Hormone Research in Paediatrics最新文献

{"title":"Increasing Contribution of Adolescent Type 1 Diabetes Drives Incidence Rates in Poland: A 40-Year-Long Observational Study.","authors":"Agnieszka Szadkowska, Iwona Pietrzak, Arkadiusz Michalak, Jędrzej Chrzanowski, Agnieszka Zmysłowska, Anna Hogendorf, Anna Baranowska-Jaźwiecka, Hanna Kuśmierczyk-Kozieł, Aleksandra Olejniczak, Aleksandra Dynowska, Aleksandra Kordialik, Wojciech Fendler, Beata Mianowska","doi":"10.1159/000545304","DOIUrl":"10.1159/000545304","url":null,"abstract":"<p><strong>Introduction: </strong>The incidence of childhood type 1 diabetes (T1D) has increased globally in recent decades. Analyzing incidence trends can elucidate patterns and predict future healthcare burdens. We aimed to assess changes in the incidence and prevalence of pediatric type 1 diabetes over 40 years in Central Poland.</p><p><strong>Methods: </strong>This prospective observational study in Lodz Province registered all new-onset type 1 diabetes cases in children 0-14 years old admitted from 1983 to 2022 to reference centers for pediatric diabetes. Diagnoses were based on established guidelines, and other types of diabetes were excluded. Population data were obtained from Poland's General Statistical Office.</p><p><strong>Results: </strong>The incidence rate of type 1 diabetes increased tenfold, from 3.29/100,000 (95% CI: 1.85-4.73) in 1983 to 32.43 (26.42-38.44) in 2022, with an annual percentage change of 5.73% (4.99%-6.44%) and two distinct increase periods: rapid in 1983-2005 (7.38% [6.30-10.52%]) and slower in 2005-2022 (3.65% [-0.86-5.13%]). Incidence rates in 0-4-year-olds were significantly lower than in 5-9 and 10-14-year-olds (p < 0.0001). While incidence plateaued in the 0-4-year-olds after 2007, it consistently increased in older children. Most new cases were diagnosed in winter (December-February, a mean difference from the remaining seasons of 29 ± 11.6% points, p < 0.0001). The prevalence of type 1 diabetes increased, reaching 177.21/100,000 (163.18-191.24) in 2022.</p><p><strong>Conclusions: </strong>Over the past 40 years, the incidence of pediatric type 1 diabetes in Central Poland has increased significantly, though the rate is slowing. Most new cases occur in children 10 years old and older, so healthcare systems should adapt to young adults who are extensive users of new diabetes technologies.</p>","PeriodicalId":13025,"journal":{"name":"Hormone Research in Paediatrics","volume":" ","pages":"1-8"},"PeriodicalIF":2.6,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119056/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144017707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam of Kerstin Albertsson-Wikland.","authors":"Martin Ritzen, Olle Söder, Anna Olivecrona, Stefano Cianfarani","doi":"10.1159/000545758","DOIUrl":"https://doi.org/10.1159/000545758","url":null,"abstract":"","PeriodicalId":13025,"journal":{"name":"Hormone Research in Paediatrics","volume":" ","pages":"1-2"},"PeriodicalIF":2.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143965539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In memoriam of Prof. Kerstin Albertsson-Wikland.","authors":"Martin Ritzen, Olle Soder, Anna Olivecrona, Stefano Cianfarani","doi":"10.1159/000545758","DOIUrl":"https://doi.org/10.1159/000545758","url":null,"abstract":"","PeriodicalId":13025,"journal":{"name":"Hormone Research in Paediatrics","volume":" ","pages":"1-4"},"PeriodicalIF":2.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143811324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Memoriam of Kerstin Albertsson-Wikland.","authors":"Martin Ritzen, Olle Söder, Anna Olivecrona, Stefano Cianfarani","doi":"10.1159/000545758","DOIUrl":"https://doi.org/10.1159/000545758","url":null,"abstract":"","PeriodicalId":13025,"journal":{"name":"Hormone Research in Paediatrics","volume":" ","pages":"1-2"},"PeriodicalIF":2.6,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Care for Children and Adolescents with Severe and/or Genetic Obesity.","authors":"Melanie Schirmer, Stefanie Zorn, Julia von Schnurbein, Martin Wabitsch","doi":"10.1159/000544177","DOIUrl":"10.1159/000544177","url":null,"abstract":"<p><strong>Background: </strong>Children and adolescents with severe and/or genetic obesity require continuous care and long-term treatment due to the chronic, relapsing, and progressive nature of their disease. Understanding the molecular mechanisms underlying the regulation of hunger, satiety, body weight, and the development of obesity enables a personalized treatment approach. Individualized, multimodal treatment strategies are essential for effective, long-term management of severe and/or genetic obesity in affected children and adolescents. New pharmacological treatments, such as mechanism-based medications for genetic obesity and incretin-based drugs for severe obesity, represent significant advances in chronic weight management and are valuable adjuncts to individualized lifestyle interventions.