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Novel Therapeutics: Response and Resistance of Ovarian Cancer最新文献

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Abstract NT-114: CATALYTIC SUBUNITS SWITCH DRIVES RESISTANCE TO EZH2 INHIBITORS IN ARID1A-MUTATED CELLS 摘要NT-114:催化亚基开关驱动arid1a突变细胞对EZH2抑制剂的抗性
Novel Therapeutics: Response and Resistance of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-nt-114
Shuai Wu, N. Fatkhutdinov, T. Fukumoto, Benjamin G. Bitler, P. Park, A. Kossenkov, M. Trizzino, Alessandro Gardini, D. Speicher, Rugang Zhang
{"title":"Abstract NT-114: CATALYTIC SUBUNITS SWITCH DRIVES RESISTANCE TO EZH2 INHIBITORS IN ARID1A-MUTATED CELLS","authors":"Shuai Wu, N. Fatkhutdinov, T. Fukumoto, Benjamin G. Bitler, P. Park, A. Kossenkov, M. Trizzino, Alessandro Gardini, D. Speicher, Rugang Zhang","doi":"10.1158/1557-3265.ovcasymp18-nt-114","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-nt-114","url":null,"abstract":"","PeriodicalId":137391,"journal":{"name":"Novel Therapeutics: Response and Resistance of Ovarian Cancer","volume":"119 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116368803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract NT-109: VAL-083 (DIANHYDROGALACTITOL) SYNERGIZES WITH PARP INHIBITORS IN BRCA-PROFICIENT AND BRCA-DEFICIENT OVARIAN CANCER MODELS 摘要NT-109: VAL-083(二氢半乳糖醇)在brca精通和brca缺乏的卵巢癌模型中与PARP抑制剂协同作用
Novel Therapeutics: Response and Resistance of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-nt-109
A. Steinø, G. He, J. Bacha, Dennis Brown, Z. Siddik
{"title":"Abstract NT-109: VAL-083 (DIANHYDROGALACTITOL) SYNERGIZES WITH PARP INHIBITORS IN BRCA-PROFICIENT AND BRCA-DEFICIENT OVARIAN CANCER MODELS","authors":"A. Steinø, G. He, J. Bacha, Dennis Brown, Z. Siddik","doi":"10.1158/1557-3265.ovcasymp18-nt-109","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-nt-109","url":null,"abstract":"","PeriodicalId":137391,"journal":{"name":"Novel Therapeutics: Response and Resistance of Ovarian Cancer","volume":"241 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130121162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract NT-107: CHEMORESISTANT OVARIAN CANCER STEM CELLS REVEAL NOVEL THERAPEUTIC TARGETS 摘要NT-107:化疗耐药卵巢癌干细胞揭示了新的治疗靶点
Novel Therapeutics: Response and Resistance of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-nt-107
Allison C Sharrow, Richard J. Jones, Lily Wu
{"title":"Abstract NT-107: CHEMORESISTANT OVARIAN CANCER STEM CELLS REVEAL NOVEL THERAPEUTIC TARGETS","authors":"Allison C Sharrow, Richard J. Jones, Lily Wu","doi":"10.1158/1557-3265.ovcasymp18-nt-107","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-nt-107","url":null,"abstract":"","PeriodicalId":137391,"journal":{"name":"Novel Therapeutics: Response and Resistance of Ovarian Cancer","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125518425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract AP29: A SINGLE CELL RNA-SEQUENCING APPROACH TO UNCOVERING HUMAN OVARIAN TUMOR AND IMMUNE CELL HETEROGENEITY, AND THEIR RESPONSE TO MULLERIAN INHIBITING SUBSTANCE USING PATIENT ASCITES SAMPLES 摘要AP29:单细胞rna测序方法揭示人卵巢肿瘤和免疫细胞的异质性，以及它们对患者腹水样本中缪勒管抑制物质的反应
Novel Therapeutics: Response and Resistance of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-ap29
Raghav Mohan, Motohiro Kano, H. Saatcioglu, Nobuhiro Takahashi, Lihua Zhang, N. Nagykery, Joy Poulo, P. Donahoe, D. Pépin
