Sarah M Obeidat, Mohammad S Nazzal, Ziad Audat, Noor Ismael, Mohammad Mansi, Mohannad Hawamdeh, Saddam F Kanaan
{"title":"Mental and physical quality of life among patients with scoliosis in Jordan: a cross-sectional study.","authors":"Sarah M Obeidat, Mohammad S Nazzal, Ziad Audat, Noor Ismael, Mohammad Mansi, Mohannad Hawamdeh, Saddam F Kanaan","doi":"10.1515/ijamh-2025-0091","DOIUrl":"10.1515/ijamh-2025-0091","url":null,"abstract":"<p><strong>Objectives: </strong>Individuals with scoliosis may experience physical symptoms such as pain, fatigue, and difficulty breathing. They may also experience psychological symptoms, such as anxiety, depression, and low self-esteem. Consequently, this leads to a decrease in their quality of life (QOL). This study aimed to assess the mental and physical QOL levels of individuals with scoliosis in Jordan and their associated factors.</p><p><strong>Methods: </strong>A cross-sectional study with a representative sample of 109 individuals with scoliosis. Participants completed a self-administered questionnaire including the World Health Organization Disability Assessment Schedule (WHODASS II), the Short Form (SF-12) Health Survey, the Nordic Musculoskeletal Questionnaire (NMQ), the Spinal Appearance Questionnaire, and the Depression, Anxiety and Stress Scale (DASS-21).</p><p><strong>Results: </strong>Participation in low physical activity levels (β=-1.315, p=0.049), high WHODASS II overall score (β=-0.060, p<0.001), presence of ankle and foot pain (β=-1.905, p=0.002), and high DASS21-Depression score (β=-0.094, p=0.002) were associated with lower levels of the physical component of QOL. While high DASS21-Depression (β=-0.150, p=0.003) and DASS21-Stress score (β=-0.189, p=0.005), low DASS21-Anxiety score (β=0.122, p=0.001), presence of neck pain (β=-1.479, p=0.011), presence of hip pain (β=-1.378, p=0.022), and high WHODASS II overall score (β=-0.046, p=0.003) were significantly associated with the lower levels of the mental component of QOL.</p><p><strong>Conclusions: </strong>The findings suggest that assessing quality of life (QOL) in individuals with scoliosis and screening its predictors can provide practical strategies to improve QOL. These strategies may include increasing physical activity, psychological counseling, and pain management.</p>","PeriodicalId":13823,"journal":{"name":"International Journal of Adolescent Medicine and Health","volume":" ","pages":"203-212"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147369351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"An exploration of psychosocial aspects of the school-home food environment in addressing double and triple burden of malnutrition among adolescent girls.","authors":"Sitti Patimah, Halida Thamrin, Yade Kurnia Yasin, Nurhayati, Asmuni, Andi Imam Arundhana, Muhammmad Rachmat","doi":"10.1515/ijamh-2025-0243","DOIUrl":"10.1515/ijamh-2025-0243","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to explore the psychosocial aspects [attitudes, awareness, motivation, and self-efficacy] of key actors in the adolescent food environment, including parents, school food vendors, and teachers.</p><p><strong>Methods: </strong>A qualitative descriptive study was conducted using focus group discussions [FGDs], semi-structured interviews, and document reviews with 28 participants from four secondary schools in Majene District, West Sulawesi. Participants included guidance counsellors, school health program coordinators, school principals, food vendors, and parents of adolescent girls. Teachers, food vendors, and parents were selected through school principals' recommendations. Data were analyzed using thematic and narrative analysis.</p><p><strong>Results: </strong>The findings indicate that collaborative attitudes, contextual awareness, multidimensional motivation [emotional and policy-related], and high self-efficacy among various actors play a significant role in addressing adolescent malnutrition.</p><p><strong>Conclusions: </strong>This study concludes that psychosocial aspects [attitudes, awareness, motivation, and self-efficacy] are crucial in shaping supportive school and home food environment to address the dual-triple burden of malnutrition among adolescent girls. It recommends cross-sector collaboration among schools, families, food vendors, and government, strengthening nutrition education, healthy canteen regulations, and community empowerment through psychosocial approaches to supports adolescent health in a sustainable manner.</p>","PeriodicalId":13823,"journal":{"name":"International Journal of Adolescent Medicine and Health","volume":" ","pages":"261-273"},"PeriodicalIF":0.0,"publicationDate":"2026-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147369227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gabriella Lavarda do Nascimento, Aline Silveira Cardoso, Gabriely Vitória Claudino, Giovanna da Silva Rangel, Matias Noll, Aline Faquin, Anelise Sonza
