Indonesian Journal of Pharmaceutics最新文献_第2页

Veterinary Drug Development from Indonesian Herbal Origin: Challenges and Opportunities 印尼草药兽药开发:挑战与机遇

Indonesian Journal of Pharmaceutics Pub Date : 2021-04-01 DOI: 10.24198/idjp.v3i1.33632

Yedi Herdiana, Nasrul Wathoni, Sriwidodo Sriwidodo, I. K. M. Adnyane

引用次数: 0

Mini Review : Sedem System as a Tool to Characterize Excipients in Solid Dosage Form 迷你回顾:Sedem系统作为表征固体剂型辅料的工具

Indonesian Journal of Pharmaceutics Pub Date : 2021-03-20 DOI: 10.24198/idjp.v3i1.34038

I. Sopyan, Rizka Guntina Khairunisa

引用次数: 1

Pharmaceutical Industrial Waste Regulation in Five Countries in Asia 亚洲五国的医药工业废物管制

Indonesian Journal of Pharmaceutics Pub Date : 2021-03-01 DOI: 10.24198/idjp.v3i1.33383

Luthfia Azzahra, N. M. Saptarini

{"title":"Pharmaceutical Industrial Waste Regulation in Five Countries in Asia","authors":"Luthfia Azzahra, N. M. Saptarini","doi":"10.24198/idjp.v3i1.33383","DOIUrl":"https://doi.org/10.24198/idjp.v3i1.33383","url":null,"abstract":"The pharmaceutical industry produces a various toxic wastes. Generated waste increases the risk of environmental and ecosystem pollution. It is necessary to have proper waste management to prevent waste pollution to the environment. In 1999, WHO published “Guidelines for the Safe Disposal of Unwanted Pharmaceuticals in and after Emergencies”, that contain treatments and safe disposal method, which is appropriate for any country. Many countries had developed and published regulations and guidelines on waste management. This article aimed to review the handling of pharmaceutical industrial waste in five countries in Asia. This review included studies from ProQuest, Crossref, and Google Scholar. The pharmaceutical industries in Indonesia, India, Japan, Thailand, and China has their own state regulations in order to protect the environment. They also had implemented pharmaceutical industrial waste management following their regulation and guidelines. The method used to treat the waste is similar with WHO guideline. Some factors affecting the country regulations are the insufficient of land and waste management facilities, lack of awareness, low penalties, limited infrastructures, lack of waste testing facilities. The challenge in the future to handle pharmaceutical waste are increasing waste volume, decreasing land for waste management, sewer methods may contaminate water, possible air pollution due to incineration, so it is necessary to have more advanced methods in waste management that are safe for the environment and humans.Keywordz: Industry, Pharmaceutical, Waste Regulation, Asia","PeriodicalId":13455,"journal":{"name":"Indonesian Journal of Pharmaceutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78420960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formulation, Characterization, and Herbal Drug Delivery Applications of Ethosome, Transfersome, and Transethosome 酶体、转移体和转位体的配方、表征和草药药物递送应用

Indonesian Journal of Pharmaceutics Pub Date : 2020-12-29 DOI: 10.24198/IDJP.V2I3.29154

Luthfia Azzahra, S. R. Mita, Sriwidodo Sriwidodo

{"title":"Formulation, Characterization, and Herbal Drug Delivery Applications of Ethosome, Transfersome, and Transethosome","authors":"Luthfia Azzahra, S. R. Mita, Sriwidodo Sriwidodo","doi":"10.24198/IDJP.V2I3.29154","DOIUrl":"https://doi.org/10.24198/IDJP.V2I3.29154","url":null,"abstract":"Herbal compounds have different physicochemical properties. Its use on the oral route often has low biological availability. Therefore, alternative transdermal routes are used through the skin. The stratum corneum skin layer is the most difficult layer to penetrate. Therefore it is necessary to use a drug delivery system such as ethosome, transfersome or transethosome to increase transdermal drug delivery. This review article aims to look at the potential of ethosome, transfersome, and transethosome in increasing their ability to deliver herbal drugs in terms of their formulation and characterization. Literature searches were performed using online search engines namely NCBI and Google Scholar with the keywords ‘Transdermal Drug Delivery System’, 'Ethosome', 'Transfersome', and 'Transethosome'. The result showed compositions of ethosomes are phospholipids, water, and ethanol. The composition of transfersome is phospholipid, water, and edge activator. Transethosomes are a combination of phospholipids, water, ethanol, and edge activators. The role of ethanol and edge activator is thought to increase skin permeation. Transdermal drug delivery systems can be used on herbal drugs to increase transdermal drug delivery.Keywords: Transdermal, Ethosome, Transfersome, Transethosome, Herbal.","PeriodicalId":13455,"journal":{"name":"Indonesian Journal of Pharmaceutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2020-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82328868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Interaction of Warfarin with Herbs Based on Pharmacokinetic and Pharmacodynamic Parameters 基于药动学和药效学参数的华法林与草药的相互作用

