Hormones & Cancer最新文献_第8页

Combinatorial Effect of Abiraterone Acetate and NVP-BEZ235 on Prostate Tumor Progression in Rats. 醋酸阿比特龙联合NVP-BEZ235对大鼠前列腺肿瘤进展的影响。

IF 3 4区医学

Hormones & Cancer Pub Date : 2018-06-01 DOI: 10.1007/s12672-018-0323-z

Bianca Facchim Gonçalves, Silvana Gisele Pegorin de Campos, Wagner José Fávaro, Joyce Zalotti Brandt, Cristiane Figueiredo Pinho, Luis Antônio Justulin, Sebastião Roberto Taboga, Wellerson Rodrigo Scarano

{"title":"Combinatorial Effect of Abiraterone Acetate and NVP-BEZ235 on Prostate Tumor Progression in Rats.","authors":"Bianca Facchim Gonçalves, Silvana Gisele Pegorin de Campos, Wagner José Fávaro, Joyce Zalotti Brandt, Cristiane Figueiredo Pinho, Luis Antônio Justulin, Sebastião Roberto Taboga, Wellerson Rodrigo Scarano","doi":"10.1007/s12672-018-0323-z","DOIUrl":"https://doi.org/10.1007/s12672-018-0323-z","url":null,"abstract":"Use of drug combinations that target different pathways involved in the development and progression of prostate cancer (PCa) has emerged as an alternative to overcome the resistance caused by drug monotherapies. The antiandrogen abiraterone acetate and the PI3K/Akt inhibitor NVP-BEZ235 (BEZ235) may be suitable options for the prevention of drug resistance and the inhibition of PCa progression. The aim of the present study was to evaluate whether abiraterone acetate and BEZ235 achieve superior therapeutic effects to either drug administered as monotherapy, in the early stages of PCa in an androgen-dependent system. Our study showed that each drug might impair tumor growth by reducing proliferation and increasing cell death when administered as monotherapy. However, tumor growth continued to progress with each drug monotherapy and some important side effects were related to BEZ. Conversely, when used in combination, the drugs impaired the inflammatory response, decreased hyperplastic lesions, and blocked tumor progression from premalignant to a malignant stage. Our data showed that the strategy to block the androgenic and PI3K/AKT/mTOR pathway is an effective therapeutic option and should be investigated including distinct PI3K pathway inhibitors.","PeriodicalId":13060,"journal":{"name":"Hormones & Cancer","volume":"9 3","pages":"175-187"},"PeriodicalIF":3.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12672-018-0323-z","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9837477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Fasting Blood Glucose Level in Locally Advanced Non-Small Cell Lung Cancer: a New Prognostic Factor? 局部晚期非小细胞肺癌的空腹血糖水平:一个新的预后因素?

IF 3 4区医学

Hormones & Cancer Pub Date : 2018-06-01 DOI: 10.1007/s12672-018-0322-0

Esra Korkmaz Kirakli, Ufuk Yilmaz, Hasan Yilmaz, Berna Komurcuoglu

{"title":"Fasting Blood Glucose Level in Locally Advanced Non-Small Cell Lung Cancer: a New Prognostic Factor?","authors":"Esra Korkmaz Kirakli, Ufuk Yilmaz, Hasan Yilmaz, Berna Komurcuoglu","doi":"10.1007/s12672-018-0322-0","DOIUrl":"https://doi.org/10.1007/s12672-018-0322-0","url":null,"abstract":"Hyperglycemia may lead to proliferation, invasion, apoptosis inhibition, migration, and eventually metastasis of cancer cells by several mechanisms. In this study, the effect of hyperglycemia on overall survival (OS), disease-free survival (DFS), and locoregional recurrence (LRR) was investigated in NSCLC. One stage IIIA-IIIB NSCLC patient treated with chemoradiotherapy between 2010 and 2015 was enrolled. Fasting blood glucose (FBG) levels were recorded in pre-treatment, treatment, and post-treatment periods. Median age was 54 years (51-62). Fifty-two patients had squamous cell carcinoma (SCC); 19 had adenocarcinoma. Median follow-up was 19 (11-30), median survival was 19 (13-24), and DFS was 9 (7-11) months. Diabetic patients had shorter survival than non-diabetics 12 (95%CI, 10-14) vs. 25 months (95%CI,18-32), p = 0.005. Number of patients with LRR was also higher in diabetics compared to non-diabetics (8/12 vs. 11/37, p = 0.039). OS was shorter in patients with hyperglycemic-FBG and diabetic-FBG levels in pre-treatment period (log-rank p = 0.03 and 0.023, respectively). Diabetic-FBG level in pre-treatment period was found to be the only independent risk factor for survival. In subgroup analysis, these differences were apparent in SCC (log-rank p = 0.009 for hyperglicemic, log-rank p = 0.017 for diabetic-FBG). LRR was 68% in patients with diabetic-FBG, 36.5% in patients with non-diabetic-FBG in post-treatment period (p = 0.015). Patients with LRR had significantly higher median FBG value in post-treatment period compared to non-relapsing patients, 138 mg/dL (119-228) and 111 mg/dL (99-164), respectively (p = 0.022). The patients with hyperglycemic and diabetic-FBG levels in pre-treatment period had shorter survival compared to normoglycemic ones. The patients with diabetic-FBG level in post-treatment period had higher LRR, and relapsing patients had higher FBG levels in post-treatment period.","PeriodicalId":13060,"journal":{"name":"Hormones & Cancer","volume":"9 3","pages":"188-196"},"PeriodicalIF":3.0,"publicationDate":"2018-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12672-018-0322-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9844603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Thyroid Hormone in the Clinic and Breast Cancer. 甲状腺激素在临床和乳腺癌中的应用。

