Human pathology最新文献_第3页

Lymphoplasmacytic lymphoma and Waldenström macroglobulinemia, a decade after the discovery of MYD88L265P 淋巴浆细胞性淋巴瘤和Waldenström巨球蛋白血症，MYD88L265P发现十年后。

IF 2.7 2区医学

Human pathology Pub Date : 2025-02-01 DOI: 10.1016/j.humpath.2024.105708

Lianqun Qiu, Pei Lin

{"title":"Lymphoplasmacytic lymphoma and Waldenström macroglobulinemia, a decade after the discovery of MYD88L265P","authors":"Lianqun Qiu, Pei Lin","doi":"10.1016/j.humpath.2024.105708","DOIUrl":"10.1016/j.humpath.2024.105708","url":null,"abstract":"<div><div>There has been remarkable progress over the past 80 years since Jan Waldenstrom first described patients with a hyperviscosity syndrome related to IgM paraprotein in 1944. The definition of Waldenstrom macroglobulinemia (WM) has evolved from a clinical syndrome to a distinct clinicopathologic entity with characteristic morphology, immunophenotype and molecular features. The landmark discovery of <em>MYD88</em> mutation among most WM cases in 2012 marked the dawning of an era of molecular genomic exploration that led to a paradigm shift in clinical practice. In the current World Health Organization (WHO) classification of hematologic neoplasms, WM is included in the category of lymphoplasmacytic lymphoma (LPL) of which WM represents over 90% of cases. LPL/WM is also better defined, resolving ambiguity in many cases that would have been classified as “low-grade B-cell lymphoma with plasmacytic differentiation” a decade before. Nevertheless, challenges still face pathologists because criteria for distinguishing LPL/WM from other types of low-grade B-cell lymphoma, particularly marginal zone lymphoma (MZL), remain imperfect. In this review, we highlight the current understanding of LPL and WM brought to light by new discoveries, which in turn are increasingly translated to improved diagnosis and personalized therapy. Key concepts in the diagnosis and their clinical implications are emphasized. Controversies and challenges are also discussed.</div></div>","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"156 ","pages":"Article 105708"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142864111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aberrant expression in lymphoma, a diagnostic pitfall 淋巴瘤中的异常表达，诊断缺陷。

IF 2.7 2区医学

Human pathology Pub Date : 2025-02-01 DOI: 10.1016/j.humpath.2024.105706

Joo Y. Song , Zenggang Pan

引用次数: 0

Marginal zone lymphoma of extranodal sites: A review with an emphasis on diagnostic pitfalls and differential diagnosis with reactive conditions 结节外边缘区淋巴瘤：以诊断陷阱和与反应性疾病的鉴别诊断为重点的综述。

