Nowotwory. Journal of Oncology最新文献

{"title":"Consensus on methods of development of clinical practice guidelines in oncology under the auspices of Maria Sklodowska-Curie National Research Institute of Oncology and the Agency for Health Technology Assessment and Tariff System","authors":"J. Walewski, D. Dziurda, M. Bidziński, B. Bobek-Bilewicz, M. Dedecjus, I. Hus, B. Jagielska, J. Jassem, A. Kawecki, D. Kowalski, M. Krasztel, M. Krzakowski, T. Kubiatowski, P. Potemski, R. Mądry, P. Rutkowski, Anna Rychert, J. Ryš, K. Składowski, R. Tarnawski, Hanna Tchórzewska-Korba, A. Tysarowski, P. Wysocki, R. Topor-Madry","doi":"10.5603/njo.2022.0005","DOIUrl":"https://doi.org/10.5603/njo.2022.0005","url":null,"abstract":"Jan Walewski1*, Dominik Dziurda2*, Mariusz Bidziński3, Barbara Bobek-Bilewicz4, Marek Dedecjus5, Iwona Hus6, Beata Jagielska7, Jacek Jassem8, Andrzej Kawecki9, Dariusz Kowalski10, Magdalena Krasztel2, Maciej Krzakowski11, Tomasz Kubiatowski12, Piotr Potemski13, 14, Radosław Mądry15, Piotr Rutkowski16, Anna Rychert2, Janusz Ryś17, Krzysztof Składowski18, Rafał Tarnawski4, Hanna Tchórzewska-Korba19, Andrzej Tysarowski20, Piotr J. Wysocki21, Roman Topór-Mądry2","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"29 2 Suppl 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116568892","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of sex in patients with primary tracheal tumors – a retrospective, single-center study","authors":"A. Piórek, A. Płużański, D. Kowalski, M. Krzakowski","doi":"10.5603/njo.a2021.0069","DOIUrl":"https://doi.org/10.5603/njo.a2021.0069","url":null,"abstract":"Introduction. We aimed to assess the prognostic significance of the sex of patients with primary tracheal tumors based on our own results as well as the literature review. Material and methods. We carried out a retrospective analysis of 89 patients with primary tracheal tumors treated at the Maria Sklodowska-Curie National Research Institute of Oncology in Warsaw, Poland, between January 2000 and December 2016. Men and women were compared in terms of overall survival, disease-free survival, and progression-free survival. Results. In the entire study group, the median overall survival was 61.30 months in women and 8.55 months in men (p < 0.0001). 5-year overall survival rates were 2.1% in men versus 50.6% in women (p < 0.0001). Among those receiving radical treatment, women had improved survival rates compared with men. Sex was an independent prognostic factor in both the total study population and among those undergoing radical treatment. Conclusions. According to our results, women with primary tracheal tumors have significantly better survival than men. Because female sex is an independent prognostic factor in patients with primary tracheal tumors, the ratio of women to men should be taken into consideration in reports comparing the outcomes of different treatments.","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"24 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114658020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Off-label use of medicinal products in oncology: exercising due diligence or experimental activity?","authors":"Justyna Estera Król-Całkowska, Janusz Jaroszyński","doi":"10.5603/njo.2022.0003","DOIUrl":"https://doi.org/10.5603/njo.2022.0003","url":null,"abstract":"One of the primary responsibilities of a physician is to diagnose and treat diseases with due diligence. Exercising due diligence in treatment process involves, among others, the use of optimal diagnostic, therapeutic and follow-up management in accordance with the current state of medical knowledge. Each medicinal product has the Summary of Product Characteristics which defines, among others, registered indications, the age group for which the product is registered, the dosing scheme, and route of administration of the product. Polish law does not refer directly to the admissibility of products that use off-label nor does it include regulations forbidding such activities. Considering a number of problems associated with products which use off-label and, on the other hand, commonness of such activities, it is necessary to introduce legal regulations defining the legitimacy and admissibility of such methods of proceeding.","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"195 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123231100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Poly(ADP-ribose) polymerase inhibitors in pancreatic cancer","authors":"Katarzyna Zubik, Julia Talaśka, D. Sigorski, S. Nawrocki","doi":"10.5603/njo.2022.0004","DOIUrl":"https://doi.org/10.5603/njo.2022.0004","url":null,"abstract":"1Collegium Medicum, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland 2Department of Oncology, Collegium Medicum, University of Warmia and Mazury in Olsztyn, Olsztyn, Poland 3Department of Oncology and Immuno-Oncology, Warmian-Masurian Cancer Center of The Ministry of The Interior and Administration’s Hospital, Olsztyn, Poland 4Department of Radiotherapy, Warmian-Masurian Cancer Center of The Ministry of The Interior and Administration’s Hospital, Olsztyn, Poland * co senior-authorship","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132819760","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hepatocellular cancer and colorectal liver metastasis treatment in the older population","authors":"J. Kenig","doi":"10.5603/njo.2022.0006","DOIUrl":"https://doi.org/10.5603/njo.2022.0006","url":null,"abstract":"More than 60% of patients with primary and secondary liver tumors are older than 65 years. Thanks to improvements in radiological staging, anesthesia, surgical technique, and perioperative care it is possible to offer complex liver surgery to older patients. However, chronological age or functional status alone should not be a contraindication for multimodal radical treatment in older patients. Fit patients, according to the Comprehensive Geriatric Assessment, should be qualified for the same treatment as younger patients to ensure the same outcomes. Prefrail patients should undergo prehabilitation, and be reevaluated. Frail patients should be discussed in an oncogeriatric meeting. All patients with liver malignant tumors must be operated on in high-volume hospitals by an experienced surgeon. The introduction of parenchymal sparing surgery (instead of a major resection) in combination with other treatment tools, minimal invasive techniques, and enhanced postoperative recovery demonstrated being beneficial for older patients. In particular, frail, older patients can benefit from the wide variety of treatment options.","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"37 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131713439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is the elimination of cervical cancer now 3 times easier? One-dose vaccine efficacy has far-reaching implications","authors":"P. Koczkodaj, J. Dillner, M. Mańczuk","doi":"10.5603/njo.a2021.0078","DOIUrl":"https://doi.org/10.5603/njo.a2021.0078","url":null,"abstract":"Jak cytować / How to cite: Koczkodaj P, Dillner J, Mańczuk M. Is the elimination of cervical cancer now 3 times easier? One-dose vaccine efficacy has far-reaching implications. NOWOTWORY J Oncol 2022; 72: 65–66. More and more studies have proven that low trust in vaccines has become a universal phenomenon, regardless of the region of the world and type of vaccine [1–3]. Particularly intense public debate on vaccines efficacy and safety has been (and still is) visible during the COVID-19 pandemic. A plethora of misconceptions, myths and fake news on vaccines has come to the fore recently, causing a lack of trust, not only in COVID-19 vaccines. Searching for new paths to cope with this public health challenge should be one of the key points of current international and national health policy agendas. In this context, recent research results look very promising, i.e. a single dose of vaccination against HPV has a similar efficacy to two and three doses [4]. These results may have far-reaching implications – primarily in a public health context, as it may enable a much faster eradication of HPV regionally and worldwide, moreover, those reluctant to get the HPV vaccine will be more likely to take just one dose, rather than three. Europe’s Beating Cancer Plan launched by the European Commission at the beginning of 2021 assumes vaccinations of target population of girls will be at the level of 90% by 2030 as well as acceleration of vaccinations among boys. However, the document describes a “fully vaccinated” target population, implying having completed a 3-dose scheme which can be much more difficult taking into consideration high social HPV vaccine hesitancy. Moreover, in the coming years (at least 4-5 years), due to rapidly growing demand, there are predictions of further HPV-vaccine shortages on the world market. Furthermore, despite the plans of new manufacturers to enter the market, it will take some time to begin efficient production (even 4 years are needed for manufacturing the final product). Moreover, legal difficulties impede shifting HPV vaccinations supplies from one country to another [5]. Discussing all of these obstacles, it is crucial to significantly increase social trust in HPV vaccinations. Implementation of the one-dose vaccination scheme seems to be one of the easiest and most beneficial ways to achieve this goal. Additionally, faster HPV eradication can be obtained by combining vaccination and screening in organised programs [6, 7] and this strategy would be greatly facilitated if both screening and vaccination could be completed in a single visit. The WHO has specifically called for further research on innovative ways to achieve the elimination goal faster. The fact that it has also now been shown for the quadrivalent vaccine (that a single-dose HPV vaccination is as effective as a 3-doses full scheme), means the results could help to overcome one of the most important barriers to broad vaccine coverage – low social trust.","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126300991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melanoma metastases to the intestines – presentation and management","authors":"Michal