Indian journal of leprosy最新文献_第2页

Pityriasis Rosea Localized to the Skin Patches of Leprosy. A Wolf's Isotopic Response? 红斑糠疹局限于麻风病的皮肤斑块。狼的同位素反应?

Indian journal of leprosy Pub Date : 2016-07-01

K Shilpa, B Leelavathy, K Kavya, D V Lakshmi, G Divya

引用次数: 0

Evaluation of anti-bacterial activity of Rifapentine, Clarithromycin, Minocycline, Moxifloxacin, Ofloxacin and their combinations in Murine Model of Rifampicin Resistant Leprosy. 利福喷丁、克拉霉素、米诺环素、莫西沙星、氧氟沙星及其联合用药对耐利福平麻风小鼠模型的抑菌活性评价

Indian journal of leprosy Pub Date : 2016-07-01

P Joseph, J Ponnaiya, M Das, V S Chaitanya, S Arumugam, M Ebenezer

{"title":"Evaluation of anti-bacterial activity of Rifapentine, Clarithromycin, Minocycline, Moxifloxacin, Ofloxacin and their combinations in Murine Model of Rifampicin Resistant Leprosy.","authors":"P Joseph, J Ponnaiya, M Das, V S Chaitanya, S Arumugam, M Ebenezer","doi":"","DOIUrl":"","url":null,"abstract":"Leprosy, a debilitating disease of the skin and peripheral nerves is caused by Mycobacterium leprae (M. leprae) and is treated by multidrug therapy (MDT) comprising of Dapsone, Rifampicin and Clofazimine. Resistance to any of these drugs poses a threat to the current disease control strategies. With the emergence of Rifampicin resistance in leprosy, it is important that alternative drugs need to be tested to develop a treatment strategy to combat drug resistant leprosy. In the current study, we have investigated WHO MDT, Rifapentine, Clarithromycin, Minocycline, Moxifloxacin, Ofloxacin and their combinations in intermittent and daily dose regimens in rifampicin resistant strains of M. leprae through mouse foot pad experiments in order to determine the loss in viability of M. leprae in response to these drugs and their combinations. Our findings suggest that WHO MDT is still the best combination in Rifampicin resistance cases. Combination of Moxifloxacin with Minocycline and Clarithromycin may also be taken up for clinical trials in cases with Rifampicin resistant leprosy. Rifapentine and Moxifloxacin can be effective alternative drugs to replace Rifampicin where required either in daily dose shorter duration regimens or intermittent dose longer regimen to treat resistant strains.","PeriodicalId":13412,"journal":{"name":"Indian journal of leprosy","volume":"88 3","pages":"147-58"},"PeriodicalIF":0.0,"publicationDate":"2016-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36484365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cutaneous Sarcoidosis Misdiagnosed as Leprosy. Report of Two Cases and Review of Literature. 皮肤结节病误诊为麻风病。两例报告及文献复习。

Indian journal of leprosy Pub Date : 2016-07-01

K N Chowdhary, R Rao, P Priya, M Valiathan, S Shetty, S Pai

引用次数: 0

Histoid Leprosy Presenting with Keloid Like Lesions. 组织性麻风病表现为瘢痕疙瘩样病变。

Indian journal of leprosy Pub Date : 2016-04-01

S P Nair, G N Kumar, R Mathew

引用次数: 0

Elastophagocytosis and Elastolysis in Leprosy. 麻风病的Elastophagocytosis和Elastolysis。

Indian journal of leprosy Pub Date : 2016-04-01

K D Rambhia, U S Khopkar

引用次数: 0

Clinico-radiological Correlation of Bone Changes in Leprosy Patients Presenting with Disabilities/Deformities. 伴有残疾/畸形的麻风病患者骨变化的临床-放射学相关性

