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Nowotwory. Journal of Oncology最新文献

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The molecular portrait of triple-negative breast cancer: the LAG3 gene single nucleotide polymorphism rs2365094 has no impact on the clinical picture 三阴性乳腺癌分子图谱:LAG3基因单核苷酸多态性rs2365094对临床图谱无影响
Nowotwory. Journal of Oncology Pub Date : 2023-06-27 DOI: 10.5603/njo.a2023.0023
Katarzyna Boguszewska-Byczkiewicz, Thomas Wow, B. Szymańska, Michał Kosny, Agnieszka Kolacinska-Wow
{"title":"The molecular portrait of triple-negative breast cancer: the LAG3 gene single nucleotide polymorphism rs2365094 has no impact on the clinical picture","authors":"Katarzyna Boguszewska-Byczkiewicz, Thomas Wow, B. Szymańska, Michał Kosny, Agnieszka Kolacinska-Wow","doi":"10.5603/njo.a2023.0023","DOIUrl":"https://doi.org/10.5603/njo.a2023.0023","url":null,"abstract":"Introduction. Triple-negative breast cancer (TNBC) is characterized by a lack of oestrogen, progesterone and human epidermal growth factor receptors. It is the one of most heterogeneous and highly-aggressive breast cancers, resulting in fast progression. In humans, the lymphocyte activation gene 3 ( LAG3 ) is located on chromosome 12p13 and encodes an immune-regulatory molecule. The aim of the study was to perform a molecular analysis of LAG3 gene polymorphisms. Material and method. The presence of single-nucleotide polymorphisms (SNPs) at rs2365094 was determined in 30 TNBC patients and 30 healthy controls using a polymerase chain reaction (PCR) and commercially-available TaqMan SNP Genotyping Assays. SNP status was then compared with the clinical outcome. Results. The allelic alterations in LAG3 gene SNP in rs2365094 appear to have no influence on the clinicopathological picture among TNBC patients. The carriage rate for a single allele did not differ significantly between patients and controls. Conclusions. No significant relationship was observed between the rs2365094 SNP status and clinicopathological determinants.","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133510869","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular diagnostics of cancers – practical approach 癌症分子诊断-实用方法
Nowotwory. Journal of Oncology Pub Date : 2023-06-27 DOI: 10.5603/njo.2023.0028
A. Tysarowski, A. Szumera-Ciećkiewicz, A. Marszałek, A. Kowalik, K. Seliga, M. Bidziński, E. Senkus-Konefka, L. Wyrwicz, R. Mądry, A. Płużański, Magdalena Sakowicz, M. Krzakowski, P. Rutkowski, T. Kubiatowski
{"title":"Molecular diagnostics of cancers – practical approach","authors":"A. Tysarowski, A. Szumera-Ciećkiewicz, A. Marszałek, A. Kowalik, K. Seliga, M. Bidziński, E. Senkus-Konefka, L. Wyrwicz, R. Mądry, A. Płużański, Magdalena Sakowicz, M. Krzakowski, P. Rutkowski, T. Kubiatowski","doi":"10.5603/njo.2023.0028","DOIUrl":"https://doi.org/10.5603/njo.2023.0028","url":null,"abstract":"Introduction of targeted therapies based on monoclonal antibodies or small-cell kinase inhibitors in cancer treatment led to major improvements of treatment outcomes in selected patients. However, achievement of prolonged progression-free survival or overall survival involves necessity to test a range of molecular markers at the diagnostic stage. Their number is determined by provisions of drug programmes and leads to serious problems with the right selection of individual markers. It is also an important challenge in the process of financial settlement of the performed tests. The present paper summarises the major aspects of molecular cancer diagnosis recommended and available in clinical practice in Poland","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"115 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115166600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophil-to-lymphocyte ratio as a prognostic factor in patients during palliative treatment of pancreatic ductal adenocarcinoma with a FOLFIRINOX regimen 中性粒细胞与淋巴细胞比率作为姑息性治疗胰腺导管腺癌患者的预后因素
Nowotwory. Journal of Oncology Pub Date : 2023-04-27 DOI: 10.5603/njo.a2023.0009
