Iberoamerican Journal of Medicine最新文献_第7页

A case of Brucella pyelonephritis: a rare case 布鲁氏菌肾盂肾炎1例:罕见病例

Iberoamerican Journal of Medicine Pub Date : 2022-02-23 DOI: 10.53986/ibjm.2022.0012

S. Alkan, Emine Kübra Dindar Demiray, Nurullah Tarhan, T. Önder

引用次数: 1

Fibrosis-4 index: A new marker to predict non-dipper blood pressure pattern in patients with newly diagnosed hypertension 纤维化-4指数:预测新诊断高血压患者非低血压模式的新指标

Iberoamerican Journal of Medicine Pub Date : 2022-01-18 DOI: 10.53986/ibjm.2022.0011

U. Küçük, K. Arslan

{"title":"Fibrosis-4 index: A new marker to predict non-dipper blood pressure pattern in patients with newly diagnosed hypertension","authors":"U. Küçük, K. Arslan","doi":"10.53986/ibjm.2022.0011","DOIUrl":"https://doi.org/10.53986/ibjm.2022.0011","url":null,"abstract":"Introduction: Epicardial fat tissue (EFT) is a significant risk factor for cardiovascular diseases. This study aimed to investigate whether there is a relationship between the fibrosis-4 index (FIB-4 index) and EFT in newly-diagnosed hypertensive patients and explore the usability of the FIB-4 index in predicting non-dipper blood pressure (BP) pattern. Materials and methods: Our case–control study consisted of 210 patients in 3 groups according to BP values, namely normotensive, dipper, and non-dipper groups. Transthoracic echocardiography and 24-h ambulatory BP monitoring were performed in all patients. Results: The median FIB-4 index was higher in the non-dipper group [1.56 (1.10-2)] than in the dipper [1 (0.71-1.32)] and normotensive groups [0.96 (0.69-1.32)] (p < 0.001, for both). A positive correlation was observed between EFT and the FIB-4 index (r=0.389, p<0.001). In multivariate logistic regression analysis, EFT (odds ratio (OR): 0.506, 95% confidence interval (CI): 1.288-2.135; p<0.001) and FIB-4 index (OR: 1.099, 95% CI: 1.621–5.556; p<0.001) were found to be independent predictors of non-dipper BP. In the receiver operating characteristic curve analysis, the FIB-4 index had 68% sensitivity and 72% specificity at a value >1.25 (area under the curve: 0.751, 95%CI: 0.679-0.823, p<0.001). Conclusions: In newly-diagnosed hypertensive people, the FIB-4 index is related to non-dipper BP patterns. FIB-4 index appears to be a helpful tool in assessing risk associated with cardiovascular disease.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"216 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74936868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alterations of gut bacteria Akkermansia muciniphila and Faecalibacterium prausnitzii in late post-transplant period after liver transplantation 肝移植术后后期肠道细菌嗜粘阿克曼氏菌和prausnitzfaecalibacterium的变化

Iberoamerican Journal of Medicine Pub Date : 2022-01-17 DOI: 10.53986/ibjm.2022.0010

A. Kukov, M. Peruhova, Atanas Syarov, I. Altankova, N. Yurukova, A. Goncharov, R. Vazharova, Anoaneta Mihova, T. Velikova, Y. Uzunova

