International Journal of Cancer Science and Therapy最新文献

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Prostate Cancer-Induced Changes in Urinary Odors at Biomarker Concentrations of PPQ with Validation by Sniffer Mouse Behavioural Assays 前列腺癌引起的尿液气味在PPQ生物标志物浓度下的变化与嗅探小鼠行为测定的验证

International Journal of Cancer Science and Therapy Pub Date : 2021-07-28 DOI: 10.31487/j.ijcst.2021.01.02

Takaaki Sato, M. Nonomura, K. Yoneda, Sho Mizutani, Y. Mizutani

{"title":"Prostate Cancer-Induced Changes in Urinary Odors at Biomarker Concentrations of PPQ with Validation by Sniffer Mouse Behavioural Assays","authors":"Takaaki Sato, M. Nonomura, K. Yoneda, Sho Mizutani, Y. Mizutani","doi":"10.31487/j.ijcst.2021.01.02","DOIUrl":"https://doi.org/10.31487/j.ijcst.2021.01.02","url":null,"abstract":"Although prostate-specific antigen (PSA) is a significant tumor marker for prostate cancer at present, the \u0000low specificity (approximately 33%) and so on likely lead to an overdiagnosis and patient suffering from \u0000highly invasive prostate biopsy. Complementary measures with cancer-characteristic biomarkers could \u0000improve the specificity and accuracy of diagnosis before the biopsy. Previously, “sniffer mice” were shown \u0000to be super-sensitive to differences in odors and to discriminate between odors of urine mixtures from \u0000patients with bladder cancer before and after tumor resection as well as urine odors of mice with or without \u0000experimental tumors. Here, we showed that the sniffer mice discriminate efficiently urinary odors of patients \u0000with prostate cancer using an odor plume-guided Y-maze behavioural assay. Through discrimination \u0000training in forced-odor choice, statistically significant increases in correct odor choice rates showed the \u0000super-sensitivity of sniffer mice to the olfactory cue of ppq-level urinary biomarkers for prostate cancer in \u0000106\u0000-fold diluted urine samples, where donor-unique odors were below the threshold. Moreover, we validated \u0000eight volatile urinary biomarkers nearly at their original relative concentrations as the prostate cancer cue \u0000even when adding a similar biomarker profile to the post-radical prostatectomy urine samples by the same \u0000behavioural score of the sniffer mice. These biomarkers and profiles could be useful for non-invasive tests \u0000for prostate and bladder cancers.","PeriodicalId":13867,"journal":{"name":"International Journal of Cancer Science and Therapy","volume":"65 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86779222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Robotic Sentinel Lymph Node Procedure After Endoscopic Submucosal Dissection of High Risk Early Gastric Cancer: A Case Report 内镜下粘膜下清扫术后机器人前哨淋巴结手术治疗高危早期胃癌一例报告

International Journal of Cancer Science and Therapy Pub Date : 2020-07-15 DOI: 10.31487/j.ijcst.2020.01.02

A. Borgstein, W. Eshuis, S. Gisbertz, M. V. B. Henegouwen

引用次数: 0

Identification of BAP1-associated MicroRNAs and Implications in Cancer Development bap1相关microrna的鉴定及其在癌症发展中的意义

International Journal of Cancer Science and Therapy Pub Date : 2019-11-09 DOI: 10.31487/j.ijcst.2019.01.01

Tikam Chand

引用次数: 2

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