International journal of basic and clinical pharmacology最新文献

Assessment of KaraShieldTM properties in supporting the immune health of healthy subjects: a randomized, parallel, double-blind, placebo-controlled clinical study 评估KaraShieldTM支持健康受试者免疫健康的特性:一项随机、平行、双盲、安慰剂对照的临床研究

International journal of basic and clinical pharmacology Pub Date : 2023-11-08 DOI: 10.18203/2319-2003.ijbcp20233521

Frank Lichtenberger, Krishna Rajendran, Keri Layton, Sucharitha Lakshminarayan, Latha Krishnamurthy, Dheeraj K. Deep

{"title":"Assessment of KaraShieldTM properties in supporting the immune health of healthy subjects: a randomized, parallel, double-blind, placebo-controlled clinical study","authors":"Frank Lichtenberger, Krishna Rajendran, Keri Layton, Sucharitha Lakshminarayan, Latha Krishnamurthy, Dheeraj K. Deep","doi":"10.18203/2319-2003.ijbcp20233521","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20233521","url":null,"abstract":"Background: This study aims to investigate whether a novel herbal extract blend, KaraShieldTM could be used to help build a healthy immune system that could reduce the number of incidences or severity of common upper respiratory tract infections (URTIs). Methods: A randomized, parallel, double-blind, placebo-controlled clinical study of 60 days was done on 120 healthy subjects allocated to a treatment arm (500 mg/day, KaraShieldTM) or placebo arm (500 mg/day). Results: A 500 mg daily dosage of KaraShieldTM significantly improved the subjects' immune health as measured by parameters such as the frequency and severity of upper respiratory tract conditions, the serum IgG level, mean ISQ raw score, WURSS scale score, CRP level in the serum and WHOQOL-BREF score at the end of the study period of sixty days from the baseline compared to that of the placebo. The investigated product was found to be safe and well tolerated by the subjects. Conclusions: KaraShieldTM may represent a promising safe and effective formulation for building a healthy immune system that could then counteract URTIs.","PeriodicalId":13898,"journal":{"name":"International journal of basic and clinical pharmacology","volume":"16 19","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135391840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prescription pattern of antibiotics in various clinical departments of a tertiary care health institution: a retrospective observational study 某三级医疗机构临床各科室抗生素处方模式的回顾性观察研究

International journal of basic and clinical pharmacology Pub Date : 2023-10-25 DOI: 10.18203/2319-2003.ijbcp20233196

None Ramesh, Meenakshi Vadhwa, None Ridhima

{"title":"Prescription pattern of antibiotics in various clinical departments of a tertiary care health institution: a retrospective observational study","authors":"None Ramesh, Meenakshi Vadhwa, None Ridhima","doi":"10.18203/2319-2003.ijbcp20233196","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20233196","url":null,"abstract":"Background: Antimicrobial resistance has been considered as one of the greatest challenges to the general public health today. The Antibiotic Stewardship Program has emphasized on prevention of drug resistant bacterial infection, targeted therapy against susceptible or resistant microorganism and to curtail unnecessary and irrational use of antibiotics. Present study aimed to evaluate the pattern of antibiotic prescription amongst the hospitalized patients of IGMC Shimla in Himachal Pradesh. Methods: It was a retrospective observational study. Data was collected from hospital records of admitted patients in medicine and Surgical wards. Patient data like demographic profile, average hospital stay and number of antibiotics prescribed were extracted from their hospital records. Also, the data about oral/parenteral, generic/branded empirical/definitive and therapeutic/prophylaxis prescription in each patient were collected. Results: In medicine ward, the number of generic prescriptions 78 (71.5%) were more as compared to branded 31 (28.5%) and majority were given the parenteral 61 (55.9%) than the oral 48 (44.1%) dosage form. In surgery ward, the branded prescriptions 61 (91%) out-numbered the generic prescription 6 (9%). The route of administration was mostly oral; 56 (83.5%), while only few had parenteral prescription; 11 (16.5%) in this ward. Conclusions: It was found that majority of patients in medicine ward received generic named antibiotics for definitive management, while in surgical ward branded named antibiotics were prescribed for surgical prophylaxis. The cephalosporin was the most commonly prescribed antibiotic group. Majority of antibiotics belonged to “watch” category as far as WHO’s AWaRe classification is concerned.","PeriodicalId":13898,"journal":{"name":"International journal of basic and clinical pharmacology","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135111311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amaranthus viridis improves relative anxiety behaviour and cognitive deficit in rotenone induced Parkinsonism in albino rats 紫苋菜改善鱼藤酮诱导的白化大鼠帕金森病的相对焦虑行为和认知缺陷

