than the baseline at the end of the study in each group of patients (P<0.05). Due to significant differences in Cp and PK parameters between HT and CVA patients, close attention must be paid to the PK behavior of phenytoin in the efforts to improve the patient’s outcome after a severe HT.","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82214250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
DESIGN, DEVELOPMENT AND EVALUATION OF LABETALOL HCl GASTRO RETENTIVE FLOATING TABLETS 盐酸拉贝他洛尔胃保留漂浮片的设计、研制与评价
International Journal of Advances in Pharmacy and Biotechnology Pub Date : 2018-12-15 DOI: 10.38111/ijapb.20180402002
R. Gunda, Prasada Rao Manchineni, MV Kiran Kumar, G. K. Rao
{"title":"DESIGN, DEVELOPMENT AND EVALUATION OF LABETALOL HCl GASTRO RETENTIVE FLOATING TABLETS","authors":"R. Gunda, Prasada Rao Manchineni, MV Kiran Kumar, G. K. Rao","doi":"10.38111/ijapb.20180402002","DOIUrl":"https://doi.org/10.38111/ijapb.20180402002","url":null,"abstract":"The main aim of present research study is to formulate the floating tablets of Labetalol HCl using 32 factorial design. Labetalol HCl, non selective α, -βadreno receptor antagonist, Indicated for treatment of Hypertension/moderate Heart Failure. The Floating tablets of Labetalol HCl were prepared employing different concentrations of HPMCK4M and sodium bicarbonate in different combinations by Direct Compression technique. The concentration of HPMCK4M and sodium bicarbonate required to achieve desired drug release was selected as independent variables, X1 and X2 respectively whereas, time required for 10% of drug dissolution (t10%), 50% (t50%), 75% (t75%) and 90% (t90%) were selected as dependent variables. 9 formulations were designed and are evaluated for hardness, friability, thickness, % drug content, Floating Lag time, In-vitro drug release. From the Results concluded that all the formulation were found to be within the Pharmacopoeial limits and the In-vitro dissolution profiles of all formulations were fitted in to different Kinetic models, the statistical parameters like intercept, slope & regression coefficient were calculated. Polynomial equations were developed for t10%, t50%, t75%, t90%. Validity of developed polynomial equations were verified by designing 2 check point formulations. According to SUPAC guidelines the formulation (F8) containing combination of 20% HPMCK4M and 3.75% sodium bicarbonate, is the most identical formulation which meets the objective of work. The selected formulation (F8) follows Higuchi’s kinetics, and the mechanism of drug release was found to be NonFickian Diffusion (n= 1.033, Super Case-II transport).","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"72 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85922157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
FORMULATION AND EVALUATION OF FAST DISINTEGRATING TABLETS OF SIMVASTATIN USING LIQUISOLID TECHNOLOGY BY USING DOE APPROACH 采用doe法制备辛伐他汀快速崩解片
International Journal of Advances in Pharmacy and Biotechnology Pub Date : 2018-12-15 DOI: 10.38111/ijapb.20180402004
Urvashi B. Patel, Harshil M. Patel, Chainesh N. Shah
{"title":"FORMULATION AND EVALUATION OF FAST DISINTEGRATING TABLETS OF SIMVASTATIN USING LIQUISOLID TECHNOLOGY BY USING DOE APPROACH","authors":"Urvashi B. Patel, Harshil M. Patel, Chainesh N. Shah","doi":"10.38111/ijapb.20180402004","DOIUrl":"https://doi.org/10.38111/ijapb.20180402004","url":null,"abstract":"To obtain an enhanced in-vitro dissolution rate of simvastatin by using Liquisolid technique and Liquisolid tablets were optimized by DoE approach 32 full factorial design using Design Expert Software.Theliquisolid tablets were formulated by using propylene glycol (PG), as liquid vehicle, Avicel PH-102 as a carrier material, Aerosil as a coating material, and aspartame as sweetener and Kyron 314 as a superdisintegrant. The new mathematical model 32 full factorial design was utilized to formulate various liquisolid powder systems and to calculate amount of carrier material and coating material. All prepared liquisolid batches were subjected to weight variation, drug content uniformity, hardness, friability test, and disintegration test and dissolution tests. Liquisolid systems were also tested for DSC, FT-IR. From result of check point analysis of design data, , SMLCFDT10 shows higher Drug release (89.257 %) at less wetting time (124.682 sec.) and disintegrating time (31.843 sec). Simvasatin liquisolid compacts enhance aqueous solubility and dissolution rate in compare to other solubility enhancement technique. Hence, this research work may be useful to formulate fast disintegrating Tablets using Liquisolid Technique which may give rapid onset of action by rapid absorption, maximize efficacy, reduce dose and dose frequency & hence increase patient Compliance.","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87386393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
IN-VITRO ANTI BACTERIAL AND ANTHELMINTIC ACTIVITY OF TERMINALIA CHEBULA, MORINGA OLEIFERA AND ALLIUM SATIVUM 诃子、辣木和葱的体外抗菌和驱虫活性
International Journal of Advances in Pharmacy and Biotechnology Pub Date : 2018-12-15 DOI: 10.38111/ijapb.20180402003
