Hepatoma Research最新文献_第2页

Chinese expert consensus on composite ablation system for the treatment of primary liver cancer (2023 edition) 复合消融系统治疗原发性肝癌的中国专家共识（2023 年版）

Hepatoma Research Pub Date : 2024-03-14 DOI: 10.20517/2394-5079.2024.24

Z. Meng

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Introduction of Chinese expert consensus on neoadjuvant therapy for primary liver cancer (2023 edition) 原发性肝癌新辅助治疗中国专家共识（2023 年版）介绍

Hepatoma Research Pub Date : 2024-03-12 DOI: 10.20517/2394-5079.2024.33

Jizhou Wang, Lianxin Liu

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Advancements in hepatocellular carcinoma diagnosis and treatment: liquid biopsy and surgical as precision treatment 肝细胞癌诊断和治疗的进展：液体活检和手术精准治疗

Hepatoma Research Pub Date : 2024-02-23 DOI: 10.20517/2394-5079.2024.13

Alessandro D. Mazzotta, Desirée Bonci

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Introduction of the Chinese expert consensus on postoperative adjuvant therapy for hepatocellular carcinoma (2023 Edition) 肝细胞癌术后辅助治疗中国专家共识（2023年版）介绍

Hepatoma Research Pub Date : 2024-01-24 DOI: 10.20517/2394-5079.2024.02

Haibin Zhang

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Racial, ethnic, and socioeconomic differences in hepatocellular carcinoma across the United States 美国各地肝细胞癌的种族、民族和社会经济差异

Hepatoma Research Pub Date : 2024-01-18 DOI: 10.20517/2394-5079.2023.114

A. Díaz, Samantha M Ruff, T. Pawlik

{"title":"Racial, ethnic, and socioeconomic differences in hepatocellular carcinoma across the United States","authors":"A. Díaz, Samantha M Ruff, T. Pawlik","doi":"10.20517/2394-5079.2023.114","DOIUrl":"https://doi.org/10.20517/2394-5079.2023.114","url":null,"abstract":"Hepatocellular carcinoma (HCC) poses a significant public health challenge within the US, exerting an increasingly substantial influence on cancer-related deaths. However, the HCC burden is not uniformly distributed, with significant disparities related to race, ethnicity, and socioeconomic status. This manuscript comprehensively reviews the multifaceted origins of HCC disparities, exploring their roots in the sociocultural environment, socioeconomics, the physical/built environment, and the healthcare/political systems. The sociocultural environment highlights the unique challenges faced by racial and ethnic minority populations, including language barriers, cultural beliefs, and limited healthcare access. The socioeconomics and the physical/built environment section emphasize the impact of neighborhood poverty, geographic disparities, and healthcare infrastructure on HCC outcomes. The healthcare and political systems play a pivotal role in driving HCC disparities through practice guidelines, healthcare policies, insurance coverage, and access to care. Inconsistent practice guidelines across specialties and variations in insurance coverage contribute to disparities in HCC surveillance and treatment. In conclusion, addressing HCC disparities requires a multifaceted, patient-centered approach that includes cultural competence, infrastructure enhancements, policy changes, and improved access to care. Collaborative efforts among healthcare professionals, researchers, policymakers, and institutions are essential to reducing the burden of HCC on marginalized communities and ensuring equitable care for all individuals affected by this complex disease.","PeriodicalId":12959,"journal":{"name":"Hepatoma Research","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139526054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precise staging of advanced HCC promotes higher quality of personalized treatment management: Chinese experts consensus on precision diagnosis and management of advanced hepatocellular carcinoma (2023) 晚期肝细胞癌的精准分期有助于提高个性化治疗管理的质量：晚期肝细胞癌精准诊治的中国专家共识（2023年）

Hepatoma Research Pub Date : 2024-01-15 DOI: 10.20517/2394-5079.2023.155

Aizier Ainiwaer, Yue Chen, Yinying Lu

引用次数: 0

Interpretation of Chinese expert consensus on the whole-course management of hepatocellular carcinoma (2023 edition) 肝细胞癌全程管理中国专家共识（2023年版）》解读

Hepatoma Research Pub Date : 2024-01-12 DOI: 10.20517/2394-5079.2023.151

Yang Yang, Yu Yang, Juxian Sun, Shuqun Cheng, Qiu Li

引用次数: 0

Mutation-based therapies for intrahepatic cholangiocarcinoma: new options on the horizon 基于突变的肝内胆管癌疗法：即将出现的新选择