{"title":"Alterations of gut bacteria Akkermansia muciniphila and Faecalibacterium prausnitzii in late post-transplant period after liver transplantation","authors":"A. Kukov, M. Peruhova, Atanas Syarov, I. Altankova, N. Yurukova, A. Goncharov, R. Vazharova, Anoaneta Mihova, T. Velikova, Y. Uzunova","doi":"10.53986/ibjm.2022.0010","DOIUrl":"https://doi.org/10.53986/ibjm.2022.0010","url":null,"abstract":"Introduction: Recent studies have shown that the intestinal microbiota can modulate certain systemic metabolic and immune responses, including liver graft function and the development of complications in patients after liver transplantation (LT). Akkermansia muciniphila (AKM) and Faecalibacterium prausnitzii (FAEP) are two of the most abundant gut commensal bacteria, with mucosa-protective and anti-inflammatory effects that are important for maintaining normal intestinal homeostasis and gut barrier function. Our objective was to quantify levels of Akkermansia muciniphila and Faecalibacterium prausnitzii in immunosuppressed patients with LT. Materials and methods: Fecal samples from 23 liver transplant patients (15 adults and 8 children) and 9 non-LT controls were examined. Bacterial DNA was isolated from the samples using the stool DNA isolation kit and the obtained DNA was analyzed with commercially available qPCR kit for AKM and FAEP. Results: We found a statistically significant decrease in the amount of AKM and FAEP compared to the control group. The median values were: for AKM 8.75 for patients and 10.25 for the control group (p = 0.030), and for FAEP 9.72 and 10.47, p = 0.003, respectively. In children after LT, this difference was also statistically significant: AKM (p = 0.051) and FAEP (p = 0.014). In contrast no statistically significant differences were found between adult patients and controls, AKM (p = 0.283) and FAEP (p = 0.056), although the amount of both bacteria showed tendency for reduction. Conclusions: In this pilot study, we found a reduction in the total amount of the two studied bacteria in transplanted patients compared to the control healthy group.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79115491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of the efficacy of immune plasma treatment in COVID-19 infected intensive care unit patients 新型冠状病毒感染重症监护病房患者免疫血浆治疗效果评价

Iberoamerican Journal of Medicine Pub Date : 2022-01-06 DOI: 10.53986/ibjm.2022.0009

E. Yıldız, Murat Emre Tokur, Bugra Özlem, Özlem Arık, Canan Balcı

{"title":"Evaluation of the efficacy of immune plasma treatment in COVID-19 infected intensive care unit patients","authors":"E. Yıldız, Murat Emre Tokur, Bugra Özlem, Özlem Arık, Canan Balcı","doi":"10.53986/ibjm.2022.0009","DOIUrl":"https://doi.org/10.53986/ibjm.2022.0009","url":null,"abstract":"Introduction: Treatment approach in COVID-19 infection consists of antiviral, immunomodulatory, and supportive treatments. Convalescent plasma, immune plasma or hyperimmune plasma refers to the plasma that consisting of high titer polyclonal antibodies against the virus and are amidst the immunomodulatory treatments. Although it has been reported that immune plasma treatment of COVID-19 reduces hospital stay and mortality, the efficacy of immune plasma with COVID-19 infection is not clear yet. The present study aims to investigate the efficacy of immune plasma in patients who are followed up in the intensive care unit with the diagnosis of COVID-19. Materials and methods: In this retrospective study, the patients who were hospitalized in the intensive care unit with the diagnosis of COVID-19 infection were divided into two groups: those who received IP treatment (Group 1; n=28) and those who did not (Group 2; n=25). The biochemical C -reactive protein, lactate-dehydrogenase, ferritin, D-dimer, total bilirubin, creatine levels, hematological parameters (Leukocyte, neutrophil, lymphocyte, platelet counts), clinical sepsis scores (SOFA, APACHE scores) and mortality rates of the patients were evaluated according to groups. Results: There was no statistically significant difference between Group 1 and Group 2 in terms of the presence of mechanical ventilation support and tracheostomy, comorbidities, laboratory values, C -reactive protein, SOFA, APACHE scores. The mortality rate was 61% in Group 1 and 52% in Group 2. Conclusions: Our findings revealed that immune plasma treatment was not effective in recovery and decreasing the mortality rates in the COVID-19 infected intensive care unit patients. Further studies are needed to investigate the efficacy of administering immunomodulatory therapies on the outcome before the hyper inflammatory process starts.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"28 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84255795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reducing bacterial antibiotic resistance by targeting bacterial metabolic pathways and disrupting RND efflux pump activity 通过靶向细菌代谢途径和破坏RND外排泵活性来降低细菌抗生素耐药性

Iberoamerican Journal of Medicine Pub Date : 2022-01-04 DOI: 10.53986/ibjm.2022.0008

