Drugs and Drug Candidates最新文献_第6页

A Review of the Patentability of Rosemary-Derived Drugs and Bioactive Compounds 迷迭香衍生药物及生物活性化合物可专利性综述

Drugs and Drug Candidates Pub Date : 2023-03-16 DOI: 10.3390/ddc2010011

Reda El Boukhari, A. Fatimi

{"title":"A Review of the Patentability of Rosemary-Derived Drugs and Bioactive Compounds","authors":"Reda El Boukhari, A. Fatimi","doi":"10.3390/ddc2010011","DOIUrl":"https://doi.org/10.3390/ddc2010011","url":null,"abstract":"We reviewed the patentability of rosemary-derived drugs and bioactive compounds over the last 20 years and analyzed patent documents related to the rosemary (Rosmarinus officinalis Linné) plant using patent analysis techniques. A total of 12,320 patent documents (patent applications and granted patents) were identified, with China having the highest number of patent documents at 4384. The year 2017 had the most patent documents (1122). Patent classification codes indicate that most inventions are for medicinal preparations and cosmetics characterized by their composition. Further, expert driving forces and knowledge clusters showed that research and development has focused on methods to bring pharmaceutical products into specific physical or administering forms, which are described in the majority of patents. To demonstrate the innovation trends in rosemary-derived drugs and bioactive compounds, a selection of relevant patent documents, with publication dates between 2002 and 2022, is described at the end of the study. This selection contains a total of 13 patent documents, including six patent applications and seven granted patents, and deals with pharmaceutical and biomedical applications, processes for extracting rosemary-derived biomolecules (e.g., rosmarinic acid, carnosic acid, and carnosol), and cosmetic and food applications.","PeriodicalId":131152,"journal":{"name":"Drugs and Drug Candidates","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121398441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Recent Developments in Electrospun Nanofibers as Delivery of Phytoconstituents for Wound Healing 电纺丝纳米纤维作为植物成分输送伤口愈合的最新进展

Drugs and Drug Candidates Pub Date : 2023-03-15 DOI: 10.3390/ddc2010010

Govindaraj Ajith, G. P. Tamilarasi, G. Sabarees, S. Gouthaman, K. Manikandan, V. Velmurugan, V. Alagarsamy, V. Solomon

{"title":"Recent Developments in Electrospun Nanofibers as Delivery of Phytoconstituents for Wound Healing","authors":"Govindaraj Ajith, G. P. Tamilarasi, G. Sabarees, S. Gouthaman, K. Manikandan, V. Velmurugan, V. Alagarsamy, V. Solomon","doi":"10.3390/ddc2010010","DOIUrl":"https://doi.org/10.3390/ddc2010010","url":null,"abstract":"Wound healing is an unresolved therapeutic challenge for the medical community, as wound assessment and management is a complex procedure involving numerous factors that play a significant role in the healing process. Several factors, including bacterial infections, underlying conditions, malnutrition, obesity, aging, and smoking are the most frequent causes of a delayed wound-healing process. The shortcomings related to the currently used wound dressings include poor antimicrobial properties, weak mechanical features, poor biodegradability, biocompatibility, etc. Modern medicine has expanded the use of phytoconstituents based on nanotechnology to regenerate and repair soft and hard tissues. Electrospun nanofiber platforms are the most recent and promising among many types of conventional wound dressings due to their distinct characteristics. Many plant extracts and their phytoconstituents are well-known as adequate substitutes for wound healing agents because of their wide range of active ingredients, accessibility, and limited side effects. Incorporating these phytoconstituents into electrospun nanofibers combines the structural properties of the nanofibers with the antibacterial and therapeutic properties of the plants, making the nanofibers ideal for use as wound dressings. This review focuses on the antibacterial and therapeutic applications of nanofiber wound dressings containing phytoconstituents and their potential to revolutionize wound healing.","PeriodicalId":131152,"journal":{"name":"Drugs and Drug Candidates","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128272041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Pharmacological Blockade of TGF-Beta Reduces Renal Interstitial Fibrosis in a Chronic Ischemia–Reperfusion Animal Model 在慢性缺血-再灌注动物模型中，药理阻断tgf - β可减少肾间质纤维化

