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SunText Review of Pharmaceutical Sciences最新文献

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Taking Medicine in the Right Way: Most Important But Most Neglected 正确用药:最重要但最容易被忽视
SunText Review of Pharmaceutical Sciences Pub Date : 2022-12-19 DOI: 10.51737/2766-5232.2022.017
Mohiuddin Ak
{"title":"Taking Medicine in the Right Way: Most Important But Most Neglected","authors":"Mohiuddin Ak","doi":"10.51737/2766-5232.2022.017","DOIUrl":"https://doi.org/10.51737/2766-5232.2022.017","url":null,"abstract":"Proper use of medicine or taking medicine in correct order is essential to cure any disease. According to the WHO, lack of adherence to treatment regimens leads to major problems among patients, mostly with chronic illnesses. \"Right administration\" depends on at least 5 right factors--right patient, right drug, right time, right dose and right route. \"Medicines won't work if you don't take it right\"--This simple fact is not understood by most people in the world, as a result still more than half of the patients with chronic diseases in the developed world do not take their medicine correctly-says WHO.","PeriodicalId":131899,"journal":{"name":"SunText Review of Pharmaceutical Sciences","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128114726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
RP-HPLC Method for Development and Validation of Dasatinib in Bulk, Tablets Applied in Nano suspension, Drug Entrapment Efficiency and Serum 达沙替尼原料药、纳米混悬剂、药物包封效率及血清的RP-HPLC开发与验证
SunText Review of Pharmaceutical Sciences Pub Date : 1900-01-01 DOI: 10.51737/2766-5232.2020.002
Alekhya Ch, Krishnamurty Vs
{"title":"RP-HPLC Method for Development and Validation of Dasatinib in Bulk, Tablets Applied in Nano suspension, Drug Entrapment Efficiency and Serum","authors":"Alekhya Ch, Krishnamurty Vs","doi":"10.51737/2766-5232.2020.002","DOIUrl":"https://doi.org/10.51737/2766-5232.2020.002","url":null,"abstract":"A simple, precise, accurate and robust RP-HPLC method was developed and validated for the determination of dasatinib in bulk and its Tablets, Nano-suspension drug entrapment efficiency and serum. The software used is EZ Chrome and the column employed is Syncronis C18 (250 mm × 4.6 mm, 5 μm particle size). Acetonitrile: Methanol: water 45:35:20 (v/v) was used as mobile phase at a flow rate of 1 mL min with UV detection at 325 nm. Linearity was observed in the concentration range of 1–6 μg mL with regression equation y =40966x-6534(R = 0.999). The Nanosuspension prepared by novel precipitation-combined ultra-sonic homogenization technique and was then characterized by using particle size analysis, zeta potential measurement. Liquidliquid extraction is performed for isolation of the drug and elimination of serum interferences samples of serum was extracted with 50μL of ortho phosphoric acid and 3ml of methanol was added and spiked with dasatinib. The method was validated as per ICH guidelines. The RSD for intra-day (99.2) and inter-day (98.3) precision were found to be less than 2 %.The developed method is simple, precise and robust for the determination of dasatinib in bulk and applied to tablets, Nano-suspension, drug entrapment efficiency and serum.","PeriodicalId":131899,"journal":{"name":"SunText Review of Pharmaceutical Sciences","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122448306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Strategy to Enhance Bioavailability of Drug Candidates: Natural Bioenhancers 提高候选药物生物利用度的策略:天然生物增强剂
SunText Review of Pharmaceutical Sciences Pub Date : 1900-01-01 DOI: 10.51737/2766-5232.2021.008
V. S