{"title":"Abstract AP29: A SINGLE CELL RNA-SEQUENCING APPROACH TO UNCOVERING HUMAN OVARIAN TUMOR AND IMMUNE CELL HETEROGENEITY, AND THEIR RESPONSE TO MULLERIAN INHIBITING SUBSTANCE USING PATIENT ASCITES SAMPLES","authors":"Raghav Mohan, Motohiro Kano, H. Saatcioglu, Nobuhiro Takahashi, Lihua Zhang, N. Nagykery, Joy Poulo, P. Donahoe, D. Pépin","doi":"10.1158/1557-3265.ovcasymp18-ap29","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-ap29","url":null,"abstract":"","PeriodicalId":137391,"journal":{"name":"Novel Therapeutics: Response and Resistance of Ovarian Cancer","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132301432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract NT-113: SC-003, AN ANTIBODY-DRUG CONJUGATE TARGETING DIPEPTIDASE 3, EXHIBITS POTENT ANTI-TUMOR ACTIVITY IN PATIENT-DERIVED XENOGRAFT MODELS OF HIGH GRADE SEROUS OVARIAN CANCER 摘要NT-113: SC-003是一种靶向二肽酶3的抗体-药物偶联物，在患者来源的高级别浆液性卵巢癌异种移植模型中显示出强大的抗肿瘤活性
Novel Therapeutics: Response and Resistance of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-nt-113
W. Wiedemeyer, S. Bheddah, Christine Saechao, D. French, E. Huntzicker, A. Kempema, J. Gavrilyuk, David R. Liu, V. Sisodiya, Alina T. He, Zhaomei Zhang, M. Aujay, K. Hayashi, S. Vivona, Xi Zhao, K. Walter, L. Saunders, J. Hampl, S. Madhavan, Marybeth Pysz, A. Bankovich, H. Karsunky, S. Dylla
{"title":"Abstract NT-113: SC-003, AN ANTIBODY-DRUG CONJUGATE TARGETING DIPEPTIDASE 3, EXHIBITS POTENT ANTI-TUMOR ACTIVITY IN PATIENT-DERIVED XENOGRAFT MODELS OF HIGH GRADE SEROUS OVARIAN CANCER","authors":"W. Wiedemeyer, S. Bheddah, Christine Saechao, D. French, E. Huntzicker, A. Kempema, J. Gavrilyuk, David R. Liu, V. Sisodiya, Alina T. He, Zhaomei Zhang, M. Aujay, K. Hayashi, S. Vivona, Xi Zhao, K. Walter, L. Saunders, J. Hampl, S. Madhavan, Marybeth Pysz, A. Bankovich, H. Karsunky, S. Dylla","doi":"10.1158/1557-3265.ovcasymp18-nt-113","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-nt-113","url":null,"abstract":"","PeriodicalId":137391,"journal":{"name":"Novel Therapeutics: Response and Resistance of Ovarian Cancer","volume":"45 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114033145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract NT-095: ERADICATION OF CHEMORESISTANT METASTATIC OVARIAN CANCER WITH IMMUNOTARGETED EPIGENOMIC NANOSURGERY (IEN) NT-095:免疫靶向表观基因组纳米手术根除化疗耐药转移性卵巢癌(IEN)
Novel Therapeutics: Response and Resistance of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-nt-095
J. Giannios
{"title":"Abstract NT-095: ERADICATION OF CHEMORESISTANT METASTATIC OVARIAN CANCER WITH IMMUNOTARGETED EPIGENOMIC NANOSURGERY (IEN)","authors":"J. Giannios","doi":"10.1158/1557-3265.ovcasymp18-nt-095","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-nt-095","url":null,"abstract":"","PeriodicalId":137391,"journal":{"name":"Novel Therapeutics: Response and Resistance of Ovarian Cancer","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129322507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract NT-105: ANTI-TUMOUR EFFECTS OF ALL-TRANS RETINOID ACID, AN ANNEXIN A2-S100A10 PATHWAY INHIBITOR ON SEROUS OVARIAN CANCER 摘要NT-105:膜联蛋白A2-S100A10途径抑制剂全反式维a酸对浆液性卵巢癌的抗肿瘤作用
Novel Therapeutics: Response and Resistance of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-nt-105
N. Lokman, R. Ho, Kavyadharshini Gunasegaran, W. Bonner, M. Oehler, C. Ricciardelli