Drugs and Drug Candidates Pub Date : 2023-03-13 DOI: 10.3390/ddc2010009

Zesergio Melo, Julio Palomino, A. Franco-Acevedo, D. García, Ricardo González-González, Maritza G. Verdugo-Molinares, E. Portilla-de Buen, B. Moreno-Carranza, C. Fuentes-Orozco, F. J. Barbosa-Camacho, E. A. Reyes-Elizalde, L. Cortés-Sanabria, A. González-Ojeda

{"title":"Pharmacological Blockade of TGF-Beta Reduces Renal Interstitial Fibrosis in a Chronic Ischemia–Reperfusion Animal Model","authors":"Zesergio Melo, Julio Palomino, A. Franco-Acevedo, D. García, Ricardo González-González, Maritza G. Verdugo-Molinares, E. Portilla-de Buen, B. Moreno-Carranza, C. Fuentes-Orozco, F. J. Barbosa-Camacho, E. A. Reyes-Elizalde, L. Cortés-Sanabria, A. González-Ojeda","doi":"10.3390/ddc2010009","DOIUrl":"https://doi.org/10.3390/ddc2010009","url":null,"abstract":"The targeting of transforming growth factor β (TGF-β) has been shown to reduce complications related to ischemia-reperfusion injury (IRI) post-surgically. Pirfenidone (PFD) specifically inhibits TGF-β expression and has been demonstrated to provide protection from IRI in short-term allograft models, though not yet in long-term models. A chronic unilateral IRI model was established using male Wistar rats. The animals were divided into two groups: one with IRI and a pre-treatment of PFD (0.5 mg/kg) followed by 0.5 mg/kg/day of orally administered PFD for 30 days, and a control group without PFD treatment. A sham group was also included. Kidneys and blood samples were collected after 30 days, and the renal function was evaluated by measuring the serum creatinine and KIM-1 levels. RT-PCR was used to analyze fibrosis-related genes, and Luminex to quantify the pro-inflammatory serum IL-18 cytokine. Renal section staining and histological analysis were used to detect collagen deposits. Comparison within the groups showed an increase in serum creatinine and KIM-1 expression after IRI in the control group, while PFD reduced COLL1A1 and TGF-β expression and demonstrated a reduction in fibrosis through histological stains. The treatment group also showed a reduction in IL-18. Our results suggest that PFD exerts protective effects on chronic renal IRI, reducing fibrosis development and inflammation. This study provides new insights into the treatment and management of chronic renal function loss after IRI.","PeriodicalId":131152,"journal":{"name":"Drugs and Drug Candidates","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115263941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Do Certain Anaesthetic Drugs Affect Postoperative Cancer Recurrence Rates? Implications for Drug Discovery 某些麻醉药物会影响肿瘤术后复发率吗?对药物发现的启示

Drugs and Drug Candidates Pub Date : 2023-03-07 DOI: 10.3390/ddc2010008

Ben A. Wilson, J. Pandit

引用次数: 0

An Investigation on the Relationships between Mass Spectrometric Collisional Data and Biological Activity/Stability of Some N-Acylethanolamine Acid Amidase (NAAA) β-Lactone Inhibitors 一些n -酰基乙醇胺酸酰胺酶(NAAA) β-内酯抑制剂质谱碰撞数据与生物活性/稳定性关系的研究

