Biotechnology Kiosk最新文献

Folate receptor-mediated Therapeutics and Imaging 叶酸受体介导的治疗和成像

Biotechnology Kiosk Pub Date : 2023-07-21 DOI: 10.37756/bk.23.5.7.1

L. C. Mishra, J. Gupta, S. Dwivedi, Gauri Mishra

{"title":"Folate receptor-mediated Therapeutics and Imaging","authors":"L. C. Mishra, J. Gupta, S. Dwivedi, Gauri Mishra","doi":"10.37756/bk.23.5.7.1","DOIUrl":"https://doi.org/10.37756/bk.23.5.7.1","url":null,"abstract":"Cancer is the second leading cause of death globally. Before a probable treatment approach is adopted based on early-stage diagnosis, there is a requirement for specific constructive and efficacious strategies. Identifying solid tumors through targeted detection of cancerous cells is one of the most reliable approaches to treatment. Over the past decade, the investigation of folate receptors (FR) has led to the development of several novel cancer treatments. Many tumor types exhibit high overexpression of FR, which was found to be associated with tumor progression and prognosis. Monitoring FR expression levels can prove a useful criterion as it is correlated with the advancement and prognosis of tumors. Due to the strong affinity of the FR towards folate and folate-conjugates, it can be designated as a tumor-associated antigen that is involved in the active transportation of the bound cargo within cells through an endocytic process. A wide range of payloads, from tiny radioactive imaging agents up to massive DNA-containing formulations, may be delivered to FR-positive cells using folate or an analog of it as the ligand. The FR targeting anticancer therapies are being developed currently and the response-predictive aspect of FR expression could serve as a biomarker for these treatments. By boosting delivery to the target tissue as well as an improved target-non-target tissue ratio, targeted drug delivery systems aim to increase the therapeutic windows of molecules. In turn, this results in a decreased minimum effective dose of the drug, lower drug toxicity, and improved treatment efficacy at comparable plasma concentrations. Targeted delivery is especially appealing for drugs with small therapeutic windows and/or those activated at very low concentrations due to the few targeted receptor sites on the specified target tissue. This review discusses recent developments in FR-mediated targeting for therapeutics and its applications in imaging, as well as highlights their potential and anticipated challenges.","PeriodicalId":137587,"journal":{"name":"Biotechnology Kiosk","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115257372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Surface Modification of Advanced Biomaterials for Applications in the Pharmaceutical and Medical Fields 先进生物材料的表面改性及其在制药和医疗领域的应用

Biotechnology Kiosk Pub Date : 2022-03-21 DOI: 10.37756/bk.22.4.3.1

Ishita Agrawal, Piyush Dua

{"title":"Surface Modification of Advanced Biomaterials for Applications in the Pharmaceutical and Medical Fields","authors":"Ishita Agrawal, Piyush Dua","doi":"10.37756/bk.22.4.3.1","DOIUrl":"https://doi.org/10.37756/bk.22.4.3.1","url":null,"abstract":"Lately, there has been a great deal of emphasis on developing novel biomaterials for next generation biomedical technologies. Especially, research efforts have focused on biomaterials that meet the demand for precisely engineered three-dimensional structures. These research efforts seek to design advanced biomaterials that mimic the natural environments of tissues more closely, and thus enhance the functional performance of these materials. To this end, surface modification/functionalization of biomaterials is considered pivotal to achieve the goals. Recent progress in biomaterials fabrication techniques has shown huge promise for surface engineering of biomaterials leading to realization of devices that have complex surface geometries for various biomedical applications in the pharmaceutical and medical fields. These include next generation drug delivery, diagnosis and biosensors, to name a few. In this review, we have highlighted important surface modification processes that have been employed for surface engineering of biomaterials. Further, an overview of the cellular response of surface modified biomaterial is presented. We have also discussed precise engineering of three-dimensional surface modification of biomaterials by initiated chemical vapor deposition (i-CVD) method. Notable biomedical applications have been described. Finally, we have presented a brief future perspective.","PeriodicalId":137587,"journal":{"name":"Biotechnology Kiosk","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120936687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

3D Tissue Constructs from the Ground Up for Game Changing New Applications in Tissue Engineering and Regenerative Medicine 3D组织结构从地面到改变游戏规则的组织工程和再生医学的新应用