{"title":"Excessive screen time on posture, musculoskeletal pain, and quality of life in generation Z adolescents: a cross-sectional study with comparison between the sexes.","authors":"Gabriella Lavarda do Nascimento, Aline Silveira Cardoso, Gabriely Vitória Claudino, Giovanna da Silva Rangel, Matias Noll, Aline Faquin, Anelise Sonza","doi":"10.1515/ijamh-2025-0210","DOIUrl":"10.1515/ijamh-2025-0210","url":null,"abstract":"<p><strong>Objectives: </strong>Excessive use of electronic devices can cause postural changes, pain, and negatively impact generation Z adolescents' quality of life (QoL). The goals of this study were to evaluate and compare between sexes the static posture, postural self-perception, screen time, musculoskeletal pain, and QoL in generation Z adolescents.</p><p><strong>Methods: </strong>Cross-sectional study with adolescents. Postural analysis was conducted using the Software SAPo, self-reported posture, back pain, and screen time were assessed with the BackPei-CA, and QoL was evaluated using the Kidscreen-27 questionnaire. Statistical analyses included t-test or Mann-Whitney U test, Spearman's correlation, and adjusted logistic regression, with correction for multiple comparisons (p≤0.05).</p><p><strong>Results: </strong>408 adolescents were included (204 of each sex), with a mean age of 14.58 ± 1.98 years (males) and 14.56 ± 1.84 years (females). Postural assessment revealed head anteriorization and pelvic misalignment, with females showing greater head and pelvic angular deviations. No significant associations were found between cell phone use and cervical or pelvic alignment. Cell phones/tablets were the most frequently used devices, with higher daily use among females. Musculoskeletal pain was highly prevalent, particularly in the cervical and lumbar regions, and more frequent in females; however, cell phone use was not independently associated with musculoskeletal pain after adjustment. The total sample of adolescents has a good QoL.</p><p><strong>Conclusions: </strong>Adolescents, especially females, showed head anteriorization and pelvic misalignments, high screen time, and self-perceived inadequate postural habits. Musculoskeletal pain was frequent and more prevalent among females, despite good quality of life. Screen time alone was not associated with postural changes or pain, indicating a multifactorial etiology.</p>","PeriodicalId":13823,"journal":{"name":"International Journal of Adolescent Medicine and Health","volume":" ","pages":"213-224"},"PeriodicalIF":0.0,"publicationDate":"2026-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147326059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Raising environmental awareness: evaluating microplastic education interventions in Jakarta's high schools.","authors":"Ajeng Tias Endarti, Inggit Meliana Anggarini, Loveria Sekarrini","doi":"10.1515/ijamh-2025-0231","DOIUrl":"10.1515/ijamh-2025-0231","url":null,"abstract":"<p><strong>Objectives: </strong>Microplastics have emerged as a growing environmental and public health concern, found in air, water, and food, with potential health impacts including respiratory, digestive, and endocrine disruption. Therefore, the preventive effort needs to be amplified. This study aimed to evaluate the effectiveness of three different microplastic education interventions, lecture-based education, peer group education, and infographic distribution, among high school students in DKI Jakarta.</p><p><strong>Methods: </strong>A quasi-experimental design was employed involving 334 students from six schools, with pre- and post-intervention assessments of knowledge and attitudes. Data were analyzed using the Wilcoxon Signed-Rank Test and Kruskal-Wallis Test, followed by Dunn's post hoc test.</p><p><strong>Results: </strong>Findings revealed that peer group and infographic interventions significantly improved knowledge scores, with the peer group showing the most substantial gains. However, lecture-based education did not yield significant improvement in knowledge. Attitude changes across all interventions were not statistically significant, although numerical improvements were observed, especially in the peer group. The Kruskal-Wallis test indicated significant differences in knowledge improvement across groups (p=0.0041), and Dunn's test confirmed a statistically significant difference between peer group and lecture-based education.