Idiopathic interstitial pneumonias最新文献_第10页

Matrix metalloproteinases, as markers of the severity of idiopathic pulmonary fibrosis 基质金属蛋白酶，作为特发性肺纤维化严重程度的标志

Idiopathic interstitial pneumonias Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa4706

K. Gashynova, V. Rodionova, O. Karasyova, O. Shaulska, O. Khmel

引用次数: 1

Late Breaking Abstract - BBT-877, a Potent Autotaxin Inhibitor in Clinical Development to Treat Idiopathic Pulmonary Fibrosis 摘要:BBT-877，一种治疗特发性肺纤维化的强效自taxin抑制剂

Idiopathic interstitial pneumonias Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1293

Gwanghee Lee, Sang-Uk Kang, Jeong-Hyun Ryou, Jongwon Lim, Yong-Hee Lee

{"title":"Late Breaking Abstract - BBT-877, a Potent Autotaxin Inhibitor in Clinical Development to Treat Idiopathic Pulmonary Fibrosis","authors":"Gwanghee Lee, Sang-Uk Kang, Jeong-Hyun Ryou, Jongwon Lim, Yong-Hee Lee","doi":"10.1183/13993003.congress-2019.pa1293","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa1293","url":null,"abstract":"Idiopathic Pulmonary Fibrosis (IPF) is a progressive, irreversible and fatal lung disease with unmet medical needs. Autotaxin (ATX) is an extracellular enzyme involved in the generation of lysophosphatidic acid (LPA). Preclinical and clinical data have suggested the ATX – LPA – LPA receptor (LPAR) axis plays a pivotal role in the pathogenesis and the progression of IPF. BBT-877 is an orally available small molecule inhibitor against ATX. In ex vivo enzymatic assays using human plasma, IC50 of BBT-877 was measured 6.5 – 6.9 nM (LPA 18:2) whereas that of GLPG1690 was measured 75 – 132 nM. To determine in vivo anti-fibrotic efficacy of BBT-877, bleomycin was intranasally administrated in mice at day 0, and BBT-877 was administrated orally twice a day from day 7 to 21. The BBT-877 treatment showed anti-fibrotic efficacy as revealed by significantly reduced body weight loss, lung weight and Ashcroft score as well as collagen content compared to the vehicle-treated group. During phase 1 clinical trial with 80 healthy volunteers, in which 50 – 800 mg (SAD) and 200 – 800 mg QD or 100 – 200 mg BID for two weeks (MAD) doses were administrated, only mild adverse events were noted. Pharmacokinetic analysis revealed the dose-proportional increase in systemic exposure with elimination half-life of 12hr. The decrease of plasma LPA level was maintained at 80% or higher for 24hr when 400 mg BBT-877 was administrated. Taken together, nonclinical data suggest BBT-877 is a potent, selective, and potentially best-in-class ATX inhibitor. Phase 1 clinical data demonstrate BBT-877 is a safe and well-tolerated drug with excellent pharmacokinetic-pharmacodynamic profiles.","PeriodicalId":13242,"journal":{"name":"Idiopathic interstitial pneumonias","volume":"78 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80289693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Pulmonary fibrosis modulation by mesenchymal stem cells and conditioned medium 间充质干细胞和条件培养基对肺纤维化的调节作用

Idiopathic interstitial pneumonias Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1284

R. Felix, A. L. C. Bovolato, P. D. Leão, M. Golim, W. Teodoro, A. Fabro, E. Deffune, V. Capelozzi

引用次数: 2

Interstitial lung disease related surfactant protein-C mutations alter the transcriptome and progenitor cell function of alveolar epithelial cells in mice 肺间质性疾病相关表面活性剂蛋白- c突变改变小鼠肺泡上皮细胞的转录组和祖细胞功能

Idiopathic interstitial pneumonias Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1291

J. Katzen, A. Venosa, Y. Tomer, Meghan C. Kopp, Michael Morely, A. Diwadkar, E. Morrisey, B. Himes, S. Mulugeta, M. Beers

引用次数: 1

Predictive value of 18F-FDG PET/CT for chemotherapy-related acute exacerbation of interstitial lung disease in lung cancer patients with interstitial lung disease 18F-FDG PET/CT对肺癌间质性肺病患者化疗相关急性加重的预测价值

Idiopathic interstitial pneumonias Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1313