Biotechnology Kiosk Pub Date : 2022-03-21 DOI: 10.37756/bk.22.4.3.2

Pallavi Tripathi, Sunny O. Abarikwu

{"title":"3D Tissue Constructs from the Ground Up for Game Changing New Applications in Tissue Engineering and Regenerative Medicine","authors":"Pallavi Tripathi, Sunny O. Abarikwu","doi":"10.37756/bk.22.4.3.2","DOIUrl":"https://doi.org/10.37756/bk.22.4.3.2","url":null,"abstract":"In view of the very expensive modern healthcare system, sudden loss or failure of organs and tissues could pose a very difficult and costly medical problem to patients. Further, the limited supply of organs globally that a patient can afford for replacement in the event of an organ failure makes the problem even more challenging and complicated. These medical and healthcare challenges have triggered research and developments into tissue engineering to advance the field of regenerative medicine. Especially, the research focus has been on the design, development and optimization of a cell-scaffold-microenvironment to promote the regeneration of various types of tissue including skin, cartilage, bone, tendon and cardiac tissue, to name a few. Studies have been undertaken to produce functional three-dimensional (3D) tissue substitutes or constructs that are based on bio scaffolds from the ground up. To this end, bioprinting strategies have been considered for fabrication of complex 3D functional living tissues or artificial organs. Here, we describe some notable advances in laser bioprinting enabled tissue engineering, which is a rapidly emerging field in 3D bio fabrication technology for applications in regenerative medicine.","PeriodicalId":137587,"journal":{"name":"Biotechnology Kiosk","volume":"56 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121453002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electron Microscopy for Structural Determination and Analysis of Viruses 用于病毒结构测定和分析的电子显微镜

Biotechnology Kiosk Pub Date : 2022-02-21 DOI: 10.37756/bk.22.4.2.2

Sandeep Kumar Yadav

{"title":"Electron Microscopy for Structural Determination and Analysis of Viruses","authors":"Sandeep Kumar Yadav","doi":"10.37756/bk.22.4.2.2","DOIUrl":"https://doi.org/10.37756/bk.22.4.2.2","url":null,"abstract":"Viruses are known to be associated with large-scale, dynamic conformational changes that take place to facilitate cell entry and genome delivery. It is also known that a replication machinery is involved in the advanced stage of the infectious cycle that enables to read and synthesize nucleic acid strands. This process results in the generation of new copies of genetic material. In this process, the function of structural proteins helps to assemble and package the appropriate contents to produce new infectious particles. Lately, there has been a great deal of research interest on structural elucidation of these events. This interest is primarily driven by the significance of virus structural identification, which helps understand these processes and also their inhibition by antiviral agents such as neutralizing antibodies and drugs. To this end, the development of electron microscopy (EM) techniques for studies in virology has played a major role for structural determination and analysis of viruses. In this mini-review, we have highlighted some of the latest developments in this field. We have briefly described important role of EM in virology. We have also discussed notable application examples of EM in elucidating various virus structures to gain insights into identification of deadly pathogens and other infectious agents and outbreaks along with anti-viral developmental strategies.","PeriodicalId":137587,"journal":{"name":"Biotechnology Kiosk","volume":"40 9","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"120992060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Rapid Diagnosis and Analysis of Infectious Agents in Human Blood Stream 人血流感染因子快速诊断与分析的最新进展

Biotechnology Kiosk Pub Date : 2022-02-21 DOI: 10.37756/bk.22.4.2.1

Pradeep K. Singh, Shweta Kusmakar Singh

引用次数: 0

Sequence polymorphism within erythrocyte binding domain of EBA175 in Indian and African field isolates 印度和非洲野株EBA175红细胞结合区序列多态性

Biotechnology Kiosk Pub Date : 2022-01-21 DOI: 10.37756/bk.22.4.1.1

Monal Sharma, Shailja Singh

{"title":"Sequence polymorphism within erythrocyte binding domain of EBA175 in Indian and African field isolates","authors":"Monal Sharma, Shailja Singh","doi":"10.37756/bk.22.4.1.1","DOIUrl":"https://doi.org/10.37756/bk.22.4.1.1","url":null,"abstract":"Invasion of erythrocyte by Plasmodium merozoites is mediated by specific molecular interactions between proteins expressed on merozoite surface and the receptors present on erythrocytes. Erythrocyte binding antigen 175 (EBA175) is one such protein that interacts with the sialic acid residues on glycophorin A present on erythrocytes’ surface during invasion. The FII region (PfFII) of EBA175 has been mapped to be critical for binding to erythrocytes. It is reported that antibodies against FII region blocks binding. Polymorphisms in FII region of EBA175 are already reported. The goal of this study was to investigate whether polymorphism in FII region of African P. falciparum field isolates has any effect on erythrocyte binding and also to find whether antibodies raised against FII region from P. falciparum Malayan Camp strain (Camp) can inhibit erythrocyte binding. Genomic DNA of parasites from the blood samples of P. falciparum infected individuals was isolated and PfFII region from these genomic DNA were amplified, cloned and sequenced. Following sequence analysis, we selected three isolates harboring higher PfFII polymorphisms, expressed them on the surface of COS cells as chimeric proteins using secretory signal and transmembrane segments of Herpex simplex virus glycoprotein D (HSVg D) and tested for their erythrocyte binding ability. We further tested the inhibition of erythrocyte binding of these polymorphic FII regions using anti-campPfF2 antibodies. Our results reveal that the polymorphisms in different field isolates included in this study do not have any significant effect on erythrocyte binding and antibodies raised against FII region of camp strain could inhibit erythrocyte binding by all the polymorphic PfFII. This observation strengthens the possibility that PfFII can be a potential candidate vaccine.","PeriodicalId":137587,"journal":{"name":"Biotechnology Kiosk","volume":"34 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125676238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Remote Sensing and Artificial Intelligence Based Technologies Benefit Modern Agriculture and Food Production Systems? 遥感和人工智能技术能使现代农业和粮食生产系统受益吗?

