I.P.Pavlov Russian Medical Biological Herald最新文献

{"title":"The Role of Inflammatory Biomarkers of Crevicular Fluid Involved in Modulating of Immune Protection Mechanisms in Chronic Periodontitis","authors":"Aleksandra S. Galieva, Nataliya V. Davidovich, Aleksandr S. Opravin, Ol'ga A. Khar'kova, Elena A. Polivanaya, Tat'yana A. Bazhukova","doi":"10.17816/pavlovj321217","DOIUrl":"https://doi.org/10.17816/pavlovj321217","url":null,"abstract":"INTRODUCTION: Chronic periodontal inflammation is provoked by persistence of subgingival bacterial flora and is mediated through the production of proinflammatory cytokines that induce the innate immune reactions.
 АIM: To establish the interrelation of secretion of interleukin 1 and immune component of soluble CD14 co-receptor with the main periodontopathogenic microorganisms in patients with chronic generalized periodontitis.
 MATERIALS AND METHODS: A clinical and laboratory examination of patients with chronic generalized periodontitis (n = 100) and individuals with the intact parodontium (n = 63) was conducted. Molecular genetic studies (isolation of periodontal pathogens by polymerase chain reaction in real time), immune enzyme assay (isolation of interleukin 1 and soluble CD14 co-receptor) and statistical analysis of the data obtained were performed.
 RESULTS: The frequency of isolation of periodontopathogenic bacteria in patients with the diagnosis of chronic periodontitis was 96.4% (T. forsythia 81%, р 0.001; P. gingivalis 69%, р 0.001; Tr. denticola 63%, р = 0.054). In 25% of cases, C. Albicans (р 0.001), in 37% Pr. intermedia (р 0.001) and in 30% A. actinomycetemcomitans (р 0.001) were isolated. The average concentrations of soluble CD14 co-receptor were 2.13 [1.89; 2.76] pg/ml in the control group and 20.3 [17.3; 22.5] ng/ml in the group of patients with chronic periodontitis (р 0.001). Concentrations of interleukin 1 were 3.187 [2.356; 4.633] pg/ml in the control group and 33.68 [17.255; 56.915] pg/ml in the group of patients with chronic periodontitis (р 0.001).
 CONCLUSION: Inflammation of periodontal tissues is supported by the factors of aggression and toxins not only of known periodontal pathogens, but also by their associations, which leads to enhancement of virulence factors and increase in secretion of interleukin 1 and soluble CD14 co-receptor, which, in turn, causes destruction of alveolar bone.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136012712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overload of the Right Ventricle in Patients with Pulmonary Embolism: Analysis of New Evaluation Criteria","authors":"Andrey G. Pronin, Nataliya Yu. Sivokhina, Mikhail A. Goncharov","doi":"10.17816/pavlovj119868","DOIUrl":"https://doi.org/10.17816/pavlovj119868","url":null,"abstract":"INTRODUCTION: The increasing incidence of pulmonary embolism (PE) and high mortality from it necessitates development of new echocardiographic (EchoCG) criteria for assessing the severity of pressure and volume overload of the right ventricle (RV) in patients with PE. \u0000AIM: To perform critical analysis of the developed EchoCG criteria of overload of the right heart chambers in PE with the aim to determine severity of the course and outcomes of the disease. \u0000MATERIALS AND METHODS: The study included 428 patients with PE divided to 4 groups: group 1 42 patients with recorded death, group 2 51 patients with hemodynamically significant disease, group 3 193 hemodynamically stable patients with EchoCG signs of the overload of the right ventricle, group 4 142 patients with no identified symptoms. Comparison of the developed EchoCG criteria was conducted: the volume of tricuspid regurgitation, its ratio to the volume of the right atrium and the stroke volume of the heart, and also the pressure in the pulmonary trunk, the pressure gradient