Human reproduction最新文献_第2页

Recurrent implantation failure: science or fiction?

IF 6 1区医学

Human reproduction Pub Date : 2025-03-01 DOI: 10.1093/humrep/deaf007

Juan J Fraire-Zamora, George Liperis, Munevver Serdarogullari, Omar F Ammar, Paul Pirtea, Paola Viganò, Laurentiu Craciunas, Micah J Hill, Kashish Sharma

引用次数: 0

Association between endometriosis and working life among Danish women. 丹麦妇女子宫内膜异位症与工作寿命的关系

IF 6 1区医学

Human reproduction Pub Date : 2025-03-01 DOI: 10.1093/humrep/deae298

Eeva-Liisa Røssell, Oleguer Plana-Ripoll, Marie Josiasen, Karina Ejgaard Hansen, Bodil Hammer Bech, Dorte Rytter

{"title":"Association between endometriosis and working life among Danish women.","authors":"Eeva-Liisa Røssell, Oleguer Plana-Ripoll, Marie Josiasen, Karina Ejgaard Hansen, Bodil Hammer Bech, Dorte Rytter","doi":"10.1093/humrep/deae298","DOIUrl":"10.1093/humrep/deae298","url":null,"abstract":"Study question: What is the association between endometriosis and working life (lost), workforce participation, and productivity?Summary answer: Women with endometriosis experienced more working years lost due to disability pension and to a smaller degree sick leave, they were less frequently working or enrolled in education, had more sick days, were less productive, and had lower work ability.What is known already: Endometriosis is associated with negative consequences on working life; however, previous studies are based on self-reported data or smaller samples of women. To the best of our knowledge, no previous studies have quantified the average reduction in working hours during the entire span of working life using population-based registers.Study design, size, duration: This study included two Danish data sources. In the register-based cohort study (main analysis), a total of 2 650 554 women aged 18-65 years were followed for a total of 42.8 million person-years from 1992 to 2021. In the questionnaire-based cross-sectional study (Supplementary Analysis), 35 490 women aged 26-51 years were invited to participate and 7298 women completed the questionnaire.Participants/materials, setting, methods: For the main analysis, 42 741 (1.6%) were diagnosed with endometriosis. We estimated working years lost decomposed into disability pension, voluntary early retirement, or death for women with endometriosis and the general female population. For the supplementary analysis, 270 (4.0%) reported to have endometriosis. We analysed these recent questionnaire data on women's health to further investigate working life and productivity among women with and without endometriosis.Main results and the role of chance: Based on the main analysis, women with endometriosis lost on average an additional 0.26 years (95% CI: 0.17-0.37) of working life compared to the general female population. This was due to sick leave and especially disability pension. For the supplementary analysis, the participation rate was 20.6%. Women with endometriosis reported to be less frequently working or enrolled in education (74.1% (95% CI 68.4%-79.2%) with endometriosis, 82.7% (95% CI 81.8%-83.7%) without) and had more sick days (4-28 sick days last 4 weeks: 16.2% (95% CI 11.6%-21.8%) with endometriosis, 7.9% (95% CI 7.2%-8.7%) without). In addition, they reported lower productivity and work ability.Limitations, reasons for caution: Endometriosis is underdiagnosed in the register data as only hospital diagnoses are registered and diagnoses from private practicing gynaecologists and general practitioners are missing. In addition, sick leave might be underestimated as shorter periods of sick leave are not included in the registers. Questionnaire data were self-reported including endometriosis and participants might be a selected","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":" ","pages":"461-468"},"PeriodicalIF":6.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11879171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142970633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraovarian platelet-rich plasma injection for ovarian rejuvenation.

IF 6 1区医学

Human reproduction Pub Date : 2025-02-27 DOI: 10.1093/humrep/deaf030

Gorka Barrenetxea

引用次数: 0

Reply: Follicular activation, not ovarian rejuvenation: terminology matters, but outcomes remain unchanged after platelet-rich plasma administration.

IF 6 1区医学

Human reproduction Pub Date : 2025-02-27 DOI: 10.1093/humrep/deaf031

Andres Reig, Nola Herlihy, Yigit Cakiroglu, Christine Whitehead, Bulent Tiras, Richard T Scott, Emre Seli

引用次数: 0

Effectiveness and safety of consecutive single embryo transfer compared to double embryo transfer: results from the UK HFEA registry.

