Journal of Surgical Endocrinology最新文献

{"title":"Hormonal Pathology of the Endometrium and Endometrial Carcinoma","authors":"Schor Liane Deligdisch, Miceli Angelica Mareş","doi":"10.36959/608/460","DOIUrl":"https://doi.org/10.36959/608/460","url":null,"abstract":"Endometrial cancer is the most common gynecologic cancer in the USA, with over 66,570 new cases and 13,000 deaths due to the disease, estimated for 2021. Worldwide, mostly in the industrialized countries, the incidence of this neoplasm has risen by about 20% over the two last decades, with over 380.000 new cases predicted for 2021, while other gynecologic malignancies such as uterine cervical cancer have decreased in spectacular proportions.","PeriodicalId":136163,"journal":{"name":"Journal of Surgical Endocrinology","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126814204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enucleation of Pancreatic Insulinomas with the use of Intraoperative Ultrasonography","authors":"T. Patricio Cabané, E. Patricio Gac, C. Miren Carredano, M. Francisco Rodríguez, R. Patricio Palavecino, M. Iván Gallegos, A. Francisco Cordero, K. José De La Torre, V. José Amat","doi":"10.36959/608/466","DOIUrl":"https://doi.org/10.36959/608/466","url":null,"abstract":"","PeriodicalId":136163,"journal":{"name":"Journal of Surgical Endocrinology","volume":"33 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123984135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Parathyroid Carcinoma Management in an Underdeveloped Country: A Case Series","authors":"Cabrera-Luis Jasmin, Herrera Laura, Hache-Marliere Manuel, R. Juliá, Crespo Aldo, Batista Sylvia","doi":"10.36959/608/464","DOIUrl":"https://doi.org/10.36959/608/464","url":null,"abstract":"Parathyroid carcinoma (PC) is a rare type of cancer that presents in individuals during their 4th or 5th decade of life; most cases are sporadic and of unknown etiology [1]. Approximately 1-2% of cases of hyperparathyroidism are caused by PC; with the average serum calcium levels higher in patients with PC than parathyroid adenomas (15.9 vs 12 mg/dL). Clinical diagnosis is often difficult and almost always invariably obtained after postoperative histopathological confirmation; making this disease rare and likely under diagnosed. Para fibromin immunostaining is currently the gold standard for definitive diagnosis; albeit its availability may be limited in resource-poor settings. We report a case series of five PCs who were diagnosed with primary hyperparathyroidism (pHPT) and underwent parathyroidectomy in a 10-year period. All of the patients in this case series presented post-surgery hungry bone syndrome (HBS). Efforts should be taken to establish more reliable and precise diagnostic tools to establish concrete guidelines for the management of PCs.","PeriodicalId":136163,"journal":{"name":"Journal of Surgical Endocrinology","volume":"54 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127595822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent Hypoglycemia as a Presenting Symptom for Rare IGF-2 Secreting Retroperitoneal Spindle Cell Neoplasm","authors":"T. David, S. Lux","doi":"10.36959/608/465","DOIUrl":"https://doi.org/10.36959/608/465","url":null,"abstract":"Spindle cell neoplasms are a broad group of connective tissue cancers that have spindle-shaped cells under microscopy [1]. Solitary Fibrous Tumors (SFT) are a rapidly growing and rare spindle cell neoplasm that generally occur in the thorax and comprise roughly 2% of all soft-tissue masses [2]. Due to their rarity, it is difficult to ascertain a true incidence rate. Memorial Sloan-Kettering Cancer Center has studied their cases of SFTs from 1982-2000, inclusively. This data can shine light on the rarity of this malignancy along with providing a good look into the varied presentations and patterns of SFTs. In the 18 year study period, 134 cases of SFTs were identified, 55 cases were excluded, and 79 were studied further [3]. Out of the 79 confirmed cases, 1 was retroperitoneal and 54 were thoracic masses. The remaining 24 were varied between the head/neck, pelvis, and extremities. The most common characteristics for the tumors were that they were nonnecrotic (77%), had no malignant component (80%), lacked macroscopic surgical margins (95%), and lacked microscopic surgical margins (82%). A statistically significant amount of patients with extra thoracic SFTs were symptomatic (83%). An unexpected symptom for someone with a solid tumor is recurrent hypoglycemia.","PeriodicalId":136163,"journal":{"name":"Journal of Surgical Endocrinology","volume":"60 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129281306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Operative Chloride Phosphate and Calcium Phosphate Ratios in Hyperparathyroidism