Infusionstherapie und Transfusionsmedizin最新文献

{"title":"[Proclamation of the Blood Working Group \"Recommendation for appointment and responsibilities of transfusion coordinators, transfusion personnel, transfusion commissions and professional groups for hemotherapy\": clarification and implementation].","authors":"P Hanfland, E Götz, V Kretschmer","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13632,"journal":{"name":"Infusionstherapie und Transfusionsmedizin","volume":"22 6","pages":"379-83"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19569622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Induction of cytokines by colloidal plasma substitutes?].","authors":"F Krombach","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13632,"journal":{"name":"Infusionstherapie und Transfusionsmedizin","volume":"22 6","pages":"330-1"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19569092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Post-transfusion rise in thrombocytes: observations in a hematologic-oncologic patient sample].","authors":"M Böck,&nbsp;K H Muggenthaler,&nbsp;U Schmidt,&nbsp;M U Heim,&nbsp;W Mempel","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>Aim of the present analysis was the evaluation of clinical conditions and product-specific parameters influencing posttransfusion platelet increment.</p><p><strong>Design: </strong>400 single-donor platelet transfusions were analyzed for patient- and concentrate-specific factors influencing posttransfusion platelet increment. Statistical analysis was performed by the General Mixed Model Analysis of Variance.</p><p><strong>Setting: </strong>Department of hematology and oncology at a university hospital.</p><p><strong>Patients: </strong>46 patients (24 male, 22 female; age 17-80 years).</p><p><strong>Interventions: </strong>Single-donor platelet transfusions.</p><p><strong>Results: </strong>As demonstrated earlier, splenomegaly, body temperature, and bone marrow transplantation could be proven as factors reducing posttransfusion platelet increment. In addition, hepatomegaly and application of antibiotics had negative effects on platelet increment. Among the product-specific parameters leukocyte contamination and pretransfusion storage time reduced transfusion success significantly.</p><p><strong>Conclusions: </strong>Clinical factors influencing posttransfusion platelet increment can hardly be controlled. In contrast, concentrate-specific parameters can be influenced by preparation technique and storage procedure. Therefore, high value should be set on low leukocyte contamination and short pretransfusion storage time of platelet concentrates.</p>","PeriodicalId":13632,"journal":{"name":"Infusionstherapie und Transfusionsmedizin","volume":"22 6","pages":"350-4"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19569618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[IgG subclass distribution in intravenous immunoglobulin products: determination of reproducibility of a method of IgG subclass determination. Ring Study of the \"Plasma Blood Components\" Section of the German Society of Transfusion Medicine and Immunohematology].","authors":"R Kotitschke,&nbsp;H Lang,&nbsp;M Page","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The working group \"Blood Plasma Constituents\" of the DGTI has carried out a multicenter study with human immunoglobulins for intravenous administration (IVIG) and a NIBSC serum, with the designation 67/98C, since the European Pharmacopoeia IVIG monograph gives no information for the IgG subclass determination. Aim of the ring study was 1) the determination of the IgG subclass distribution with a standardized method and 2) the determination of the IgG subclass distribution in the NIBSC serum 67/98C and to test if the NIBSC serum coded 67/98C is suited as a reference serum for the IgG subclass determination.</p><p><strong>Material and methods: </strong>Ten laboratories from Europe participated in the ring study. The IgG subclasses were determined by radial immunodiffusion (RID).</p><p><strong>Results: </strong>The results showed good consistency between the participating laboratories and showed distinct differences in the IgG subclass composition of the tested IVIGs. The reproducibility of the method showed coefficients of variation of approximately 10%.</p><p><strong>Conclusion: </strong>The NIBSC serum 67/98C is suitable as reference serum for the IgG subclass determination in sera and IVIGs.