IF 6 1区医学

Human reproduction Pub Date : 2025-02-25 DOI: 10.1093/humrep/deaf028

Jack Tighe, Sophie Broughton, Rachel Roberts, Lorraine S Kasaven, Rachel Cutting, Elliot Bridges, Abigail Ng, Amanda Evans, Efstathios Theodorou, Jara Ben Nagi, Benjamin P Jones

{"title":"Effectiveness and safety of consecutive single embryo transfer compared to double embryo transfer: results from the UK HFEA registry.","authors":"Jack Tighe, Sophie Broughton, Rachel Roberts, Lorraine S Kasaven, Rachel Cutting, Elliot Bridges, Abigail Ng, Amanda Evans, Efstathios Theodorou, Jara Ben Nagi, Benjamin P Jones","doi":"10.1093/humrep/deaf028","DOIUrl":"https://doi.org/10.1093/humrep/deaf028","url":null,"abstract":"Study question: How does two-consecutive single embryo transfer (2xSET) affect reproductive outcomes of IVF and ICSI compared to double embryo transfer (DET)?Summary answer: Two-consecutive SET may provide greater or comparable live birth rate (LBR); with lower multiple birth, preterm birth, and pregnancy loss or neonatal death rates compared to DET.What is known already: Elective SET in IVF/ICSI is widely encouraged over DET to minimize the risk of multiple births and associated morbidities. Despite this, multiple birth rates following IVF remain higher than the 10% target across Europe and the USA. Currently, the majority of evidence regarding SET and DET is based on various studies assessing outcomes such as LBR per treatment cycle, as opposed to per oocyte retrieval. As such, the representation of SET is mostly unfavourable. Analysis of cumulative LBR following the transfer of two embryos over consecutive cycles, rather than in one transfer event (DET) is more effective at distinguishing the two methods and will therefore provide more valuable information relevant to clinical practice.Study design, size, duration: This retrospective cohort study was conducted using Human Fertilisation and Embryology Authority (HFEA) register data, which encompasses national data from all IVF clinics in the UK. All women who underwent their first oocyte retrieval and IVF or ICSI treatment cycle with subsequent SET, DET, or 2xSET between 2010 and 2019 using blastocyst embryos were included (N = 71 807).Participants/materials, setting, methods: The rate of live birth, liveborn baby rate, multiple birth, preterm birth, and pregnancy loss or neonatal death was compared between SET, DET, and 2xSET IVF/ICSI pregnancies using blastocyst-stage embryos, where data were stratified by maternal age. Data analysis was conducted in RStudio v4.2, alpha equals 0.05.Main results and the role of chance: Blastocyst-stage 2xSET achieved a greater median LBR of 0.47 (interquartile range [IQR] 0.13) than SET, 0.41 (IQR 0.13), and DET, 0.38 (IQR 0.13) (P < 0.05). Using SET as the reference standard, 2xSET was associated with a significantly lower odds of multiple births compared to DET ((odds ratio [OR] 6.87, 95% CI 6.14-7.68) vs 28.20, 95% CI 25.20-31.57). The odds of preterm birth were also lower following 2xSET (OR 1.11, 95% CI 1.06-1.15) compared to DET (OR 2.80, 95% CI 2.67-2.94). Similarly, the odds of pregnancy loss or neonatal death were lower following 2xSET (OR 1.14, 95% CI 1.08-1.21) compared to DET (OR 2.11, 95% CI 1.98-2.24). LBR was consistently higher following 2xSET than DET and SET in women aged 39 years and under (P < 0.05). However, results were comparable in women over 39 years (P > 0.05). Across all age groups, DET pregnancies had the highest multiple birth rate (P < 0.05). In women aged 39 years and under, DET was associate","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":" ","pages":""},"PeriodicalIF":6.0,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143500417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-time monitoring reveals the effects of low concentrations of volatile organic compounds in the embryology laboratory

IF 6.1 1区医学

Human reproduction Pub Date : 2025-02-25 DOI: 10.1093/humrep/deaf008

Jiali Cai, Liying Zhou, Lanlan Liu, Zhenfang Liu, Jinghua Chen, Kaijie Chen, Xiaolian Yang, Xiaoming Jiang, Jianzhi Ren