International journal of basic and clinical pharmacology Pub Date : 2023-10-25 DOI: 10.18203/2319-2003.ijbcp20233187

Eugene O. Ohanme, Uzochukwu Ofonakara, Casimir C. Ofor, Benjamin N. Nwakelu, Mansur A. Ramalan, Clementina N. Eze, Amauchechukwu V. Nwafor, Donatus O. Anele, Godwin C. Akuodor

{"title":"Amaranthus viridis improves relative anxiety behaviour and cognitive deficit in rotenone induced Parkinsonism in albino rats","authors":"Eugene O. Ohanme, Uzochukwu Ofonakara, Casimir C. Ofor, Benjamin N. Nwakelu, Mansur A. Ramalan, Clementina N. Eze, Amauchechukwu V. Nwafor, Donatus O. Anele, Godwin C. Akuodor","doi":"10.18203/2319-2003.ijbcp20233187","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20233187","url":null,"abstract":"Background: Parkinson’s disease (PD) is typically characterised by motor shortfalls. However, non-motor symptoms like mood disorders (anxiety, depression) and impaired cognition are also associated features. Previous studies have demonstrated a neuroprotective effect a plant against a disease. Consequently, this current study was focused on assessing its efficacy in extenuating non-motor shortfalls such as anxiety-like behaviour and impaired cognition induced by rotenone. Methods: PD was induced in rats by administering rotenone (10 mg/kg BW orally) for 28 days. The vehicle and the test drug were given orally daily for one hour prior to rotenone administration. The protective effect of methanol extract of A. viridis (500 mg/kg BW) was assessed through an array of tests; elevated plus maze test, Morris water maze test, and novel object recognition test. The rats were sacrificed on day 28th and neurobiochemical analyses of the hippocampus were performed using HPLC. Results: The findings of this study showed that co-administration of A. viridis reversed the rotenone-induced anxiety-like behaviour and cognitive shortfalls to a significant extent (p<0.001). It also restored the hippocampal neurotransmitters [(5-hydroxytryptamine (5-HT), 5-hydroxy indole acetic acid (5-HIAA), and dopamine (Da)] significantly (p<0.001). Conclusions: Amaranthus viridis offered neuroprotective effects that ameliorate non-motor symptoms in PD. This could be a novel insight into the therapy of PD. This study provides scientific evidence that A. viridis attenuates non-motor symptoms like anxiety-like behaviour and cognitive deficits in Parkinsonism. This extract can be a potential candidate in herbal formulations as a neuroprotectant against PD.","PeriodicalId":13898,"journal":{"name":"International journal of basic and clinical pharmacology","volume":"434 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134974290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of β-blockers dosage regimen rationality in heart failure patients 心力衰竭患者β受体阻滞剂给药方案合理性评价

International journal of basic and clinical pharmacology Pub Date : 2023-10-25 DOI: 10.18203/2319-2003.ijbcp20233197

Anna Sira Coulibaly, Shibi Mary Thomas, Prashant Kumar Sah, Balakeshwa Ramaiah, Prestley F. Chia-Sani, Salimata Kone

{"title":"Evaluation of β-blockers dosage regimen rationality in heart failure patients","authors":"Anna Sira Coulibaly, Shibi Mary Thomas, Prashant Kumar Sah, Balakeshwa Ramaiah, Prestley F. Chia-Sani, Salimata Kone","doi":"10.18203/2319-2003.ijbcp20233197","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20233197","url":null,"abstract":"Background: β-Blockers are often associated with further cardiac function deterioration, ledding to them being often underused/underdosed by certain physicians in heart failure treatment, although they were seen to be beneficial in decreasing the rates of mortality and morbidity, duration of hospitalization in HFrEF patients, but data on their benefits in HFmEF and HFpEF patients is limited. Objective was to evaluate rationality of β-blockers’ dosage regimen and its effectiveness in HF patients. Methods: 43 HF patients have been enrolled. Data were collected from the medication chart (dose, route, frequency); dosage regimen was evaluated and compared to that of ESC guidelines for HF treatment. Heart rates pre/post drug treatments, ejection fraction (at admission & post-discharge) were recorded; effectiveness was evaluated through heart rate control, reduction in: duration of hospitalization, rehospitalization and mortality rate. Post-discharge updates of the patients were obtained through out-patient consultation reports. Results: In All 43 patients dosage regimen of selected β-Blockers was found to be rational and following the ESC guideline for HF treatment. 65% of patients spent not more than 5 days in the hospital, 16% Re-hospitalized for cardiovascular diseases, and death rate was 4%. Conclusions: The dosage regimen of selected β-Blockers was found to be as per that of ESC-guidelines HF treatment. β-Blockers have also been found to have reduced: hospitalization stay, frequency of rehospitalization, and death rate among patients under study.","PeriodicalId":13898,"journal":{"name":"International journal of basic and clinical pharmacology","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of coronavirus disease pandemic on antimicrobials consumption and antimicrobial resistance during the first and second wave in a tertiary care hospital, in India 冠状病毒病大流行对印度三级保健医院第一和第二波抗菌素消费和耐药性的影响