IF 3 4区医学

Hormones & Cancer Pub Date : 2018-06-01 Epub Date: 2018-02-13 DOI: 10.1007/s12672-018-0326-9

Aleck Hercbergs, Shaker A Mousa, Matthew Leinung, Hung-Yun Lin, Paul J Davis

引用次数: 40

Harnessing a Different Dependency: How to Identify and Target Androgen Receptor-Positive Versus Quadruple-Negative Breast Cancer. 利用不同的依赖性:如何识别和靶向雄激素受体阳性与四阴性乳腺癌。

IF 3 4区医学

Hormones & Cancer Pub Date : 2018-04-01 DOI: 10.1007/s12672-017-0314-5

Jessica L Christenson, Jane B Trepel, Haythem Y Ali, Sunmin Lee, Joel R Eisner, Edwina S Baskin-Bey, Anthony D Elias, Jennifer K Richer

引用次数: 20

The Two Faces of Adjuvant Glucocorticoid Treatment in Ovarian Cancer. 卵巢癌糖皮质激素辅助治疗的两面性。

IF 3 4区医学

Hormones & Cancer Pub Date : 2018-04-01 DOI: 10.1007/s12672-017-0319-0

Vladimir Djedovic, Yoo-Young Lee, Alexandra Kollara, Taymaa May, Theodore J Brown

{"title":"The Two Faces of Adjuvant Glucocorticoid Treatment in Ovarian Cancer.","authors":"Vladimir Djedovic, Yoo-Young Lee, Alexandra Kollara, Taymaa May, Theodore J Brown","doi":"10.1007/s12672-017-0319-0","DOIUrl":"https://doi.org/10.1007/s12672-017-0319-0","url":null,"abstract":"Adjuvant glucocorticoid treatment is routinely used in the treatment of ovarian cancer to mitigate the undesirable side effects of chemotherapy, thereby enhancing tolerability to higher cytotoxic drug doses and frequency of treatment cycles. However, in vitro and preclinical in vivo and ex vivo studies indicate that glucocorticoids may spare tumor cells from undergoing cell death through enhanced cell adhesion, promotion of anti-inflammatory signaling, and/or inhibition of apoptotic pathways. The implications of laboratory studies showing potential negative impact on the efficacy of chemotherapy have been long overlooked since clinical investigations have found no apparent survival detriment attributable to adjuvant glucocorticoid use. Importantly, these clinical studies were not randomized and most did not consider glucocorticoid receptor status, a vital determinant of tumor response to glucocorticoid administration. Additionally, the clinically beneficial elements of increased chemotherapy treatment adherence and dosing afforded by adjuvant glucocorticoids may offset and therefore mask their anti-chemotherapy activities. This review summarizes the current evidence on the impact of glucocorticoids in ovarian cancer and discusses the need for further research and development of alternative strategies to ameliorate untoward side effects of chemotherapy.","PeriodicalId":13060,"journal":{"name":"Hormones & Cancer","volume":"9 2","pages":"95-107"},"PeriodicalIF":3.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12672-017-0319-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10223746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Mechanisms Linking Obesity and Thyroid Cancer Development and Progression in Mouse Models. 小鼠模型中肥胖与甲状腺癌发生发展的联系机制

IF 3 4区医学

Hormones & Cancer Pub Date : 2018-04-01 DOI: 10.1007/s12672-017-0320-7

Won Gu Kim, Sheue-Yann Cheng

引用次数: 24

Elevated Aromatase (CYP19A1) Expression Is Associated with a Poor Survival of Patients with Estrogen Receptor Positive Breast Cancer. 芳香化酶(CYP19A1)表达升高与雌激素受体阳性乳腺癌患者的低生存率相关

IF 3 4区医学

Hormones & Cancer Pub Date : 2018-04-01 Epub Date: 2018-01-23 DOI: 10.1007/s12672-017-0317-2