Patients","authors":"W. Courtney, King Deanne, Silva-Nash Jennifer, Stack Brendan C","doi":"10.36959/608/462","DOIUrl":"https://doi.org/10.36959/608/462","url":null,"abstract":"Background: To determine significance of longitudinal laboratory testing and their ratios after parathyroidectomy in patients with primary hyperparathyroidism (pHPT). Methods: Patients referred for evaluation of pHPT. Patient data was collected prospectively preoperatively as well as one month and one year post op. Changes in data were analyzed. T tests were used to determine significance. Results: Post op there were significant decreases in parathyroid hormone (PTH) and calcium when comparing to preoperative data, however no significant difference between one month and one year post op, p = .170 (PTH) and p = .315 (calcium) were noted. The average Ca: PO 4 decreased post op from 3.73 to 2.65, p = .000. There was a significant increase to 2.74 at one year. Cl: PO4 decreased preop to postop, p = .000 and there was no difference when comparing one month and year postop values. Conclusions: Our study highlights the value of using common lab values and their ratios to aid in post-operative follow up of a spectrum of patients with pHPT.","PeriodicalId":136163,"journal":{"name":"Journal of Surgical Endocrinology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122197509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Robot-Assisted Laparoscopic Adrenalectomy for Large Adrenocortical Carcinoma in a 17-year old Patient","authors":"Boncaldo Michael, S. Imran","doi":"10.36959/608/463","DOIUrl":"https://doi.org/10.36959/608/463","url":null,"abstract":"Surgical resection remains the standard of care for adrenocortical carcinoma (ACC). The optimal approach for complete surgical resection is constantly evolving as surgeons seek to attain more minimally invasive methods that align with appropriate patient care. While an open approach is most frequently employed, as surgeons seek more minimally invasive methods, laparoscopy is being used more and more in practice. Although robotic-assisted laparoscopy as a means to resect ACC has only been mentioned a handful of times in the literature, it has been when pertaining to tumors under 10 cm and in adults. We seek to describe the first reported robot-assisted-laparoscopic adrenalectomy used to resect an 11cm ACC in a pediatric patient. Check for updates time.Other than a blood pressure of 175/113, his vital signs were within normal limits. On examination, he had findings of moon-like facies, plethora, acne, prominent abdominal striae, and supraclavicular fat maldistribution. In addition to a urinalysis consistent with a ureteral stone, his blood demonstrated low eosinophils, neutrophilia, lymphopenia, hypokalemia, and hypernatremia. On imaging, the CT scan showed both a 9.1 x 10.8 x 9.1 cm heterogeneously-enhancing right suprarenal mass and a 3mm ureteral stone in the right ureter. After being discharged the same day with plans for medical management of the ureteral stone, the patient followed up the following week with the endocrinologist for the right adrenal mass. His blood work demonstrated high levels of cortisol consistent with the diagnosis of ACC causing Cushing’s syndrome. After a PET scan showed no signs of distant metastases, the patient was placed on appropriate doses of Eplenerone, Labetalol, and Potassium Chloride to manage his symptoms prior to surgery. He underwent a robot-assisted laparoscopic right radical adrenalectomy with lymphadenectomy utilizing a trans abdominal approach. Citation: Boncaldo M, Siddiqui I (2022) Robot-Assisted Laparoscopic Adrenalectomy for Large Adrenocortical Carcinoma in a 17-year old Patient. J Surgical Endocrinol 4(1):136-138 Boncaldo M, et al. J Surgical Endocrinol 2022, 4(1):136-138 Open Access | Page 137 | 67 proliferation index and tumor markers such as TP53, IGF2, and cyclin E [11]. The neoplasm is staged based on TNM staging system from the AJCC/UICC, in which Stage IV disease exclusively refers to disease with distant metastases. The 5-year, disease-specific survival rates range from 82% at stage I disease down to 13% at stage IV with an overall rate of 51% [12]. Due to such an aggressive form of cancer, surgical resection is the only curative form of management and is always performed unless the patient is a poor surgical candidate. Because of the rarity of ACC, the standard surgical procedure is constantly being re-evaluated and altered. Historically, open adrenalectomy has been the recommended treatment, but the use of laparoscopy and robot-assisted laparoscopy is being explored more often over time.","PeriodicalId":136163,"journal":{"name":"Journal of Surgical Endocrinology","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117214419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synchronous