</p><p><strong>Conclusions: </strong>The results suggest that interactive and peer-driven educational approaches may be more effective in enhancing students' understanding of microplastic pollution compared to traditional lectures. However, attitude change may require more prolonged or multifaceted interventions that integrate psychosocial and behavioral elements. Given the formative nature of adolescence and their potential as agents of environmental change, incorporating targeted and participatory education into school curricula is essential. These findings underscore the importance of using context-specific, engaging methods for environmental health education, contributing to the achievement of Sustainable Development Goals (SDGs), particularly SDG 12 and SDG 13.</p>","PeriodicalId":13823,"journal":{"name":"International Journal of Adolescent Medicine and Health","volume":" ","pages":"245-252"},"PeriodicalIF":0.0,"publicationDate":"2026-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Banu Turhan, Gönül Büyükyılmaz, Demet Taş, Mehmet Ali Sungur, Mehmet Boyraz
{"title":"The association of sleep duration, wake-up time, and lifestyle habits with obesity in adolescents.","authors":"Banu Turhan, Gönül Büyükyılmaz, Demet Taş, Mehmet Ali Sungur, Mehmet Boyraz","doi":"10.1515/ijamh-2025-0236","DOIUrl":"10.1515/ijamh-2025-0236","url":null,"abstract":"<p><strong>Objectives: </strong>Obesity is linked to excessive caloric intake, sleep behaviors, and the environment. Few studies explore the connection between wake-up time and obesity. This research aims to examine sleep patterns, timing, lifestyle, and sociodemographic factors associated with obesity among adolescents aged 15-17.</p><p><strong>Methods: </strong>This cross-sectional study at Ankara Bilkent City Hospital's Pediatric Endocrinology Outpatient Clinic from December 2023 to November 2024 included 453 adolescents (217 normal weight, 236 obese) without comorbidities. Data on demographics, sleep patterns, physical activity, sedentary behavior, and diet were collected via face-to-face questionnaires. Obese participants were classified into Class 1 and Class 2-3 based on body mass index.</p><p><strong>Results: </strong>Obese participants woke up significantly later on weekdays (p=0.001). While normal-weight adolescents often woke between 7:00 and 8:00 AM, more obese adolescents woke after 9:00 AM. They also slept for more than 9 h more often (p=0.002). Obese adolescents spent more than 3 h in sedentary activity (p=0.022). Those with Class 2-3 obesity who did not exercise and had prolonged sedentary time were more common. Bedtimes did not differ significantly.</p><p><strong>Conclusions: </strong>A delayed morning wake-up time was significantly associated with obesity among adolescents. Sleep timing appears to be as relevant to metabolic health as sleep duration. Reduced physical activity coupled with increased sedentary behavior is associated with obesity. Therefore, advocating for improved sleep hygiene, fostering consistent physical activity routines, and implementing behavioral awareness training in adolescents should be regarded as essential elements of obesity prevention initiatives.</p>","PeriodicalId":13823,"journal":{"name":"International Journal of Adolescent Medicine and Health","volume":" ","pages":"193-201"},"PeriodicalIF":0.0,"publicationDate":"2026-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146213060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Enoch Kordjo Azasu, Ali Lateef, Graham Zulu, Elizabeth Ali, Yaa Adutwumwaa Obeng, Abass Tando Abubakar, Sefakor Kpeklu, Gloria Aidoo-Frimpong
{"title":"\"It's a sin against God\": understanding how Ghanaian adolescents frame suicide as sin, taboo, and crime.","authors":"Enoch Kordjo Azasu, Ali Lateef, Graham Zulu, Elizabeth Ali, Yaa Adutwumwaa Obeng, Abass Tando Abubakar, Sefakor Kpeklu, Gloria Aidoo-Frimpong","doi":"10.1515/ijamh-2025-0202","DOIUrl":"10.1515/ijamh-2025-0202","url":null,"abstract":"<p><strong>Objectives: </strong>Suicide remains a significant public health concern among adolescents in Ghana, yet limited research exists on how young people conceptualize suicide within their cultural context. This study aimed to examine how Ghanian high school students conceptualize suicide in relation to religious, cultural, and legal frameworks that shape their understanding.</p><p><strong>Methods: </strong>This descriptive qualitative study was conducted as part of the 2024 Ghana Youth Mental Health Survey. Twenty junior high school students were purposively selected from rural, peri-urban, and urban schools across four major regions to ensure diverse representation. In-depth, semi-structured cognitive interviews were conducted in English. Data was analyzed using Braun and Clarke's approach, with multiple coders contributing to thematic development and refinement.