{"title":"Folate status during pregnancy and lactation in a West African rural community.","authors":"C J Bates, N J Fuller, A M Prentice","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Red cell folate concentration was used to measure folate status in 89 rural Gambian women, 81 of whom were pregnant or lactating for the duration of the study. During pregnancy, the women received a haematinic supplement of 500 micrograms pteroyl glutamic acid and 47 mg iron a day, and a food supplement was also given to some of the women during either pregnancy, or lactation, or both. During pregnancy, the red cell folate levels reached a peak around the fifth month, attributable to the haematinic supplement. By the third month of lactation they had fallen back to a low plateau, which was below the accepted lower limit of normality in 56 per cent of those who did not receive a food supplement during lactation. In addition to these changes, there was a significant cyclical variation with season, peak values occurring in the rainy season. Plasma iron values followed the red cell folate patterns quite closely. Changes in blood haemoglobin levels during pregnancy were similar to those reported from other communities; there was also an increase in mean red cell volume during the first half of pregnancy, reaching a peak at the same stage as the peaks of red cell folate and plasma iron. There was no indication of the presence of raised cell volumes in association with low folate indices which might suggest megaloblastosis. It is concluded that the 500 micrograms daily folate supplement is both necessary and adequate to maintain red cell folate levels during pregnancy in this community, but that in the absence of further supplements during lactation, red cell folate levels will fall to undesirably low levels in many subjects by the third-to-sixth month of lactation.</p>","PeriodicalId":13078,"journal":{"name":"Human nutrition. Clinical nutrition","volume":"40 1","pages":"3-13"},"PeriodicalIF":0.0,"publicationDate":"1986-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15071113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
C Plath, W Heine, L Krienke, I Richter, K D Wutzke, J Töwe, K Krawielitzki
{"title":"15N-tracer-kinetic studies on the nitrogen metabolism of very small preterm infants on a diet of mother's milk.","authors":"C Plath, W Heine, L Krienke, I Richter, K D Wutzke, J Töwe, K Krawielitzki","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Protein synthesis and breakdown, nitrogen flux and other parameters of nitrogen metabolism were measured in five male preterm infants with a mean gestational age of 30.4 +/- 1.95 complete weeks of gestation and a mean body weight of 1592 +/- 517 g. The infants were fed on mothers' milk; the measurements were made at a post-conceptional age of 31.6 +/- 1.9 weeks of gestation (Ia) and were repeated at 34.4 +/- 1.9 weeks of gestation (Ib). [15N]-glycine (95 atom per cent) was used as a tracer, administered as a single enteral dose of 20 mg/kg. Whole-body protein parameters were calculated from an assumed three-pool model. The results were compared with data from moderately small preterm (II) and full-term (III) infants measured at post-conceptional ages of 36.1 +/- 1.4 and 48.0 +/- 2.8 weeks respectively. Protein synthesis rates tended to decrease with increasing post-conceptional age: 14.3 +/- 4.5 g/kg/d (Ia); 11.8 +/- 2.9 g/kg/d (Ib); 7.9 +/- 2.7 g/kg/d (II); and 7.7 +/- 1.4 g/kg/d (III). Protein breakdown and nitrogen flux showed the same trends. Possible consequences for the appropriate nutrition of very small preterm infants are discussed.</p>","PeriodicalId":13078,"journal":{"name":"Human nutrition. Clinical nutrition","volume":"39 6","pages":"399-409"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15188718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S A Sarker, M M Rahaman, A Ali, S Hossain, A N Alam
{"title":"Prolonged depression of serum zinc concentrations in children following post-measles diarrhoea.","authors":"S A Sarker, M M Rahaman, A Ali, S Hossain, A N Alam","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Serum zinc levels were measured in three groups of children aged 6 months to 6 years. In group I, there were 25 children with diarrhoea, who had a history of measles within the 2 weeks preceding the zinc level tests (post-measles diarrhoea); in group II there were 17 children who had diarrhoea only; and in group III there were 20 children who were apparently healthy and had neither diarrhoea nor measles (controls). Serum zinc concentrations of less than 5 mumol/l were observed in 5 out of 16 children in group I, but none of the children in group II had such low levels. The serum zinc level in group II rose significantly during the recovery stage compared to the acute stage (P less than 0.01). Children with post-measles diarrhoea showed a continued and prolonged depression of serum zinc levels.