{"title":"Real-time monitoring reveals the effects of low concentrations of volatile organic compounds in the embryology laboratory","authors":"Jiali Cai, Liying Zhou, Lanlan Liu, Zhenfang Liu, Jinghua Chen, Kaijie Chen, Xiaolian Yang, Xiaoming Jiang, Jianzhi Ren","doi":"10.1093/humrep/deaf008","DOIUrl":"https://doi.org/10.1093/humrep/deaf008","url":null,"abstract":"STUDY QUESTION Could real-time monitoring of volatile organic compounds (VOCs) in the embryology laboratory provide meaningful early warning for potential harm from the environment? SUMMARY ANSWER Even in a laboratory environment with a total VOC concentration lower than the recommendation of the Cairo Consensus, the real-time monitored VOC concentrations are associated with changes in embryo morphological parameters. WHAT IS KNOWN ALREADY VOCs have been considered a key environmental detriment in embryology laboratories. However, the current VOC thresholds established by the Cairo consensus were based on the practical experience of air pollution cases, and a scientifically derived threshold is lacking. STUDY DESIGN, SIZE, DURATION The study included 7076 oocyte collection (OPU) cycles carried out between June 2020 and December 2022 in the Center for Reproductive Medicine of the affiliated Chenggong Hospital of Xiamen University, 6306 of which resulted in at least one embryo transfer (ET) attempt during the study. VOC monitoring data were recorded every 10 min. The average and peak concentrations of total VOCs and formaldehyde during culture were associated with embryo parameters and implantation following the first ET attempt of the cycle in generalized estimating equations and generalized additive models. MAIN RESULTS AND THE ROLE OF CHANCE Real-time monitoring of VOCs showed a dynamic of VOC concentration in the laboratory. The concentration reached peaks during the working hours of the days and working days of the week and fell quickly at night and on weekends. The average concentrations of VOCs during the culture period were linearly associated with decreased early cleavage (OR 0.92, 95% CI: 0.85, 0.99), decreased Day 3 compaction (OR 0.51, 95% CI: 0.32, 0.83), increased asymmetry (OR 1.13, 95% CI: 1.01, 1.25), and increased grade C trophectoderm (TE) (OR 1.99, 95% CI: 1.32, 3.01). On the other hand, increased Day 3 arrest, delayed blastocyst formation, and decreased grade A TE showed a non-linear association with VOCs, suggesting a possible threshold of effect. In the first transfer attempt, negative associations were observed between maximal formaldehyde concentrations and pregnancy in both fresh transfer (RR 0.971, 95% CI: 0.94, 0.99) and freeze-all frozen-thawed ET (RR 0.959, 95% CI: 0.92, 0.99) cycles. LIMITATIONS, REASONS FOR CAUTION The sensitivity and specificity of the monitor are not comparable to the standard protocols, such as chromatography-mass spectroscopy. Due to the lack of ability to identify the chemical nature of the components of VOCs, the toxicity and source of the VOCs were largely unknown. The representative sampling of the laboratory air may not necessarily reflect the exposure of embryos. WIDER IMPLICATIONS OF THE FINDINGS While the environment of the embryology laboratory has been significantly improved, the data suggested that a low VOC level could still be a concern. Due to the dynamic of VOC concentration in the","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":"15 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mapping the way to successful euploid frozen embryo transfer: a prospective pilot study of uterine elastography

IF 6.1 1区医学

Human reproduction Pub Date : 2025-02-25 DOI: 10.1093/humrep/deaf029

Cheri Margolis, Nicolás Garrido, Leah Roberts, Andres Reig, Pavan Gill, Stephanie Willson, Haley Genovese, Francesca Barrett, Caroline Zuckerman, Christine Whitehead, Paul Bergh, Emre Seli, Marie Werner