Drugs and Drug Candidates Pub Date : 2023-03-02 DOI: 10.3390/ddc2010007

I. Isak, A. Duranti, P. Traldi

{"title":"An Investigation on the Relationships between Mass Spectrometric Collisional Data and Biological Activity/Stability of Some N-Acylethanolamine Acid Amidase (NAAA) β-Lactone Inhibitors","authors":"I. Isak, A. Duranti, P. Traldi","doi":"10.3390/ddc2010007","DOIUrl":"https://doi.org/10.3390/ddc2010007","url":null,"abstract":"The rationale of the present study is that relationships between in vitro biological activity and mass spectrometric (MS) collisional data of molecular species have been already reported in the literature. Herein, the same approach has been employed to investigate possible correlations between MS stability and biological activity/stability data of a series of β-lactone amides and carbamates N-acylethanolamine acid amidase (NAAA) inhibitors. Electrospray ionization MS experiments were performed using an LCQ Deca ion trap and samples were introduced by direct infusion. Mass spectra of positive and negative ions have been obtained, and collisional experiments were performed on selected ionic species. Collisional-induced fragmentation pathways of molecular species related to β-lactone amide inhibitors are different in comparison to those of carbamates, being the former species more stable than the latter, due to β-lactone reactivity. Correlations were found between the characteristic collision energy (CE50) obtained by the breakdown curves and in vitro NAAA inhibitory potency of the β-lactone amides and carbamates analyzed. In the case of carbamates, a relationship between CE50 values and bovine serum albumin (BSA) stability data was also found, while any correlation was not found for amides due to their instability to BSA. β-Lactone NAAA inhibitors’ activity can be qualitatively associated with their lability, as measured by CE50 values. The results obtained could suggest that MS may be used as a preliminary experimental tool to identify carbamate NAAA inhibitors endowed with good biological stability.","PeriodicalId":131152,"journal":{"name":"Drugs and Drug Candidates","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123811687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stearylamine Liposome as an Anti-Parasitic Agent 硬脂胺脂质体的抗寄生虫作用

Drugs and Drug Candidates Pub Date : 2023-02-27 DOI: 10.3390/ddc2010006

Janani Vassoudevane, Monika Mariebernard, V. Rajendran

{"title":"Stearylamine Liposome as an Anti-Parasitic Agent","authors":"Janani Vassoudevane, Monika Mariebernard, V. Rajendran","doi":"10.3390/ddc2010006","DOIUrl":"https://doi.org/10.3390/ddc2010006","url":null,"abstract":"The uncontrolled increasing clinical resistance to the current anti-parasitic drugs towards important protozoan parasites (Plasmodium, Leishmania, Trypanosoma and Toxoplasma) has stimulated the search for novel and safe therapeutic agents at affordable prices for countries in which these parasites are endemic. For the past few decades, the criticality of the cationic lipid stearylamine (SA) in liposomes has been explored in these human parasites. Previously, SA was incorporated in the liposomal formulation to impart a net positive charge for enhanced cellular uptake. However, the discovery of SA in liposomes alone elicits a strong anti-parasitic activity with immunomodulatory potential. Additionally, the SA liposome possesses a significant inhibitory potential on multiple life stages of the parasite cycle and delivers an equal effect on both drug-sensitive and resistant parasites. Moreover, the delivery of standard anti-parasitic drugs using SA liposome vesicles has enhanced the efficacy of drugs due to the synergistic impacts without causing any apparent toxicity on the host cells. In addition, the delivery of antigens as vaccine candidates using SA liposomes elicits a pronounced immune response in clearing the infection compared to other cationic lipids and SA-free liposomes. Nonetheless, SA liposome mediates its anti-parasitic activity by targeting the negatively charged phosphatidylserine-exposed infected host cell surface or by interaction with negatively charged sialic acid of free-living parasites. Overall, SA liposome confers its protection by acting as a chemotherapeutic agent with immunomodulatory activity. Therefore, a broadly acting anti-parasitic agent (SA liposome) is promising in tackling the deadly parasitic infections in endemic regions and warrants further clinical investigations.","PeriodicalId":131152,"journal":{"name":"Drugs and Drug Candidates","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125496738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Testolactone: The Rise and Fall of a Drug 睾丸内酯:一种药物的兴衰