Bilateral Retroperitoneoscopic Cortical Sparring Adrenalectomies - Case Series and Literature Review","authors":"Kendric Tan Jun Guang, Wong Sze Ling","doi":"10.36959/608/458","DOIUrl":"https://doi.org/10.36959/608/458","url":null,"abstract":"Pheochromocytomas occur bilaterally in 3-11% of all patients and up to 60% of patients with hereditary syndromes such as Von Hippel-Lindau (VHL) disease and Multiple Endocrine Neoplasia 2 (MEN2) [1-2]. Hence, treatment inevitably involves removal of both adrenal glands [3]. Favourable data supporting cortical sparing bilateral adrenalectomy for bilateral hereditary pheochromocytomas was first reported in 1996 [4], and current guidelines continue to support this approach to prevent permanent hypocortisolism [5].","PeriodicalId":136163,"journal":{"name":"Journal of Surgical Endocrinology","volume":"27 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121990107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Literature Review and Case-Series of Atypical Anatomic Locations for Parathyroid Glands","authors":"Vidovich Stefan, Wickemeyer Johanna, Keirkhah Pouyan, Rubenfeld Ari","doi":"10.36959/608/457","DOIUrl":"https://doi.org/10.36959/608/457","url":null,"abstract":"Specialty area: Endocrine surgery. Introduction: Essential to successful parathyroid surgery is understanding of the possible anatomic variations in parathyroid gland location. In this case-series, we highlight three patients with uniquely located parathyroid glands as noted during primary neck exploration. Methods: This is a case-series that details three different patients’ health histories, diagnostic workups, intraoperative findings, and surgical pathology analyses. All three patients were evaluated and treated with parathyroidectomy for hyperparathyroidism between May and September of 2020. All data was collected from patient electronic medical records at UIHealth – University of Illinois at Chicago and de-identified in December of 2020. Results: The first case demonstrated an inferiorly descended left superior parathyroid gland in the mediastinum. The second case exhibited bilateral intrathymic inferior parathyroid. The third case demonstrated a parathyroid adenoma intimately associated with the left vagus nerve, deep in the carotid sheath. Conclusion: These three unique cases demonstrate the variations in parathyroid anatomy that may be encountered prior to and during parathyroid surgery. Increased vigilance for parathyroid ectopy amongst endocrine surgeons in the preoperative imaging and intraoperative settings affords an opportunity to maximize success of primary neck exploration.","PeriodicalId":136163,"journal":{"name":"Journal of Surgical Endocrinology","volume":"91 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116295824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant Parathyroid Adenoma: A Case of Primary Hyperparathyroidism","authors":"Cabrera Jasmin N, R. Juliá, Batista Sylvia","doi":"10.36959/608/456","DOIUrl":"https://doi.org/10.36959/608/456","url":null,"abstract":"We report an adult male with the sole condition of recurrent nephrolithiasis, with no other associated symptoms nor family history, who was later diagnosed with Primary Hyperparathyroidism due to a giant right superior parathyroid adenoma. To the best of our knowledge, this is one of the few well-documented cases of this rare presentation in a male patient of the Dominican Republic. This case should affect the practice of physicians who interact with primary hyperparathyroidism and are involved in their management.","PeriodicalId":136163,"journal":{"name":"Journal of Surgical Endocrinology","volume":"360 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126696524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bilateral Synchronous Adrenal Tumors in Lynch Syndrome","authors":"Vierra Mason, Ganeles Arina","doi":"10.36959/608/455","DOIUrl":"https://doi.org/10.36959/608/455","url":null,"abstract":"A 65-year-old Hispanic male with Lynch Syndrome and a history colon cancer was incidentally found to have bilateral adrenal tumors by CT scan. A PET scan revealed marked FDG avidity of both adrenal masses; with an SUV of up to 24.5. The patient was asymptomatic at the time. The patient underwent bilateral adrenalectomy and left nephrectomy. Final pathology demonstrated high-grade malignant spindle cell neoplasm with sarcomatoid features. Immunohistochemistry for the MMR proteins showed decreased protein expression of MLH1, negative staining for PMS2, and intact tumor staining of MSH2 and MSH6.","PeriodicalId":136163,"journal":{"name":"Journal of Surgical Endocrinology","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124425535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}