on the pulmonic valve and its ratio to the pressure gradient on the tricuspid valve in the studied groups with the determination of threshold values having diagnostic and prognostic significance. \u0000RESULTS: It was found that the level of the estimated pressure gradient on the pulmonic valve has statistically significant correlation with the hemodynamic significance of the course of the disease (r = 0.91, р 0.01) and fatal outcome (r = 0.99, р 0.01) and possesses high sensitivity (more than 92.7%) and specificity (more than 97.8%). This parameter is proved to be the most important prognostic EchCG criterion. To determine the expression of the RV dysfunction and the priority flow of blood from its cavity, the following parameters equivalent to EhcoCG, such as the ratio of pressure gradient on the pulmonic artery to the pressure gradient on the tricuspid valve and the ratio of the tricuspid regurgitation volume to the stroke volume, are also significant. \u0000CONCLUSION: Calculation of the pressure gradient on the pulmonic valve and its correlation with the pressure gradient on the tricuspid valve, just as the ratio of the volume of tricuspid regurgitation to the stroke volume can be reliable criteria for assessment of the hemodynamic significance of PE and predictors of its outcome.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136012967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peculiarities of Clinical Symptoms, Somatic Complications, Approaches to Therapy and Outcomes of Delirium Induced by Exposure to Synthetic Cannabinoids: Systematic Review","authors":"Ilya A. Fedotov, Boris Yu. Volodin, Vladimir V. Novikov, Dmitriy I. Shustov","doi":"10.17816/pavlovj259737","DOIUrl":"https://doi.org/10.17816/pavlovj259737","url":null,"abstract":"INTRODUCTION: The use of synthetic cannabinoids (SCs) is an urgent healthcare problem, due to, among other things, a high number of complications.
 AIM: To systematize the peculiarities of clinical presentation, somatic complications, effectiveness of empirical approaches to therapy, and probable outcomes of delirium induced by exposure to SCs.
 MATERIALS AND METHODS: The analysis of scientific publications selected by the keywords in eLibrary, СNKI, PubMed databases, was conducted. According to PRISMA recommendations, 20 articles were taken for analysis.
 RESULTS: Today, it is impossible to predict the period when SC-induced delirium may occur. It can start after one-time intake of even small dose, and can occur both due to intoxication and with the underlying withdrawal state on the 2nd4th days after the last use. Besides classic symptoms, the clinical picture of delirium is characterized by many symptoms of schizophrenic psychoses: hallucinations of threatening or drug-addicted content; secondary paranoid delusion, less expressed than hallucinations; aggressiveness and agitated behavior; some formal thinking disorders; rarely, KandinskiClerambault and oneiroid syndromes. There are reported cases of severe somatic complications in the form of depression of consciousness, rhabdomyolysis, acute renal failure, cardiomyopathy, myocardial infarction, epilepsy, infectious complications with the underlying weakened immunity. Therapy of SC-induced delirium includes detoxification and metabolic therapy, administration of antipsychotics and tranquilizers; use of resuscitation measures in case of depression of consciousness and development of life-threatening conditions. SC-induced delirium lasts from several hours to several days. In most cases, it terminates with complete recovery with amnesia of the period of confusion and asthenia, but in some cases fatal outcomes are reported caused not only by accidents such as road accidents or suicide, but also by somatic complications (most often of infectious character, or multi-organ failure).