Drugs and Drug Candidates Pub Date : 2023-02-04 DOI: 10.3390/ddc2010005

Marina P. Savić, Ivana Z. Kuzminac, Andrea R. Nikolić

{"title":"Testolactone: The Rise and Fall of a Drug","authors":"Marina P. Savić, Ivana Z. Kuzminac, Andrea R. Nikolić","doi":"10.3390/ddc2010005","DOIUrl":"https://doi.org/10.3390/ddc2010005","url":null,"abstract":"Testolactone is structurally related to testosterone and belongs to the first generation of aromatase inhibitors. It is a non-selective irreversible aromatase enzyme inhibitor that was one of the first steroids used in the clinical treatment of breast cancer. The use of testolactone in the treatment of breast cancer started in 1970, although its ability to inhibit aromatase was not discovered until 1975. Its use was primarily based on the inhibition of estrogen synthesis, which was applied in the treatment of estrogen-dependent breast cancers, in the treatment of disorders of sex steroid excess, familial male-limited precocious puberty, or in the treatment of patients with McCune–Albright syndrome, etc. The weak inhibitory activity of testolactone, and the moderate clinical response, prevented its widespread use, which ultimately resulted in withdrawal from the drug market in 2008. This review paper is dedicated to testolactone, its rise in the second half of the 20th century, and its fall in the first decade of the 21st century. Regardless of withdrawal from the market, for many years testolactone was a drug that improved the quality of life of patients facing one of the most serious diseases today, and for this reason, this paper describes medicinal application, synthesis, and modifications of testolactone.","PeriodicalId":131152,"journal":{"name":"Drugs and Drug Candidates","volume":"47 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127462863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Betulinic Acid: Triterpenoid Derivative Induced NADPH-d Expression in the Urinary System with a Possible Renal Protective Role of Nitric Oxide 白桦酸:三萜衍生物诱导NADPH-d在泌尿系统中的表达，可能具有一氧化氮的肾保护作用

Drugs and Drug Candidates Pub Date : 2023-02-02 DOI: 10.3390/ddc2010004

S. Yin, S. Ayesha, C. Panneerselvam, A. I. Alalawy, F. Almutairi, M. A. Seyed

{"title":"Betulinic Acid: Triterpenoid Derivative Induced NADPH-d Expression in the Urinary System with a Possible Renal Protective Role of Nitric Oxide","authors":"S. Yin, S. Ayesha, C. Panneerselvam, A. I. Alalawy, F. Almutairi, M. A. Seyed","doi":"10.3390/ddc2010004","DOIUrl":"https://doi.org/10.3390/ddc2010004","url":null,"abstract":"The birch tree-derived pentacyclic lupine type-triterpenoid Betulinic acid has demonstrated a variety of biological activities BetA is known for its harmlessness on normal healthy cells. However, recent investigations have indicated that BetA can cause cellular changes in mouse normal embryonic fibroblasts even with a minimal concentration. This report cautioned the use of BetA at the clinical level, which encouraged us to examine whether BetA could produce any key effect on normal healthy cells of any organs in mice. The present study extended its investigation to evaluate whether BetA could induce any changes in the renal system and the expression pattern of NADPH-diaphorase an indirect marker of the enzyme nitric oxide synthase in mice. Our results indicated that BetA exposure induced NADPH-d expression in both organs without causing any significant morphological changes. Moreover, NADPH-d activity patterns in the organs of BetA-treated animals tremendously increased (from day 4 until day 12) when compared to controls. The expression of NADPH-d in both the kidney and bladder implies that NADPH-d-mediated nitric oxide signaling could be a mechanism involved in BetA-induced nephroprotection. These outcomes are of direct clinical importance and could pay the way for the improvement of BetA as an important pharmaceutical product.","PeriodicalId":131152,"journal":{"name":"Drugs and Drug Candidates","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114836781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Isolation and Characterization of Prophylactic Antimalarial Agents from Ochna kibbiensis Leaves 桔梗叶预防性抗疟药的分离与鉴定

