Oxford Textbook of Rheumatoid Arthritis最新文献_第2页

Oxford Textbook of Rheumatoid Arthritis Pub Date : 2020-09-01 DOI: 10.1093/med/9780198831433.003.0032

N. Hassan, E. Choy

引用次数: 11

Clinical outcomes 临床结果

Oxford Textbook of Rheumatoid Arthritis Pub Date : 2020-09-01 DOI: 10.1093/med/9780198831433.003.0042

D. Scott

{"title":"Clinical outcomes","authors":"D. Scott","doi":"10.1093/med/9780198831433.003.0042","DOIUrl":"https://doi.org/10.1093/med/9780198831433.003.0042","url":null,"abstract":"The clinical outcomes measured in rheumatoid arthritis span three broad areas. Firstly, disease measures reflecting the presence and severity of joint inflammation. Secondly, end-organ damage particularly the extent and severity of joint damage. Thirdly, quality of life measures made by patients indicating the impact of their disease on their lives. Some are disease specific such as the Health Assessment Questionnaire (HAQ). Others are generic and applicable across all disease, such as the Short Form 36 (SF-36) and EuroQol. Several new patient-assessed outcome measures have been developed, such as the Patient-Reported Outcome Measurement Information System (PROMIS) and the Rheumatoid Arthritis Impact of Disease (RAID) score. Whether one of these new measures becomes dominant is currently uncertain. Clinical outcomes need to measure what is intended and have face, content, construct, and criterion validity. They also need to discriminate between states of interest reliably, exhibit sensitivity to change, and be easily measured and applied, given constraints of time, money, and interpretability. Different clinical outcomes are closely interrelated. Finally, clinical outcomes such as the EuroQol can be used to generate quality-adjusted life years (QALY), which are used in health economic studies. Measuring disease outcomes is essential for good medical care, which can only improve when clinicians know the results of their treatments and incorporate patients’ views.","PeriodicalId":135409,"journal":{"name":"Oxford Textbook of Rheumatoid Arthritis","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122283664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The history of rheumatoid arthritis 类风湿关节炎的病史

Oxford Textbook of Rheumatoid Arthritis Pub Date : 2020-09-01 DOI: 10.1093/med/9780198831433.003.0001

D. Scott

引用次数: 1

Magnetic resonance imaging in rheumatoid arthritis 类风湿关节炎的磁共振成像

Oxford Textbook of Rheumatoid Arthritis Pub Date : 2020-09-01 DOI: 10.1007/978-1-907673-91-7_6

M. Østergaard, M. Axelsen, M. Boesen

引用次数: 0

Pre-rheumatoid arthritis Pre-rheumatoid关节炎

Oxford Textbook of Rheumatoid Arthritis Pub Date : 2020-09-01 DOI: 10.1093/med/9780198831433.003.0012

K. Raza, Catherine M. McGrath, L. Boheemen, D. Schaardenburg

{"title":"Pre-rheumatoid arthritis","authors":"K. Raza, Catherine M. McGrath, L. Boheemen, D. Schaardenburg","doi":"10.1093/med/9780198831433.003.0012","DOIUrl":"https://doi.org/10.1093/med/9780198831433.003.0012","url":null,"abstract":"The typical evolution of rheumatoid arthritis (RA) is that a person, with genetic risk factors, develops autoantibodies and subclinical inflammation under relevant environmental influences. There are indications that the primary site of the pathology is at mucosal surfaces (e.g. in the gums, lungs, and/or the gut), after which the disease translocates to the joints. Preclinical RA can be defined at the phase during which no clinically apparent features are present (i.e. no symptoms of inflammatory arthritis or clinically apparent joint swelling) but during which RA related biologic derangements such as the presence of autoantibodies are present. This chapter presents an overview of the risk factors, stages, and events occurring during the pre-RA phase. A better understanding of the factors involved will enable more accurate prediction of RA at the individual level and selection of high-risk individuals for inclusion in preventive studies. Several pharmacologic and non-pharmacologic studies aiming to prevent or delay the onset of RA in at-risk individuals are currently underway. It is hoped that such interventions in the pre-RA and indeed in the preclinical-RA phases will allow us to reduce the risk of RA and prevent RA developing in at least a proportion of at-risk patients.","PeriodicalId":135409,"journal":{"name":"Oxford Textbook of Rheumatoid Arthritis","volume":"101 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129330607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synovial biopsies 滑膜活检

Oxford Textbook of Rheumatoid Arthritis Pub Date : 2020-09-01 DOI: 10.1093/med/9780198831433.003.0016

Douglas J. Veale, Ursula Fearon

引用次数: 0

Diagnosis 诊断。

Oxford Textbook of Rheumatoid Arthritis Pub Date : 2020-09-01 DOI: 10.1093/med/9780198831433.003.0002

D. Aletaha, H. Radner

引用次数: 0

Clinical features of rheumatoid arthritis 类风湿关节炎的临床特征

Oxford Textbook of Rheumatoid Arthritis Pub Date : 2020-09-01 DOI: 10.1093/med/9780198831433.003.0011

A. Mil

引用次数: 2