INNOSC Theranostics and Pharmacological Sciences最新文献_第5页

Molecular Docking Studies of Glabrene and Human Epidermal Growth Factor Receptor Kinase 光烯与人表皮生长因子受体激酶的分子对接研究

INNOSC Theranostics and Pharmacological Sciences Pub Date : 2022-04-29 DOI: 10.36922/itps.v4i1.56

N. Katari, R. Gundla, P. K. Reddy, Anuradha Vanam, Aruna Talatam, N. Motohashi, Rao Gollapudi

{"title":"Molecular Docking Studies of Glabrene and Human Epidermal Growth Factor Receptor Kinase","authors":"N. Katari, R. Gundla, P. K. Reddy, Anuradha Vanam, Aruna Talatam, N. Motohashi, Rao Gollapudi","doi":"10.36922/itps.v4i1.56","DOIUrl":"https://doi.org/10.36922/itps.v4i1.56","url":null,"abstract":"Background: Human epidermal growth factor receptor 2 (Her2) gene located in human chromosome17, encodes Her2 tyrosine kinase protein, and is overexpressed in breast cancer cells. Her2 is activated on phosphorylation of tyrosine by adenosine triphosphate (ATP). Nonetheless, Her2 excessively partakes in the development and prognosis of specific types of aggressive breast cancers. Therefore, Her2 inhibition therapy is primary target for the treatment of aggressive breast cancer. At present, lapatinib is one of the Food and Drug Administration approved Her2 inhibitors used in cancer therapy. In molecular docking process, glabrene with slightly higher binding energy competitively bound to the active receptor site comparable to lapatinib and ATP. Therefore, glabrene could emerge as a potential candidate for restricting Her2 overexpressed breast cancer. \u0000Objective: The present study aimed to demonstrate the inhibitory activity of glabrene, an isoflavene and xenoestrogen found in liquorice root, along with known Her2 inhibitor, lapatinib. \u0000Methods: ATP, lapatinib, and glabrene were docked on human Her2 protein 3D structure which revealed glabrene as a competitive Her2 inhibitor akin to lapatinib. Results: The docking results suggested the binding site similarities of ATP, lapatinib, and glabrene. The binding energies of docked ATP, lapatinib, and glabrene complexes with Her2 were −9.1 kcal/mol, −10.5 kcal/mol, and −11.3 kcal/mol, respectively. \u0000Conclusion: The in silico docking simulation of ATP, lapatinib, and glabrene suggested that glabrene is likewise a competitive Her2 inhibitor.","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83091839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Conjugation of Silver and Gold Nanoparticles for Enhancing Antimicrobial Activity 银和金纳米颗粒的偶联增强抗菌活性

INNOSC Theranostics and Pharmacological Sciences Pub Date : 2022-04-22 DOI: 10.36922/itps.v4i2.70

Muhamad Shakir Yusoff, S. Gopinath, M. Uda, T. LakshmiPriya, Ahmad Radi Wan Yaakub, P. Anbu

{"title":"Conjugation of Silver and Gold Nanoparticles for Enhancing Antimicrobial Activity","authors":"Muhamad Shakir Yusoff, S. Gopinath, M. Uda, T. LakshmiPriya, Ahmad Radi Wan Yaakub, P. Anbu","doi":"10.36922/itps.v4i2.70","DOIUrl":"https://doi.org/10.36922/itps.v4i2.70","url":null,"abstract":"Silver and gold nanoparticles are promising agents that can enhance the antibacterial activity of conjugated/capped extract of plant compounds. The aim of our study is to synthesize silver nanoparticles from Gymnema sylvestre plant extract. In this study, the antimicrobial activity of conjugated silver which was green synthesized and gold nanoparticle that was obtained from a commercial source was evaluated using disk-diffusion method against Escherichia coli and Aspergillus niger. Transmission electron microscopy, scanning electron microscopy, ultraviolet-visible spectroscopy, and Fourier transform infrared spectroscopy analyses were also carried out to characterize the conjugated silver and gold nanoparticles. The conjugation of silver and gold nanoparticles was performed chemically using 16-mercaptodecanoic acid. Our results revealed that conjugated silver and gold nanoparticle both showing larger inhibition zones against E. coli and A. niger. The minimum inhibitory concentration (MIC) of the above metallic conjugation was found to be stable with MIC was reported to be 1 mM. When comparing the sample analysis on conjugation of gold and silver nanoparticles against E. coli and A. niger, the antimicrobial activity recorded was 2.0 ± 0.01 and 2.32 ± 0.04 cm, respectively, with no significance difference was found (P = 0.85). In conclusion, the combination of two different nanoparticles is efficient for microbial inhibition and can be useful for studying antimicrobial activities with the combination of different nanomaterials in future.","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81729009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Horizontal Gene Transfer: Generating Antibiotic-resistant Bacteria 水平基因转移:产生耐抗生素细菌