International journal of basic and clinical pharmacology Pub Date : 2023-10-25 DOI: 10.18203/2319-2003.ijbcp20233194

Ankit Bhardwaj, Mala Mangesh, Avyukt Bhardwaj

{"title":"Impact of coronavirus disease pandemic on antimicrobials consumption and antimicrobial resistance during the first and second wave in a tertiary care hospital, in India","authors":"Ankit Bhardwaj, Mala Mangesh, Avyukt Bhardwaj","doi":"10.18203/2319-2003.ijbcp20233194","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20233194","url":null,"abstract":"Background: This study measured the impact of the first and second wave of COVID-19 pandemic (in the year 2020-21) on the antibiotics uses and their effect on gram nehative bacterial species Klebsiella, Enterobacter, Pseudomonas and Acinetobacter. Methods: The number of patient admission month-wise, antibiotic consumption, blood cultures collected, number of positive BCs, and antibiotic resistance were analysed retrospectively for the years 2020, 2021, and 2019 for comparison, in tertiary care hospital (ca. 840 beds). Results: Half of patients admitted in years 2020 and 2021 in our hospital had COVID-19. A significant increase in total antibiotic consumption during the years 2020 (75.53 DDD per 100 admissions) and 2021 (91.71 DDD per 100 admissions) occurred in comparison to the year 2019 (52.5 DDD per 100 admissions). The rate ratio of BCs per 100 admissions increased by 74% in the year 2020, and 118% in the year 2021 in comparison with the rate ratio to the year 2019. The BSI rate per 100 admissions increased overall by 24% in March 2020 and 115% in April 2020, the rate ratio of BSIs per 100 admissions raised 58.4% for Klebsiella and 239.3% for E. coli, but remain the same for Acinetobacter and Aeruginosa. A sharp increase in the rate of BSIs caused by microorganisms resistant to cephalosporins was also observed in the years 2020 and 2021. Conclusions: present study highlights the impact of the first and second waves of the COVID-19 pandemic on antibiotic consumption and the increasing prevalence hospital-acquired infections and antimicrobial resistance.","PeriodicalId":13898,"journal":{"name":"International journal of basic and clinical pharmacology","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A case study of an adverse drug reaction caused by long term use of proton pump inhibitors 长期使用质子泵抑制剂引起的药物不良反应的案例研究

International journal of basic and clinical pharmacology Pub Date : 2023-10-25 DOI: 10.18203/2319-2003.ijbcp20233200

Swetha Sathish Kumar, Sivani Ravindran, Merin Levy Philips, Syaam Ganesh B.

{"title":"A case study of an adverse drug reaction caused by long term use of proton pump inhibitors","authors":"Swetha Sathish Kumar, Sivani Ravindran, Merin Levy Philips, Syaam Ganesh B.","doi":"10.18203/2319-2003.ijbcp20233200","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20233200","url":null,"abstract":"Proton pump inhibitors (PPI) are the class of drugs used to treat a wide variety of disorders related to the stomach's acid production. Although it is considered safe for short term use, reports revealed that many serious life-threatening adverse reactions occurred from long term use. Here we report a case of hypomagnesemia and hypocalcemia induced by long-term use of PPIs in a patient with crest syndrome. From his past history, it was revealed that he was on pantoprazole 40 mg for more than 3 months. While he was admitted here for other complaints, we were able to discover that he had hypomagnesemia defined by low magnesium level of 1.3 mg/dL. As a consequence, he also showed signs of hypocalcemia with a low calcium level of 7 mg/dL. A peculiar complaint seen in this patient was three episodes of supraventricular tachycardia which is the most common cardiac manifestations of hypomagnesemia. As a conclusion, hypomagnesemia can sometimes be asymptomatic and cause unspecific and serious manifestations such as asthenia, paresthesia’s, seizures, arrhythmias, and cardiac arrest. Hence routine monitoring of serum magnesium and calcium levels should be made mandatory in practice for patients on long term use of PPI. Besides, it should be kept in mind that interchanging PPI class with histamine 2 receptor antagonist or fitful use of PPI may not cause hypomagnesemia.","PeriodicalId":13898,"journal":{"name":"International journal of basic and clinical pharmacology","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Case series of macroalbuminuria and toe-brachial index in type 2 diabetes mellitus 2型糖尿病患者巨量蛋白尿与手足指数的病例分析