{"title":"Mapping the way to successful euploid frozen embryo transfer: a prospective pilot study of uterine elastography","authors":"Cheri Margolis, Nicolás Garrido, Leah Roberts, Andres Reig, Pavan Gill, Stephanie Willson, Haley Genovese, Francesca Barrett, Caroline Zuckerman, Christine Whitehead, Paul Bergh, Emre Seli, Marie Werner","doi":"10.1093/humrep/deaf029","DOIUrl":"https://doi.org/10.1093/humrep/deaf029","url":null,"abstract":"STUDY QUESTION Does the objective and quantitative assessment of uterine tissue stiffness via ultrasound shear wave elastography (SWE) predict the outcome after single euploid frozen embryo transfer (FET)? SUMMARY ANSWER Uterine SWE data might be predictive of clinical pregnancy in good prognosis patients undergoing single euploid FET. WHAT IS KNOWN ALREADY Few prior studies have evaluated the usefulness of strain uterine elastography in assessing the likelihood of conception in an infertile patient population following IUI or FET. These studies suggest that elastography parameters may be predictive of pregnancy following ART treatments. However, these studies are limited based on their use of strain uterine elastography, which provides a relative measurement between two areas of interest. No prior study has evaluated the more robust technology of SWE, which provides quantitative and objective measurements, on likelihood of conception following infertility treatment. STUDY DESIGN, SIZE, DURATION This is a prospective pilot study of 153 patients with no known uterine pathology undergoing single euploid FET at a university-affiliated center between June 2022 and December 2022. PARTICIPANTS/MATERIALS, SETTING, METHODS Patients scheduled for upcoming single euploid blastocyst FET during the study period were evaluated for study participation. On the day prior to embryo transfer, SWE assessment of 15 regions of interest of the sagittal uterus measuring 6 mm in diameter was performed on included participants. Regions of interest included the cervix, anterior/posterior distal myometrium, anterior/posterior lower uterine segment, fundus, endometrium, and the anterior myometrial/endometrial interface. The elastography data points generated were collected in a standardized fashion by a single investigator blinded to patient outcome. The elasticity parameters analyzed included the mean, SD, minimum, and maximum values in kilopascals and meters per second. These data were assessed for relationship to clinical pregnancy, defined as discharge from fertility care at 9 weeks’ gestation. MAIN RESULTS AND THE ROLE OF CHANCE There were 22 uterine elastography parameters that showed a significant relationship to clinical pregnancy with P &lt; 0.10 using univariant analyses. Regions of interest that were predictive of clinical pregnancy with P &lt; 0.10 included the cervix, the anterior myometrium, the posterior myometrium, the fundus, and the anterior myometrial/endometrial interface. Increased mean (stiffer elastography metrics) in the posterior myometrium and anterior myometrial/endometrial interface was associated with increased likelihood of clinical pregnancy in comparison to FETs that did not result in clinical pregnancy. These values were then subjected to a multivariable logistic regression model to estimate areas under the curves and predictive values with and without clinical parameters. Using elastography data only, the model for predicting clinic","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":"82 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143495159","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Patterns of health service use before and after diagnosis of endometriosis: a data linkage prospective cohort study

IF 6.1 1区医学

Human reproduction Pub Date : 2025-02-23 DOI: 10.1093/humrep/deaf026

Gita D Mishra, Dereje G Gete, Mohammad R Baneshi, Grant Montgomery, Jessica Taylor, Jenny Doust, Jason Abbott

{"title":"Patterns of health service use before and after diagnosis of endometriosis: a data linkage prospective cohort study","authors":"Gita D Mishra, Dereje G Gete, Mohammad R Baneshi, Grant Montgomery, Jessica Taylor, Jenny Doust, Jason Abbott","doi":"10.1093/humrep/deaf026","DOIUrl":"https://doi.org/10.1093/humrep/deaf026","url":null,"abstract":"STUDY QUESTION What are the patterns of health service use (HSU) before and after endometriosis diagnosis? SUMMARY ANSWER Women with endometriosis had higher rates of visits to general practitioners (GPs), specialists, and diagnostic imaging before and after diagnosis compared to those without the condition; however, after diagnosis, their visits to GPs and specialists other than obstetricians/gynaecologists decreased compared to before, while visits to obstetricians/gynaecologists and use of diagnostic imaging increased. WHAT IS KNOWN ALREADY Women with endometriosis have higher rates of healthcare use compared to those without the condition; however, no longitudinal study has examined patterns of HSU over a prolonged period before and after diagnosis. STUDY DESIGN, SIZE, DURATION The Australian Longitudinal Study on Women’s Health linked to a national administrative health record. A total of 30 473 women, born in 1973–1978 and 1989–1995, from two cohorts with data collected from 1996 to 2021, as online or postal questionnaires. PARTICIPANTS/MATERIALS, SETTING, METHODS Women with endometriosis were identified using the self-report surveys and their administrative health records. A control group of women without endometriosis was randomly selected and age-matched with women with endometriosis. The final sample included 9545 women from the 1973–1978 cohort (1909 cases, 7636 controls) and 7510 from the 1989–1995 cohort (1502 cases, 6008 controls). Women’s HSU was assessed using the Medicare Benefits Schedule database. A random intercept zero-inflated negative binomial model was used to compare outcomes between cases and controls, addressing skewed data, over-dispersion, and excess zeros. MAIN RESULTS AND THE ROLE OF CHANCE In both cohorts, women with endometriosis had a higher level of HSU, both before and after diagnosis, compared with those without the condition. For the 1973–1978 cohort, women with endometriosis had a higher rate of visits to GPs before and after diagnosis (adjusted incidence rate ratio: 1.19, 95% CI 1.14, 1.23 and 1.24, 95% CI 1.19, 1.30, respectively), specialists other than obstetricians/gynaecologists (1.50, 95% CI 1.40, 1.61, and 1.36, 95% CI 1.27, 1.46), and for diagnostic imaging (1.15, 95% CI 1.10, 1.21, and 1.20, 95% CI 1.15, 1.26). The average number of these visits remained consistent in the early years, peaked around 3 years before diagnosis, and then partly declined post-diagnosis, to later stabilize at a higher level than those without the condition. Following the diagnosis, women with endometriosis had a higher number of visits to obstetricians/gynaecologists (1.11, 95% CI 1.05, 1.17) than their matched controls, with a marked increase in the first 6 years post-diagnosis, but gradually returned to same levels as the control group. After diagnosis, women with endometriosis had a lower rate of visits to GPs (0.95, 95% CI 0.93, 0.98) and specialists other than obstetricians/gynaecologists (0.88, 95% CI 0.82, 0.93) co","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":"774 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does gonadotoxic chemotherapy deplete the ovarian reserve through activation of primordial follicles?

