Indian journal of leprosy最新文献_第9页

Is there a relation between hemicrania continua and leprosy? 持续性偏头痛和麻风病有关系吗?

Indian journal of leprosy Pub Date : 2012-10-01

K S Ferreira, D J Freitas, J G Speciali

{"title":"Is there a relation between hemicrania continua and leprosy?","authors":"K S Ferreira, D J Freitas, J G Speciali","doi":"","DOIUrl":"","url":null,"abstract":"The association of hemicrania continua and leprosy has been described in 2008. This relation can be causal or casual. Hemicrania continua is a strictly unilateral, moderate to severe, continuous, indomethacin-responsive primary headache with autonomic cranial symptoms and leprosy is an usual cause of peripheral neuropathy. Prevalence has fallen in the past years, but transmission continues and leprosy remains a public health problem. The objective of this study is to report one case of headache fulfilling the IHS criteria for HC, presented during the course of leprosy. A 61 years old woman started hypo and hiperpigmented lesions with impaired sensation to touch on right side of face (malar). She had biopsy in facial lesion and histopathology compatible with a borderline leprosy form. At the same time, she reported new headaches, daily and continuous, without pain-free periods, unilateral (which were located in the same side of the leprosy lesion in face), throbbing and severe (VAS = 8) with ipsilateral conjuntival injection and lacrimation that improved with indomethacin. We hypothesize that the local injury on the face of this patient predisposes a mechanism of central sensitization, resulting in trigeminal autonomic cephalgia. Relation between trigemino-autonomic cephalalgias and leprosy provides insights into craniofacial pain mechanisms.","PeriodicalId":13412,"journal":{"name":"Indian journal of leprosy","volume":"84 4","pages":"317-20"},"PeriodicalIF":0.0,"publicationDate":"2012-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31561058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Increased need for health education and communication services in contemporary practice. 在当代实践中对健康教育和交流服务的需求增加。

Indian journal of leprosy Pub Date : 2012-10-01

M S Raju

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Jhum-Jhum - A sensation - revisited. Jhum-Jhum -一种感觉-再次出现。

Indian journal of leprosy Pub Date : 2012-07-01

Sudhir U K Nayak, S D Shenoi

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Efficacy of single-dose chemotherapy (rifampicin, ofloxacin and minocycline-ROM) in PB leprosy patients with 2 to 5 skin lesions, India: randomised double-blind trial. 印度，单剂量化疗(利福平、氧氟沙星和米诺环素- rom)治疗伴有2 - 5个皮肤病变的PB麻风患者的疗效:随机双盲试验

Indian journal of leprosy Pub Date : 2012-07-01

P Manickam, B Nagaraju, V Selvaraj, S Balasubramanyam, V N Mahalingam, S M Mehendale, V K Pannikar, M D Gupte

{"title":"Efficacy of single-dose chemotherapy (rifampicin, ofloxacin and minocycline-ROM) in PB leprosy patients with 2 to 5 skin lesions, India: randomised double-blind trial.","authors":"P Manickam, B Nagaraju, V Selvaraj, S Balasubramanyam, V N Mahalingam, S M Mehendale, V K Pannikar, M D Gupte","doi":"","DOIUrl":"","url":null,"abstract":"Unlabelled: We conducted randomized double-blind trial for single-dose of Rifampicin, Ofloxacin and Minocycline (ROM) compared to WHO-PB-MDT among paucibacillary (PB) leprosy patients with 2-5 skin lesions. We enrolled 1526 patients from five centres (ROM=762; WHO-PB-MDT=764) and followed them for 36 months posttreatment during 1998-2003. We generated information on clearance of skin lesions and relapse rates per 100 person-years (PY) for all the five centres. At base-line, the patients in the two arms were comparable. Complete clearance of skin lesions was similar (72% vs. 72.1%; p=0.95) in both the arms. Clinical scores declined steadily and equally. Difference in relapse rates was statistically highly significant (ROM=1.13 and WHO-PB-MDT=0.35 per 100 PY; mid-p exact=0.001016). Twenty eight of 38 of these relapses occurred within 18 months. In all, 10 suspected adverse drug reactions were.observed (ROM=2; WHO-PB-MDT=8). We extended the follow-up to 48 months for 1082 of 1526 patients from two programme-based centres. No further relapses occurred. Decline in clinical score was not dependent on age, gender, number of lesions or affected body parts. Single dose ROM, though less effective than the standard WHO-PB-MDT regimen conceptually offers an alternative treatment regimen for PB leprosy patients with 2-5 lesions only when careful follow-up for relapse is possible. Registered at the Clinical Trials Registry of India;Registration number: CTRI/2012/05/002645","PeriodicalId":13412,"journal":{"name":"Indian journal of leprosy","volume":"84 3","pages":"195-207"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31301602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Severe cutaneous adverse reactions due to isoniazid in a HIV positive patient. HIV阳性患者异烟肼引起的严重皮肤不良反应。

