Gynecologic and Obstetric Investigation最新文献

{"title":"Retraction Statement.","authors":"","doi":"10.1159/000551418","DOIUrl":"10.1159/000551418","url":null,"abstract":"<p><p>The article \"Effects of Low Luteinizing Hormone Serum Levels on Oocyte Retrieval, Fertilization Rate, and Embryo Quality during Controlled Ovarian Stimulation: Results from a Prospective Cohort Analysis\" [Gynecol Obstet Invest. 2024;89(1):50-58; https://doi.org/10.1159/000534860] by Jessica Dragotto, Giovanni Buzzaccarini, Andrea Etrusco, Antonio Simone Laganà, Renato Venezia, Sanja Terzic, Miriam Dellino, Chrysoula Margioula-Siarkou, Vittorio Unfer, Bianca Bianco, Paolo Casadio, and Giovanni Bracchitta has been retracted by the Publisher and the Editors.Following publication, concerns were raised regarding the mean demographic values in the article. The authors responded to the request for comment and provided original data for the study. Review of the provided data raised further concerns regarding a nonnormal distribution of participant ages and a difference between the data reported in the article and that calculated from the data. The authors responded to the concerns and stated that the data provided is that underlying the article and discrepancies may be due to a small cohort size and differences in the statistical tools used for mean calculations. The response was found by the editors to be unsatisfactory to address the concerns, which was determined to undermine the reliability of the results in the article and therefore, the article has been retracted.Andrea Etrusco acknowledged the retraction decision and stated that his role in the study was limited to administrative/correspondence communications and stated that he had no role in the study design, conduct, data management, data verification, or analysis. Jessica Dragotto acknowledged the retraction decision and affirmed the above regarding the role of Andrea Etrusco in the study. Bianco Bianco acknowledged the retraction, agreed with the decision and stated that her role was limited to critical review of the manuscript after its completion and without responsibilities or any relation with the study as a whole, from the inception to the manuscript elaboration. The remaining authors did not respond to notification of the retraction decision within the timeframe specified.</p>","PeriodicalId":12952,"journal":{"name":"Gynecologic and Obstetric Investigation","volume":" ","pages":"383"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maternal and Microbiological Outcomes in GBS-Positive Patients Receiving Intrapartum Ampicillin versus Clindamycin: A Retrospective Cohort Study.","authors":"Raneen Abu Shqara, Shany Or, Gabriela Goldinfeld, Nadir Ganem, Lior Lowenstein, Maya Frank Wolf","doi":"10.1159/000549302","DOIUrl":"10.1159/000549302","url":null,"abstract":"&lt;p&gt;&lt;p&gt;&lt;p&gt;Objectives: Early-onset Group B Streptococcus (GBS) infection is a major cause of neonatal morbidity and mortality, which can be prevented through intrapartum antibiotic prophylaxis (IAP). First-line β-lactams (penicillin or ampicillin) are preferred, whereas clindamycin is reserved for patients with a confirmed high-risk penicillin allergy and documented susceptibility. Increasing clindamycin resistance and concerns about intra-amniotic efficacy highlight the need to evaluate maternal outcomes. This study examined maternal infectious morbidity, neonatal outcomes, and microbiological findings in GBS-positive term patients receiving ampicillin versus clindamycin IAP.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;This retrospective cohort study was conducted between March 2021 and March 2024 at a tertiary university-affiliated hospital. Participants/Materials: Singleton term pregnancies (≥37 weeks) with a documented positive GBS vaginal-rectal culture obtained within 5 weeks before delivery were included. Patients received either ampicillin (n = 1,833) according to the institutional protocol or clindamycin (n = 78) if they reported a severe β-lactam allergy. No intrapartum clindamycin susceptibility testing was performed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting: &lt;/strong&gt;The study was conducted at a tertiary university-affiliated hospital between March 2021 and March 2024.