{"title":"Abstract NT-105: ANTI-TUMOUR EFFECTS OF ALL-TRANS RETINOID ACID, AN ANNEXIN A2-S100A10 PATHWAY INHIBITOR ON SEROUS OVARIAN CANCER","authors":"N. Lokman, R. Ho, Kavyadharshini Gunasegaran, W. Bonner, M. Oehler, C. Ricciardelli","doi":"10.1158/1557-3265.ovcasymp18-nt-105","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-nt-105","url":null,"abstract":"","PeriodicalId":137391,"journal":{"name":"Novel Therapeutics: Response and Resistance of Ovarian Cancer","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127548112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract NT-119: TARGET DISCOVERY OF NATURAL PRODUCT INSPIRED PHYLLANTHUSMINS FOR TREATMENT OF HIGH GRADE SEROUS OVARIAN CANCER 摘要NT-119:天然产物激发的千余香用于治疗高级别浆液性卵巢癌的靶点发现
Novel Therapeutics: Response and Resistance of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-nt-119
Alexandria N. Young, Steven J Kurina, Andrew C. Huntsman, Rathnayake A C Rathnayake, Melissa A. Korkmaz, A. Kinghorn, L. Aldrich, S. Cologna, J. Fuchs, J. Burdette
{"title":"Abstract NT-119: TARGET DISCOVERY OF NATURAL PRODUCT INSPIRED PHYLLANTHUSMINS FOR TREATMENT OF HIGH GRADE SEROUS OVARIAN CANCER","authors":"Alexandria N. Young, Steven J Kurina, Andrew C. Huntsman, Rathnayake A C Rathnayake, Melissa A. Korkmaz, A. Kinghorn, L. Aldrich, S. Cologna, J. Fuchs, J. Burdette","doi":"10.1158/1557-3265.ovcasymp18-nt-119","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-nt-119","url":null,"abstract":"","PeriodicalId":137391,"journal":{"name":"Novel Therapeutics: Response and Resistance of Ovarian Cancer","volume":"42 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132585059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract NT-092: FUNCTIONAL HETEROGENEITY OF ACQUIRED PARP INHIBITOR RESISTANCE IN BRCA1-DEFICIENT CELLS 摘要NT-092: brca1缺陷细胞中获得性PARP抑制剂耐药的功能异质性
Novel Therapeutics: Response and Resistance of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-nt-092
A. Färkkilä, A. Rodriquez, Jaana Olkkonen, Larissa A. Sambel, Julieta Dominiquez, Niraj R. Joshi, Connor S. Clairmont, Jia Zhou, K. Lim, S. Hautaniemi, Alan D’Andrea
{"title":"Abstract NT-092: FUNCTIONAL HETEROGENEITY OF ACQUIRED PARP INHIBITOR RESISTANCE IN BRCA1-DEFICIENT CELLS","authors":"A. Färkkilä, A. Rodriquez, Jaana Olkkonen, Larissa A. Sambel, Julieta Dominiquez, Niraj R. Joshi, Connor S. Clairmont, Jia Zhou, K. Lim, S. Hautaniemi, Alan D’Andrea","doi":"10.1158/1557-3265.ovcasymp18-nt-092","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-nt-092","url":null,"abstract":"","PeriodicalId":137391,"journal":{"name":"Novel Therapeutics: Response and Resistance of Ovarian Cancer","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117098873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Abstract NT-102: CHEMICALLY INDUCED HYPOXIA PROMOTES OVARIAN CANCER CHEMORESISTANCE 摘要NT-102:化学诱导的缺氧促进卵巢癌化疗耐药
Novel Therapeutics: Response and Resistance of Ovarian Cancer Pub Date : 2019-11-15 DOI: 10.1158/1557-3265.ovcasymp18-nt-102
Andrea Nieto-Veloza, Q. Zhong, V. Dia
{"title":"Abstract NT-102: CHEMICALLY INDUCED HYPOXIA PROMOTES OVARIAN CANCER CHEMORESISTANCE","authors":"Andrea Nieto-Veloza, Q. Zhong, V. Dia","doi":"10.1158/1557-3265.ovcasymp18-nt-102","DOIUrl":"https://doi.org/10.1158/1557-3265.ovcasymp18-nt-102","url":null,"abstract":"","PeriodicalId":137391,"journal":{"name":"Novel Therapeutics: Response and Resistance of Ovarian Cancer","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114175199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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