Andrea Friesenhengst, Tamara Pribitzer-Winner, Heidi Miedl, Katharina Pröstling, Martin Schreiber

{"title":"Elevated Aromatase (CYP19A1) Expression Is Associated with a Poor Survival of Patients with Estrogen Receptor Positive Breast Cancer.","authors":"Andrea Friesenhengst, Tamara Pribitzer-Winner, Heidi Miedl, Katharina Pröstling, Martin Schreiber","doi":"10.1007/s12672-017-0317-2","DOIUrl":"https://doi.org/10.1007/s12672-017-0317-2","url":null,"abstract":"Genetic variants in CYP19A1, the gene encoding aromatase, have been reported to be associated with circulating estrogen concentrations, a key risk factor for breast cancer. The mechanism underlying this association is still unclear; it has been suggested that some of these variants may alter the expression and/or activity of aromatase. Here we analyzed the expression of intra-tumoral CYP19A1 messenger RNA (mRNA) and the genotypes of rs10046, a well-characterized single nucleotide polymorphism in CYP19A1, in 138 breast cancer patients and 15 breast cancer cell lines. The genotype TT was detected in 36 patients and six cell lines, genotype CT in 55 patients and five cell lines, and genotype CC in 28 patients and four cell lines. We found no evidence for a significant association of CYP19A1 levels with rs10046 genotypes, although expression tended to be higher in tumors and cell lines with the homozygous risk genotype TT. We also found no evidence for a significant association of rs10046 genotypes with breast cancer prognosis. In contrast, high CYP19A1 expression was highly significantly associated with a poor overall, disease-free, and metastasis-free survival in estrogen receptor-positive but not negative breast cancer patients. Moreover, CYP19A1 mRNA was significantly elevated in postmenopausal patients and in patients older than 50 years, and a trend towards a positive correlation with ER status and ESR1 mRNA expression was observed. These findings highlight the key role of aromatase in estrogen receptor-positive breast cancer biology.","PeriodicalId":13060,"journal":{"name":"Hormones & Cancer","volume":" ","pages":"128-138"},"PeriodicalIF":3.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12672-017-0317-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35762383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Circulating Hormones and Mammographic Density in Premenopausal Women. 绝经前妇女的循环激素和乳房x线摄影密度。

IF 3 4区医学

Hormones & Cancer Pub Date : 2018-04-01 DOI: 10.1007/s12672-017-0321-6

Kimberly A Bertrand, A Heather Eliassen, Susan E Hankinson, Bernard A Rosner, Rulla M Tamimi

{"title":"Circulating Hormones and Mammographic Density in Premenopausal Women.","authors":"Kimberly A Bertrand, A Heather Eliassen, Susan E Hankinson, Bernard A Rosner, Rulla M Tamimi","doi":"10.1007/s12672-017-0321-6","DOIUrl":"https://doi.org/10.1007/s12672-017-0321-6","url":null,"abstract":"Prior research suggests that several endogenous hormones in premenopausal women are associated with breast cancer risk; however, few studies have evaluated associations of endogenous hormones with mammographic density (MD) in premenopausal women. We conducted a cross-sectional study of plasma hormone levels in relation to MD among 634 cancer-free premenopausal women in the Nurses' Health Study II. We measured percent MD from screening mammograms using a computer-assisted method. We assayed estradiol, estrone, and estrone sulfate in blood samples timed in early follicular and mid-luteal phases of the menstrual cycle as well as testosterone, androstenedione, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate, sex hormone-binding globulin (SHBG), and anti-Müllerian hormone in luteal or untimed samples. We used multivariable linear regression to quantify the association of %MD with quartiles of each hormone, adjusting for age, body mass index, and breast cancer risk factors. Women in the highest quartile of follicular estradiol levels had significantly greater %MD compared to those in the lowest quartile [difference, 6.7 percentage points; 95% confidence interval (CI) 2.2, 11.3; p-trend < 0.001]. Similar associations were observed for follicular free estradiol but not luteal-phase estradiol. Also, women in the top (vs. bottom) quartile of free testosterone had significantly lower %MD (difference, - 4.7; 95% CI - 8.7, - 0.8; p-trend = 0.04). Higher SHBG was significantly associated with higher percent MD (difference, 4.8; 95% CI 1.1, 8.6; p-trend = 0.002). Percent MD was not strongly associated with other measured hormones. Results were similar in analyses that excluded women with anovulatory cycles. Our findings suggest that follicular estradiol and SHBG may play an important role in premenopausal percent MD.","PeriodicalId":13060,"journal":{"name":"Hormones & Cancer","volume":"9 2","pages":"117-127"},"PeriodicalIF":3.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12672-017-0321-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9851439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 17