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The co-primary outcomes were clinical chorioamnionitis and admission to the neonatal intensive care unit (NICU). Secondary maternal outcomes included intrapartum fever, postpartum fever, postpartum antibiotic administration use, and cesarean delivery. Secondary neonatal outcomes included a 5-min Apgar score of &lt;7, umbilical cord pH at &lt;7.1, respiratory distress, and ventilatory support. Chorioamniotic swabs were obtained after delivery. Data were analyzed using chi-square or Fisher's exact tests for categorical variables, t tests or Mann-Whitney U tests for continuous variables, and multivariable logistic regression to identify independent predictors.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Baseline maternal and obstetric characteristics were similar. Compared with ampicillin, clindamycin was associated with significantly higher rates of intrapartum fever (23.1% vs. 2.3%, p &lt; 0.001), clinical chorioamnionitis (9.0% vs. 0.5%, p &lt; 0.001), postpartum fever (5.1% vs. 1.0%, p = 0.001), and postpartum antibiotic use (7.6% vs. 0.8%, p &lt; 0.001). Cesarean delivery rates did not differ significantly (19.2% vs. 11.6%, p = 0.084). NICU admission and other neonatal outcomes were comparable. Compared with ampicillin, clindamycin IAP was identified as a strong independent predictor of clinical chorioamnionitis (adjusted odds ratio [aOR] 20.1, 95% confidence interval [CI] 6.6-61.4, p &lt; 0.001), together with prolonged rupture of membranes &gt;18 h (aOR 4.9, 95% CI 1.6-15.7, p = 0.006) and cervical ripening by catheter balloon (aOR 4.1, 95% CI 1.2-13.6, p = 0.023). Postpartum, GBS-positive chorioamni","PeriodicalId":12952,"journal":{"name":"Gynecologic and Obstetric Investigation","volume":" ","pages":"331-338"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12707870/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145408765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salvage Surgery for Localized Recurrent Ovarian Clear Cell Carcinoma: A Retrospective Case Series.","authors":"Daisuke Watanabe, Mari Deguchi, Yutaka Yoneoka, Atsushi Murakami, Yuji Tanaka, Hiroyuki Yamanaka, Akimasa Takahashi, Shunichiro Tsuji, Tsukuru Amano","doi":"10.1159/000550764","DOIUrl":"10.1159/000550764","url":null,"abstract":"<p><p><p>Objectives: The aim of this study was to evaluate the clinical outcomes of salvage surgery for localized recurrent ovarian clear cell carcinoma (OCCC), a chemoresistant subtype with poor prognosis.</p><p><strong>Design: </strong>We retrospectively analyzed 75 patients who underwent primary surgery for OCCC between January 1996 and December 2022.</p><p><strong>Participants and methods: </strong>Twenty-two patients experienced recurrence after complete resection, of whom 10 met the institutional criteria for localized, resectable recurrence and underwent 17 salvage procedures. The clinical characteristics, surgical outcomes, and survival data were also reviewed. Progression-free survival (PFS) and post-recurrence survival (PRS) were analyzed using the Kaplan-Meier method.</p><p><strong>Results: </strong>Complete resection was achieved in all procedures. The median PFS after the first salvage surgery was 30 months and the median PRS was not reached. Four patients underwent a second and third salvage surgery, with several achieving long-term disease control or remaining disease-free. At the last follow-up, 7 of the 10 patients were alive without evidence of disease, including multiple survivors beyond five years. In contrast, the chemotherapy-only cohort (n = 12) showed a median PFS of 5 months and PRS of 10 months. No perioperative mortality occurred, and all complications were Clavien-Dindo grade II or lower.</p><p><strong>Conclusion: </strong>Salvage surgery for localized recurrent OCCC can achieve durable disease control and long-term survival in carefully selected patients, particularly when complete resection is possible. Even in chemoresistant diseases, repeated cytoreductive surgery may offer meaningful benefits, supporting its role as a viable treatment option within a multidisciplinary framework. </p>.</p>","PeriodicalId":12952,"journal":{"name":"Gynecologic and Obstetric Investigation","volume":" ","pages":"450-459"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13002227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146092966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Statement.","authors":"","doi":"10.1159/000549419","DOIUrl":"10.1159/000549419","url":null,"abstract":"<p><p>The article \"Evaluation of Serum Nidogen-2 as a Screening and Diagnostic Tool for Ovarian Cancer\" [Gynecol Obstet Invest. 