Tatiana Hillman

{"title":"Reducing bacterial antibiotic resistance by targeting bacterial metabolic pathways and disrupting RND efflux pump activity","authors":"Tatiana Hillman","doi":"10.53986/ibjm.2022.0008","DOIUrl":"https://doi.org/10.53986/ibjm.2022.0008","url":null,"abstract":"Antibiotic resistance is a significant issue for the medical community, worldwide. Many bacteria develop drug resistance by utilizing multidrug resistant or MDR efflux pumps that can export antibiotics from bacterial cells. Antibiotics are expelled from bacteria by efflux pumps a part of the resistance nodulation division (RND) family. Types of RND efflux pumps include the AcrAB-TolC tripartite protein pump. There are an excessive number of antibiotic compounds that have been discovered; however, only a few antibiotics are effective against MDR bacteria. Many bacteria become drug resistant when sharing genes that encode MDR efflux pump expression. MDR efflux pump encoding genes are incorporated into plasmids and then shared among bacteria. As a consequence, advancements in genetic engineering can sufficiently target and edit pathogenic bacterial genomes for perturbing drug resistance mechanisms. In this perspective and review, support will be provided for utilizing genetic modifications as an antimicrobial approach and tool that may effectively combat bacterial MDR. Ayhan et al. found that deleting acrB, acrA, and tolC increased the levels of antibiotic sensitivity in Escherichia coli. Researchers also found that glucose, glutamate, and fructose all induced the absorption of antibiotics by upregulating the gene expression of maeA and maeB that is a part of the MAL-pyruvate pathway. Therefore, the current perspective and review will discuss the potential efficacy of reducing antibiotic resistance by inhibiting genes that encode efflux protein pump expression while simultaneously upregulating metabolic genes for increased antibiotic uptake.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"183 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86813367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

The impact of COVID-19 Lockdown on Children with Autism Spectrum Disorder and their families in Tripoli, Libya COVID-19封锁对利比亚的黎波里自闭症谱系障碍儿童及其家人的影响

Iberoamerican Journal of Medicine Pub Date : 2022-01-02 DOI: 10.53986/ibjm.2022.0007

Adel M. Zeglam, M. Al-Ogab

{"title":"The impact of COVID-19 Lockdown on Children with Autism Spectrum Disorder and their families in Tripoli, Libya","authors":"Adel M. Zeglam, M. Al-Ogab","doi":"10.53986/ibjm.2022.0007","DOIUrl":"https://doi.org/10.53986/ibjm.2022.0007","url":null,"abstract":"Introduction: During COVID-19 pandemic, when social distancing becomes compulsory for all, a nation-wide school closure was implemented. The aim of this paper is to assess the impact of COVID-19 lockdown on children with ASD and their families in Tripoli, Libya. Materials and Methods: We conducted face-to-face interviews with parents of children with Autism Spectrum Disorder (ASD) during the period of the outbreak between June to December 2020. The Modified Check list of Autism in Toddlers (M-CHAT) was used to evaluate patients. Results: 250 children diagnosed of ASD were included. The prevalence of aggressive behaviour had increased by 47% that of loss of communication is 33%, that of poor interaction is 52% and that of anxiety among families is 27%, although rates were lower among girls. .60% of Young children aged between 5 to 10 years exhibit increased stereotyped behaviour, attachment to certain TV programs and other electronic devices (such as tablet, smartphone) more often and for longer periods of the day, temper tantrums, and crying and screaming for no obvious reasons as well as difficulty sleeping alone and frequent awakenings. 10% of children complained of psychosomatic symptoms, such as tummy pains, and diarrhoea. 16% of Adolescents had been found to have significantly higher rates of aggressive and antisocial behaviour when trying to switch them from one activity to another. Conclusions: Children with existing behavioural problems and those with ASD in particular had faced additional social and educational challenges during their special education years and had experienced the most negative consequences of living in a stressful situation like home lockdown, and are therefore had been particularly hard hit. COVD-19 pandemic was a neglected medical cause of deteriorating child behaviour, and the acute and chronic effects of this pandemic on these children’s health and education are among the greatest child harms of the 21st century.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75034095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Platelet Count as Useful Indicator for Gram-Type of Bacteria Causing Urinary Tract Infection in Women 血小板计数作为女性尿路感染革兰氏型细菌的有用指标

Iberoamerican Journal of Medicine Pub Date : 2021-12-20 DOI: 10.53986/ibjm.2022.0006