 CONCLUSION: SСs remain relevant due to high frequency of their use and continuous emergence of new analogs to substances of this group. They have multidirectional effect, and so far it is difficult to predict at what period the delirium induced by them may occur.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135968290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic Significance of Proinflammatory Cytokines in Planning Dental Implantation in Patients with General Somatic Pathologies","authors":"Aleksandr V. Gus'kov, Mariyat A. Abdurakhmanova, Aleksandr A. Nikiforov, Aleksandr A. Oleynikov, Anzhela S. Kokunova","doi":"10.17816/pavlovj108371","DOIUrl":"https://doi.org/10.17816/pavlovj108371","url":null,"abstract":"INTRODUCTION: The current stage of development of dental implantology permits to perform a complete dental rehabilitation even in complicated clinical situations. However, there are some difficulties which prevent achievement of a high success of implantological treatment in certain somatic pathologies that manifest in the form of systemic inflammation, and present relative contraindications for implantation. Important general somatic pathologies include chronic obstructive pulmonary disease, atherosclerosis, non-insulin-dependent diabetes mellitus, osteoporosis, etc., they are associated with the risk of acute inflammatory response of an organism to surgical implantological intervention. The risk of unpredictable complications also increases because of insufficiently wide laboratory diagnostic spectrum for planning dental implantation that includes a biochemical blood test, coagulogram, reaction to the presence of specific infections and viral diseases. This list of diagnostic data is not always sufficient for a complete prognosis of success of planned treatment in patients with a complicated general somatic or dental status. Besides, the interrelation between dental chronic diseases and general somatic pathologies which in some cases have common etiopathogenetic factors, is often not taken into account, but without the adequate diagnostic range they often remain unnoticed and lead to persistent complications in different periods after completion of treatment. Development of technologies of surgical and orthopedic dentistry permits to provide full dental care to patients even with different pathologies of organs and systems. But in this case, of importance is extended laboratory diagnostics aimed at identification of factors of chronic systemic inflammation, vascular risk, bacterial threats, for example, evaluation of some interleukins, tumor necrosis factor, C-reactive protein.
 CONCLUSION: A complex of clinical, laboratory and instrumental diagnostic methods will permit to adequately evaluate risk for treatment failure and construct a prognostic tactics of complex therapy, thereby reducing the probability for unpredictable complications in dental implantation in patients with different somatic pathologies.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136013000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peculiarities of Systemic Hemodynamics and Autonomic Status in Medical Personnel of PCR-Laboratories with Different Emotional Intelligence","authors":"Vladimir V. Shkarin, Dmitriy V. Orlov, Rodion A. Kudrin","doi":"10.17816/pavlovj111858","DOIUrl":"https://doi.org/10.17816/pavlovj111858","url":null,"abstract":"INTRODUCTION: The ongoing pandemic of a new coronavirus infection COVID-19 (COronaVIrus Disease 2019) places high demands on the activity of PCR-laboratories (laboratories performing polymerase chain reaction). The medical personnel experience overloads due to stay in the red zone wearing the individual protection means, and also in association with a high personal responsibility for the result of their work. One of the criteria that is proposed for professional selection with the aim of increasing the effectiveness of the work of personnel of PCR-laboratories, is the emotional quotient (EQ).
 AIM: To analyze the state of systemic hemodynamics and heart rate variability in medical workers of PCR-laboratories with different emotional intelligence working in condition of COVID-19 pandemic using means of individual protection against the biological factor.
 MATERIALS AND METHODS: The extent of health risk and tension of adaptation mechanisms during the work were evaluated by parameters of systemic hemodynamics (tonometry, pulse oximetry) and heart rate variability (cardiorhythmography). Thirty three individuals with the working period in a PCR-laboratory from 1 to 33 months were examined. The average age of the participants at the time of inclusion in the study was 32.4 1.44 years. In 33.7%, EQ corresponded to the medium level (81120 points), and in 66.7% to the high level (121168 points).
 RESULTS: Before the start of the work shift, increased blood supply to tissues in personnel with high EQ was achieved by increased heart activity: cardiac output (CO) 3938.9 ml/min, interquartile range (IQR) = 3404.24230.2 ml/min with the underlying reduction of vessel tone: total peripheral vascular resistance (TPVR) 1922.8 dyn s/cm5, IQR = 1636.52085.8 dyn s/cm5. After the end of the shift, to these compensatory mechanisms (CO 4284.7 ml/min, IQR = 3935.44688.8 ml/min; TPVR 1692.4 dyn s/cm5, IQR = 1584.61903.1 dyn s/cm5), increased myocardial oxygen consumption (MOC; 7917.5 RU, IQR = 7430.28811.0 RU) added as a reaction to the muscular component of labor activity. In individuals with average EQ, these mechanisms were less pronounced in considerable mental stress: before the shift CO 3722.0 ml/min, IQR = 3163.13739.0 ml/min, p = 0.013; TPVR 2303.1 dyn s/cm5, IQR = 2058.12402.1 dyn s/cm5, p = 0.016; after the shift CO 3375.0 ml/min, IQR = 3372.04402.0 ml/min, p = 0.010; TPVR 2010.5 dyn s/cm5, IQR = 1972.62351.9 dyn s/cm5, p = 0.017; MOC 7450.0 RU, IQR = 6653.37867.3 RU, p = 0.023.