</p><p><strong>Results: </strong>Participants described suicide through four overlapping constructs: as a sin, taboo, mental health issue, and crime. Religious framings emphasized divine ownership of life, biblical teachings, and spiritual consequences. Cultural perspectives focused on shame, communal identity, and ancestral values. Others associated suicide with criminality and police involvement. Across interviews, students expressed coexisting views, drawing from diverse belief systems to explain suicide occurrence and treatment.</p><p><strong>Conclusions: </strong>Ghanaian adolescents do not conceptualize suicide in singular terms. Their understandings are shaped by the interplay of religious, cultural, psychological, and institutional narratives. Suicide prevention must be grounded in these lived meanings and avoid one-size-fits-all approach. Preventive strategies should engage religious leaders, affirm community values, reduce mental health stigma, and provide safe spaces for adolescents to alleviate distress. Addressing the nuanced logics adolescents draw upon is essential to designing interventions that resonate with their realities.</p>","PeriodicalId":13823,"journal":{"name":"International Journal of Adolescent Medicine and Health","volume":" ","pages":"235-243"},"PeriodicalIF":0.0,"publicationDate":"2026-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146207014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"First appointment with a gynecologist in Poland.","authors":"Zuzanna Walewska, Barbara Suchońska","doi":"10.1515/ijamh-2025-0182","DOIUrl":"10.1515/ijamh-2025-0182","url":null,"abstract":"<p><strong>Objectives: </strong>According to media reports, young women in Poland are not fully aware of the importance of regular gynecological examinations. The Expert Group of the Polish Society of Gynecologists and Obstetricians recommends that girls have their first visit between the ages of 12 and 15. These recommendations differ from the prevailing norms in Polish population. The purpose of this study was to determine the age of female patients and analyze their perceptions about their first visit.</p><p><strong>Methods: </strong>An online survey was conducted among 970 women between the ages of 16 and 30 in February 2024.</p><p><strong>Results: </strong>The number of 144 respondents (15 %) had never visited a gynecologist. The age range in this group was 16-27. The most common reason reported was fear and shame (72 %). In the second group of patients who had already had their first consultation, the average age at the first visit was 18. When asked about their choice of specialist, 42 % said their decision was influenced by their mother's experience, and additional 55 % preferred a female doctor. The main reason for the first visit was a health check (32 %). Most female respondents (47 %) had a positive experience.</p><p><strong>Conclusions: </strong>The results confirmed that young women attend their first gynecological consultation later than recommended.</p>","PeriodicalId":13823,"journal":{"name":"International Journal of Adolescent Medicine and Health","volume":" ","pages":"25-30"},"PeriodicalIF":0.0,"publicationDate":"2026-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146097097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Gauri A Oka, Kalyani Deshmukh, Pritam Halder, Divya Ilanchoorian, Aravind P Gandhi
{"title":"Corrigendum to: A systematic review and meta-analysis to determine the effect of pranayama in reducing anxiety and stress in adolescents.","authors":"Gauri A Oka, Kalyani Deshmukh, Pritam Halder, Divya Ilanchoorian, Aravind P Gandhi","doi":"10.1515/ijamh-2025-0221","DOIUrl":"10.1515/ijamh-2025-0221","url":null,"abstract":"","PeriodicalId":13823,"journal":{"name":"International Journal of Adolescent Medicine and Health","volume":" ","pages":"159"},"PeriodicalIF":0.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145911379","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Association of nutrition education and exercise with cardiometabolic health risk factors among overweight and obese adolescents: an odds ratio analysis.","authors":"Jeanne Martin Grace, Jaron Ras","doi":"10.1515/ijamh-2025-0194","DOIUrl":"10.1515/ijamh-2025-0194","url":null,"abstract":"<p><strong>Objective: </strong>To explore the association of nutrition education and exercise with cardiometabolic health risk factors among overweight and obese adolescents.</p><p><strong>Methods: </strong>This quasi-experimental study utilised a pretest-posttest design to evaluate changes in body mass index (BMI), blood pressure, and fasting biochemical markers [(glucose, insulin, high-density lipoprotein cholesterol (HDL-C); low-density lipoprotein cholesterol (LDL-C); triglycerides, glycated haemoglobin (HbA1c); homeostatic model assessment of insulin resistance (HOMA-IR)] among 41 participants. The intervention combined supervised aerobic and resistance exercise sessions thrice weekly with a weekly nutrition education session over 10 weeks. The Statistical Package for the Social Sciences was used for data analysis, with p<0.05 indicating statistical significance.