IF 2.7 2区医学

Human pathology Pub Date : 2025-02-01 DOI: 10.1016/j.humpath.2024.105683

Roman Segura-Rivera , Sergio Pina-Oviedo

{"title":"Marginal zone lymphoma of extranodal sites: A review with an emphasis on diagnostic pitfalls and differential diagnosis with reactive conditions","authors":"Roman Segura-Rivera , Sergio Pina-Oviedo","doi":"10.1016/j.humpath.2024.105683","DOIUrl":"10.1016/j.humpath.2024.105683","url":null,"abstract":"<div><div>Marginal zone lymphoma of the mucosa-associated lymphoid tissue (MALT lymphoma) represents 8% of all B-cell lymphomas and it is the most common small B-cell lymphoma arising at extranodal sites. The gold-standard test to establish a diagnosis of MALT lymphoma remains histopathologic analysis with the aid of immunohistochemistry (IHC) and/or flow cytometry immunophenotypic analysis. MALT lymphoma represents a progression from a persistent chronic inflammatory process, and therefore distinguishing MALT lymphoma from chronic inflammation by histopathology may be challenging in some cases. Despite recent trends to consider <em>IGH</em> rearrangement/clonality as a confirmatory diagnostic test of MALT lymphoma, this method is far from ideal for this purpose since a positive or a negative result does not necessarily confirm or exclude that a process is lymphoma or reactive. This test must be correlated with the morphologic findings. Moreover, MALT lymphoma may arise in association with underlying autoimmune conditions where clonal lymphoid populations are not uncommonly detected. Therefore, we believe that an integrated approach including detailed morphologic review in combination with IHC and/or flow cytometry is best to establish a diagnosis of MALT lymphoma in most cases. We present helpful morphologic tips to avoid potential diagnostic pitfalls at some of the most common extranodal sites, including the stomach, ocular adnexa/conjunctiva, salivary gland, lung, thymus, breast, thyroid, small and large intestine and the dura. The differential diagnosis of MALT lymphoma with IgG4-related disease is also discussed.</div></div>","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"156 ","pages":"Article 105683"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142619268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of flow cytometry immunophenotypic analysis for the diagnosis of mature B-cell lymphomas/leukemias 流式细胞术免疫表型分析在成熟b细胞淋巴瘤/白血病诊断中的应用。

IF 2.7 2区医学

Human pathology Pub Date : 2025-02-01 DOI: 10.1016/j.humpath.2024.105711

Hong Fang, Sa A. Wang, L. Jeffrey Medeiros, Wei Wang

引用次数: 0

Contemporary approach to the diagnosis and classification of intestinal T-cell lymphomas

IF 2.7 2区医学

Human pathology Pub Date : 2025-02-01 DOI: 10.1016/j.humpath.2025.105720

Sanam Loghavi, L. Jeffrey Medeiros

{"title":"Contemporary approach to the diagnosis and classification of intestinal T-cell lymphomas","authors":"Sanam Loghavi, L. Jeffrey Medeiros","doi":"10.1016/j.humpath.2025.105720","DOIUrl":"10.1016/j.humpath.2025.105720","url":null,"abstract":"<div><div>We provide an overview of recent advances in the diagnosis and classification of intestinal T- and NK-cell lymphomas and lymphoproliferative disorders that primarily involve the gastrointestinal (GI) tract. It should be mentioned that systemic T- and NK-cell lymphomas can present initially in the GI tract but are not the focus of this review. Here, we focus on the clinical and pathologic findings of enteropathy-associated T-cell lymphoma, monomorphic epitheliotropic intestinal T-cell lymphoma, intestinal T-cell lymphoma, not otherwise specified, indolent T-cell lymphoma of the GI tract and indolent NK-cell lymphoproliferative disorder of the GI tract (previously known as NK-cell enteropathy). These diseases are uncommon, and their clinical manifestations and pathologic features can show overlap, but are associated with different outcomes making accurate diagnosis essential. In most cases, the diagnosis of intestinal T- and NK-cell lymphomas and lymphoproliferative disorders requires integrating the clinical context with the morphologic, immunophenotypic, and molecular alterations. In this review, we also emphasize the current understanding of the genetic drivers of these diseases.</div></div>","PeriodicalId":13062,"journal":{"name":"Human pathology","volume":"156 ","pages":"Article 105720"},"PeriodicalIF":2.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143038174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Introduction to special issue on lymphoma

IF 2.7 2区医学

Human pathology Pub Date : 2025-02-01 DOI: 10.1016/j.humpath.2025.105721

L. Jeffrey Medeiros

引用次数: 0

Classic Hodgkin lymphoma: An illustrative review of select diagnostic limitations and immunomorphological challenges 经典霍奇金淋巴瘤：对部分诊断局限性和免疫形态学挑战的说明性回顾。

IF 2.7 2区医学

Human pathology Pub Date : 2025-02-01 DOI: 10.1016/j.humpath.2024.105678

Siba El Hussein , Dennis P. O'Malley

引用次数: 0

Primary mediastinal large B-cell lymphoma from the clinic to genomics: Insights for pathologists 原发性纵隔大b细胞淋巴瘤从临床到基因组学：病理学家的见解。