Biotechnology Kiosk Pub Date : 2021-12-21 DOI: 10.37756/bk.21.3.12.1

Abhijit Biswas

{"title":"Can Remote Sensing and Artificial Intelligence Based Technologies Benefit Modern Agriculture and Food Production Systems?","authors":"Abhijit Biswas","doi":"10.37756/bk.21.3.12.1","DOIUrl":"https://doi.org/10.37756/bk.21.3.12.1","url":null,"abstract":"The ever-changing climate coupled with increasing demand for more land and water resources along with the threats of global pandemic have put a lot of pressure on modern agriculture and food production systems. It is critical to maintain environmental and economic sustainability of current and future food supply systems in order to secure enough food to feed and sustain a fast-growing global population. To this end, new innovations in scientific and technological advances are thought to be essential to gain insights into the interaction of various components of the agricultural system ranging from the cell to the field level. There have been advances in genetic tools that have enabled superior food production. However, the large-scale assessment of crop status in the field still remains a formidable challenge. Recent innovations in remote sensing and Artificial Intelligence (AI) based agriculture and food production have shown a lot promise in quantifying field scale phenotypic information accurately. In addition, studies have suggested the possibility to integrate the big data into predictive and prescriptive management tools. In this opinion, we have assessed the use of remote sensing and AI technologies that could potentially improve the resilience of agricultural systems and help address the agricultural and human nutrition challenges over the next decades.","PeriodicalId":137587,"journal":{"name":"Biotechnology Kiosk","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122367813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Superhydrophobic Materials for Advanced Healthcare 高级医疗保健用超疏水材料

Biotechnology Kiosk Pub Date : 2021-11-20 DOI: 10.37756/bk.21.3.11.1

Abhijit Biswas, Rajeev Gupta

引用次数: 0

Optimization of Bio-Electrochemical Systems 生物电化学系统的优化

Biotechnology Kiosk Pub Date : 2021-10-20 DOI: 10.37756/bk.21.3.10.1

Abhijit Biswas

{"title":"Optimization of Bio-Electrochemical Systems","authors":"Abhijit Biswas","doi":"10.37756/bk.21.3.10.1","DOIUrl":"https://doi.org/10.37756/bk.21.3.10.1","url":null,"abstract":"The ongoing research in the sustainable energy sector has shown tremendous potential of microbes or electro-active biofilms (EABfs). These biofilms act as the important component of bioprocessing technologies that are based on bio-electrochemical systems (BESs). EABfs exhibit unique characteristics including redox reactions and resilience against otherwise harmful products that make BESs promising for important applications in energy recovery in the form of electricity or hydrogen or even production of fuels or chemicals from CO2. A deeper understanding of the mechanisms of EABfs characteristics is considered essential for the optimization of BESs for practical applications. To this end, a wide range of characterization techniques based on electrochemical, visual and chemical methods have been employed for the analyses of EABfs. These techniques can provide very valuable and wide-ranging information about EABfs that include performance, morphology and biofilm composition. Especially, significant attention has been paid to developing non-destructive visual techniques for EABfs characterization. The goal is to obtain in-situ information of EABfs functioning for industrial-scale development of BESs. Visual techniques are considered extremely useful for EABfs monitoring studies that can complement the information obtained with other characterization techniques. In this perspective, we have provided a short overview of various visual characterization techniques that have been proposed to study EABfs for the optimization of BESs.","PeriodicalId":137587,"journal":{"name":"Biotechnology Kiosk","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116940282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Biomedical Use of Radioisotopes of Thallium: A Potential Gateway to the Diagnosis of Chronic Diseases 铊放射性同位素的生物医学应用:慢性疾病诊断的潜在途径

Biotechnology Kiosk Pub Date : 2021-09-21 DOI: 10.37756/bk.21.3.9.1

R. Gupta, Dp Singh

引用次数: 0