 CONCLUSION: The extent of tension of mechanisms of self-regulation of systemic circulation, apart from characteristics of used technical means and the working regime, significantly depends on the level of emotional intelligence. With this, personnel with high emotional intellect are preferable for the work in the red zone because of lower tension of regulatory mechanisms.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"25 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136013154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Influence of Cigarette Smoke on Signaling Pathways of Innate Immune System in Monocytes of Peripheral Blood","authors":"Stanislav N. Kotlyarov, Igor′ A. Suchkov, Oleg M. Uryas'yev, Elena N. Yakusheva, Aleksey V. Shchulkin, Anna A. Kotlyarova","doi":"10.17816/pavlovj306495","DOIUrl":"https://doi.org/10.17816/pavlovj306495","url":null,"abstract":"INTRODUCTION: Tobacco smoking is an important medical problem since it has a significant impact on the development and progression of chronic obstructive pulmonary disease (COPD). The components of tobacco smoke can initiate and support local and systemic inflammation with participation of monocytes and macrophages.
 AIM: To study molecular mechanisms associated with the impact of cigarette smoke on signaling pathways of the innate immune system in monocytes of peripheral blood.
 MATERIALS AND METHODS: The methods of in silico analysis was used to identify genes associated with the impact of tobacco smoke. On the basis of the data obtained, a cellular model of inflammation was created in vitro using tobacco smoke extract and monocytes of peripheral blood isolated by immunomagnetic separation. An enzyme-linked immunoassay (ELISA) kit was used to measure the concentration of tumor necrosis factor- (TNF-), interleukin-1 (IL-1) in cell supernatants, and of Toll-like receptor 4 (TLR4), ATP-binding cassette A1 (ABCA1) in homogenates of cell membranes of native monocytes and monocytes exposed to 4% tobacco smoke extract. These data were compared with the levels of TNF-, IL-1, TLR4 and ABCA1 in monocytes of peripheral blood of patients with COPD with frequent exacerbation phenotype and with obliterating atherosclerosis of lower limb arteries (OALLA). For statistical processing and visualization of the data, MedCalc 20.1.4 and R (version 4.2.2) software was used.
 RESULTS: Tobacco smoke influences TLR4, TNF- signaling pathways and lipid metabolism. Cigarette smoke extract enhanced the expression of proinflammatory cytokines TNF- and IL-1 in cell supernatants, increased the level of TLR4 and decreased that of ABCA1 in plasmolemma of monocytes of peripheral blood. In patients with COPD with frequent exacerbation phenotype and with OALLA, there were shown increase in the levels of proinflammatory TNF- and IL-1 cytokines in cell supernatants, increase in the level of TLR4 and reduction of the level of ABCA1 in plasmolemma of monocytes of peripheral blood compared to native monocytes of healthy individuals.
 CONCLUSION: Cigarette smoke enhances the production of proinflammatory TNF- and IL-1 cytokines, increases the levels of TLR4 protein and reduces the amount of ABCA1 transporter in membranes of monocytes of peripheral blood. This may partially explain the cause of the influence of cigarette smoke on development of the pulmonary and cardiovascular diseases. COPD with frequent exacerbation phenotype and OALLA are characterized by enhancement of inflammation with participation of monocytes.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136013576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of Adaptive Capabilities of Frequently Ill Primary School-Aged Children","authors":"Ol'ga V. Smirnova, Elizaveta S. Ovcharenko, Eduard V. Kasparov, Vera V. Fefelova","doi":"10.17816/pavlovj112614","DOIUrl":"https://doi.org/10.17816/pavlovj112614","url":null,"abstract":"INTRODUCTION: In childhood, the immune system is actively formed, among other things, through the contact with viral and bacterial pathogens. Children over 5 years who suffer from acute respiratory diseases more than 4 times a year, are referred to the group of frequently ill children (FIC) requiring increased attention of doctors.
