Infection Control and Hospital Epidemiology最新文献

{"title":"Assessing for race, ethnicity, and socioeconomic disparities in central line-associated bloodstream infection risk in a large academic health system.","authors":"Lindsey B Gottlieb, Radhika Prakash-Asrani, William Dube, Zanthia Wiley, Giancarlo Licitra, Scott K Fridkin","doi":"10.1017/ice.2024.133","DOIUrl":"https://doi.org/10.1017/ice.2024.133","url":null,"abstract":"<p><strong>Objective: </strong>To examine the relationship between race and ethnicity and central line-associated bloodstream infections (CLABSI) while accounting for inherent differences in CLABSI risk related to central venous catheter (CVC) type.</p><p><strong>Design: </strong>Retrospective cohort analysis.</p><p><strong>Setting: </strong>Acute care facilities within an academic healthcare system.</p><p><strong>Patients: </strong>Adult inpatients from January 2012 through December 2017 with CVC present for ≥2 contiguous days.</p><p><strong>Methods: </strong>We describe variability in demographics, comorbidities, CVC type/configuration, and CLABSI rate by patient's race and ethnicity. We estimated the unadjusted risk of CLABSI for each demographic and clinical characteristic and then modelled the effect of race on time to CLABSI, adjusting for total parenteral nutrition use and CVC type. We also performed exploratory analysis replacing race and ethnicity with social vulnerability index (SVI) metrics.</p><p><strong>Results: </strong>32,925 patients with 57,642 CVC episodes met inclusion criteria, most of which (51,348, 89%) were among non-Hispanic White or non-Hispanic Black patients. CVC types differed between race/ethnicity groups. However, after adjusting for CVC type, configuration, and indication in an adjusted cox regression, the risk of CLABSI among non-Hispanic Black patients did not significantly differ from non-Hispanic White patients (adjusted hazard ratio [aHR] 1.19; 95% confidence interval [CI]: 0.94, 1.51). The odds of having a CLABSI among the most vulnerable SVI subset compared to the less vulnerable was no different (odds ratio [OR] 0.95; 95% CI: 0.75-1.2).</p><p><strong>Conclusions: </strong>We did not find a difference in CLABSI risk between non-Hispanic White and non-Hispanic Black patients when adjusting for CLABSI risk inherent in type and configuration of CVC.</p>","PeriodicalId":13663,"journal":{"name":"Infection Control and Hospital Epidemiology","volume":" ","pages":"1-6"},"PeriodicalIF":3.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enabling laboratory readiness and preparedness for the evaluation of suspected viral hemorrhagic fevers: development of a laboratory toolkit.","authors":"Sarah E Turbett, Jacob E Lazarus, Mia A Nardini, Joseph E Braidt, Stefanie A Lane, Eileen F Searle, Paul D Biddinger, Erica S Shenoy","doi":"10.1017/ice.2024.143","DOIUrl":"10.1017/ice.2024.143","url":null,"abstract":"<p><strong>Purpose: </strong>Viral hemorrhagic fevers (VHFs), such as Ebola virus disease, Marburg virus disease, and Lassa fever, are associated with significant morbidity and mortality and the potential for person-to-person transmission. While most individuals in whom VHF is suspected will ultimately be diagnosed with a non-VHF illness, such patients may present to any United States healthcare facility (HCF) for initial evaluation; therefore, all HCFs must be prepared to evaluate and initiate care for suspect VHF patients, especially if they are acutely ill. Included within this evaluation is the ability to perform basic routine laboratory testing before VHF-specific diagnostic test results are available, as well as rapid malaria testing to assess for a common, dangerous \"VHF mimic.\"</p><p><strong>Objective: </strong>To improve laboratory preparedness and readiness in the initial care of suspect VHF patients who may present to acute care hospitals.