INNOSC Theranostics and Pharmacological Sciences Pub Date : 2022-04-15 DOI: 10.36922/itps.v4i1.66

Mohamad Amin Awang, T. Ismail, Thangavel, Lakshmipriya, Subash, C., B., Gopinath, SUMITHA

{"title":"Horizontal Gene Transfer: Generating Antibiotic-resistant Bacteria","authors":"Mohamad Amin Awang, T. Ismail, Thangavel, Lakshmipriya, Subash, C., B., Gopinath, SUMITHA","doi":"10.36922/itps.v4i1.66","DOIUrl":"https://doi.org/10.36922/itps.v4i1.66","url":null,"abstract":"This study aims to understand the gene mobility and its benefits. In this experiment, we transferred the significant gene horizontally under the appropriate condition and generated an antibiotic-resistant bacterial strain. The process of gene mobility is known as horizontal gene transfer, in which three different modes have been acknowledged that are transduction, transformation, and conjugation. Conjugation is a simple natural occurrence of cell-to-cell contact for transferring gene. The gene sequence that was analyzed in this study is responsible for tetracycline resistance in Proteus mirabilis; the gene was transferred horizontally to Klebsiella pneumoniae. Two methods were used for the conjugation, namely, plate- and broth-mating. The conjugation results were analyzed statistically, where events of probability across the time intervals at the highest spectrophotometric absorbance of 0.43 are tabulated. Broth mating was performed in 25 samples and the probability of an event is successful at P = 0.88. Further, broth mating was accredited to be better than plate-mating as claimed with a 95% confidence interval that yields the value of Z normal test of 4.49. This study suggests a feasible method for generating drug-resistant bacterial strains for use in medical research and industrial applications.","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90333882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Geriatric Oral Health: The Role of Oral Disease Prevention in Vulnerable Patients 老年口腔健康:口腔疾病预防在弱势患者中的作用

INNOSC Theranostics and Pharmacological Sciences Pub Date : 2021-06-04 DOI: 10.36922/ITPS.V4I1.966

M. Goldberg

{"title":"Geriatric Oral Health: The Role of Oral Disease Prevention in Vulnerable Patients","authors":"M. Goldberg","doi":"10.36922/ITPS.V4I1.966","DOIUrl":"https://doi.org/10.36922/ITPS.V4I1.966","url":null,"abstract":"Prevention of oral diseases plays a crucial role in maintaining the health of vulnerable patients. In this context, vulnerable patients include the adults with no or restricted access to dental treatments, adults above the age of 65 years, and adults residing in Établissement d’hébergement pour personnes âgées dépendantes (EHPADs), which is a type of nursing home for dependent elderly people in France. These vulnerable patients display frailty and/or may need specialized treatment. In addition, oral disease prevention of those living in economically weak countries is equally important. As the global population is increasing at an annual rate of 1.7% while the population of those over 65 years rises at a rate of 2.5%, it is expected that the adults older than 80 years will make up of nearly 20% of the world population in the near future. Therefore, it is without a doubt that early prevention is an important and effective approach to minimize the prevalence of oral disease in the aged population, thereby reducing the related economic repercussions. In general, four levels of prevention have been defined [1,2]. The four levels of prevention are as follows: • Primary prevention aims to prevent the occurrence of a disease or an injury. • Secondary prevention aims to reduce the spread of an already established disease or a progressing disease in a population. It should reduce the impact of a disease or injury that has already occurred or abrogate the progression of a disease and deterioration. • Tertiary prevention aims to reduce the symptoms and complications of a disease and impact of an ongoing illness to improve patient’s functional abilities, quality of life, and life expectancy. Despite that, there is still a risk of recurrence of the disease. Tertiary prevention focuses on the prevention of an already established disease or a progressing disease. • Quaternary prevention aims to identify patients at risk of over-medicalization and suggest interventions that are ethically acceptable, thereby protecting patients from unnecessary medical interventions.","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90769428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Coronavirus Disease 2019: An Overview of the Complications and Management 2019冠状病毒病:并发症及治疗概述