International journal of basic and clinical pharmacology Pub Date : 2023-10-25 DOI: 10.18203/2319-2003.ijbcp20233199

Joshua Kuruvilla Mathew, Mohan Varughese, Felix Manoharan, Vipitha Thomas

引用次数: 0

Probable fluoxetine-induced hepatomegaly: a case report 氟西汀所致肝肿大1例

International journal of basic and clinical pharmacology Pub Date : 2023-10-25 DOI: 10.18203/2319-2003.ijbcp20233201

Jarnail S. Braich, Amiya Sharma, Harsh Vasistha

引用次数: 0

Maximizing learning efficiency: exploring the impact of ChatGPT in pharmacology assessment for undergraduates 学习效率最大化:探讨ChatGPT在大学生药理学评估中的影响

International journal of basic and clinical pharmacology Pub Date : 2023-10-25 DOI: 10.18203/2319-2003.ijbcp20233203

Sabahat Hasan

引用次数: 0

Comparison of efficacy of azilsartan with olmesartan in patients of hypertension: randomized controlled trial 阿齐沙坦与奥美沙坦治疗高血压的疗效比较:随机对照试验

International journal of basic and clinical pharmacology Pub Date : 2023-10-25 DOI: 10.18203/2319-2003.ijbcp20233190

Deeksha Sharma, Atal Sood, Dinesh Kansal, Dhiraj Kapoor, Akshay Sharma

{"title":"Comparison of efficacy of azilsartan with olmesartan in patients of hypertension: randomized controlled trial","authors":"Deeksha Sharma, Atal Sood, Dinesh Kansal, Dhiraj Kapoor, Akshay Sharma","doi":"10.18203/2319-2003.ijbcp20233190","DOIUrl":"https://doi.org/10.18203/2319-2003.ijbcp20233190","url":null,"abstract":"Background: Azilsartan and olmesartan are members of ARBs, used in the management of hypertension. Objective was to evaluate efficacy of azilsartan with olmesartan in patients of hypertension. Methods: A randomized, prospective, open label, comparative study was carried out in Pharmacology and Medicine department at Dr. RPGMC Kangra at Tanda, HP. The study stretched over one year and blood pressure was monitored at first, third and sixth month. Out of 69 patients, 35 patients in group A were prescribed tablet azilsartan 40 mg/day and 34 patients in group B patients were prescribed tablet olmesartan 20 mg/day. Tablet chlorthalidone 12.5 mg/day was add on in both the groups. Data was presented as mean+SD. Student’s t test was used and p value <0.05 was considered significant. Results: In group A, systolic blood pressure (SBP) values improved from baseline of 153±10 mmHg to 111±18 mmHg (p<0.001) at 3 months and 109±6.1 mmHg (p<0.001) at 6 months and diastolic blood pressure (DBP) values from baseline of 87±7 mmHg to 67.1±4.6 mmHg (p<0.001) at 3 months and 67.6±2.5 mmHg (p < 0.001) at 6 months. In group B, SBP values improved from baseline of 154±8.5 mmHg to 127±3.6 mmHg (p<0.001) at 3 months and 123±4 mmHg (p<0.001) at 6 months and DBP values from baseline of 85±6.5mm Hg to 75.7±3.3 mmHg (p<0.001) at 3 months and 73±3.3 mmHg (p<0.001) at 6 months. On intergroup comparison improvement in hypertension was better in azilsartan group (p<0.001). Conclusions: The study concluded that azilsartan is significantly better than olmesartan in controlling the hypertension.","PeriodicalId":13898,"journal":{"name":"International journal of basic and clinical pharmacology","volume":"9 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134973512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0