</p><p><strong>Design: </strong>Plan-Do-Study-Act quality improvement model.</p><p><strong>Setting: </strong>Frontline healthcare facilities and their clinical laboratories.</p><p><strong>Methods: </strong>We describe the development of a laboratory testing toolkit for a suspect VHF patient that can assist frontline HCFs in providing basic laboratory testing required for the care of these patients.</p><p><strong>Results: </strong>The toolkit provides guidance on infection prevention and control, waste management, occupational health, laboratory test collection, processing, and resulting, in the context of suspect VHF patient evaluation.</p><p><strong>Conclusions: </strong>The toolkit is designed to be readily adapted by any frontline HCF in the US. With the guidance provided, facilities will be able to support safer initial evaluation of VHF suspects and ensure high-quality patient care.</p>","PeriodicalId":13663,"journal":{"name":"Infection Control and Hospital Epidemiology","volume":" ","pages":"1-7"},"PeriodicalIF":3.0,"publicationDate":"2024-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518664/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142400188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibiotic spectrum coverage scoring as a potential metric for evaluating the antimicrobial stewardship team activity: a single-center study.","authors":"Kazutaka Oda, Hideyuki Hayashi, Keiichi Yamamoto, Shoji Kondo, Tomomi Katanoda, Shinichiro Okamoto, Toshikazu Miyakawa, Eisaku Iwanaga, Kisato Nosaka, Tatsuya Kawaguchi, Hirotomo Nakata","doi":"10.1017/ice.2024.137","DOIUrl":"https://doi.org/10.1017/ice.2024.137","url":null,"abstract":"<p><strong>Objective: </strong>Days of antibiotic spectrum coverage (days of ASC: DASC) is a metric for antibiotic usage calculated by ASC scores for spectrum and addresses limitations of days of therapy (DOT), which does not include spectrum. This study aims to investigate whether ASC-related metrics offer different aspects compared to aggregated DOT for all antibiotics (DOT_total) and to assess their correlation in evaluating the impact of antimicrobial stewardship team (AST) programs.</p><p><strong>Design: </strong>Retrospective.</p><p><strong>Setting: </strong>A single center within an 845-bed hospital.</p><p><strong>Methods: </strong>Trends in DOT_total, DASC, and the DASC/DOT ratio, representing the average spectrum coverage per therapy day, were analyzed pre- and post-AST programs (April 2018) from January 2015 to December 2023, using interrupted time series analysis. Independent of the DASC/DOT, we also advocated ASC-stratified DOT (ASDOT), which facilitates comprehensive evaluation of DOT across ASC scores of <6, 6-10, and >10, representing narrow-, intermediate-, and broad-spectrum antibiotics.</p><p><strong>Results: </strong>Among inpatients, AST programs significantly moderated the increasing trends of these metrics. Specifically, although the rates of increase in DOT_total and DASC were slowed or plateaued, the DASC/DOT ratio decreased (<i>P</i> < 0.001). ASDOT metrics revealed a decrease and subsequent plateau in DOT_total for the broad- and intermediate-spectrum antibiotics, with an increase observed for the narrow-spectrum antibiotics (<i>P</i> < 0.001 for each). DASC did not provide additional insights in the outpatient's population.</p><p><strong>Conclusions: </strong>The study demonstrates that ASC-related metrics may yield different and useful conclusions about the effectiveness of AST programs for inpatients.</p>","PeriodicalId":13663,"journal":{"name":"Infection Control and Hospital Epidemiology","volume":" ","pages":"1-9"},"PeriodicalIF":3.