INNOSC Theranostics and Pharmacological Sciences Pub Date : 2021-05-03 DOI: 10.36922/ITPS.V4I1.1037

Huimin Shao, Hany Sadek Ayoub Ghaly, P. Varamini

{"title":"Coronavirus Disease 2019: An Overview of the Complications and Management","authors":"Huimin Shao, Hany Sadek Ayoub Ghaly, P. Varamini","doi":"10.36922/ITPS.V4I1.1037","DOIUrl":"https://doi.org/10.36922/ITPS.V4I1.1037","url":null,"abstract":"The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative agent of coronavirus disease 2019 (COVID-19). Since the first report of COVID-19 emerging in Wuhan, China, authorities in 216 countries and territories have reported about 47.3 million COVID-19 cases and 1.2 million deaths. The WHO guidelines for the management of COVID-19 are very limited to recommendations for managing symptoms and advice on careful management of pediatric patients, pregnant women, and patients with underlying comorbidities. There is no approved treatment for COVID-19 and guidelines vary between countries. In this review, first, a brief overview is provided on the basic knowledge about the virus, clinical features of the disease, and different diagnostic methods. Then, the relationship between COVID-19, various body systems, and other complications is discussed. Finallly, different management strategies are discussed, including those drawn on computational chemistry analyses, pre-clinical investigations, and clinical trials which involve pharmacological and non-pharmacological interventions. In conclusion, despite the recent approval of different vaccine candidates, more virological characteristics of SARS-CoV-2 are required to be explored, which may result in the discovery of more potential therapeutic targets leading to safer and more effective treatment to COVID-19.","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89887222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Skin Ultrasound as a Diagnostic Approach for Non-melanocytic Benign Skin Tumors 皮肤超声诊断非黑素细胞良性皮肤肿瘤的研究

INNOSC Theranostics and Pharmacological Sciences Pub Date : 2020-12-30 DOI: 10.36922/itps.v3i2.944

María Elena Del Prado, R. Ruiz-Villaverde, P. Giavedoni, Ana Rodríguez, D. Vidal, G. Roustán, F. Queipo, J. Aneiros-Fernández, Paola Castillo, E. Ruiz, I. Moysset, Lola Suárez, L. Nájera, Fernando Alfajeme

{"title":"Skin Ultrasound as a Diagnostic Approach for Non-melanocytic Benign Skin Tumors","authors":"María Elena Del Prado, R. Ruiz-Villaverde, P. Giavedoni, Ana Rodríguez, D. Vidal, G. Roustán, F. Queipo, J. Aneiros-Fernández, Paola Castillo, E. Ruiz, I. Moysset, Lola Suárez, L. Nájera, Fernando Alfajeme","doi":"10.36922/itps.v3i2.944","DOIUrl":"https://doi.org/10.36922/itps.v3i2.944","url":null,"abstract":"Background. The diagnostic imaging techniques in dermatology, such as skin ultrasound, could improve the diagnosis of non-melanocytic benign tumor lesions, especially those of intradermal and subcutaneous nature. \u0000Objective. The general objective of this study was to evaluate the validity and diagnostic safety of high-frequency ultrasound as a diagnostic test for non-melanocytic benign skin tumor detection. The specific objectives were to measure the sensitivity and specificity of ultrasound as a measure of the validity relative to the gold-standard test – diagnostic-therapeutic biopsy. \u0000Methods. This study was carried out between January 2017 and June 2019. The patients (n = 641) included in this study comprised of 318 women and 323 men who were between 48 and 74 years. All of them underwent an ultrasound examination of the skin tumor in the dermatology clinic, the removal of the non-melanocytic tumor, and a final histopathological examination. \u0000Results. The skin ultrasound has a sensitivity and specificity of 93% and 88%, respectively. Furthermore, the positive and negative predictive values of using skin ultrasound are 84% and 94%, respectively. \u0000Conclusion. Skin ultrasound is a diagnostic technique with high sensitivity and specificity in the diagnosis of non-melanocytic skin tumors.","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88505119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Community Pharmacy Services During the COVID-19 Pandemic: A Systematic Review COVID-19大流行期间的社区药房服务:系统综述