Abdulaziz Dwaya, A. Urayet, Mohamed B. Milad, Abdulhamid M. Alkout

{"title":"Platelet Count as Useful Indicator for Gram-Type of Bacteria Causing Urinary Tract Infection in Women","authors":"Abdulaziz Dwaya, A. Urayet, Mohamed B. Milad, Abdulhamid M. Alkout","doi":"10.53986/ibjm.2022.0006","DOIUrl":"https://doi.org/10.53986/ibjm.2022.0006","url":null,"abstract":"Introduction: Urinary Tract infection (UTI) is considered as the most common infections disease among women. UTI may lead to a serious complication in both kidneys. In this study, we tried to determine whether the alternation in platelet count during UTI is related to specific Gram-type of bacteria causing the infection. This assists the medical staff in selection of suitable antimicrobial drug. Material and Methods: Data of all urine cultures from Gynecology Department/ Albaraa Hospital/Tripoli processed at the Laboratory during a period of three years (2017 - 2019). All Data analysis and statistics were made with the SPSS software version 16 and performed with one-way ANOVA and a parametric test was used for categorical values and not normally distributed values. Results: A growth was detected in 101 of 193 (52%) samples and 22 (11%) were mixed growth. Gram-negative bacteria identified in 57% (45/79) while 43% (34/79) occurred with Gram-positive bacteria. Regarding to platelets count alteration, it is revealed that there was a significant difference between cases infected by Gram-negative bacteria compared to others infected by Gram-positive bacteria and control group. Conclusions: Results of the current study suggest that the change in platelet count during UTI is associated with causative bacteria’s Gram-type.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"243 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77260104","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Morning surge blood pressure as a phenotype of systemic hemodynamic atherothrombotic syndrome 晨涌血压作为全身性血流动力学动脉粥样硬化综合征的一种表型

Iberoamerican Journal of Medicine Pub Date : 2021-12-02 DOI: 10.53986/ibjm.2022.0005

Carolay Paola Ojeda-Uparela, Natalia Sofía Pancho-Villareal, Fernando Jesús Yi-Quesada, Camilo Andrés Ramírez-Salgado, Luis Felipe Arias-Guerra, M. G. Ortega-Sierra, M. M. Rahman

引用次数: 0

A Pulmonary Mucormycosis Case Related to the Use of Home-Ventilator Machine 与家用呼吸机使用有关的肺毛霉菌病1例

Iberoamerican Journal of Medicine Pub Date : 2021-11-27 DOI: 10.53986/ibjm.2022.0003

C. Özlü, Ü. Ergene, S. Alkan

引用次数: 0

Overview on pressure ulcers studies based on bibliometric methods 基于文献计量学方法的压疮研究综述

Iberoamerican Journal of Medicine Pub Date : 2021-11-27 DOI: 10.53986/ibjm.2022.0004

Hatice Öntürk Akyüz, Sevda Alkan, Oruç Numan Gökçe

{"title":"Overview on pressure ulcers studies based on bibliometric methods","authors":"Hatice Öntürk Akyüz, Sevda Alkan, Oruç Numan Gökçe","doi":"10.53986/ibjm.2022.0004","DOIUrl":"https://doi.org/10.53986/ibjm.2022.0004","url":null,"abstract":"Introduction: Pressure ulcers (PU) are a major health problem, causing increased health costs as well as workload of health workers. In this study, we aimed to analyze the developments in PUs and to add perspective to future studies by examining the research articles published on PUs, which is an increasing health problem worldwide. Material and methods: Bibliometric analysis method was used in this study. The data was obtained by searching the Elsevier Scopus database with using the keywords “pressure ulcer” or “bedsore” or “decubitus ulcer” or “decubitus” or “pressure sore”. Results: 4,361 articles were analyzed in terms of study criteria. The first article was published in the year 1849 and 52.94 % of articles were published after the year 2011. Most of the articles were written in English (87.6%) language. The majority 29.32%) of articles were from the United States of America (USA). USA, United Kingdom and Japan were the top three publishing countries. Most of the articles were in the area of medicine [n =2896(66.4%)] and nursing [n=1903(43.63%)]. The highest number of articles on PUs were published in the journals of Ostomy Wound Management (n=177), Journal of Wound Care (n=156), International Wound Journal (n=144), Journal of Wound Ostomy And Continence Nursing (n=141) and Journal of Tissue Viability (n=126). Conclusions: As the number of immobile and debiliated patients increase globally, the publications on PUs seem to be increase too. Studies outside of Europe and the USA should also be supported and the number of publications should be increased, especially from developing countries.","PeriodicalId":13190,"journal":{"name":"Iberoamerican Journal of Medicine","volume":"199 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80048984","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11