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing the use of highly bioavailable oral antibiotic therapy for the treatment of prosthetic joint infections.","authors":"Marie-Félixe Granger, Jerome A Leis, Amanda Hempel, Daniel Pincus, Bheeshma Ravi, Nick Daneman, Philip W Lam","doi":"10.1017/ice.2024.159","DOIUrl":"https://doi.org/10.1017/ice.2024.159","url":null,"abstract":"<p><p>We conducted a retrospective cohort study to identify factors influencing intravenous (IV) versus oral antibiotic therapy in first-episode prosthetic joint infections. Of the 34/78 (44%) cases treated intravenously, negative cultures (26%), concomitant infections necessitating IV antibiotics (21%), and delays in susceptibility testing (15%) were the most common reasons for IV therapy.</p>","PeriodicalId":13663,"journal":{"name":"Infection Control and Hospital Epidemiology","volume":" ","pages":"1-4"},"PeriodicalIF":3.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dilution dysfunction: evaluation of automated disinfectant dispenser systems in 10 hospitals demonstrates a need for improved monitoring to ensure that correct disinfectant concentrations are delivered.","authors":"Jennifer L Cadnum, Claire E Kaple, Elizabeth C Eckstein, Elie A Saade, Amy J Ray, Trina F Zabarsky, Bernardino J Guerrero, Mohamed H Yassin, Curtis J Donskey","doi":"10.1017/ice.2024.148","DOIUrl":"https://doi.org/10.1017/ice.2024.148","url":null,"abstract":"<p><p>Automated dispensers that dilute concentrated disinfectants with water are commonly used in healthcare facilities. In a point-prevalence product evaluation, 9 of 10 (90%) hospitals using dilutable disinfectants had 1 or more malfunctioning dispensers. Twenty-nine of 107 (27.1%) systems dispensed product with lower-than-expected concentrations, including 15 (14.0%) with no detectable disinfectant.</p>","PeriodicalId":13663,"journal":{"name":"Infection Control and Hospital Epidemiology","volume":" ","pages":"1-4"},"PeriodicalIF":3.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of invasive group A streptococcal puerperal sepsis in Calgary, Alberta: clinical consequences and policy implications.","authors":"Amro Qaddoura, Megan McQuiston, Gregory Tyrrell, Matthew Croxen, Vincent Li, Rhonda Demarco, Suzanne Pinfield, Ruziyya Ramazanova, Karen Hope, Edith-Rose Cairns, Judy MacDonald, Jia Hu, Oscar Larios, Joseph Kim, Bayan Missaghi, Joseph Vayalumkal, Irene Martin, Valerie Marsten, Jennifer Soucie, Robert Douglas Wilson, Colin Birch, John Conly","doi":"10.1017/ice.2024.154","DOIUrl":"10.1017/ice.2024.154","url":null,"abstract":"<p><p>We analyzed invasive group A streptococcal puerperal sepsis cases in a large health zone in Alberta, Canada between 2013 and 2022. Of the 21 cases, 85.7% were adjudicated as hospital/delivery-acquired, with 2 clusters having identical isolates found through whole genome sequencing. We implemented policy interventions across Alberta aimed at preventing future infections.</p>","PeriodicalId":13663,"journal":{"name":"Infection Control and Hospital Epidemiology","volume":" ","pages":"1-4"},"PeriodicalIF":3.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11518661/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of rehospitalization due to <i>Clostridioides difficile</i> infection among hospitalized patients with <i>Clostridioides difficile</i>: a cohort study.","authors":"Emily N Drwiega, Stuart Johnson, Larry H Danziger, Andrew M Skinner","doi":"10.1017/ice.2024.155","DOIUrl":"https://doi.org/10.1017/ice.2024.155","url":null,"abstract":"<p><strong>Background: </strong>Reducing rehospitalization has been a primary focus of hospitals and payors. Recurrence of <i>Clostridioides difficile</i> infection (CDI) is common and often results in rehospitalization. Factors that influence rehospitalization for CDI are not well understood.</p><p><strong>Objective: </strong>To determine the risk factors that influence rehospitalization caused by CDI.</p><p><strong>Design: </strong>A retrospective cohort study from January 1, 2018, to December 31, 2018, of patients aged ≥18 who tested positive for <i>C. difficile</i> while hospitalized.