M. Domagała-Haduch, J. Wnuk, Ł. Michalecki, I. Gisterek
{"title":"Neutrophil-to-lymphocyte ratio as a prognostic factor in patients during palliative treatment of pancreatic ductal adenocarcinoma with a FOLFIRINOX regimen","authors":"M. Domagała-Haduch, J. Wnuk, Ł. Michalecki, I. Gisterek","doi":"10.5603/njo.a2023.0009","DOIUrl":"https://doi.org/10.5603/njo.a2023.0009","url":null,"abstract":"","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128384457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Osteoporosis – a partially recognized challenge for oncology 骨质疏松症——肿瘤学部分公认的挑战
Nowotwory. Journal of Oncology Pub Date : 2023-04-27 DOI: 10.5603/njo.2023.0018
K. Jeziorski
{"title":"Osteoporosis – a partially recognized challenge for oncology","authors":"K. Jeziorski","doi":"10.5603/njo.2023.0018","DOIUrl":"https://doi.org/10.5603/njo.2023.0018","url":null,"abstract":"Osteoporosis is a huge challenge for medicine, especially public health and geriatrics, but also oncology, because it is a chronic disease requiring long-term, sometimes lifelong care. With the ageing of the population, falls are the third most common cause of disability in the elderly and one of the main reasons for admissions to nursing homes. Although there are approximate data on the incidence of osteoporosis worldwide, there are unfortunately no data on the incidence of osteoporosis in cancerous diseases. The incidence of cancer-related osteoporosis is expected to increase as the incidence of cancer in general increases. There are specific problems that concern osteoporosis in cancer patients, including: the mechanisms of development of osteoporosis in cancer diseases, the distinction between cancerous and osteoporotic lesions, undertreatment of patients, the lack of an integrated care system for osteoporosis in cancer patients.","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"161 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129003578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Radiotherapy and targeted therapy – a review of the literature 放射治疗和靶向治疗-文献综述
Nowotwory. Journal of Oncology Pub Date : 2023-04-27 DOI: 10.5603/njo.a2023.0013
Maksymilian Kruczała, B. Sas-Korczyńska
{"title":"Radiotherapy and targeted therapy – a review of the literature","authors":"Maksymilian Kruczała, B. Sas-Korczyńska","doi":"10.5603/njo.a2023.0013","DOIUrl":"https://doi.org/10.5603/njo.a2023.0013","url":null,"abstract":"","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130618355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Results of the treatment of adrenocortical cancer patients at the Maria Sklodowska-Curie National Research Institute of Oncology – Krakow Branch 玛丽亚·斯克洛多夫斯卡-居里国家肿瘤研究所克拉科夫分院肾上腺皮质癌患者的治疗结果
Nowotwory. Journal of Oncology Pub Date : 2023-04-27 DOI: 10.5603/njo.2023.0015
E. Pluta, Magdalena Michta, A. Patla, A. Mucha-Małecka, K. Wojcicki, P. Madej
{"title":"Results of the treatment of adrenocortical cancer patients at the Maria Sklodowska-Curie National Research Institute of Oncology – Krakow Branch","authors":"E. Pluta, Magdalena Michta, A. Patla, A. Mucha-Małecka, K. Wojcicki, P. Madej","doi":"10.5603/njo.2023.0015","DOIUrl":"https://doi.org/10.5603/njo.2023.0015","url":null,"abstract":"","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127292305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Autophagy in cancer cytopathology: a case of intraoperative touch imprint of lung metastasis from TFE3-rearranged renal cell carcinoma 肿瘤细胞病理学中的自噬:术中触印tfe3重排肾细胞癌肺转移一例
Nowotwory. Journal of Oncology Pub Date : 2023-04-27 DOI: 10.5603/njo.a2023.0008
G. Gaggero, Marta Ingaliso, Davide Taietti