K. Akaike, K. Saruwatari, S. Oda, S. Hamada, Y. Tomita, S. Saeki, H. Ichiyasu, K. Fujii, S. Shiraishi, T. Sakagami

{"title":"Predictive value of 18F-FDG PET/CT for chemotherapy-related acute exacerbation of interstitial lung disease in lung cancer patients with interstitial lung disease","authors":"K. Akaike, K. Saruwatari, S. Oda, S. Hamada, Y. Tomita, S. Saeki, H. Ichiyasu, K. Fujii, S. Shiraishi, T. Sakagami","doi":"10.1183/13993003.congress-2019.pa1313","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa1313","url":null,"abstract":"Background: Acute exacerbation (AE) of interstitial pneumonia disease (ILD) in lung cancer (LC) patients with ILD could be one of the lethal adverse effect related to chemotherapy. The purpose of this study was to determine if the result of 18F-FDG PET/CT before chemotherapy could predict onset of chemotherapy-related AE-ILD in LC patients with ILD. Methods: Between April 2006 and March 2018, 33 patients with LC and ILD performed 18F-FDG PET/CT and treated with chemotherapy in Kumamoto University Hospital. The SUVmax of interstitial lesion was measured to quantify the background ILD activity. A prediction model chemotherapy-related AE of ILD was developed using a logistic regression and ROC curve analysis. Results: Among 33 patients, 7 experienced AE of ILD (AE group) and 26 did not (non-AE group), the SUVmax of contralateral interstitial lesion in AE group was significantly higher than that in non-AE group (median SUVmax 2.22 vs. 1.80, P = 0.041). An univariable logistic regression analysis showed that the SUVmax of contralateral interstitial lesion had potential to be associated with chemotherapy-related AE of ILD (odds ratio, 8.683; 95% confidence interval [CI], 0.88–85.83; P = 0.064). The AUC of the SUVmax for predicting chemotherapy-related AE of ILD was 0.780 (95% CI: 0.579-0.982, P = 0.025). The optimal cut-off value for SUVmax was 2.005. Sensitivity and specificity value for this cut-off point were 0.857 and 0.769, respectively. Conclusions: The SUVmax of contralateral interstitial lesion in 18F-FDG PET/CT might be useful to predict chemotherapy-related AE of ILD in LC with ILD.","PeriodicalId":13242,"journal":{"name":"Idiopathic interstitial pneumonias","volume":"95 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85471504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

STARMAP: an observational study to assess disease-relevant outcomes using home-monitoring devices in patients with idiopathic pulmonary fibrosis (IPF) STARMAP:一项观察性研究，评估特发性肺纤维化(IPF)患者使用家庭监测设备的疾病相关结果

Idiopathic interstitial pneumonias Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1333

J. Swigris, S. Nathan, R. Tighe, Sunny Nagra, C. Rabe, Douglas O. Kelkhoff, Thomas Switzer, N. Kolatkar, P. Belloni, J. Golden

引用次数: 5

Late Breaking Abstract - Transbronchial lung cryobiopsy for interstitial lung disease diagnosis: results of the COLDICE Study 经支气管肺低温活检诊断间质性肺疾病:COLDICE研究的结果

Idiopathic interstitial pneumonias Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.rct1886

L. Troy, C. Grainge, T. Corte, J. Williamson, M. Vallely, W. Cooper, A. Mahar, J. Myers, Simon Lai, Ellie Mulyadi, P. Torzillo, M. Phillips, H. Jo, Susanne E Webster, Qi Lin, J. Rhodes, M. Salamonsen, J. Wrobel, B. Harris, G. Don, P. Wu, B. Ng, C. Oldmeadow, G. Raghu, E. Lau, Coldice Investigators

{"title":"Late Breaking Abstract - Transbronchial lung cryobiopsy for interstitial lung disease diagnosis: results of the COLDICE Study","authors":"L. Troy, C. Grainge, T. Corte, J. Williamson, M. Vallely, W. Cooper, A. Mahar, J. Myers, Simon Lai, Ellie Mulyadi, P. Torzillo, M. Phillips, H. Jo, Susanne E Webster, Qi Lin, J. Rhodes, M. Salamonsen, J. Wrobel, B. Harris, G. Don, P. Wu, B. Ng, C. Oldmeadow, G. Raghu, E. Lau, Coldice Investigators","doi":"10.1183/13993003.congress-2019.rct1886","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.rct1886","url":null,"abstract":"Transbronchial lung cryobiopsy (TBLC) is a novel technique for sampling lung tissue for interstitial lung disease (ILD) diagnosis. Despite increasing use, the diagnostic accuracy of TBLC compared to surgical lung biopsy (SLB) remains unclear. Methods: We conducted a prospective, multicenter study investigating agreement between TBLC and SLB. ILD patients referred for lung biopsy after central screening underwent sequential TLBC and SLB, under one anesthetic. Blinded analysis of samples was conducted by 3 pathologists, individually and by consensus. At multidisciplinary discussion (MDD), deidentified cases were discussed twice with either TBLC or SLB along with clinical and radiology data, in random non-consecutive order. Primary endpoints were agreement of TBLC and SLB for 1) “definite/probable usual interstitial pneumonia (UIP)”, “indeterminate for UIP” and “alternative diagnosis” histopathologic patterns; and for 2) MDD diagnoses. Concordance and kappa values were calculated. Results: 65 patients (30 males; age 66±9yrs; FVC 84±14%; DLCO 63±13%) were enrolled. TBLC (7.1±1.9mm) and SLB samples (47±15mm) were taken from two separate ipsilateral lobes. Histopathological agreement between TBLC and SLB was 70.8%, weighted κ 0.70 (95%CI 0.55-0.86); agreement at MDD was 76.9%, κ 0.62 (95%CI 0.47-0.78). For TBLC with high/definite diagnostic confidence at MDD (39/65, 60% cases), 94.9% were concordant with SLB diagnoses. In the 26 with low-confidence/unclassifiable TBLC diagnoses, SLB reclassified only 6 to alternative high/definite MDD diagnoses. Conclusion: High agreement between TBLC and SLB for pathologic and MDD diagnoses support the clinical utility of TBLC in ILD diagnostic algorithms.","PeriodicalId":13242,"journal":{"name":"Idiopathic interstitial pneumonias","volume":"60 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77117128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Risk factors for diagnostic delay in a prospective IPF-cohort 在一个前瞻性ipf队列中诊断延迟的危险因素