</p><p><strong>Setting: </strong>Academic hospital.</p><p><strong>Methods: </strong>The risk of rehospitalization was assessed across exposures during and after the index hospitalization using a Cox proportional hazards model. The primary outcome of this study was 60-day CDI-related rehospitalization.</p><p><strong>Results: </strong>There were 559 hospitalized patients with a positive CD test during the study period, and 408 patients were included for analysis. All-cause rehospitalization was 46.1% within 60 days of the index hospital discharge. Within 60 days of discharge, 68 patients developed CDI, of which 72.5% (49 of 68) were rehospitalized specifically for the management of CDI. The risk of rehospitalization in patients with CDI was higher among patients who were exposed to systemic antibiotics ([adjusted hazard ratio] aHR: 2.78; 95% CI, 1.36-5.64) and lower among patients who had post-discharge follow-up addressing <i>C. difficile</i> (aHR: 0.53; 95% CI, 0.28-0.98).</p><p><strong>Conclusions: </strong>Exposure to systemic antibiotics increased the risk of rehospitalization due to CDI, while post-discharge follow-up decreased the risk of rehospitalization due to CDI. Comprehensive transitions of care for hospitalized patients with <i>C. difficile</i> may reduce the risk of CDI-related rehospitalization.</p>","PeriodicalId":13663,"journal":{"name":"Infection Control and Hospital Epidemiology","volume":" ","pages":"1-7"},"PeriodicalIF":3.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exeporfinium chloride (XF-73) nasal gel significantly reduces <i>Staphylococcus aureus</i> nasal carriage in cardiac surgery patients throughout surgery and the early recovery period: results from a randomized placebo-controlled Phase 2 study.","authors":"Julie E Mangino, Michael S Firstenberg, William Rhys-Williams, James P Lees, Aaron Dane, William G Love, Jesus Gonzalez Moreno, Yuri Martina, Debra Barker","doi":"10.1017/ice.2024.122","DOIUrl":"https://doi.org/10.1017/ice.2024.122","url":null,"abstract":"<p><p><i>Staphylococcus aureus</i> nasal carriers were randomized (1:1) to XF-73 or placebo nasal gel, administered 5x over ∼24hrs pre-cardiac surgery. <i>S. aureus</i> burden rapidly decreased after 2 doses (-2.2log₁₀ CFU/mL; placebo -0.01log₁₀ CFU/mL) and was maintained to 6 days post-surgery. Among XF-73 patients, 46.5% received post-operative anti-staphylococcal antibiotics versus 70% in placebo (<i>P</i> = 0.045).</p>","PeriodicalId":13663,"journal":{"name":"Infection Control and Hospital Epidemiology","volume":" ","pages":"1-3"},"PeriodicalIF":3.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk factors for central line-associated bloodstream infection in the pediatric intensive care setting despite standard prevention measures.","authors":"Kaitlyn T Marks, Katherine D Rosengard, Jennifer D Franks, Steven J Staffa, Jenny Chan Yuen, Jeffrey P Burns, Gregory P Priebe, Thomas J Sandora","doi":"10.1017/ice.2024.131","DOIUrl":"https://doi.org/10.1017/ice.2024.131","url":null,"abstract":"<p><strong>Objective: </strong>Identify risk factors for central line-associated bloodstream infections (CLABSI) in pediatric intensive care settings in an era with high focus on prevention measures.</p><p><strong>Design: </strong>Matched, case-control study.</p><p><strong>Setting: </strong>Quaternary children's hospital.</p><p><strong>Patients: </strong>Cases had a CLABSI during an intensive care unit (ICU) stay between January 1, 2015 and December 31, 2020. Controls were matched 4:1 by ICU and admission date and did not develop a CLABSI.</p><p><strong>Methods: </strong>Multivariable, mixed-effects logistic regression.