Hormone research最新文献_第3页

Effects of growth hormone treatment on growth in children with juvenile idiopathic arthritis. 生长激素治疗对幼年特发性关节炎患儿生长发育的影响。

Hormone research Pub Date : 2009-11-01 Epub Date: 2009-11-27 DOI: 10.1159/000229765

D Simon, S Bechtold

引用次数: 22

Natural history of growth and body composition in juvenile idiopathic arthritis. 青少年特发性关节炎的生长和身体组成的自然史。

Hormone research Pub Date : 2009-11-01 Epub Date: 2009-11-27 DOI: 10.1159/000229758

S Bechtold, J Roth

{"title":"Natural history of growth and body composition in juvenile idiopathic arthritis.","authors":"S Bechtold, J Roth","doi":"10.1159/000229758","DOIUrl":"https://doi.org/10.1159/000229758","url":null,"abstract":"Background: In patients with juvenile idiopathic arthritis (JIA), growth impairment and altered body composition, including disturbed skeletal development, are well-known long-term complications. Data on longitudinal growth in patients with systemic and polyarticular JIA reveal growth impairment in the active phases of the disease. With reduction in disease activity and lower glucocorticoid (GC) doses, some patients experience 'catch-up' growth; however, many have only a slight improvement in height standard deviation during puberty or after cessation of GC treatment. The consequence is a final height below the 3rd percentile and below the genetic height potential. Although few studies have specifically addressed body composition in children with JIA, studies on the development of bone mass have described notable deficits in both GC-treated and GC-naïve children. In recent years, the deficits in bone mass have been related, in part, to the deficits in muscle mass, which are prevalent in these patients.Conclusions: The major goal for physicians caring for patients with JIA is optimal disease control while maintaining normal growth. Early recognition of patients who develop prolonged growth disturbances and altered body composition is important as these abnormalities contribute to long-term morbidity and need to be addressed both diagnostically and therapeutically when treating children with JIA.","PeriodicalId":13225,"journal":{"name":"Hormone research","volume":"72 Suppl 1 ","pages":"13-9"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000229758","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28530090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 43

Promoting growth in chronic inflammatory disease: lessons from studies of the growth plate. 促进慢性炎症疾病的生长:来自生长板研究的教训。

Hormone research Pub Date : 2009-11-01 Epub Date: 2009-11-27 DOI: 10.1159/000229763

S F Ahmed, L Sävendahl

{"title":"Promoting growth in chronic inflammatory disease: lessons from studies of the growth plate.","authors":"S F Ahmed, L Sävendahl","doi":"10.1159/000229763","DOIUrl":"https://doi.org/10.1159/000229763","url":null,"abstract":"Background: Growth disorders are commonly observed in children with chronic inflammatory disease. It is likely that these disorders are mediated by a combination of factors, including the disease process and its treatment (with drugs such as glucocorticoids [GCs]). These factors affect the growth hormone-insulin-like growth factor I (IGF-I) axis, which is crucial for promoting linear growth at the level of the growth plate. Recent advances in our knowledge of the effects of GCs and proinflammatory cytokines on the growth plate have led to an improved understanding of the biological rationale for the use of growth-promoting therapy in children with chronic inflammatory disease and concurrent growth retardation.Conclusions: Both GCs and proinflammatory cytokines can adversely affect a number of components of growth plate chondrogenesis, and these effects can be ameliorated by raising local IGF-I exposure. However, this intervention does not lead to complete normalization of the growth plate. In children with chronic inflammation, the cornerstone of improving growth remains the judicious use of GCs while ensuring effective control of the disease process.","PeriodicalId":13225,"journal":{"name":"Hormone research","volume":"72 Suppl 1 ","pages":"42-7"},"PeriodicalIF":0.0,"publicationDate":"2009-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000229763","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28530095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 31

Can growth hormone counteract the catabolic effects of steroids? 生长激素能抵消类固醇的分解代谢作用吗?

Hormone research Pub Date : 2009-11-01 Epub Date: 2009-11-27 DOI: 10.1159/000229764

Nelly Mauras

引用次数: 17

Abstracts of the LWPES/ESPE 8th Joint Meeting Global Care in Paediatric Endocrinology, in collaboration with APEG, APPES, JSPE and SLEP. New York City, New York, USA. September 9-12, 2009. LWPES/ESPE第八届全球儿科内分泌护理联合会议，与APEG、APPES、JSPE和sleep合作。美国纽约，纽约市。2009年9月9日至12日。

Hormone research Pub Date : 2009-09-01 DOI: 10.1159/000239668

引用次数: 23

Advances in understanding pituitary adenomas. 垂体腺瘤的认识进展。

Hormone research Pub Date : 2009-04-01 Epub Date: 2009-04-29 DOI: 10.1159/000192441