{"title":"Autophagy in cancer cytopathology: a case of intraoperative touch imprint of lung metastasis from TFE3-rearranged renal cell carcinoma","authors":"G. Gaggero, Marta Ingaliso, Davide Taietti","doi":"10.5603/njo.a2023.0008","DOIUrl":"https://doi.org/10.5603/njo.a2023.0008","url":null,"abstract":"1UO Anatomia patologica ospedaliera, Istituto di Ricovero e Cura a Carattere Scientifico, Ospedale Policlinico San Martino, Genova, Italy 2Division of Anatomic Pathology, Department of Integrated Surgical and Diagnostic Sciences, Scuola di Scienze Mediche e Farmaceutiche, Università di Genova, Genova, Italy 3Pathology Unit, Azienda Socio-Sanitaria Territoriale del Garda, Desenzano del Garda, Brescia, Italy","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125834506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Histophysiology study of interleukin-4 in thyroid cancer patients 甲状腺癌患者白细胞介素-4的组织生理学研究
Nowotwory. Journal of Oncology Pub Date : 2023-04-27 DOI: 10.5603/njo.2023.0017
Ali Reda Hussein, D. Suker, S. Thamer, M. Alabbood
{"title":"Histophysiology study of interleukin-4 in thyroid cancer patients","authors":"Ali Reda Hussein, D. Suker, S. Thamer, M. Alabbood","doi":"10.5603/njo.2023.0017","DOIUrl":"https://doi.org/10.5603/njo.2023.0017","url":null,"abstract":"Introduction. Interleukins have promising prospects in the clinical treatment of cancer. Interleukin-4 (IL-4) is an anti-inflammatory cytokine with an immunosuppressive effect on antitumor activity by immune cells, but the mechanical action of IL-4 in thyroid cancer is unknown. Aim: to investigate the effect of IL-4 expression in thyroid cancer patients. Furthermore, to clarify the association between obesity and thyroid cancer. Material and methods. The present study was conducted on 115 subjects with thyroid nodules (36 with thyroid cancer and 79 with benign lesions) in Basrah, Iraq, from November 2019 to April 2022. To conduct a histophysiology study of IL-4. Results. There was a significant difference in serum IL-4 between the thyroid cancer and control subjects. A higher level of serum IL-4 was observed in the Hashimoto thyroiditis group. There was no significant difference in body mass index (BMI) between thyroid cancer and control subjects. The expression of tissue IL-4 in thyroid cancer patients was strong in 8 (22.22%) slides, moderate in 7 slides (19.44%), weak in 8 slides (22.22%), and negative in 13 slides (36.11%), while in the control group, it was strong in 7 (30.44%) slides, moderate in 8 slides (34.79%), weak in 5 slides (21.74%) and negative in 3 slides (13.03%). Conclusions. These findings indicate that serum levels of IL-4 may help diagnose thyroid cancer and identify patients with active disease who deserve closer medical attention. Furthermore, the secretion of IL-4 was systematic and not localized in thyroid cancer tissues. Obesity was not associated with a prevalence of thyroid cancer","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134176908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
External hemipelvectomy. A last resort operation 外部hemipelvectomy。万不得已的手术
Nowotwory. Journal of Oncology Pub Date : 2023-04-27 DOI: 10.5603/njo.a2023.0014
L. Kołodziejski, Józef Duber, Piotr Pomykacz, A. Komorowski
{"title":"External hemipelvectomy. A last resort operation","authors":"L. Kołodziejski, Józef Duber, Piotr Pomykacz, A. Komorowski","doi":"10.5603/njo.a2023.0014","DOIUrl":"https://doi.org/10.5603/njo.a2023.0014","url":null,"abstract":"","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"469 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132024533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cancerogenic food contaminants in European countries 欧洲国家的致癌食品污染物
Nowotwory. Journal of Oncology Pub Date : 2023-04-27 DOI: 10.5603/njo.a2022.0063
E. Gliwska, P. Koczkodaj, M. Mańczuk
{"title":"Cancerogenic food contaminants in European countries","authors":"E. Gliwska, P. Koczkodaj, M. Mańczuk","doi":"10.5603/njo.a2022.0063","DOIUrl":"https://doi.org/10.5603/njo.a2022.0063","url":null,"abstract":"","PeriodicalId":130080,"journal":{"name":"Nowotwory. Journal of Oncology","volume":"99 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124189853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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