</p><p><strong>Results: </strong>Post-intervention, males had lower triglyceride (p=0.045) and LDL-C concentrations (p=0.043). In female adolescents, the intervention reduced diastolic blood pressure (p=0.045), LDL-C (p=0.012), insulin (p<0.001), and HOMA-IR concentrations (p=0.001). The intervention was a significant predictor of reduced LDL-C (p=0.003), HOMA-IR (p=0.010), blood glucose concentrations (p=0.020), and HbA1c levels (p=0.011).</p><p><strong>Conclusions: </strong>The improvements in CMD risk factors suggest potential long-term benefits supporting the usefulness of such an intervention. However, divergent sex-specific responses to the intervention underscore the importance of developing sex-specific intervention programs.</p>","PeriodicalId":13823,"journal":{"name":"International Journal of Adolescent Medicine and Health","volume":" ","pages":"173-182"},"PeriodicalIF":0.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145900367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elanur Yolal Karimov, Elnur Karimov, Kazım Okan Dolu, Mustafa Özçetin, Ayşe Kılıç
{"title":"Early effects of cigarette smoke on adolescent endothelial functions: a novel endocan/cotinine ratio approach.","authors":"Elanur Yolal Karimov, Elnur Karimov, Kazım Okan Dolu, Mustafa Özçetin, Ayşe Kılıç","doi":"10.1515/ijamh-2025-0174","DOIUrl":"10.1515/ijamh-2025-0174","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the early effects of cigarette smoke exposure on endothelial function in healthy adolescents by analyzing blood endocan levels and urinary cotinine concentrations. A novel endocan/cotinine ratio was proposed to enhance the assessment of endothelial response to tobacco exposure.</p><p><strong>Methods: </strong>In this cross-sectional case-control study, 88 adolescents aged 13-18 years were recruited from Istanbul University between January and August 2021. Participants were divided into two groups: exposed (n=44) and non-exposed (n=44) to cigarette smoke. Blood endocan and urine cotinine levels were measured using ELISA. Statistical analysis included the Mann-Whitney U test and Spearman's correlation.</p><p><strong>Results: </strong>Among the exposed participants, 11.4 % (n=5) were active smokers and 88.6 % (n=39) were passive smokers. Systolic blood pressure was significantly higher in the exposed group (p=0.03). Although endocan levels did not differ significantly between groups (p=0.74), median values were higher in the exposed group (1847.5 pg/mL, range: 14.79-3,121.63) compared to controls (1806.2 pg/mL, range: 116.83-4,618.90). Urinary cotinine levels were markedly elevated in the exposed group (p<0.001).Significant positive correlations were found between exposure duration (pack-years) and both endocan levels (r=0.318, p=0.01) and cotinine levels (r=0.524, p<0.001). A significant negative correlation was identified between cotinine and endocan levels specifically in the exposed group (r=-0.435, p=0.003), with regression analysis showing that each 1 ng/mL increase in urinary cotinine was associated with a 3.23 pg/mL reduction in serum endocan (R<sup>2</sup>=0.189, p=0.003), suggesting that cotinine levels accounted for 18.9 % of the variability in endocan concentrations. No such correlation was observed in the control group (r=-0.015, p=0.925).The endocan/cotinine ratio showed a decreasing trend in the exposed group (median: 25.69, mean: 28.76 ± 21.45) compared to non-exposed participants (median: 34.24, mean: 47.31 ± 53.89), though this difference did not reach statistical significance (U=1,149.0, p=0.132). A negative correlation was found between BMI and endocan levels (r=-0.337, p=0.001), while a weak positive correlation was observed between age and cotinine concentration (r=0.222, p=0.038).</p><p><strong>Conclusions: </strong>Cigarette smoke exposure in adolescents leads to elevated cotinine levels and increased blood pressure (p=0.03), indicating early vascular changes. The observed negative correlation between cotinine and endocan levels (r=-0.435, p=0.003) may reflect a compensatory endothelial response. The endocan/cotinine ratio could serve as a novel, early biomarker for endothelial dysfunction in youth exposed to cigarette smoke.</p>","PeriodicalId":13823,"journal":{"name":"International Journal of Adolescent Medicine and Health","volume":" ","pages":"161-172"},"PeriodicalIF":0.0,"publicationDate":"2026-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145892488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}