</p>","PeriodicalId":13632,"journal":{"name":"Infusionstherapie und Transfusionsmedizin","volume":"22 6","pages":"360-3"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19569620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Flow cytometry detection of erythrocyte antigens and antibodies. Technical aspects and new clinical applications].","authors":"K Fischer,&nbsp;S Wester,&nbsp;A Grundmann,&nbsp;A Poschmann","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>Although hemagglutination techniques have proved worthwhile since many years in immunohematology, they also have several disadvantages. They are manual and subjective visual methods, which make it difficult to quantitate red cell antibodies or surface antigens. Flow cytometric analysis overcomes these limitations because of its ability to analyze individual populations of cells by sensitive, reproducible, and objective methods.</p><p><strong>Materials and methods: </strong>Washed red cells from regular blood donors and patients were analyzed natively and after treatment with enzymes (sialidase, protease) or pneumococcal polysaccharides, using monoclonal Rh antibodies, human 7s-immunoglobulin, and FITC-labeled anti-human IgG or FITC anti-T lectin. The fluorescence intensity of single red cells was determined in the Ortho Cytoron Absolute flow cytometer.</p><p><strong>Results: </strong>We determined the optimal test conditions and normal values by investigation of 50 blood donors. The fluorescence intensity of untreated red cells proved to be constant and therefore was used to adjust the instrument. Furthermore, the data of experimental adsorptions of red cells with pneumococcal antigens, sialidase (Vibrio cholerae) and protease (papain) as well as data from patients suffering from chronic HBV infection and autoimmune hemolytic anemia and acute pancreatitis are presented. A special software program was developed for statistical analysis and graphical presentation of the raw data. The computer program permits to analyze results from different experiments or from different dates and depicts them comparatively in overlay histograms, which may be useful in a serial study of changes of the antibody concentration or antigen expression.</p><p><strong>Conclusion: </strong>The flow cytometric analysis of red cells proves to be a simple, rapid, reproducible, and objective method for antigen and antibody quantitation. Furthermore, this technique may be a useful new tool for the investigation of acute, infection-associated hemolytic anemia.</p>","PeriodicalId":13632,"journal":{"name":"Infusionstherapie und Transfusionsmedizin","volume":"22 6","pages":"344-9"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19569617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Establishing a quality assurance system in transfusion medicine exemplified by the Heidelberg University Blood Bank].","authors":"D Stahl,&nbsp;A Kluge,&nbsp;D Roelcke","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Background: </strong>The 'Zweite Verordnung zur Anderung der Betriebsverordnung für pharmazeutische Unternehmer vom 13. Juli 1994' requires a quality assurance system for the manufacturing of blood products.</p><p><strong>Methods: </strong>On the basis of national law and guidelines we worked out a concept for establishing a quality assurance system at a university blood bank and applied it to the university blood bank at Heidelberg.</p><p><strong>Results: </strong>The quality assurance system of the university blood bank at Heidelberg is based on the components 'quality of structure', 'quality of process' and 'quality of result'. The internal standard is specified in written form for every aspect of structure, process and result by standard operating procedures (SOP). The SOP serve as a basis for the quality system manual and the laboratory reference books. The quality assurance system described here integrates a programme for carrying out internal quality audits as well as a concept for updating SOP at regular intervals.</p><p><strong>Conclusions: </strong>The concept underlying the quality assurance system of the university blood bank at Heidelberg allows continuous quality improvement in transfusion medicine; moreover, it offers the chance to integrate quality assurance in transfusion medicine in an interdisciplinary, patient-orientated, not only regional concept of quality assurance.</p>","PeriodicalId":13632,"journal":{"name":"Infusionstherapie und Transfusionsmedizin","volume":"22 6","pages":"364-77"},"PeriodicalIF":0.0,"publicationDate":"1995-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19569621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Glutamine supplemented nutrition in clinical practice--use of glutamine-containing dipeptides].","authors":"P Fürst,&nbsp;P Stehle","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Objective: </strong>In this review, the central role of glutamine in a large number of pathways is elucidated and the consequences of bodily glutamine deprivation observed during trauma, hypercatabolism and malnutrition on vital functions of organs and tissues are discussed. Subsequently, the use of glutamine and glutamine-containing dipeptides in the frame of clinical nutrition is critically evaluated. Finally, the prospective importance of glutamine nutrition in routine clinical settings is discussed.