 AIM: To identify peculiarities of the autonomic regulation, metabolic, regulatory parameters of immune system cells in FIC of the primary school age.
 MATERIALS AND METHODS: The study involved 114 children aged 711 years. On the basis of the data of the card of childs individual development, a group of FIC was identified with recurrence rate of acute respiratory diseases more than 4 times a year (n = 28). A control group included episodically ill children (13 times a year, n = 86). The condition of the autonomic system of a child was evaluated by the data of heart rate variability using ORTO Valeo hardwaresoftware complex. The content of serotonin and catecholamines in blood lymphocytes was determined using luminescent histochemical method. Activity of succinate dehydrogenase and acid phosphatase were evaluated by cytochemical methods.
 RESULTS: The study of regulatory-metabolic parameters of immune cells in the group pf FIC showed reduced activity of succinate dehydrogenase (р 0.01) and reduced content of serotonin (р 0.01), and high activity of acid phosphatase (р 0.05) and catecholamines (р 0.001) in comparison with the control group. The analysis of parameters of autonomic regulation in FIC group showed predominance of parameters characterizing the sympathetic division of the autonomic nervous system and reduction of parameters characterizing the activity of the parasympathetic division (р 0.05).
 CONCLUSION: The results evidence a sharp imbalance between metabolic and catabolic processes in the immune system of FIC of the primary school age with the underlying predominant activity of the sympathetic nervous system. This gives the ground to study the reasonability of administration of medications and physiotherapeutic procedures for correction of the parameters of the autonomic regulation in the inter-recurrence period with the aim of improving the general adaptive capacities of FIC of the primary school age.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"114 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136012718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pathogenetic Aspects of Intraventricular Hemorrhages in Extremely Premature Infants","authors":"Ol'ga P. Saryeva, Elena V. Protsenko","doi":"10.17816/pavlovj119975","DOIUrl":"https://doi.org/10.17816/pavlovj119975","url":null,"abstract":"INTRODUCTION: Intraventricular hemorrhage (IVH) is one of the most common types of the brain damage in newborns with extremely low and very low body mass. The main source of IVH in the extremely premature infants is the germinal matrix. This is a subependymal structure of the brain consisting of poorly differentiated, randomly arranged cells, well vascularized with vessels with a poor connective-tissue support. The germinal matrix a key supplier of neurons and glial cells of the brain is unique among the brain regions for its specific rate of angiogenesis and selective vulnerability to hemorrhages during its development. Etiology and pathogenesis of IVH in premature infants are highly multifactorial and have not been fully studied. In this review, the data on the key points of the pathogenesis of IVH in premature infants are generalized.
 CONCLUSION: IVH is a potentially destructive disease, in the study of which a certain progress has been achieved in elucidating the causes and mechanisms of brain damage. In-depth understanding of the key points of the pathogenesis of intraventricular hemorrhage will permit to choose the optimal management tactics and develop new approaches to prevention and treatment of this pathology.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135967892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcultural Validity of Concept of Internalized Stigma in Patients with Mental Illnesses (Psychometric Properties of Russian Version of Internalized Stigma of Mental Illness Scale)","authors":"Mariya O. Bocharova, Kirill F. Vasil'chenko, Nataliya B. Lutova, Ol'ga V. Makarevich, Mariya A. Khobeysh, Mikhail Yu. Sorokin, Ekaterina S. Gerasimchuk","doi":"10.17816/pavlovj321239","DOIUrl":"https://doi.org/10.17816/pavlovj321239","url":null,"abstract":"INTRODUCTION: One of the commonest methods of evaluation of internalized stigma is Internalized Stigma of Mental Illness (ISMI) scale where the differences in the prevalence and perception of mental stigma in different cultures are specified.
 AIM: Validation of Russian version of ISMI scale and evaluation of peculiarities of perception of stigma by Russian-speaking patients with severe psychiatric disorders.