Indian journal of leprosy Pub Date : 2016-04-01

W Mohammad, S K Malhotra, P K Garg

{"title":"Clinico-radiological Correlation of Bone Changes in Leprosy Patients Presenting with Disabilities/Deformities.","authors":"W Mohammad, S K Malhotra, P K Garg","doi":"","DOIUrl":"","url":null,"abstract":"Leprosy is a medical - social disease, it is associated with stigma in the society due to the resulting deformities in some persons. Although stigma has decreased after the widespread use of MDT, some disabilities do occur which are mostly due to late initiation of treatment and inappropriate care. Besides the nerve and skin involvement bone changes have been reported to be common in leprosy. These bony changes need to be understood in the present MDT era specially in the context of clinical spectrum and duration of disease/ deformities. Fifty clinically diagnosed and histologically classified leprosy patients with deformities/ disabilities of either hands/feet/face who attended the OPD of Department of Dermatology, Venereology and Leprosy, Government Medical College, Amritsar were examined and evaluated in the study. Radiological examination of hands, feet and skull was done in each case and the bone changes in hands and feet; and skull and paranasal sinus changes were correlated with clinical parameters. Bone changes were observed in 90% of cases radiologically. Specific bone changes in hands and feet, non-specific bone changes in hands, feet, skull and paranasal sinuses were seen in 66%, 82% and 32% of cases respectively. Common specific bone changes in hands and feet observed were primary periostitis (14%), honey combing (46%), bone cyst (36%), thinning and irregularity of cortex (28%) and area of bone destruction (20%); Among the non-specific bone changes observed were contracted fingers/claw hands/claw toes (64%) and absorption of terminal phalanges (40%). The maxillary sinus, and paranasal sinus changes were the most common radiological findings observed in skull. The study of the radiological changes may help the clinicians to understand the gravity of the situation and undertake steps for timely prevention of permanent loss of function and the occurrence of deformities and disabilities.","PeriodicalId":13412,"journal":{"name":"Indian journal of leprosy","volume":"88 2","pages":"83-95"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36095749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Leprosy: A Great Mimicking Disease. 麻风病:一种伟大的模仿疾病。

Indian journal of leprosy Pub Date : 2016-04-01

G Garg, A Gogia, A Kakar

{"title":"Leprosy: A Great Mimicking Disease.","authors":"G Garg, A Gogia, A Kakar","doi":"","DOIUrl":"","url":null,"abstract":"Leprosy may mask a variety of diseases. One such disease is systemic lupus erythematosus. The early differentiation between the two diseases is of utmost importance to institute appropriate treatment and reduce patient morbidity and mortality. Leprosy is a communicable, chronic granulomatous disease caused by Mycobacterium leprae. This clinically manifests predominantly with neurological and cutaneous features. However, it may also manifest with a variety of autoimmune phenomena indicative of autoimmune diseases, such as Systemic Lupus Erythematosus (SLE) or Rheumatoid Arthritis. Infection with Mycobocterium leprae not only mimics lupus flares, but possibly may also act as a trigger for lupus reactivation; however, its relationship is still not fully understood and explored. We report a case that was diagnosed as leprosy but retrospective analysis revealed that it was probablythe initial manifestations of Lupus. During hospitalization the patient suddenly developed hypoxia and was found to have pulmonary haemorrhage. He was successfully managed with steroids, Mycophenolatemofetil along with other supportive treatment. Our case highlights the rare presentation of pulmonary haemorrhage in a male lupus patient and focuses on leprosy mimicking lupus.","PeriodicalId":13412,"journal":{"name":"Indian journal of leprosy","volume":"88 2","pages":"123-127"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36095682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Profile of Childhood Leprosy Cases Attending a Tertiary Care Centre. 在三级医疗中心接受治疗的儿童麻风个案简介。