INNOSC Theranostics and Pharmacological Sciences Pub Date : 2020-12-21 DOI: 10.36922/itps.v3i2.971

A. Mendonça, C. Santos, Isabel C. Pinto

{"title":"Community Pharmacy Services During the COVID-19 Pandemic: A Systematic Review","authors":"A. Mendonça, C. Santos, Isabel C. Pinto","doi":"10.36922/itps.v3i2.971","DOIUrl":"https://doi.org/10.36922/itps.v3i2.971","url":null,"abstract":"Background. As a central part of the healthcare system, the community pharmacies are afflicted by the repercussions of the pandemic. Therefore, they have to adapt their services according to the needs of their communities. \u0000Objective. This article presents a systematic review with the aim to identify the additional services that community pharmacies are providing during the COVID-19 pandemic. \u0000Methods. The PubMed, Web of Science, and ScienceDirect databases were searched systematically for relevant articles between December 2019 and April 2020, using “Community Pharmacy,” “Services,” “COVID-19,” “Coronavirus,” and “Pandemic” as the keywords. Fifty-nine articles in English, Portuguese, or Spanish were obtained and after applying the filtering criteria, nine of them were selected and included in the study. \u0000Results. Community pharmacies should provide pharmaceutical services that are according to the needs of the communities. During the COVID-19 pandemic, changes of these services must be in line with the common goal of preventing the spread of the disease. In addition to the pre-existing services such as medication dispensing and personalized care, community pharmacists must promote other types of services, for example, informing, advising, and educating the community, maintaining a stable supply of pharmaceuticals and health products, and screening of suspected cases. \u0000Conclusion. While remaining engaged in the coordinated efforts, community pharmacists should apply innovations in their practices to help prevent the spread of coronavirus.","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72927631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Epidemiological Model for COVID-19 in China 中国COVID-19流行病学模型

INNOSC Theranostics and Pharmacological Sciences Pub Date : 2020-12-11 DOI: 10.36922//itps.v3i2.938

Shanshan Wu, P. Sun, Ruiling Li, Yanli Wang, Lifang Jiang, J. Deng

{"title":"Epidemiological Model for COVID-19 in China","authors":"Shanshan Wu, P. Sun, Ruiling Li, Yanli Wang, Lifang Jiang, J. Deng","doi":"10.36922//itps.v3i2.938","DOIUrl":"https://doi.org/10.36922//itps.v3i2.938","url":null,"abstract":"Background. The epidemic of coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 first broke out in Wuhan, Hubei Province in China, and then spread quickly worldwide. \u0000Objective. This study aimed to dissect the spread and end of the epidemic in China with a precise mathematical model. \u0000Methods. Various data were obtained from the official websites of the Chinese National Health from January 20 to July 8, 2020. The Chinese study participants were divided into three groups, namely, Hubei (including Wuhan), nationwide without Hubei, and Henan. The basic reproduction number (R0), effective reproduction number (Rt), and gender and age ratio of COVID-19 were calculated, and the epidemic’s predicted curves or fitting curves with peak time and end time were plotted with SIR model. These predicted curves were compared with actual scatter plots. \u0000Results. The fitting curve of the Hubei group showed a parabola with a peak on February 18, 2020, with 51,673 cases and the gradual decrease of infected patients, which culminates with a downhill after May 2020. During early outbreak, the highest recorded R0 was 6.13, which declined gradually forming a S-type curve, and it approached zero in early May. Similar to Hubei group, the fitting curve of the nationwide without Hubei group also showed a parabola, recording a peak of 9145 cases on February 10, 2020. At first, its R0 was as high as 2.35 but declined to zero in early April. The epidemic in the Henan group also reached its peak on February 10, 2020, and ended in early April as well. \u0000Conclusion. The epidemic development of COVID-19 in China followed the shape of parabolic curves. This model provides insights into how to strategize for epidemic control.","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83615768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Importance and Feasibility of Point-of-care Testing in Takayasu’sArteritis 高须性肠炎即时检测的重要性和可行性