Indonesian Journal of Pharmaceutics Pub Date : 2020-06-05 DOI: 10.24198/idjp.v2i2.27289

A. Soyata, Aliya Nur Hasanah, T. Rusdiana

引用次数: 0

Solubility Enhancement of Clozapine Through Co-Crystal Formation with Isonicotinamide 氯氮平与异烟酰胺共晶增强溶解度的研究

Indonesian Journal of Pharmaceutics Pub Date : 2019-11-26 DOI: 10.24198/idjp.v2i1.23957

Fikri Alatas, Hestiary Ratih, Hesti Kurnia, S. N. Soewandhi

{"title":"Solubility Enhancement of Clozapine Through Co-Crystal Formation with Isonicotinamide","authors":"Fikri Alatas, Hestiary Ratih, Hesti Kurnia, S. N. Soewandhi","doi":"10.24198/idjp.v2i1.23957","DOIUrl":"https://doi.org/10.24198/idjp.v2i1.23957","url":null,"abstract":"Clozapine (CLO) is an effective atypical antipsychotic to control the symptoms of psychosis and schizophrenia. Clozapine has low solubility and high permeability, so it is classified as a class II in the biopharmaceutical classification system. The aim of this study was to improve the solubility and dissolution rate of clozapine by clozapine-isonicotinamide (CLO-INA) co-crystal formation. CLO-INA co-crystal was prepared by solvent-drop grinding (SDG) method using water as a solvent. Characterization of SDG result was conducted by powder X-ray diffraction (PXRD) and Fourier transform infrared (FTIR). Solubility test was performed in water at room temperature. The dissolution test was performed in 900 mL of pH 6.8 phosphate buffer solution, 50 rotation per minute of paddle rotation, and at 37±0.5 °C. The PXRD pattern of SDG result of CLO-INA has many different peaks from its parent components, and this may indicate the co-crystal formation. The solubility of the co-crystal clozapine was fifteen folds higher than pure clozapine. The dissolution rate of CLO-INA co-crystal increased in the first 10 minutes compared to pure clozapine. Percentage of clozapine dissolved after 10 minutes from CLO-INA co-crystal and pure CLO were 10.2 and 2.4%, respectively. CLO and INA can form co-crystal by SDG method that can improve the solubility and dissolution rate of clozapine.Keywords: Clozapine, Isonicotinamide, Co-crystal, Solubility, Dissolution","PeriodicalId":13455,"journal":{"name":"Indonesian Journal of Pharmaceutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86921482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Solvent Evaporation as an Efficient Microencapsulating Technique for Taste Masking in Fast Disintegrating Oral Tablets 快速崩解口服片中溶剂蒸发掩味微胶囊技术的研究

Indonesian Journal of Pharmaceutics Pub Date : 2019-10-01 DOI: 10.24198/idjp.v1i3.23491

N. Belali, A. Chaerunisaa

{"title":"Solvent Evaporation as an Efficient Microencapsulating Technique for Taste Masking in Fast Disintegrating Oral Tablets","authors":"N. Belali, A. Chaerunisaa","doi":"10.24198/idjp.v1i3.23491","DOIUrl":"https://doi.org/10.24198/idjp.v1i3.23491","url":null,"abstract":"Microencapsulation is an extensively used technology of present era, that has been applied to various fields like pharmaceutical industry, agriculture, cosmetics and food technology. With the help of which liquid or solid material can be encapsulated inside a polymeric coating film for various reasons such as taste masking, control release and enhancing stability and etc. Microencapsulation can be achieved with different approaches and methods but one of the popular and frequently used feasible method is Solvent evaporation. Solvent evaporation is based on emulsification, solvent evaporation and extraction of microspheres, recently many variations have been made in this technology to improve the yield and properties of microspheres. Solvent evaporation has been widely used in microencapsulating for different purposes one of which is taste masking of bitter drugs in fast disintegrating oral tablets, for pediatric and geriatric use. FDTs are center of attraction due to their merits and feasibility of use for people with problem of dysphagia at the same time, it can also improve bioavailability and time of action of drugs. The main focus of current review is use of solvent evaporation technique for taste masking of bitter drugs in production of fast disintegrating oral tablets. In this review, we will summarize uses, novelties and variations in Solvent Evaporation technique, preparation technique, materials used, merits and demerits of this method over other microencapsulation method in taste masking.Keywords: Microencapsulation, Solvent Evaporation, FDTs, extraction, microspheres","PeriodicalId":13455,"journal":{"name":"Indonesian Journal of Pharmaceutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89311533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Formulation and Physical Evaluation of Cream Containing Neem Oil 5% 含5%印楝油乳膏的配方及物理评价