T. Kalpana, M. Madhavi, P. Mounika Rani, R. Kavitha, M. Manisha, K. Kalyani
{"title":"IN-VITRO ANTI BACTERIAL AND ANTHELMINTIC ACTIVITY OF TERMINALIA CHEBULA, MORINGA OLEIFERA AND ALLIUM SATIVUM","authors":"T. Kalpana, M. Madhavi, P. Mounika Rani, R. Kavitha, M. Manisha, K. Kalyani","doi":"10.38111/ijapb.20180402003","DOIUrl":"https://doi.org/10.38111/ijapb.20180402003","url":null,"abstract":"Received: 18 August 2018 Revised: 24 August 2018 Accepted: 29 August 2018 The objective of the current research work is to investigate the in-vitro antibacterial and anthelmintic activity.The combined tri-herbal methanolic extract made up of equal quantities of leaves of Moringa oleifera, seeds of Terminalia chebula, and fresh bulbs of Allium sativum was evaluated for its in-vitro antibacterial and anthelmintic activity and was compared with its individual methanolic extracts of Terminalia chebula. The anti-bacterial activity was evaluated against gram neagative and gram positive bacteria. Streptomycin was used as a standard drug. The Anthelmintic activity was evaluated against Pheretima posthuma. Albendazole was used as a standard drug. The experimental results showed that triherbal methanolic plant extracts possess better activity on both microorganisms and earthworms. The combined activity of Moringa oleifera, Terminalia chebula and Allium sativum has been reported for the first time.","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86628491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
EVALUATION OF ANTI DIABETIC ACTIVITY OF ICHNOCARPUS FRUTESCENS L. 鱼爪鱼抗糖尿病活性评价[j]。
International Journal of Advances in Pharmacy and Biotechnology Pub Date : 2018-12-15 DOI: 10.38111/ijapb.20180402001
Mohsina Fp, Faheem Ip, S. Priya, Shaikh Mohammed Azhar Husain
{"title":"EVALUATION OF ANTI DIABETIC ACTIVITY OF ICHNOCARPUS FRUTESCENS L.","authors":"Mohsina Fp, Faheem Ip, S. Priya, Shaikh Mohammed Azhar Husain","doi":"10.38111/ijapb.20180402001","DOIUrl":"https://doi.org/10.38111/ijapb.20180402001","url":null,"abstract":"The plant Ichnocarpus frutescens L. is from the family Apocynaceae, which extensively cultivated in most regions of the world and common avenue tree, commonly called as black creeper in English .The literature survey reveals that Ichnocarpus frutescens L.roots has been used as tonic, diuretic, demulcent, diaphoretic and anti diabetic.Young stems and leaves are also used for diabetes. Young stems and leaves contain triterpenoids, α –amyrin, acetalupeol and its acetates, friedelin, epifriedelinol and β-sitosterol. Flowers and fruits contain flavonoids-Quercetin, Kaepferol-3-glucoside. The Ethanolic and Aqueous extracts of dried flowers of Ichnocarpus frutescens L.were screened for anti-diabetic activity in normal rats, STZ induced diabetic rats and on serum glucose levels in glucose over loaded rats. The effect on the insulin level with treatment by aqueous and ethanolic extract of Ichnocarpus frutescens L. flowers suggest that the mode of action is similar to that of glibenclamide. Oral administration of both the extracts for 21 days significantly reduced blood glucose level in STZ induced diabetic rats. Both the extracts exhibited antihyperglycemic effect in glucose loaded rats and STZ induced rats.","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"39 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87089409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF PARA PHENYLENEDIAMINE IN HAIR DYES 分光光度法测定染发剂中对苯二胺的含量
International Journal of Advances in Pharmacy and Biotechnology Pub Date : 2018-11-16 DOI: 10.38111/ijapb.20180404003
N. R. Babu, Syeda Sana Mahveen, Y. Padmavathi, Ananddas Ramesh Priyadharshini, P. Ravi Kumar, A. Divya, Anil Kumar Tallam
{"title":"SPECTROPHOTOMETRIC METHOD FOR ESTIMATION OF PARA PHENYLENEDIAMINE IN HAIR DYES","authors":"N. R. Babu, Syeda Sana Mahveen, Y. Padmavathi, Ananddas Ramesh Priyadharshini, P. Ravi Kumar, A. Divya, Anil Kumar Tallam","doi":"10.38111/ijapb.20180404003","DOIUrl":"https://doi.org/10.38111/ijapb.20180404003","url":null,"abstract":"A new visible spectrophotometric method was developed for the determination of paraphenylenediamine (PPD) in pure and marketed forms using β‐naphthol as chromogenic reagent. This is based on reaction of PPD with β‐naphthol in acidic media to yield reddish‐pink coloured chromogen exhibiting absorption maximum at 552.4 nm. Beer’s law is obeyed in the concentration range of 200‐1000 ng/mL with coefficient of determination as 0.9976. The limit of detection (LOD) and limit of quantitation (LOQ) were found to be 64.2 ng/mL and 194.8 ng/mL respectively. The developed method has been validated as per the ICH Q2 (R1) guidelines. The results demonstrate that the method is linear, precise and accurate. The proposed method was successfully applied for determination of PPD in different brands of hair dyes with good recovery and reproducibility.","PeriodicalId":13904,"journal":{"name":"International Journal of Advances in Pharmacy and Biotechnology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88823453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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