2018;83:461-465; https://doi.org/10.1159/000481798] by Haitham A. Torky, Ahmed Sherif, Ashraf Abo-Louz, Mohamed Ali, Ali Ahmed, and Ahmad Ali has been retracted by the Publisher and the Editors.Following publication, concerns were raised about a higher-than-expected frequency of even numbers for the dichotomous variables reported in the article. When asked to comment on this and provide the original data, the corresponding author stated that the data is not available. As the concerns raised cannot be addressed or resolved, the reliability of the findings presented in the article can not be guaranteed and the article is being retracted.The authors did not respond to correspondence about this retraction within the timeframe specified.</p>","PeriodicalId":12952,"journal":{"name":"Gynecologic and Obstetric Investigation","volume":" ","pages":"149-150"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145707927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms of KLF10 in Regulating Proliferation of Endometriotic Stromal Cells in Endometriosis.","authors":"Boyao Xia, Yang Liu, Jing Li, Shan Jiang","doi":"10.1159/000546836","DOIUrl":"10.1159/000546836","url":null,"abstract":"<p><strong>Objectives: </strong>Endometriotic stromal cells (ESCs) are extensively found in endometriosis (EM). This study aims to investigate the effects and regulatory mechanisms of KLF10 on the proliferation of ESCs in EM.</p><p><strong>Methods: </strong>Human ESCs from eutopic and ectopic endometrium were isolated and identified. Levels of KLF10, miR-200c-3p, and lncRNA NEAT1 in cells were detected by reverse transcription-quantitative polymerase chain reaction and Western blot analysis. Expression of KLF10, miR-200c-3p, and NEAT1 were silenced in ectopic ESCs, followed by an assessment of cell proliferation. Chromatin immunoprecipitation and dual-luciferase reporter assays were conducted to analyze the binding of KLF10 to the miR-200c-3p promoter. RNA immunoprecipitation and dual-luciferase reporter assays were performed to analyze the interaction between miR-200c-3p and NEAT1. NEAT1 RNA stability was measured.</p><p><strong>Results: </strong>Compared to Eut-ESCs, Ect-ESCs exhibited decreased KLF10 and miR-200c-3p expression and increased NEAT1 expression. Overexpression of KLF10 inhibited the proliferation of Ect-ESCs. Mechanistically, KLF10 transcriptionally promoted miR-200c-3p expression, reducing the binding of miR-200c-3p to NEAT1 and downregulating NEAT1 expression. Combined experimental results showed that miR-200c-3p downregulation or NEAT1 overexpression could alleviate the inhibitory effect of KLF10 overexpression on the proliferation of Ect-ESCs.</p><p><strong>Limitations: </strong>We only investigated the function of KLF10 in Ect-ESC proliferation of EM on the cellular level, but the effect of KLF10 on abnormal Ect-ESC migration and invasion remains to be explored. Besides, there is no interference experiments performed on Eut-ESCs, and no animal experiment was included.</p><p><strong>Conclusions: </strong>KLF10 transcriptionally promoted miR-200c-3p expression reduced the binding of miR-200c-3p to NEAT1, thus downregulating NEAT1 expression and inhibiting the proliferation of Ect-ESCs.</p>","PeriodicalId":12952,"journal":{"name":"Gynecologic and Obstetric Investigation","volume":" ","pages":"210-219"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are the Morphokinetics of Embryos Obtained from HPV-Positive Sperm Altered? A Retrospective Cohort Study.","authors":"Giorgio Maria Baldini, Daniele Ferri, Dario Lot, Antonio Malvasi, Marco Cerbone, Antonio Simone Laganà, Miriam Dellino, Domenico Baldini, Giuseppe Trojano","doi":"10.1159/000546754","DOIUrl":"10.1159/000546754","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;The objective of the study was to evaluate the impact of male human papillomavirus (HPV) sexually transmitted infection on sperm parameters, embryo morphokinetics, and clinical pregnancy outcomes in assisted reproductive technology (ART) procedures.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Setting: &lt;/strong&gt;Between 2019 and 2023, 3,360 ART cycles were performed at the private IVF center MOMO' Fertilife (Bisceglie, Italy), including 1,035 first-time cycles. Of the 787 males tested for seminal HPV, 62 tested positive.