Indonesian Journal of Pharmaceutics Pub Date : 2019-10-01 DOI: 10.24198/idjp.v1i3.23715

P. Husni, A. Amalia, S. R. Mita, N. Putriana

引用次数: 0

Dissolution Behaviours of Acetaminophen and Ibuprofen Tablet Influenced By L–HPC 21, 22, and Sodium Starch Glycolate as Disintegrant l - hpc21、22和乙醇酸淀粉钠对对乙酰氨基酚和布洛芬片溶出行为的影响

Indonesian Journal of Pharmaceutics Pub Date : 2019-10-01 DOI: 10.24198/idjp.v1i3.23508

Yoga Windhu Wardhana, D. Priambodo

{"title":"Dissolution Behaviours of Acetaminophen and Ibuprofen Tablet Influenced By L–HPC 21, 22, and Sodium Starch Glycolate as Disintegrant","authors":"Yoga Windhu Wardhana, D. Priambodo","doi":"10.24198/idjp.v1i3.23508","DOIUrl":"https://doi.org/10.24198/idjp.v1i3.23508","url":null,"abstract":"The dissolution of tablets is one of a drug absorption determinant. Disintegrant agent has play an important role on determining the dissolution of tablets. In this experiment, the dissolution behaviours of Acetaminophen and Ibuprofen Tablet was studied using various disintegrant agent such as Low substituted – Hydroxypropyl Cellulose (L–HPC) 21, L–HPC 22 and Sodium Starch Glycolate (SSG) as comparator. Those disintegrant agents were used at three concentration (6%, 7% and 8%) for every tablets formula. Tablets were made by wet granulation method and pressed using single punch 13 mm flat E. Korsch machine. Evaluation of each tablets quality were conducted include for uniformity of weight and size (diameter and thickness), hardness, friability, disintegration time and dissolution. Physically standards from tablets were in good condition, the standards of the weight and thickness uniformity, hardness and friability met the requirement. The dissolution profile on Acetaminophen Tablets showed that only tablet with 6 % L–HPC 21 did not meet the requirement of FI V (Q = 80%, 30 minutes), but on Ibuprofen Tablets where met the requirement of FI V (Q = 80%, 60 minutes) only tablet with 8% L– HPC 21, 7% and 8% SSG. The conclusion of the study was the L–HPC has more disintegrant character at hydrophilic active ingredients. Key words: Acetaminophen Tablet, Ibuprofen Tablet, SSG, L-HPC 21 and 22, Dissolution Profile","PeriodicalId":13455,"journal":{"name":"Indonesian Journal of Pharmaceutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74145078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticles Targeted Drug Delivery Aystem via Epidermal Growth Factor Receptor: a Review 表皮生长因子受体纳米颗粒靶向给药系统研究进展

Indonesian Journal of Pharmaceutics Pub Date : 2019-09-22 DOI: 10.24198/idjp.v1i3.23613

Agus Rusdin, Nasrul Wathoni, K. Motoyama, I. Joni, R. Lesmana, M. Muchtaridi

{"title":"Nanoparticles Targeted Drug Delivery Aystem via Epidermal Growth Factor Receptor: a Review","authors":"Agus Rusdin, Nasrul Wathoni, K. Motoyama, I. Joni, R. Lesmana, M. Muchtaridi","doi":"10.24198/idjp.v1i3.23613","DOIUrl":"https://doi.org/10.24198/idjp.v1i3.23613","url":null,"abstract":"Overexpressing of epidermal growth factor receptor (EGFR) in specific organ implicates tumour aggression and proliferation. Therefore, EGFR becomes a primary consideration for targeted cancer therapy. Nanoparticle drug delivery system is a promising multifunctional technique to provide the targeted drug delivery system. This review was aimed to discuss the nanoparticles formulation for targeted drug delivery system via EGFR. The data were collected from published journals recorded in the Scopus database. Various types of nanoparticles were widely studied to provide an EGFR-targeted drug delivery system. The formulations using specific targeting mediators were conjugated on several technologies such as polymeric nanoparticles, nanometals, and miscellaneous nanoparticles. Most of nanoparticles formulation become an excellent delivery carrier for drugs or gene to site-specific targeted by in vitro and in vivo evaluations. EGFR-targeted drug delivery system could be a promising technique to provide high effectiveness of drugs in EGFR-positive cells cancers with lower side effects to non-tumour cells.Keywords : Epidermal growth factor receptor, Cancer, Nanoparticle, targeted drug","PeriodicalId":13455,"journal":{"name":"Indonesian Journal of Pharmaceutics","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82999589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4