Vera Popović-Brkić

{"title":"Advances in understanding pituitary adenomas.","authors":"Vera Popović-Brkić","doi":"10.1159/000192441","DOIUrl":"https://doi.org/10.1159/000192441","url":null,"abstract":"signalling pathways have been identified as important factors in the development of pituitary tumours, our understanding of pituitary tumorigenesis remains incomplete and is the focus of current research. This is because current treatment modalities fail to completely control this disorder and prevent the associated morbidity and mortality. Pituitary microadenomas, which have a diameter of less than 1 cm, are exceedingly common at autopsy and on pituitary imaging, with a prevalence of 25%. Most microadenomas remain clinically occult and stable in size without an increase in tumour cells and without local mass effects. Recent studies try to explain this cessation of growth in a neoplasm, which would not be expected to occur. It was thought that apoptosis may play a role in curtailing outgrowth, but this did not explain the maintenance of a stable size for years. Lack of induction of vascular stroma was thought to be relevant, but again was an insufficient explanation. Proliferative activity of microadenomas is very low, indicating that the tumour cells are growth arrested, and in his presentation at the 10th KIGS/ KIMS Expert Meeting, Wolter Mooi introduced the currently most likely factor for growth arrest. The hypothesis is that cells after a certain number of cell divisions display a change in cell phenotype (i.e. they enter into a senescence-like state). Thus, growth arrest in pituitary microadenomas may be due to oncogene-induced cellular senescence. The demonstration that the majority of","PeriodicalId":13225,"journal":{"name":"Hormone research","volume":"71 Suppl 2 ","pages":"75-7"},"PeriodicalIF":0.0,"publicationDate":"2009-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000192441","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28217945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Genetic, molecular and clinical features of familial isolated pituitary adenomas. 家族性孤立性垂体腺瘤的遗传、分子和临床特征。

Hormone research Pub Date : 2009-04-01 Epub Date: 2009-04-29 DOI: 10.1159/000192448

Adrian F Daly, Maria A Tichomirowa, Albert Beckers

引用次数: 31

Differential gene expression in models of pituitary prolactin-producing tumoral cells. 垂体促泌乳素肿瘤细胞模型的差异基因表达。

Hormone research Pub Date : 2009-04-01 Epub Date: 2009-04-29 DOI: 10.1159/000192444

Damiana Giacomini, Mariana Haedo, Juan Gerez, Jimena Druker, Marcelo Páez-Pereda, Marta Labeur, Gunter K Stalla, Eduardo Arzt

{"title":"Differential gene expression in models of pituitary prolactin-producing tumoral cells.","authors":"Damiana Giacomini, Mariana Haedo, Juan Gerez, Jimena Druker, Marcelo Páez-Pereda, Marta Labeur, Gunter K Stalla, Eduardo Arzt","doi":"10.1159/000192444","DOIUrl":"https://doi.org/10.1159/000192444","url":null,"abstract":"Although several genes and signalling pathways have been identified as important effectors in the development of pituitary tumours, our understanding of pituitary tumorigenesis remains incomplete and is the focus of much current research. Use of the mRNA differential display technique in prolactinomas from D2-receptor knockout mice and in stable GH3 cell line clones with enhanced tumorigenicity in vivo has led to the identification of two genes that are involved in the pathogenic process--BMP-4 and RSUME. Bone morphogenetic protein-4 (BMP-4) has been found to have a crucial role in prolactinoma development and also in signalling crosstalk with oestrogens. In contrast, BMP-4 has an inhibitory role in corticotrophinomas. RSUME (RWD-containing sumoylation enhancer) was identified from a transformed lactosomatotrophic cell line that had increased tumorigenic and angiogenic potential. Expression of RSUME was induced under hypoxic conditions and it has a potential role during vascularization. The differential expression and action of BMP-4 in prolactinomas and corticotrophinomas highlights the importance of studying a gene with contrasting actions in two cell lineages of the same organ in order to understand the pituitary transformation process. Both BMP-4 and RSUME may be interesting targets for inhibiting steps involved in pituitary tumorigenesis.","PeriodicalId":13225,"journal":{"name":"Hormone research","volume":"71 Suppl 2 ","pages":"88-94"},"PeriodicalIF":0.0,"publicationDate":"2009-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000192444","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"28217948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

G-protein and signalling in pituitary tumours. 垂体肿瘤中的g蛋白和信号传导。

Hormone research Pub Date : 2009-04-01 Epub Date: 2009-04-29 DOI: 10.1159/000192446

Andrea Lania, Anna Spada

引用次数: 22

Epigenetics and imprinted genes: insights from the imprinted Gnas locus. 表观遗传学与印迹基因:来自印迹基因座的见解。

Hormone research Pub Date : 2009-04-01 Epub Date: 2009-04-29 DOI: 10.1159/000192432

Gavin Kelsey

引用次数: 18