</p><p><strong>Summary: </strong>This article outlines an innovative, structured care and treatment concept for children and adolescents with severe and/or genetic obesity tailored to their specific needs and requirements. It emphasizes the importance of providing care within specialized treatment centers under the \"Chronic Care Model,\" in close collaboration with local healthcare providers.</p><p><strong>Key message: </strong>In order to ensure long-term treatment of children and adolescents with severe and/or genetic obesity, innovative and structured care concepts consisting of individualized, multimodal treatment strategies in specialized treatment centers in collaboration with local healthcare providers are required.</p>","PeriodicalId":13025,"journal":{"name":"Hormone Research in Paediatrics","volume":" ","pages":"1-10"},"PeriodicalIF":2.6,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143752430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transition between Pediatric and Adult Diabetes Healthcare Services: An Online Global Survey of Experiences and Perceptions of Young People with Diabetes and Their Carers.","authors":"Laura Cudizio, Steven James, Nisa M Maruthur, Sze May Ng, Sarah Lyons, Aleksandra Araszkiewicz, Apoorva Gomber, Frank Snoek, Eva Toft, Jill Weissberg-Benchell, Carine de Beaufort","doi":"10.1159/000545118","DOIUrl":"10.1159/000545118","url":null,"abstract":"<p><strong>Introduction: </strong>Young adults with diabetes face many challenges during emerging adulthood. Our study aimed to identify experiences and perceptions of people with diabetes (PwD) (aged 14-25 years) and their carers, around transition planning, and the actual transfer from pediatric to adult diabetes healthcare services.</p><p><strong>Methods: </strong>Data were collected via an online global survey (seven language options), broadly advertised by the scientific societies ISPAD, EASD, patient advocates, team members and partners, via newsletters, websites, e-mails, and social media.</p><p><strong>Results: </strong>There were 146 respondents from 29 countries. Of these, 90 (61.6%) were PwD age 18.5 (±3.6 years), diagnosed at 9.0 (±4.4 years), and 56 (38.3%) carers. Respondents receiving care in pediatric units (vs. adult) (58.2%) had higher care satisfaction and more frequent appointments (p < 0.05); 65.1% of respondents reported a fixed transfer age (≥18 years). Overall, 45.2% detailed transfer-related concerns; 44.3% felt their psychosocial needs were adequately addressed, 24.7% felt unprepared for areas of self-management. Combined pediatric and adult diabetes clinics (56.2%), and psychologist support (50.7%) were most desired.</p><p><strong>Conclusion: </strong>Findings highlight the urgent need to improve the transition process. A joint ISPAD, EASD, and ADA consensus report is in preparation.</p>","PeriodicalId":13025,"journal":{"name":"Hormone Research in Paediatrics","volume":" ","pages":"1-13"},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of Endocrine Disruptors in Childhood Obesity: Unraveling the Obesogens.","authors":"Aikaterini Kapama, Charikleia Stefanaki, George Mastorakos, Maria Papagianni","doi":"10.1159/000545043","DOIUrl":"10.1159/000545043","url":null,"abstract":"<p><strong>Background: </strong>Obesity is a disease, acknowledged by WHO, characterized as an epidemic in a worldwide range, particularly in Western countries. Childhood obesity, lately, has raised major concerns. Among the complex factors contributing to obesity, environmental factors, such as endocrine disruptors, are gaining attention as emerging contributors to obesity.</p><p><strong>Summary: </strong>Toxicants, such as bisphenol A, phthalates, perfluoroalkyl and polyfluoroalkyl substances, heavy metals, and pesticides, have been associated with increases in the incidence of obesity in human populations, animals, and cellular models. These EDCs, called obesogens, disrupt the endocrine system across multiple pathways. They influence appetite, promote inflammation, disrupt the ecology and function of the gut microbiome, and induce transgenerational epigenetic changes. At the cellular level, they act as agonists of peroxisome proliferator-activated receptor γ, steroid, and aryl hydrocarbon receptors.</p><p><strong>Key messages: </strong>Children are exposed to obesogens through multiple metabolic pathways, which contribute directly and indirectly to the development of obesity. Despite the increasing evidence, more studies are needed to identify additional obesogens and elucidate their mechanisms of action to minimize exposure to pediatric and adolescent populations.