</p><p><strong>Results: </strong>129 cases were matched to 516 controls. Central venous catheter (CVC) maintenance bundle compliance was >70%. Independent CLABSI risk factors included administration of continuous non-opioid sedative (adjusted odds ratio (aOR) 2.96, 95% CI [1.16, 7.52], <i>P</i> = 0.023), number of days with one or more CVC in place (aOR 1.42 per 10 days [1.16, 1.74], <i>P</i> = 0.001), and the combination of a chronic CVC with administration of parenteral nutrition (aOR 4.82 [1.38, 16.9], <i>P</i> = 0.014). Variables independently associated with lower odds of CLABSI included CVC location in an upper extremity (aOR 0.16 [0.05, 0.55], <i>P</i> = 0.004); non-tunneled CVC (aOR 0.17 [0.04, 0.63], <i>P</i> = 0.008); presence of an endotracheal tube (aOR 0.21 [0.08, 0.6], <i>P</i> = 0.004), Foley catheter (aOR 0.3 [0.13, 0.68], <i>P</i> = 0.004); transport to radiology (aOR 0.31 [0.1, 0.94], <i>P</i> = 0.039); continuous neuromuscular blockade (aOR 0.29 [0.1, 0.86], <i>P</i> = 0.025); and administration of histamine H2 blocking medications (aOR 0.17 [0.06, 0.48], <i>P</i> = 0.001).</p><p><strong>Conclusions: </strong>Pediatric intensive care patients with chronic CVCs receiving parenteral nutrition, those on non-opioid sedative infusions, and those with more central line days are at increased risk for CLABSI despite current prevention measures.</p>","PeriodicalId":13663,"journal":{"name":"Infection Control and Hospital Epidemiology","volume":" ","pages":"1-9"},"PeriodicalIF":3.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142464351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in use of multiplex respiratory panel testing during the COVID-19 pandemic.","authors":"Jonathan D Baghdadi, Chih Chun Tung, J Kristie Johnson, Daniel J Morgan, Anthony D Harris","doi":"10.1017/ice.2024.163","DOIUrl":"https://doi.org/10.1017/ice.2024.163","url":null,"abstract":"<p><strong>Background: </strong>COVID-19 changed the epidemiology of community-acquired respiratory viruses. We explored patterns of respiratory viral testing to understand which tests are most clinically useful in the postpandemic era.</p><p><strong>Methods: </strong>We conducted a retrospective observational study of discharge data from PINC-AI (formerly Premier), a large administrative database. Use of multiplex nucleic acid amplification respiratory panels in acute care, including small (2-5 targets), medium (6-11), and large panels (>11), were compared between the early pandemic (03/2020-10/2020), late pandemic (11/2020-4/2021), and prepandemic respiratory season (11/2019 - 02/2020) using ANOVA.</p><p><strong>Results: </strong>A median of 160.5 facilities contributed testing data per quarter (IQR 155.5-169.5). Prepandemic, facilities averaged 103 respiratory panels monthly (sd 138), including 79 large (sd 126), 7 medium (sd 31), and 16 small panels (sd 73). Relative to prepandemic, utilization decreased during the early pandemic (62 panels monthly/facility; sd 112) but returned to the prepandemic baseline by the late pandemic (107 panels monthly/facility; sd 211). Relative to prepandemic, late pandemic testing involved more small panel use (58 monthly/facility, sd 156) and less large panel use (47 monthly/facility, sd 116). Comparisons among periods demonstrated significant differences in overall testing (<i>P</i> < 0.0001), large panel use (<i>P</i> < 0.0001), and small panel use (<i>P</i> < 0.0001).</p><p><strong>Conclusions: </strong>Postpandemic, clinical use of respiratory panel testing shifted from predominantly large panels to predominantly small panels. Factors driving this change may include resource availability, costs, and the clinical utility of targeting important pathogenic viruses instead of testing \"for everything.\"</p>","PeriodicalId":13663,"journal":{"name":"Infection Control and Hospital Epidemiology","volume":" ","pages":"1-6"},"PeriodicalIF":3.0,"publicationDate":"2024-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142390335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}