Urban Neighborhood and Residential Factors Associated with Breast Cancer in African American Women: a Systematic Review. 城市邻里和居住因素与非裔美国妇女乳腺癌相关:一项系统综述。

IF 3 4区医学

Hormones & Cancer Pub Date : 2018-04-01 DOI: 10.1007/s12672-018-0325-x

Brandi Patrice Smith, Zeynep Madak-Erdogan

{"title":"Urban Neighborhood and Residential Factors Associated with Breast Cancer in African American Women: a Systematic Review.","authors":"Brandi Patrice Smith, Zeynep Madak-Erdogan","doi":"10.1007/s12672-018-0325-x","DOIUrl":"https://doi.org/10.1007/s12672-018-0325-x","url":null,"abstract":"Residential characteristics in urban neighborhoods impact health and might be important factors contributing to health disparities, especially in the African American population. The purpose of this systematic review is to understand the relationship between urban neighborhood and residential factors and breast cancer incidence and prognosis in African American women. Using PubMed and Web of Science, the existing literature was reviewed. Observational, cross-sectional, cohort, and prospective studies until February 2017 were examined. Studies including populations of African American women, setting in \"urban\" areas, and a measure of a neighborhood or residential factor were reviewed. Four parameters related to neighborhood or residential factors were extracted including: neighborhood socioeconomic status (nSES), residential segregation, spatial access to mammography, and residential pollution. Our analysis showed that African American women living in low nSES have greater odds of late stage diagnosis and mortality. Furthermore, African American women living in segregated areas (higher percentage of Blacks) have higher odds of late stage diagnosis and mortality compared to White and Hispanic women living in less segregated areas (lower percentage of Blacks). Late stage diagnosis was also shown to be significantly higher in areas with poor mammography access and areas with higher Black residential segregation. Lastly, residential pollution did not affect breast cancer risk in African American women. Overall, this systematic review provides a qualitative synthesis of major neighborhood and residential factors on breast cancer outcomes in African American women.","PeriodicalId":13060,"journal":{"name":"Hormones & Cancer","volume":"9 2","pages":"71-81"},"PeriodicalIF":3.0,"publicationDate":"2018-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12672-018-0325-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9846957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 16

Expression of the Cholecystokinin-B Receptor in Neoplastic Gastric Cells. 肿瘤胃细胞中胆囊收缩素b受体的表达。

IF 3 4区医学

Hormones & Cancer Pub Date : 2018-02-01 Epub Date: 2017-10-04 DOI: 10.1007/s12672-017-0311-8

Patricia Mjønes, Ivar S Nordrum, Øystein Sørdal, Liv Sagatun, Reidar Fossmark, Arne Sandvik, Helge L Waldum

{"title":"Expression of the Cholecystokinin-B Receptor in Neoplastic Gastric Cells.","authors":"Patricia Mjønes, Ivar S Nordrum, Øystein Sørdal, Liv Sagatun, Reidar Fossmark, Arne Sandvik, Helge L Waldum","doi":"10.1007/s12672-017-0311-8","DOIUrl":"https://doi.org/10.1007/s12672-017-0311-8","url":null,"abstract":"Gastric cancer is an important disease due to its high mortality. Despite the decline in frequency, most cases are discovered late in its course, and most of the cancer patients die within a few years of diagnosis. In addition to Helicobacter pylori gastritis, gastrin is considered an important factor in the development of this disease, and thus, cholecystokinin-B receptor (CCKBR) becomes of interest. The aim of our study was to explore whether CCKBR is expressed in stomach cancers. Thirty-seven tumors from 19 men and 18 women diagnosed with either adenocarcinoma or neuroendocrine neoplasm (NENs) were included in this study. The tumors were classified into 29 adenocarcinomas and eight NENs. Immunohistochemistry with antibodies against chromogranin A (CgA), synaptophysin and CCKBR, and in situ hybridization with probes against CgA, CCKBR and histidine decarboxylase were used to further explore these tumors. Thirty-three (89%) of the tumors expressed CCKBR protein, whereas only 20 (54%) of all tumors expressed CCKBR mRNA. Of the 20 tumors expressing CCKBR mRNA, eight were NENs and 12 were adenocarcinoma. The highest amount of CCKBR was expressed in NEN. Interestingly, a high degree of co-expression of CCKBR and CgA was observed when the two markers were examined together with in situ hybridization. In conclusion, we found that all eight NENs expressed CCKBR and neuroendocrine markers in a majority of tumor cells. The same markers were also expressed in a proportion of adenocarcinomas supporting the view that gastrin is important in the development of gastric cancer.","PeriodicalId":13060,"journal":{"name":"Hormones & Cancer","volume":" ","pages":"40-54"},"PeriodicalIF":3.0,"publicationDate":"2018-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12672-017-0311-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35473700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 23