</p>","PeriodicalId":13025,"journal":{"name":"Hormone Research in Paediatrics","volume":" ","pages":"1-14"},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New Curative Treatment Strategies and New Therapies for Type 1 Diabetes.","authors":"Shlomit Shalitin, Moshe Phillip","doi":"10.1159/000545519","DOIUrl":"10.1159/000545519","url":null,"abstract":"","PeriodicalId":13025,"journal":{"name":"Hormone Research in Paediatrics","volume":" ","pages":"1-2"},"PeriodicalIF":2.6,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12060813/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nonmalignant Adrenocorticotrophic Hormone-Independent Cushing's Syndrome in Pediatric Patients: A Retrospective Observational Cohort Study.","authors":"Myriam Hassan, Dinane Samara-Boustani, Alix Besançon, Anya Rothenbuhler, Caroline Storey, Graziella Pinto, Athanasia Stoupa, Marc Nicolino, Laura Gabriela González-Briceño, Adrien Nguyen Quoc, Gaelle Vermillac, Sibylle Rovani, Isabelle Flechtner, Caroline Thalassinos, Yamina Dassa, María Beatriz Arrom Brañas, Magali Viaud, Jacques Beltrand, Virginie Ribault, Laetitia Martinerie, Agnès Linglart, Jérôme Bertherat, Thomas Blanc, Michel Polak, Dulanjalee Kariyawasam","doi":"10.1159/000545265","DOIUrl":"10.1159/000545265","url":null,"abstract":"<p><strong>Introduction: </strong>Adrenocorticotrophic hormone (ACTH)-independent Cushing's syndrome (CS) is a rare cause of pediatric CS. Our objective was to describe the features of pediatric ACTH-independent CS and to compare groups defined by etiology.</p><p><strong>Methods: </strong>We conducted a retrospective observational study of patients aged 0-18 years at diagnosis between 1992 and 2022 for ACTH-independent CS in three Paris pediatric hospitals. Additionally, we compared the outcomes of McCune-Albright syndrome (MCAS) patients with CS and without CS.</p><p><strong>Results: </strong>Of the 15 patients with CS, 7 had MCAS, 7 had primary pigmented nodular adrenocortical disease (PPNAD) as part of CNC (Carney complex), and 1 had CS with no etiology found. Age at CS diagnosis was 0.3 years old (0.17; 1) in MCAS and 9 years old (5; 15) in PPNAD. The MCAS group had more impaired growth retardation (-4.75 SDS in MCAS vs. -1 SDS in CNC, p = 0.006) and higher prevalences of intrauterine growth retardation (p = 0.01) and liver dysfunction at diagnosis (p = 0.04). All 7 MCAS patients had learning disabilities vs. only 2 CNC patients. 12 out of 15 had bilateral adrenalectomy. None of the MCAS patients received growth hormone therapy, while 4 CNC patients benefited from growth hormone therapy. At the end of follow-up, growth recovered in both groups, albeit less in the MCAS group (-1.5 SDS in MCAS vs. -0.5 SDS in CNC), in which liver dysfunction often persisted.</p><p><strong>Conclusion: </strong>ACTH-independent CS is rare but can lead to significant burden in children. Early diagnosis and management are essential. New drugs targeting adrenal steroid synthesis are awaited.</p>","PeriodicalId":13025,"journal":{"name":"Hormone Research in Paediatrics","volume":" ","pages":"1-12"},"PeriodicalIF":2.6,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143709754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SKIN-PEDIC: A Worldwide Assessment of Skin Problems in Children and Adolescents Using Diabetes Devices.","authors":"Anna Korsgaard Berg, Stefano Passanisi, Thekla von dem Berge, Agata Chobot, Nancy Samir Elbarbary, Julie Pelicand, Franco S Giraudo, Rosaline Mentink, Floris Levy-Khademi, Ana L Creo, Malene Søborg Heidemann, Claudia Piona, Emrullah Arslan, Didem Gunes Kaya, Theo C J Sas, Lars Krogvold, Stefano Tumini, Cari Berget, Tiago Jeronimo Dos Santos, Beate Karges, Mariana Zorron, Jannet Svensson","doi":"10.1159/000545428","DOIUrl":"10.1159/000545428","url":null,"abstract":"<p><strong>Introduction: </strong>Children and adolescents with diabetes are increasingly using technological devices to maintain normoglycemia. However, skin problems associated with these devices are becoming a significant issue. This study aimed to investigate prevalence of skin issues in children and adolescents with diabetes globally and identify important factors associated with these skin problems.</p><p><strong>Methods: </strong>This multinational study involved 22 pediatric diabetes centers. Over a 4-week period, pseud anonymized data were collected on children and adolescents using diabetes devices, including demographic factors, visual skin problems, type of devices and products being used. Univariate logistic regression was applied to identify associations with skin problems.</p><p><strong>Results: </strong>A total of 1,719 children and adolescents were included. Skin problems were present in 52% of pump users compared to 30% of sensor users. Eczema was found in 9% of participants at both insulin pump and glucose sensor sites, whereas scars, wounds, and lipodystrophies were significantly more frequent at insulin pump sites than at glucose sensor sites. Both xerosis cutis and keratosis pilaris were strongly associated with almost all types of skin problems, increasing the risk 2 to fivefold.</p><p><strong>Conclusion: </strong>Skin problems are a serious concern that limits the use of diabetes devices in children and adolescents, consequently increasing risk for long-term complications. This study highlights the extent of the problem in a real-world setting of unselected participants despite the use of preventive strategies. Consequently, the development of more skin-friendly devices is needed to ensure that all children and adolescents with diabetes can effectively use these devices in the long term.</p>","PeriodicalId":13025,"journal":{"name":"Hormone Research in Paediatrics","volume":" ","pages":"1-14"},"PeriodicalIF":2.6,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143700363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}