INNOSC Theranostics and Pharmacological Sciences Pub Date : 2020-04-30 DOI: 10.36922/itps.v3i1.906

S. Mehta, V. Dhawan

{"title":"Importance and Feasibility of Point-of-care Testing in Takayasu’s\u0000Arteritis","authors":"S. Mehta, V. Dhawan","doi":"10.36922/itps.v3i1.906","DOIUrl":"https://doi.org/10.36922/itps.v3i1.906","url":null,"abstract":"Takayasu’s arteritis (TAK) is known to be a unique, rare, and chronic vasculitis disease that affects large elastic arteries such as aorta and its major branches. TAK is characterized by adventitial thickening, weak pulses and ocular disturbances. The prognosis and diagnosis of TAK are challenging due to the non-specific, silent, or paucisymptomatic presentation of the disease. The effective understanding of TAK lies with the timely recognition of the symptoms and a rapid diagnosis of the disease. Point-of-care testing (POCT) is vital for the quick and reliable detection of parameters near bedside for disease diagnosis, assessment, monitoring, and therapeutics management. Ultrasonography is the most reliable POCT technique. Moreover, erythrocyte sedimentation rate and C-reactive protein assay are the two most valuable non-imaging POCT tests used to determine inflammation and onset of the disease. Other potential biomarkers such as matrix metalloproteinases, soluble receptor for advanced glycation end products, interleukin (IL)-6, and IL-18 have also been advocated for tracking the progression of TAK. Furthermore, vasculitis associated-anti-neutrophil cytoplasmic antibodies have also been reported to reflect the inflammatory phase of the disease. Therefore, the development of POCT based on these blood-based biomarkers may help in quick clinical decision-making for early diagnosis of TAK and targeted therapeutics to improve clinical outcome in patients suffering from this debilitating disease.","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73979949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Long-term Administration of Lovastatin and Rivastigmine: An In Vivo Evaluation on Cognitive Functions and Brain Acetylcholinesterase Activity 长期服用洛伐他汀和利瓦斯汀:对认知功能和脑乙酰胆碱酯酶活性的体内评价

INNOSC Theranostics and Pharmacological Sciences Pub Date : 2020-02-26 DOI: 10.36922/itps.v2i2.904

N. Badruddeen, J. Akhtar, M. Arif, Mohammad Irfan Khan, M. Mujahid, Mohammad Ahmad

{"title":"Long-term Administration of Lovastatin and Rivastigmine: An In Vivo Evaluation on Cognitive Functions and Brain Acetylcholinesterase Activity","authors":"N. Badruddeen, J. Akhtar, M. Arif, Mohammad Irfan Khan, M. Mujahid, Mohammad Ahmad","doi":"10.36922/itps.v2i2.904","DOIUrl":"https://doi.org/10.36922/itps.v2i2.904","url":null,"abstract":"Background. There is not much evidence illustrating that statins could be responsible for memory loss or dementia, although increased exposure to statins has been reported to cause cognitive side effects. The present study investigated the effect of lovastatin in combination with rivastigmine on cognitive function as well as brain acetylcholinesterase (AChE) activity in normal mice. \u0000Methods. The mice were categorized into four groups, and they were treated with normal saline, lovastatin, rivastigmine, and the combination of lovastatin and rivastigmine, respectively, by oral administration for 60 days. The treatment effect on cognitive functions was assessed by behavioral tests, namely, the passive avoidance test and spontaneous alternation test, as well as the measurement of brain AChE activity by Ellman’s method. \u0000Results. In this study, a significant reduction (P < 0.01) of brain AChE activity and positive effects (P < 0.01) on cognitive functions was observed in mice treated with the combination of lovastatin and rivastigmine as compared to rivastigmine alone. However, no significant differences (P < 0.05) were observed on brain AChE activity as well as cognitive functions in mice treated with lovastatin when compared with those treated with normal saline. \u0000Conclusion. This study suggested that lovastatin did not contribute to any improvements in cognitive functions and brain AChE activity, but it potentiated the effect of rivastigmine.","PeriodicalId":13673,"journal":{"name":"INNOSC Theranostics and Pharmacological Sciences","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81350144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1