Idiopathic interstitial pneumonias Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1724

N. Hoyer, T. Prior, E. Bendstrup, T. Wilcke, S. Shaker

引用次数: 0

Efficacy of switching antifibrotic therapy in idiopathic pulmonary fibrosis: real life data 转换抗纤维化治疗在特发性肺纤维化中的疗效:真实生活数据

Idiopathic interstitial pneumonias Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa1727

Ivonne M. Raats ten Cate, C. V. Moorsel, A. Meer, P. Zanen, J. Grutters

引用次数: 0

Change in serum surfactant protein (SP)-A, SP-D and KL-6 predict the therapeutic effect of antifibrotic drugs in IPF 血清表面活性蛋白(SP)-A、SP- d和KL-6的变化预测抗纤维化药物对IPF的治疗效果

Idiopathic interstitial pneumonias Pub Date : 2019-09-28 DOI: 10.1183/13993003.congress-2019.pa4704

Takumi Yoshikawa, M. Otsuka, Kimiyuki Ikeda, Yuki Mori, Yasuaki Umeda, Hirotaka Nishikiori, Satsuki Miyajima, Mamoru Takahashi, K. Kuronuma, H. Chiba, Hiroki Takahashi

{"title":"Change in serum surfactant protein (SP)-A, SP-D and KL-6 predict the therapeutic effect of antifibrotic drugs in IPF","authors":"Takumi Yoshikawa, M. Otsuka, Kimiyuki Ikeda, Yuki Mori, Yasuaki Umeda, Hirotaka Nishikiori, Satsuki Miyajima, Mamoru Takahashi, K. Kuronuma, H. Chiba, Hiroki Takahashi","doi":"10.1183/13993003.congress-2019.pa4704","DOIUrl":"https://doi.org/10.1183/13993003.congress-2019.pa4704","url":null,"abstract":"Background: Serum surfactant protein (SP)-A, SP-D, and KL-6 are prognostic biomarkers of patients with idiopathic pulmonary fibrosis (IPF), however, the relationship with the therapeutic effect of antifibrotic drugs has not been investigated. Aim: To clarify whether serum SP-A, SP-D and KL-6 are therapeutic predictive markers of pirfenidone and nintedanib in patients with IPF. Methods: We retrospectively investigated patients with IPF who started pirfenidone or nintedanib between January 2014 and June 2018 at our hospital. The change in clinical parameters and serum SP-A, SP-D and KL-6 levels were evaluated. Patients with a > 10% decline in forced vital capacity (FVC) or a > 15% decline in diffusing capacity of the lung for carbon monoxide (DLco) from baseline to 6 months were classified as a deterioration group and the other was classified as an effective group. Results: Forty-nine patients were included (pirfenidone; 23, nintedanib; 26). Thirty-two patients were the effective group and 17 patients were the deterioration group. In the effective group, the change in serum SP-A, SP-D, and KL-6 from baseline to 3 and/or 6 months significantly decreased compared with the deterioration group. The change in serum SP-A and SP-D showed significant negative correlations with the change in %FVC and %DLCO. According to the logistic regression analysis, the decrease in SP-A from baseline to 3 months was a predictor of the effect at 6 months (odd’ ratio 0.88). Conclusions: Change in SP-A, SP-D and KL-6 represent the therapeutic effect of antifibrotic drugs. These may be therapeutic predictive biomarkers of antifibrotic drugs.","PeriodicalId":13242,"journal":{"name":"Idiopathic interstitial pneumonias","volume":"54 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2019-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87148519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0