Drugs and Drug Candidates Pub Date : 2023-01-24 DOI: 10.3390/ddc2010003

A. Yusuf, M. Abdullahi, I. Nasir, A. Yunusa, C. O. Alebiosu, A. Muhammad

{"title":"Isolation and Characterization of Prophylactic Antimalarial Agents from Ochna kibbiensis Leaves","authors":"A. Yusuf, M. Abdullahi, I. Nasir, A. Yunusa, C. O. Alebiosu, A. Muhammad","doi":"10.3390/ddc2010003","DOIUrl":"https://doi.org/10.3390/ddc2010003","url":null,"abstract":"Ochna kibbiensis (Family: Ochnaceae) has been employed in ethnomedicine for the treatment of malaria and inflammation, among others. The aim of this study was to isolate and characterize prophylactic antimalarial agents from the leaves of O. kibbiensis against Plasmodium berghei, in vivo and in silico. The median lethal dose (LD50) of the methanol extract and its fractions (hexane, dichloromethane, ethylacetate and butanol) was determined according to Lorke’s method while the antimalarial effect of the extract and its fractions was investigated according to the method described by Peters prophylactic test using Chloroquine-sensitive Plasmodium berghei (NK65). All the extract/fractions exhibited LD50 values ≥ 5000 mg/kg with the exception of the n-butanol fraction (1702.94 mg/kg), which indicate that the plant is non-toxic. Dichloromethane fraction exhibited a significant (p < 0.05) and dose-dependent prophylactic effect with 47.62, 85.12, and 100.0% prophylaxis (at 500, 250, and 125 mg/kg), while the least effect was observed by the butanol fraction with a percentage prophylaxis of 64.29 and 76.19, respectively; the standard drug, pyrimethamine, had 95.24% prophylaxis. Based on the results obtained, dichloromethane fraction of O. kibbiensis was subjected to chromatographic purification, which led to the isolation of a mixture of two compounds identified as stigmasterol and β-sitosterol by analysis of the NMR spectral data and comparison with existing literature; the compounds exhibited good binding affinities (−5.129 and −4.889 kcal/mol) against pfLDH and a favorable ADMET profile. In conclusion, the leaves of O. kibbiensis have demonstrated a significant prophylactic antimalarial activity and the two known steroids (stigmasterol and β-sitosterol) were isolated from the dichloromethane fraction for the first time.","PeriodicalId":131152,"journal":{"name":"Drugs and Drug Candidates","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129373135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Indonesian Vegetables: Searching for Antioxidant and Antidiabetic Therapeutic Agents 印度尼西亚蔬菜:寻找抗氧化和抗糖尿病治疗剂

Drugs and Drug Candidates Pub Date : 2023-01-20 DOI: 10.3390/ddc2010002

Dinar Mutia Rani, Nursyazwani Hanafi, Sudarko, Dessy Rachmawati, T. A. Siswoyo, F. M. Christianty, I. P. Dewi, A. S. Nugraha

{"title":"Indonesian Vegetables: Searching for Antioxidant and Antidiabetic Therapeutic Agents","authors":"Dinar Mutia Rani, Nursyazwani Hanafi, Sudarko, Dessy Rachmawati, T. A. Siswoyo, F. M. Christianty, I. P. Dewi, A. S. Nugraha","doi":"10.3390/ddc2010002","DOIUrl":"https://doi.org/10.3390/ddc2010002","url":null,"abstract":"Diabetes mellitus prevalence in Indonesia reached 19.5 million cases, which has affected the productive age population. The indigenous people of Indonesia are blessed with the second largest biodiversity in the world, including vegetables, which are also prepared as medicaments. Vegetables are well-known as natural antioxidants which evolved in metabolic disease prevention, including diabetes mellitus. One of the Government of Indonesia’s strategic plans in health is to develop new antidiabetic from nature. In this study, nineteen vegetable species were collected and evaluated for their antioxidant activity followed by computational-based bioprospecting. The study indicated Ipomoea aquatica, Paederia foetida, Plumbago zeylanica, Nauclea pallida, Sauropus androgynus, Wrightia pubescens, and Psophocarpus tetragonolobus to contain high antioxidant components. Computational experiments on chemical constituents previously reported from the same species showed potent compounds with high affinity against α-glucosidase (3a4a). 7-O-β-D-glucopyranosyl-dihydroquercetin-3-O-α-D-glucopyranoside 1, stigmasterol 7, and chitanone 12 are the most potent compounds from Ipomoea aquatica, Paederia foetida, and Plumbago zeylanica, respectively, which are superior to a standard drug, acarbose. The four vegetable species are feasible for conventional drug sources or developed as botanical dosage according to the Indonesian government’s strategic plan. Further studies are necessary to ensure adequate preclinical and clinical data to meet the requirement of safe and potent medicine. Nevertheless, Nauclea pallida and Psophocarpus tetragonolobus are valuable species with potent yet understudied antioxidant sources.","PeriodicalId":131152,"journal":{"name":"Drugs and Drug Candidates","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128576445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0