Aporowicz, A. Maciejczyk, R. Matkowski, M. Ziętek","doi":"10.5603/njo.a2021.0077","DOIUrl":"https://doi.org/10.5603/njo.a2021.0077","url":null,"abstract":"","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131174429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiation dose in CT-guided microwave liver tumor ablation","authors":"Grzegorz Rosiak, Joanna Podgórska, K. Pasicz, K. Milczarek, D. Konecki, O. Rowiński","doi":"10.5603/njo.a2021.0076","DOIUrl":"https://doi.org/10.5603/njo.a2021.0076","url":null,"abstract":"Introduction. Ablation is one of most important methods of liver tumor treatment. However, radiation is one of disadvantages of CT-guided procedures including ablation. The purpose of this study is to assess the factors that have impact on radiation doses during CT-guided microwave liver tumor ablation. Material and methods. Radiation doses of CT-guided liver tumor ablations were collected in 127 patients. They were then compared in terms of number of lesions, lesion size and depth, use of additional localization needles and hydrodissection as well as tumor location. Results. The median radiation doses of ablations of multiple tumors (2348 mGy*cm) were significantly higher (p = 0.03) than those of single tumors (1784 mGy*cm). No statistically significant differences were noted when other factors (lesion size, depth, location, use of localization needles and hydrodissection) were taken into consideration. Conclusions. The number of lesions is the most important factor in terms of expected radiation doses in CT-guided microwave liver tumor ablations.","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128636727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systems for grading the strength of recommendations in clinical practice guidelines in oncology","authors":"Anna Rychert, D. Dziurda, M. Koperny, M. Krasztel, Katarzyna Joanna Kędzior, W. Wysoczański, R. Topor-Madry","doi":"10.5603/njo.2021.0074","DOIUrl":"https://doi.org/10.5603/njo.2021.0074","url":null,"abstract":"Introduction. In order to improve the applicability of clinical practice guidelines, their authors assign recommendations with grades denoting the degree of conviction regarding their practical application. Nevertheless even within one branch of medicine, significant differences between the grading systems arise. Material and methods. To identify these systems, websites of societies and institutions publishing oncology guidelines were searched. Only high-quality, regularly updated guidelines were included. Results. Five systems were analysed – all incorporate quality of evidence and strength of recommendation, but vary in the methods of their assessment and structure of the scales. Discussion. The described systems depend on the review of data, the quality of which supports the ascribed strength. Systems differ with regard to the methods of assessing the quality, quantity and consistency of evidence, potentially leading to assigning different grades of strength to recommendations based on the same studies. Conclusions. The introduction of unified grading systems across each branch of medicine could aid the development of unambiguous recommendations that are easy to introduce within the healthcare system.","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130098513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of physical activity on sex hormone levels in women. Implications for breast cancer risk","authors":"Kinga Słojewska","doi":"10.5603/njo.a2021.0067","DOIUrl":"https://doi.org/10.5603/njo.a2021.0067","url":null,"abstract":"Breast cancer is the most commonly diagnosed neoplastic disease in women, which leads to a significant deterioration in the quality of life and a reduction in the ability of women to function normally in everyday life. The main risk factor for breast cancer in both premenopausal and postmenopausal women is exposure to high levels of endogenous estrogen. It takes many years for neoplasia to develop, but lowering estrogen levels has been observed to reduce the risk of both a new diagnosis and recurrence of breast cancer. Observational studies have found that exercise reduces the level of bioavailable sex hormones, and thus may reduce the risk of developing breast cancer. Currently available evidence clearly shows that adequate levels of physical activity are associated with a 25–30% reduction in the average risk of breast cancer in women and play a role in its treatment. This review summarizes the data available in the literature on the effect of physical activity on the level of sex hormones in women, while presenting the biological mechanisms underlying the relationship between physical activity and the development of breast cancer. This issue requires further research, but already now, extensive educational campaigns are needed which can be aimed at young women to inform them on the possibility of significantly reducing their risk of breast cancer by introducing physical activity into their everyday lives.","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"119 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116210241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}