Indian journal of leprosy Pub Date : 2016-04-01

A J Asia, V Tapre, U Joge

{"title":"Profile of Childhood Leprosy Cases Attending a Tertiary Care Centre.","authors":"A J Asia, V Tapre, U Joge","doi":"","DOIUrl":"","url":null,"abstract":"In spite of 33 years of use of Multidrug Treatment (MDT) implemented by National Leprosy Eradication Programme (NLEP), leprosy continues to be a major public health problem in some regions of India. Recent increase in number of cases of leprosy at our tertiary care centre especially in children encouraged us to undertake a descriptive study for last 5 years. Records were analysed to describe the clinical pattern of leprosy in children below 15 years pertaining to the period 2010 to 2014. Amongst 664 leprosy cases registered during 2010 to 2014, 86 were found to be children between 0-15 years of age (13.1%). The number of newly detected children with leprosy increased from 7 cases (8%) in the year 2010 to 29 cases (34%) in the year 2014. Majority of patients of childhood category belonged to 10-15 years of age group 51/86 (59%), with a male preponderance. PB cases were significantly more (71%) than cases of MB (29%). Borderline tuberculoid leprosy was the commonest type seen (77%). Grade l and grade 2 deformity were observed in 8% and 6% of childhood cases respectively. 91% of these childhood cases had history of BCG vaccination: 21% of children had a contact in family or neighbourhood which shows the importance of asking the patients to bring family contacts specially children for examination or public health workers being asked to approach the families for check up of contacts. Active surveys/school surveys to find cases specially in female children should be considered. As this is a hospital based study it may be indicative of trends only which should be followed by properly designed field based studies.","PeriodicalId":13412,"journal":{"name":"Indian journal of leprosy","volume":"88 2","pages":"111-116"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36095680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasonographic Features of Ulnar Nerve Affected by Hansen's Disease. 汉森病影响尺神经的声像图特征。

Indian journal of leprosy Pub Date : 2016-04-01

Y Aswani, H Thakkar, A R Sahu, K M Anandpara

引用次数: 0

A Study of Clinical, Bacteriological & Histopathological Correlation in Leprosy Cases attending a Government Medical College in Western Odisha: Some Observations. 西奥里萨邦某公立医学院麻风病例临床、细菌学和组织病理学相关性研究

Indian journal of leprosy Pub Date : 2016-04-01

K Kakkad, T Padhi, K Pradhan, K C Agrawal

{"title":"A Study of Clinical, Bacteriological & Histopathological Correlation in Leprosy Cases attending a Government Medical College in Western Odisha: Some Observations.","authors":"K Kakkad, T Padhi, K Pradhan, K C Agrawal","doi":"","DOIUrl":"","url":null,"abstract":"The study was undertaken in VSS Institute of Medical Sciences to observe the clinical, bacteriological and histological diagnosis of leprosy patients attending the hospital who consented to undergo slit skin smear (SSS) examination, punch biopsy and participate in the study. Fifty leprosy patients aged 5 to 70 years, which included 41 male and 9 female patients participated in the study. These included 4 TT, 24 BT, 2 BB, 5 BL and 15 ILL clinically diagnosed patients as per the IAL classification (1982 ). SSS were undertaken from 4 sites, stained with ZN stain and BI calculated as per Ridley Scale. Four patients were skin smear negative all TT). Of the 24 BT patients enrolled in the study, 11 were skin smear negative while 13 were smear positive (BI ranging from 1+ to 4+); Both the BB cases, all 5 BL cases, and all the 15 LL cases were smear positive (BI range 2+ to 6+). Histologically there was complete parity and correlation in.the TT group, while the correlation was observed to be 83%, 50%, 60%, and 93% in the clinically diagnosed BT, BB, BL and LL patients respectively. The sample size in the study was small, however, the overall bacteriological skin smear negativity/positivity correlation was observed to be 53.6% for paucibacillary (TT+BT) disease and 100% for MB (BB, BL and LL) disease Histological correlation was 100%, 83%, 50%, 60% and 93% respectively for clinically diagnosed TT, BT, BB, BL and LL disease. A sizeable number of BT patients were found to be bacteriologically positive and were therefore being treated with lesser number of drugs as well duration under programme conditions, Although there is inter-observer variation and overlapping of clinical and histological diagnosis in the borderline patients (BT, BB & BL), bacteriological and histological confirmation helps in deciding on adequate treatmeht and should be undertaken.","PeriodicalId":13412,"journal":{"name":"Indian journal of leprosy","volume":"88 2","pages":"97-103"},"PeriodicalIF":0.0,"publicationDate":"2016-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36095750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0