IF 6.1 1区医学

Human reproduction Pub Date : 2025-02-23 DOI: 10.1093/humrep/deaf024

Murat Erden, Kutluk H Oktay

引用次数: 0

Burden of somatic morbidity associated with a surgically verified diagnosis of endometriosis at a young age: a register-based follow-up cohort study in Finland

IF 6.1 1区医学

Human reproduction Pub Date : 2025-02-23 DOI: 10.1093/humrep/deaf032

Elina Rasp, Kristiina Rönö, Anna But, Mika Gissler, Päivi Härkki, Oskari Heikinheimo, Liisu Saavalainen

{"title":"Burden of somatic morbidity associated with a surgically verified diagnosis of endometriosis at a young age: a register-based follow-up cohort study in Finland","authors":"Elina Rasp, Kristiina Rönö, Anna But, Mika Gissler, Päivi Härkki, Oskari Heikinheimo, Liisu Saavalainen","doi":"10.1093/humrep/deaf032","DOIUrl":"https://doi.org/10.1093/humrep/deaf032","url":null,"abstract":"STUDY QUESTION How does the burden of somatic disorders compare between women with surgically verified endometriosis diagnosed in adolescence or early adulthood, and matched women without a history of endometriosis? SUMMARY ANSWER Women with endometriosis diagnosed at a young age had a higher incidence of several somatic disorders and a higher number of hospital visits compared to women without endometriosis. WHAT IS KNOWN ALREADY Endometriosis is associated with an increased risk of several somatic disorders, including autoimmune, inflammatory, and pain-related disorders with higher utility of health care resources. There may be differences in the experience of pain relating to the subtypes of endometriosis. Depression and anxiety are linked to endometriosis and increase overall somatic comorbidity. STUDY DESIGN, SIZE, DURATION Longitudinal retrospective register-based cohort study utilizing episode data from specialized care; 2680 women under 25 years with a surgical of diagnosis endometriosis in 1998–2012, and 5338 reference women of the same age and municipality followed up from the index day to the end of 2019, emigration, death or the outcome of interest. PARTICIPANTS/MATERIALS, SETTING, METHODS We analysed incidence rates, cumulative incidence rates, and crude hazard rate ratios (HR) with 95% CIs across 15 groups of somatic disorders. Subgroup analyses were conducted among women with endometriosis, by (i) type of endometriosis—ovarian only (n = 601) versus combined types (n = 2079), and (ii) pre-existing diagnosis of depression or anxiety (n = 270) versus those without such diagnoses (n = 2410). MAIN RESULTS AND THE ROLE OF CHANCE Women reached a median age of 38 (IQR 34–42) years after a median follow-up of almost 16 (12, 19) years. Compared to the reference cohort, women with endometriosis had a higher incidence of several somatic disorders during the follow-up. By the age of 40 years, 38% of women with endometriosis and 9% of the reference cohort had diagnoses of infertility (HR 5.88 [95% CI 5.24–6.61]). The corresponding figures for genital tract infections were 24% and 6% (4.64 [4.03–5.36]), symptoms and signs of pain 62% and 28% (3.27 [3.04–3.51]), migraine 15% and 6.4% (2.49 [2.13–2.92]), and chronic pain conditions 33% and 19% (2.01 [1.83–2.22]), respectively. In women with endometriosis, a higher incidence was seen also for dyspareunia, uterine myomas, celiac disease, asthma, anaemia, high blood pressure, hypercholesterolemia or cardiovascular diseases; autoimmune diseases, and disorders of the thyroid gland. For women with ovarian endometriosis only, we observed a lower HR of high blood pressure, hypercholesterolemia or cardiovascular diseases, asthma, migraine, and pain-related disorders compared to those with other or combined types of endometriosis. Within the endometriosis cohort, women with pre-existing diagnoses of depression or anxiety had higher HRs of several somatic disorders compared to those without such diagnoses. Th","PeriodicalId":13003,"journal":{"name":"Human reproduction","volume":"8 1","pages":""},"PeriodicalIF":6.1,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143473454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0