{"title":"A Strategy to Enhance Bioavailability of Drug Candidates: Natural Bioenhancers","authors":"V. S","doi":"10.51737/2766-5232.2021.008","DOIUrl":"https://doi.org/10.51737/2766-5232.2021.008","url":null,"abstract":"ARTICLE DETAILS Nowadays herbs are increasingly being used worldwide as therapeutic agents or in collaboration with minerals and vitamins in health supplements, teas etc. There are many advantages of herbalism over modern or conventional medicine such as the herbal/traditional systems of medicine causes lesser side effects than modern medicine; herbal medicine along with lifestyle modification enhances its potency by assisting and boosting the inborn self-healing mechanisms of the patient. Thus, the chronic disorder is not only cured but the possibilities of its recurrence are highly reduced. However, despite having great in-vitro potential, herbs or herbal extracts have demonstrated very less in-vivo activity due to insufficient lipid solubility and irregular molecular size. Thus, this led to poor absorption and poor bioavailability. With the advancement in science and technology, several trials are undergone to enhance the bioavailability of drugs via novel drug delivery systems such as microspheres, nanoparticles, liposomes, transferosomes, lipid-based systems, etc. Besides these novel approaches, there are certain compounds that exist in nature that are found to exhibit enhanced bioavailability rate such as piperine, curcumin, naringin, quercetin, genistein, etc. The objective of this review is to throw light on bioavailability enhancing effects of these natural bioenhancers of herbal origin, their characteristic features and mechanisms of action.","PeriodicalId":131899,"journal":{"name":"SunText Review of Pharmaceutical Sciences","volume":"192 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133481000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Compression, Consolidation, Compaction Physics of Pharmaceutical Powders: A Comprehensive Review 医药粉末的压缩、固结、压实物理:综合综述
SunText Review of Pharmaceutical Sciences Pub Date : 1900-01-01 DOI: 10.51737/2766-5232.2022.018
Dudhat Kr
{"title":"Compression, Consolidation, Compaction Physics of Pharmaceutical Powders: A Comprehensive Review","authors":"Dudhat Kr","doi":"10.51737/2766-5232.2022.018","DOIUrl":"https://doi.org/10.51737/2766-5232.2022.018","url":null,"abstract":"","PeriodicalId":131899,"journal":{"name":"SunText Review of Pharmaceutical Sciences","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116853543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pharmacological Characteristic of Imeglimin (Twymeeg) For Dual Mechanism to Insulin Secretion and Resistance 依米霉素对胰岛素分泌和胰岛素抵抗双重机制的药理特性
SunText Review of Pharmaceutical Sciences Pub Date : 1900-01-01 DOI: 10.51737/2766-5232.2022.013
Iwatsuki N, B. H, O. M
{"title":"Pharmacological Characteristic of Imeglimin (Twymeeg) For Dual Mechanism to Insulin Secretion and Resistance","authors":"Iwatsuki N, B. H, O. M","doi":"10.51737/2766-5232.2022.013","DOIUrl":"https://doi.org/10.51737/2766-5232.2022.013","url":null,"abstract":"Latest Standards of Medical Care in Diabetes was presented in January 2022. Among oral hypoglycemic agents (OHAs), imeglimin has been topic for a novel agent for type 2 diabetes mellitus (T2DM). Pharmacologically, imeglimin is a cyclic molecule including triazine ring. It has both pharmacological mechanism of increased insulin action and elevation of glucose-stimulated insulin secretion (GSIS). Clinically, it showed HbA1c reduction for 0.46% by monotherapy and 0.56-0.92% by combined therapy with other OHAs. From compared administration of 500mg, 1000mg and 1500mg, 1000mg twice doses would be adequate. No remarkable treatment-emergent adverse events (TEAEs) were found for treatment of imeglimin.","PeriodicalId":131899,"journal":{"name":"SunText Review of Pharmaceutical Sciences","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125607262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Advanced Therapeutic Strategies for Antimalarial and Antibacterial Drug Development through Lactate and Nitrite Transport 通过乳酸和亚硝酸盐转运开发抗疟和抗菌药物的先进治疗策略