Indian journal of leprosy Pub Date : 2012-07-01

B K Viswanath, P Ranka, M Ramanjanayalu

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Stakeholders perspectives on perceived needs and priorities for leprosy control and care, Tamil Nadu, India. 利益攸关方对麻风病控制和护理的预期需求和优先事项的看法，泰米尔纳德邦，印度。

Indian journal of leprosy Pub Date : 2012-07-01

T Jaeggi, P Manickam, M G Weiss, M D Gupte

{"title":"Stakeholders perspectives on perceived needs and priorities for leprosy control and care, Tamil Nadu, India.","authors":"T Jaeggi, P Manickam, M G Weiss, M D Gupte","doi":"","DOIUrl":"","url":null,"abstract":"Although leprosy has been declared as eliminated in India, treated patients with persisting disabilities still require care. With the shift from vertical to integrated services, questions remain about case detection and maintaining the quality of patient care. We conducted a qualitative study to clarify the perceived status of elimination, patient care and other aspects of leprosy control from the perspective of various stakeholders. We interviewed leprosy programme managers, Non-governmental organization directors, healthcare providers, patients and community leaders from Kanchipuram district, Tamil Nadu. Consensus endorsed the current approach to integration of leprosy in primary healthcare, but healthcare personnel acknowledged problems from shortage of medicines and failure to fill key positions. Patients were concerned about limited clinic hours, long waits and delayed treatment. Disabled patients indicated how they were troubled by stigmatization of their condition. Programme managers mentioned limited support for needed research and some emphasized the potential threat of emerging drug resistance. Although consensus supports an integrated approach for leprosy services in primary care, the relative priority of different aspects of leprosy control vary among stakeholders. Perspectivist approaches to methodologically sound operational research could guide planning for effective case detection and patient care during the post-elimination era.","PeriodicalId":13412,"journal":{"name":"Indian journal of leprosy","volume":"84 3","pages":"177-84"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31301164","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Utility of Fite-Faraco stain for both mast cell count and bacillary index in skin biopsies of leprosy patients. Fite-Faraco染色在麻风病患者皮肤活检中肥大细胞计数和细菌指数的应用。

Indian journal of leprosy Pub Date : 2012-07-01

K R Chatura, S Sangeetha

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Clinicohistopathological concordance in leprosy - a clinical, histopathological and bacteriological study of 100 cases. 麻风病的临床组织病理学一致性——100例临床、组织病理学和细菌学研究。

Indian journal of leprosy Pub Date : 2012-07-01

M Giridhar, G Arora, K Lajpal, K Singh Chahal

{"title":"Clinicohistopathological concordance in leprosy - a clinical, histopathological and bacteriological study of 100 cases.","authors":"M Giridhar, G Arora, K Lajpal, K Singh Chahal","doi":"","DOIUrl":"","url":null,"abstract":"Leprosy is a treatable chronic infectious disease, prevalent in South Asian countries, especially India. Before labeling a patient as a case of leprosy and starting multidrug treatment for particular type, the clinical findings should be correlated and confirmed with histopathological examination and bacteriological index of skin biopsy. Skin biopsy is an important tool in diagnosing leprosy and determining the type of leprosy. In the present study, one hundred untreated clinically diagnosed cases of leprosy were studied according to Ridley-Jopling scale for confirmation of diagnosis and classification of leprosy. The study was done by routine H & E (Haematoxylin & Eosin) staining and Fite-Faraco's staining for acid-fast bacillus. The data pertaining to age, sex, clinical and histopathological classification of the type of leprosy were collected and analyzed. In analyzing the histopathology of a lesion, special attention was given to the following features, viz., invasion of the epidermis with or without erosion, involvement of the sub-epidermal zone, character and extent of granuloma, density of lymphocytic infiltrate epithelioid cells and other cellular elements, nerve involvement and the presence of Mycobacterium leprae. Histological diagnosis of leprosy was established in 98% of clinically diagnosed cases. Clinicohistopathological concordance was maximum in LL(93.75%) followed by BL(87.5%), TT(78.5%), BT(73.8%) and least in IL(27.78%). Overall, it was 60.23%. Indeterminate type of leprosy was diagnosed more on histologythan on clinical evaluation.","PeriodicalId":13412,"journal":{"name":"Indian journal of leprosy","volume":"84 3","pages":"217-25"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31301603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Awareness, social acceptance and community views on leprosy and its relevance for leprosy control, Tamil Nadu. 泰米尔纳德邦，对麻风病的认识、社会接受和社区看法及其与麻风病控制的相关性。