</p><p><strong>Design: </strong>For this compilation basic work from human physiology and nutrition science as well as all actual research work dealing with the use of glutamine and glutamine dipeptide supplements in clinical nutrition have been considered.</p><p><strong>Results: </strong>In various diseased states (like trauma, hypercatabolism, intestinal dysfunction, immunedeficiency) glutamine has to he considered a conditionally indispensable substrate and thus should be essential part of all nutritional efforts. Only adequate glutamine supply (about 10-15 g/day) can prevent bodily glutamine deprivation which may beneficially influence the clinical situation. The use of highly soluble and stable glutamine-containing dipeptides facilitates for the first time a safe and efficient glutamine supply within parenteral nutrition.</p><p><strong>Conclusions: </strong>Enteral/parenteral glutamine therapy may contribute to improve nitrogen economy, to diminish the incidence of bacterial infections, to reduce the risk for bacterial translocation, and presumably to reduce hospital stay in various patient groups.</p>","PeriodicalId":13632,"journal":{"name":"Infusionstherapie und Transfusionsmedizin","volume":"22 5","pages":"317-24"},"PeriodicalIF":0.0,"publicationDate":"1995-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19889034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of cytokine profiles of stored CPDA-1 whole blood.","authors":"R Grunenberg,&nbsp;J Krüger","doi":"10.1159/000223145","DOIUrl":"https://doi.org/10.1159/000223145","url":null,"abstract":"<p><strong>Background: </strong>The pathophysiologic mechanisms of symptoms of nonhemolytic febrile transfusion reactions (NHFTR) are complex and sometimes poorly understood. The prevalence of these reactions especially with platelet transfusions has been attributed more recently to storage-dependent cytokine levels. Until now cytokine concentrations in whole blood (WB) have found very little attention though WB is still relevant to autologous blood and a systematic evaluation of the storage lesion of WB remains of general interest.</p><p><strong>Methods: </strong>Concentrations of interleukins (IL-1beta, IL-6, IL-8), granulocyte-macrophage colony stimulating factor (GM-CSF), and tumor necrosis factors (TNF-alpha, TNF-beta) were analyzed in blood samples drawn from 7 units of WB over a storage period of 35 days. All cytokine concentrations were determined by enzyme immunoassays.</p><p><strong>Results: </strong>IL-1beta, IL-8 increased steadily in all units and TNF-beta in 3 out of 7 from undetectable levels to concentrations of the lower standard ranges. IL-6 and TNF-alpha showed a mean low level plateau. On GM-CSF release storage seemed to have a minor transient effect.</p><p><strong>Conclusions: </strong>It seems questionable that on storage the presence of cytokines in WB reaches concentrations sufficient to explain NHFTR. At present the depletion of leukocytes as the main source of cytokines may not be necessary to be carried to the extreme.</p>","PeriodicalId":13632,"journal":{"name":"Infusionstherapie und Transfusionsmedizin","volume":"22 5","pages":"292-4"},"PeriodicalIF":0.0,"publicationDate":"1995-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000223145","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19889152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proceedings of the 27th Congress of the German Society of Transfusion Medicine and Immuno-Hematology. 19-22 October 1994, Saarbrucken, Germany.","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13632,"journal":{"name":"Infusionstherapie und Transfusionsmedizin","volume":"22 Suppl 1 ","pages":"1-170"},"PeriodicalIF":0.0,"publicationDate":"1995-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"24826159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Cooperation between the clinic and transfusion medicine].","authors":"V Sachs","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":13632,"journal":{"name":"Infusionstherapie und Transfusionsmedizin","volume":"22 5","pages":"272-3"},"PeriodicalIF":0.0,"publicationDate":"1995-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"19890663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}