SunText Review of Pharmaceutical Sciences Pub Date : 1900-01-01 DOI: 10.51737/2766-5232.2022.016
Ghongade Kd
{"title":"Advanced Therapeutic Strategies for Antimalarial and Antibacterial Drug Development through Lactate and Nitrite Transport","authors":"Ghongade Kd","doi":"10.51737/2766-5232.2022.016","DOIUrl":"https://doi.org/10.51737/2766-5232.2022.016","url":null,"abstract":"","PeriodicalId":131899,"journal":{"name":"SunText Review of Pharmaceutical Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133938980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Antioxidant Activities from Biosynthesized Copper Nanoparticles (AO-Cunps) Using A. Officinalis Leaf Extracts 马尾松叶提取物生物合成纳米铜(AO-Cunps)抗氧化活性评价
SunText Review of Pharmaceutical Sciences Pub Date : 1900-01-01 DOI: 10.51737/2766-5232.2022.014
Nandan M, Samantaray Us
{"title":"Evaluation of Antioxidant Activities from Biosynthesized Copper Nanoparticles (AO-Cunps) Using A. Officinalis Leaf Extracts","authors":"Nandan M, Samantaray Us","doi":"10.51737/2766-5232.2022.014","DOIUrl":"https://doi.org/10.51737/2766-5232.2022.014","url":null,"abstract":"","PeriodicalId":131899,"journal":{"name":"SunText Review of Pharmaceutical Sciences","volume":"44 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122622518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microemulsions and Micellar Systems as Increasingly Popular Carriers of Biologically Active Compounds and Drugs – Review 微乳液和胶束系统作为生物活性化合物和药物日益流行的载体-综述
SunText Review of Pharmaceutical Sciences Pub Date : 1900-01-01 DOI: 10.51737/2766-5232.2021.012
Raoofi Asl Soofiani M, W. H
{"title":"Microemulsions and Micellar Systems as Increasingly Popular Carriers of Biologically Active Compounds and Drugs – Review","authors":"Raoofi Asl Soofiani M, W. H","doi":"10.51737/2766-5232.2021.012","DOIUrl":"https://doi.org/10.51737/2766-5232.2021.012","url":null,"abstract":"","PeriodicalId":131899,"journal":{"name":"SunText Review of Pharmaceutical Sciences","volume":"154 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132859656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Xanthine Oxidase Inhibitor Activity of Dichloromethane Fraction, Ethyl Acetate Fraction of Ethanol Extract of Nephelium Lappaceum L. Leaves 枸杞子叶乙醇提取物二氯甲烷组分、乙酸乙酯组分黄嘌呤氧化酶抑制剂活性研究
SunText Review of Pharmaceutical Sciences Pub Date : 1900-01-01 DOI: 10.51737/2766-5232.2022.015
K. P., Diniatik K, Hakim Zr
{"title":"Xanthine Oxidase Inhibitor Activity of Dichloromethane Fraction, Ethyl Acetate Fraction of Ethanol Extract of Nephelium Lappaceum L. Leaves","authors":"K. P., Diniatik K, Hakim Zr","doi":"10.51737/2766-5232.2022.015","DOIUrl":"https://doi.org/10.51737/2766-5232.2022.015","url":null,"abstract":"","PeriodicalId":131899,"journal":{"name":"SunText Review of Pharmaceutical Sciences","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122178598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Ebola Disease: Challenges for Medical Professionals 埃博拉病:医疗专业人员面临的挑战
SunText Review of Pharmaceutical Sciences Pub Date : 1900-01-01 DOI: 10.51737/2766-5232.2020.003
Mohsina Fp, A Nesar, M. Mukim, S. Roy, P. Sharma, Faheem Ip
{"title":"Ebola Disease: Challenges for Medical Professionals","authors":"Mohsina Fp, A Nesar, M. Mukim, S. Roy, P. Sharma, Faheem Ip","doi":"10.51737/2766-5232.2020.003","DOIUrl":"https://doi.org/10.51737/2766-5232.2020.003","url":null,"abstract":"","PeriodicalId":131899,"journal":{"name":"SunText Review of Pharmaceutical Sciences","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132695693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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