</p>","PeriodicalId":13078,"journal":{"name":"Human nutrition. Clinical nutrition","volume":"39 6","pages":"411-7"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15188719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Post-gastrectomy nutrition: methods of outpatient screening for early osteomalacia.","authors":"F I Tovey, D G Karamanolis, J Godfrey, C G Clark","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A cohort of 227 patients treated by partial gastrectomy between 1955-1960 has been followed up regularly for evidence of osteomalacia. Of these, 10 developed clinical or subclinical osteomalacia as proven by bone biopsy. The diagnosis of early asymptomatic osteomalacia in bone biopsies presented many difficulties. As an alternative, patients with a rising serum alkaline phosphatase (SAP) were screened for liver disease, Paget's disease, osteoporotic crush fractures and bony secondaries. In the absence of these a therapeutic trial of eight Calcium and Vitamin D tablets BPC daily was given. In 5 out of 11 patients the SAP fell to normal and these were given a maintenance daily dose of six tablets. These patients were presumed to have had subclinical osteomalacia. This approach, involving regular monitoring of the SAP, is recommended as the most applicable for routine screening of a gastrectomy population, particularly in District Hospitals.</p>","PeriodicalId":13078,"journal":{"name":"Human nutrition. Clinical nutrition","volume":"39 6","pages":"439-46"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15188721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H J Powers, C J Bates, W H Lamb, J Singh, W Gelman, E Webb
{"title":"Effects of a multivitamin and iron supplement on running performance in Gambian children.","authors":"H J Powers, C J Bates, W H Lamb, J Singh, W Gelman, E Webb","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Forty boys and girls between 11 and 14.5 years with evidence of subclinical vitamin deficiencies were allocated to two groups to receive, twice weekly, either a placebo or a multivitamin and iron supplement. Prior to supplementation and on two subsequent occasions about 5 weeks apart, the children performed an exercise regimen on a treadmill during which expired air was collected and heart rate monitored. The supplement resulted in marked improvements in riboflavin and vitamin C status and checked the decline in iron stores seen in the unsupplemented children. During the study the running performance of unsupplemented children deteriorated, and markedly so in a subgroup with initially poor nutrient status. The vitamin and iron supplement prevented this deterioration so as to produce a significant reduction in the energy cost of treadmill running in the more malnourished subgroup, relative to the changes seen in children receiving no supplement.</p>","PeriodicalId":13078,"journal":{"name":"Human nutrition. Clinical nutrition","volume":"39 6","pages":"427-37"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15188720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship between energy expenditure, expressed as the physical activity index, and body weight at low physical activity programmes.","authors":"L Garby","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The physical activity index, PAI, is defined as the energy expenditure, EE, divided by the resting metabolic rate, RMR. An expression for the body weight dependency of PAI, ie, dPAI/dBW = K, is derived. Numerical values for this coefficient were calculated on the basis of six published papers using whole-body calorimetry with observations over 24 h. It was found to be around -0.0022 per kg body weight difference in the PAI range between 1.25 and 1.70.</p>","PeriodicalId":13078,"journal":{"name":"Human nutrition. Clinical nutrition","volume":"39 6","pages":"455-8"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15188565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M D Kuizon, R L Cheong, L P Ancheta, J A Desnacido, M P Macapinlac, J S Baens
{"title":"Effect of anaemia and other maternal characteristics on birthweight.","authors":"M D Kuizon, R L Cheong, L P Ancheta, J A Desnacido, M P Macapinlac, J S Baens","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>A cross-sectional study was done on 982 mothers who delivered in four different government hospitals in Metro Manila and whose pregnancy was unassociated with pre-eclampsia, diabetes mellitus, chronic hypertension, cardiovascular disease, abruptio placenta, placenta praevia and multiple pregnancy. The relationship of birthweight and anaemia and other maternal characteristics was examined by multiple regression analysis. Birthweights did not correlate with maternal haemoglobin levels. However, anaemic mothers showed placental hypertrophy. The hypertrophy is probably a compensatory physiological response to ensure adequate oxygen supply to the fetus. Birthweight increased with gestational age affirming the fact that low birthweight is partly due to shortened gestational age. Haemoglobin level significantly increased with maternal age but decreased with increasing parity.</p>","PeriodicalId":13078,"journal":{"name":"Human nutrition. Clinical nutrition","volume":"39 6","pages":"419-26"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"14993666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R Mathur, V Reddy, A N Naidu, Ravikumar, K A Krishnamachari