 MATERIALS AND METHODS: Four hundred thirty nine patients with severe psychiatric disorders (F2 and F3 according to the International Statistical Classification of Diseases and Related Health Problems, 10th revision) were examined. The psychometric properties of the Russian version of ISMI scale were evaluated using internal consistency analysis. Exploratory and confirmatory factor analysis (EFA and CFA, respectively) were performed. To check age- and gender-related invariance, MIMIC and MIFA models were used, and discriminative power and accuracy of scoring were identified using generalized partial credit model (GPCM). The results of EFA were compared with the data obtained in the Regional Clinical Hospital (n = 120) using independent alternative version of ISMI translation into Russian.
 RESULTS: The internal consistency of the Russian version of ISMI questionnaire was high: Chronbachs 0.90. EFA permitted to identify 4 factors. The first factor (Demoralization, F1) combined elements corresponding to subscale 1 (Alienation) and subscale 2 (Social withdrawal) of the original version of ISMI questionnaire. The other three factors identified in this study according to the content of the items, corresponded to the remaining subscales of the original ISMI scale. In all kinds of the conducted analysis, item 14 had low factor weight. CFA confirmed the four-factor structure. In the sample, MIMIC and MIFA showed the general age- and gender-related invariance with their insufficient power. GPCM showed good characteristics of discriminative power and difficulties in choice of scoring for all factors except the fourth one (Resistance to stigma). EFA performed on the data of the alternative sample, neither could reliably reproduce the five-factor structure of the original ISMI scale due to eclectic mixing of the items of the original scale within five isolated structures.
 CONCLUSION: The suitability of using the internalized stigma assessment tool for the Russian-speaking population has been confirmed. The study highlights the relevance and necessity of expanding transcultural studies of psychological reactions of psychiatric patients.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"287 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135968907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Prevalence of Lower Extremity Varicose Vein Disease of in One of Major Regions of Central Federal District of Russian Federation Using Multi-Variant Approach","authors":"Maksim P. Potapov, Il'ya N. Staroverov","doi":"10.17816/pavlovj129204","DOIUrl":"https://doi.org/10.17816/pavlovj129204","url":null,"abstract":"INTRODUCTION: The majority of epidemiological studies on lower extremity varicose veins (LEVV) published to date have cross-sectional character, therefore, understanding the relationships between the disease and other epidemiological variables in them is mainly based on data analysis in a short period of time and does not take into account the influence on the main parameters of functioning national health systems. It is relevant to analyze the epidemiological parameters of LEVV in the long term, taking into account the influence of the state health system in a large region of the Russian Federation.
 AIM: To identify changes in the distribution of LEVV in different territories of the Yaroslavl region (YaR) over 10 years (20112021).
 MATERIALS AND METHODS: A retrospective study of statistical parameters of the work of medical organizations of the YaR in 20112021 was conducted, namely, of the total number of attached adult population, the dynamics of the number of attached population, the total number and dynamics of the number of patients with the established diagnosis of LEVV. The weighted average value for continuous variables with a 95% confidence interval (CI) was evaluated. Heterogeneity was evaluated based on the I2 value.
 RESULTS: The static weighted average value of the prevalence of LEVV in Yaroslavl at the end of the year in 20112021 was 1.040% (95% CI: 1.0311.049). When analyzing the data for 20112021, the trend for a decline in the recorded prevalence of LEVV was determined. At the end of 2021, the prevalence of LEVV in Yaroslavl declined by 0.715%, in Pereslavl district by 0.466%, in Tutaev district by 0.4%, in Rostov district by 0.392%, in Rybinsk by 0.192% with high heterogeneity of data depending on the territory and period (I2 99). Besides, during the analyzed 10 years, there occurred significant changes in approaches to surgical treatment of LEVV, such as appearance of hospital-substituting technologies that have become widely used in the territory of the YaR by non-governmental medical organizations in the vast majority of cases.
 CONCLUSIONS: According to official data, the decline in the morbidity with LEVV in the studied territories of the YaR over 10 years (20112021) contradicts the published results of epidemiological studies. The information obtained, together with the high heterogeneity of statistical data for individual territories and periods, may indirectly indicate the low efficiency of the existing system of providing medical care to the population with LEVV.","PeriodicalId":13184,"journal":{"name":"I.P.Pavlov Russian Medical Biological Herald","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136012561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}