Hepatoma Research Pub Date : 2024-01-12 DOI: 10.20517/2394-5079.2023.44

Si-yuan Pan, Yu-Hang Ye, Zheng-jun Zhou, Jia Fan, Jian Zhou, Shaolai Zhou

{"title":"Mutation-based therapies for intrahepatic cholangiocarcinoma: new options on the horizon","authors":"Si-yuan Pan, Yu-Hang Ye, Zheng-jun Zhou, Jia Fan, Jian Zhou, Shaolai Zhou","doi":"10.20517/2394-5079.2023.44","DOIUrl":"https://doi.org/10.20517/2394-5079.2023.44","url":null,"abstract":"Intrahepatic cholangiocarcinoma (ICC), a rare but rising global malignancy originating from the bile ducts, poses significant challenges in terms of effective treatment and patient outcomes. While surgical excision remains the curative option, its limited efficacy necessitates more therapeutic strategies, including systemic therapies. The management of ICC involves a multidisciplinary approach, with treatment decisions guided by patient-specific and tumor-specific factors. Gemcitabine-cisplatin (GEMCIS) chemotherapy has been a standard first-line therapy, but recent advancements in immunotherapy, particularly the introduction of durvalumab, have provided new hope. Additionally, gene mutation-based therapies, targeting fibroblast growth factor receptors (FGFRs), isocitrate dehydrogenase-1 (IDH1), human epidermal growth factor receptor-2 (HER2), and B-RAF proto-oncogene (BRAF), offer promising prospects for personalized treatment. High-throughput genomic profiling technologies have facilitated the identification of actionable targets and the development of innovative therapeutic approaches. This review summarizes the mutation-based therapies in ICC, including FDA-approved targeted drugs and ongoing clinical trials, highlighting the evolving landscape of ICC treatment.","PeriodicalId":12959,"journal":{"name":"Hepatoma Research","volume":"21 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139532443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Crosstalk between cancer cell plasticity and immune microenvironment in cholangiocarcinoma 胆管癌中癌细胞可塑性与免疫微环境之间的相互关系

Hepatoma Research Pub Date : 2024-01-09 DOI: 10.20517/2394-5079.2023.69

Mirko Minini, Allan Pavy, Bouchra Lekbaby, L. Fouassier

{"title":"Crosstalk between cancer cell plasticity and immune microenvironment in cholangiocarcinoma","authors":"Mirko Minini, Allan Pavy, Bouchra Lekbaby, L. Fouassier","doi":"10.20517/2394-5079.2023.69","DOIUrl":"https://doi.org/10.20517/2394-5079.2023.69","url":null,"abstract":"Cholangiocarcinoma (CCA) is a highly aggressive tumor of the biliary tree characterized by an intense desmoplastic tumor microenvironment (TME). To date, treatment of CCA remains challenging; tumor resection is the only curative treatment with a high recurrence probability. Besides resection, therapeutic options have moved forward with the advent of immunotherapies, but these remain limited and low effective. Our knowledge about the cellular interplays in CCA is still fragmentary. An area is currently emerging regarding the potential role of cancer cell plasticity in the genesis of an immunosuppressive microenvironment. The cancer cells’ ability to acquire stemness properties and to disseminate through an epithelial-mesenchymal transition (EMT) shape a tumor immune microenvironment that supports cancer progression by attracting immunosuppressive cells including myeloid-derived suppressor cells (MDSCs), regulatory T cells (Tregs), M2 macrophages, and by increasing the expression of inhibitory immune checkpoints such as PD-1/PD-L-1. EMT-inducing transcription factors (EMT-TF) have recently emerged as regulators of tumor immunity by creating an immunosuppressive microenvironment. This review delves into the molecular mechanisms underlying the existing links between EMT/stemness and tumor immune microenvironment, as well as the last discoveries in CCA.","PeriodicalId":12959,"journal":{"name":"Hepatoma Research","volume":"32 14","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139442818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between physical activity and risk of liver cancer: results from a population-based cohort study in Chinese women 体育锻炼与肝癌风险之间的关系：基于人群的中国女性队列研究结果

Hepatoma Research Pub Date : 2024-01-01 DOI: 10.20517/2394-5079.2023.73

Jing-Yu Tan, Zhuo-Ying Li, Q. Shen, Yan Zhang, J. Tuo, Da-ke Liu, Y. Tan, Honglan Li, Yong-Bing Xiang

{"title":"Associations between physical activity and risk of liver cancer: results from a population-based cohort study in Chinese women","authors":"Jing-Yu Tan, Zhuo-Ying Li, Q. Shen, Yan Zhang, J. Tuo, Da-ke Liu, Y. Tan, Honglan Li, Yong-Bing Xiang","doi":"10.20517/2394-5079.2023.73","DOIUrl":"https://doi.org/10.20517/2394-5079.2023.73","url":null,"abstract":"Aims : Epidemiological evidence has revealed varying degrees of relationship between physical activity and risk of most cancers, but the association between physical activity and risk for primary liver cancer in Chinese has seldom been reported. This study aims to characterize the associations between different physical activity types and liver cancer risk in Chinese women. Methods: We collected physical activity information through the physical activity questionnaire (PAQ) and assigned a corresponding metabolic equivalent value according to the physical activity compendium. Multivariable-adjusted Cox regression models were utilized to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the relationships between physical activity and liver cancer. Results : A total of 72,674 females were enrolled in the cohort, with a median follow-up time of 18.12 years. By the end of 2016, 255 females were identified as incident cases of liver cancer. In Multivariable-adjusted Cox regression analysis, total physical activity (TPA), daily living physical activity (DPA) and leisure-time physical activity (LTPA) were not associated with the liver cancer risk in women. The highest tertile vs . none of HRs (95%CIs) were 0.82 (0.58, 1.17) for TPA, 0.80 (0.56, 1.15) for DPA, and 1.15 (0.82, 1.61) for adult LTPA in terms of measures as the METs-hour/week. For each activity, we found that the HRs (95%CIs) were 0.77 (0.55, 1.08) for stair climbing and 0.78 (0.53, 1.15) for participation in housework after further adjusting for body mass index and type 2 diabetes. Conclusion : Null significant results were found in the association between physical activity and female liver cancer risk in China.","PeriodicalId":12959,"journal":{"name":"Hepatoma Research","volume":"17 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139125970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0