{"title":"Nutritional status and diarrhoeal morbidity: a longitudinal study in rural Indian preschool children.","authors":"R Mathur, V Reddy, A N Naidu, Ravikumar, K A Krishnamachari","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Malnutrition and diarrhoeal diseases are important interrelated health problems of preschool children in the developing countries. For a prospective study to determine the effect of malnutrition on diarrhoeal morbidity 721 children under 5 years, living in two villages near Hyderabad were registered. The children were classified into different nutritional grades based on initial body weights and heights; and diarrhoea morbidity was recorded during the subsequent one year. The aetiology of diarrhoea was determined in a subsample. The incidence of diarrhoea was observed to be about 1.6 episodes/child/year and was similar in children with different nutritional grades. The percentage of episodes leading to severe dehydration was, however, significantly higher (P less than 0.05) in children with grade III malnutrition. The isolation of ETEC was also higher in this group indicating a greater bacterial load in the gut. Although pre-existing malnutrition did not affect the incidence of diarrhoea it seems to have a significant impact on the severity of the disease.</p>","PeriodicalId":13078,"journal":{"name":"Human nutrition. Clinical nutrition","volume":"39 6","pages":"447-54"},"PeriodicalIF":0.0,"publicationDate":"1985-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15188722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Folic acid uptake characteristics of a human colon carcinoma cell line, Caco-2. A newly-described cellular model for small intestinal epithelium.","authors":"M L Vincent, R M Russell, V Sasak","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>To investigate a newly described model for differentiated small intestinal function, folic acid uptake characteristics were examined in the human colon carcinoma cell line, Caco-2. Monolayers of this cell line spontaneously exhibit structural and functional differentiation patterns characteristic of mature enterocytes, with the appearance of brush border microvilli and high activity levels of the enzymes associated with the brush border. Our results concur with other models of folic acid uptake that emphasize the importance of intraluminal factors on micronutrient absorption. Folate uptake declined rapidly between pH 5.8 and 7.5, and was dependent on the initial folate concentration in the media. A dual uptake process is suggested, with a high rate of uptake at folate concentrations below 20 nmol/ml and linear uptake characteristics at higher concentrations.</p>","PeriodicalId":13078,"journal":{"name":"Human nutrition. Clinical nutrition","volume":"39 5","pages":"355-60"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15167471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Body fat estimated from anthropometric and electrical impedance measurements.","authors":"J A Pasco, I H Rutishauser","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>Estimates of body fat based on anthropometric measurements were compared in two groups of females, one from the local community and the other from the 1984 Australian Olympic Team. Estimates of body fat based on electrical impedance measurements were also made for the community group. For estimates of total body fat based on skinfold measurements, a significant difference of approximately 1 kg fat/m2 was observed between athletes and non-athletes. In the group of non-athletes estimates of fat based on skinfold measurements were significantly higher than those based on body mass index, with estimates from electrical impedance falling between. Electrical impedance measurements may provide a means of estimating body fat which takes into account differences in fat distribution and in the ratio of fat to fat-free tissue and may thus overcome the problems associated with estimates based on measurements of subcutaneous fat (skinfolds) or body size which do not allow for these differences.</p>","PeriodicalId":13078,"journal":{"name":"Human nutrition. Clinical nutrition","volume":"39 5","pages":"365-9"},"PeriodicalIF":0.0,"publicationDate":"1985-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"15167473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}