Indian journal of leprosy Pub Date : 2012-07-01

S Thilakavathi, P Manickam, S M Mehendale

{"title":"Awareness, social acceptance and community views on leprosy and its relevance for leprosy control, Tamil Nadu.","authors":"S Thilakavathi, P Manickam, S M Mehendale","doi":"","DOIUrl":"","url":null,"abstract":"As the leprosy burden has declined considerably, we need to understand the current social status of the disease and patients. A qualitative study was conducted in a rural community near Chennai in Tamil Nadu, between March and October 2011. In-depth interviews with 72 leprosy patients from 25 villages and 3 focus group discussions (FGDs) with 26 women from 3 villages were conducted using a guide. The qualitative data were grouped into different domains and analysed. Most of them did not have basic knowledge on leprosy; instead there were misconceptions on cause and spread of leprosy. Nearly one third of the patients had not disclosed about the disease to their spouse, family members, relatives or friends for fear of social rejection, discrimination and ill treatment. In all, more than half of them had self-stigma and, most of them who had deformity faced actual stigma by way of disowning, isolation and social rejection. Many patients, particularly PB cases had the behavior of \"denial\". FGD women reported of self and actual stigma, particularly towards deformity and disfigurement, for fear of getting infected. Stigma among patients with deformity, and denial of the disease among PB cases, were highlighted. Importance of awareness programmes to remove misconceptions related to cause and spread of the disease was stressed. Need for person-centered social treatment was suggested for increased case detection.","PeriodicalId":13412,"journal":{"name":"Indian journal of leprosy","volume":"84 3","pages":"233-40"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31301605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Histological diagnosis of early and suspicious leprosy by in situ PCR. 原位PCR对早期和可疑麻风的组织学诊断。

Indian journal of leprosy Pub Date : 2012-07-01

M Natrajan, K Katoch, V M Katoch, Ram Das, V D Sharma

{"title":"Histological diagnosis of early and suspicious leprosy by in situ PCR.","authors":"M Natrajan, K Katoch, V M Katoch, Ram Das, V D Sharma","doi":"","DOIUrl":"","url":null,"abstract":"Leprosy is a chronic mycobacterial disease whose diagnosis is primarily based on clinico-pathological examination and supported by slit skin smears for the presence of acid fast bacilli (AFB). However, definitive diagnosis of early leprosy and those suspected to have the disease but not histologically confirmed pose major public health problems. The present study reports the utility of the in situ Polymerase Chain Reaction amplification (PCR) directed at a 530bp fragment of DNA encoding the 36kd antigen of the causative Mycobacterium leprae for the diagnosis of such patients using skin biopsies of lesions. Twenty five adult patients (aged 15-50yrs) each from the clinical categories of Early and clinically Suspect leprosy were selected for the study after obtaining permission. They had solitary lesions, which were negative for AFB on slit skin smear examination. Routine histopathology confirmed the diagnosis of leprosy in 8/25 (32%) cases in the category of Early leprosy with AFB being seen in 2 biopsies, and in 5/25(20%) cases of Suspect leprosy with AFB being seen in a solitary case. The Direct in situ PCR procedure which was performed in the histologically unconfirmed cases improved the diagnosis with positive results observed in 12/17 (70.6%) cases of Early (p=0.001) and in 12/20 (60%) cases of Suspect Leprosy (p=0.005 indicating the usefulness of the Direct in situ PCR to establish the diagnosis of leprosy in histologically doubtful cases.","PeriodicalId":13412,"journal":{"name":"Indian journal of leprosy","volume":"84 3","pages":"185-94"},"PeriodicalIF":0.0,"publicationDate":"2012-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31301165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0