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Design: &lt;/strong&gt;A study group of 57 HPV-positive and a matched control group of 57 HPV-negative males were selected using our clinic management software. Exclusion criteria included female age ≥42, advanced endometriosis, and HPV positivity in both partners.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Participants: &lt;/strong&gt;Couples undergoing homologous ART with only the male partner testing HPV positive were included, while those with both partners positive were excluded. HPV-positive sperm was used without standard preparation, and all semen procedures followed WHO guidelines. All couples enrolled in the study provided written informed consent, which specified that spermatozoa from HPV-positive participants would be used without undergoing standard sperm preparation procedures.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;ICSI was the only ART procedure performed in all cycles included in this study. Semen samples were collected following 3-5 days of abstinence and analyzed within 60 min post-ejaculation. Sperm concentration, motility, and morphology were assessed using phase contrast microscopy. For ICSI procedures in both groups, a standardized \"horizontal swim-up\" technique developed in-house was employed, an alternative method of semen preparation for ICSI developed in our center. Following liquefaction, an aliquot of the semen sample was sent to the virology laboratory, while a duplicate was stored at -80°C. In cases of inconclusive results, reanalysis was conducted using the frozen sample. IVF laboratory personnel were blinded to HPV status. Sperm quality, the morphokinetics of 210 resulting embryos, and pregnancy outcomes were analyzed. Statistical tests included the Student's t test, Shapiro-Wilk test, Mann-Whitney U test, and Chi-square or Fisher's exact tests.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The study found no statistically significant differences in embryo morphokinetics or ART outcomes between HPV-positive and HPV-negative groups. Pregnancy rates (33.3% vs. 31.6%) and first-trimester miscarriage rates (1 case each) were comparable between the two treatment groups, which also presented similar blastocyst transfer timing and transfer of high-quality embryos. Sperm parameters showed no clinically relevant variation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Limitations: &lt;/strong&gt;The retrospective cohort design and limited sample size represent study limitations. Furthermore, the absence of data on potentially relevant confounders constrains the analysis. Specifically, abort","PeriodicalId":12952,"journal":{"name":"Gynecologic and Obstetric Investigation","volume":" ","pages":"199-209"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144325481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-Dose Aspirin and Prevention of Spontaneous Preterm Birth: Is It Worthwhile? A Systematic Review and Meta-Analysis.","authors":"Ana Luísa Areia, Miguel Areia, Anabela Mota-Pinto","doi":"10.1159/000546964","DOIUrl":"10.1159/000546964","url":null,"abstract":"<p><strong>Introduction: </strong>Due to its anti-inflammatory properties, low-dose aspirin (LDA) has been theorized to mitigate spontaneous preterm birth (PTB). This systematic review and meta-analysis aims to report the available evidence to determine whether LDA administration prevents any spontaneous PTB.</p><p><strong>Methods: </strong>Embase, PubMed, Scopus, Cochrane Central Register, and Web of Science databases were searched, and the protocol was registered within the PROSPERO database (CRD42021288021). Data were examined using Review Manager 5.4 Software.</p><p><strong>Results: </strong>The search yielded 261 relevant articles, from which 11 pertinent studies were included in this meta-analysis. While LDA showed a reduction of spontaneous PTB rates (odds ratio [OR] 0.93; 95% confidence interval [CI] 0.84-1.04), the results lacked statistical significance. Nevertheless, LDA significantly reduced the rate of spontaneous PTB <34 weeks (6 studies; OR 0.85; 95% CI 0.78-0.93). Also, subgroup analysis of high-risk women (OR 0.96; 95% CI 0.78-1.17) and healthy women (OR 0.91; 95% CI 0.79-1.04) showed that LDA had a non-significant trend to reduce spontaneous PTB rates. Moreover, there was a statistically significant reduction in spontaneous PTB when LDA administration was initiated before 16 weeks (5 studies; OR 0.91; 95% CI 0.83-0.98), although not for LDA dosages below 100 mg (9 studies; OR 0.97; 95% CI 0.91-1.03).</p><p><strong>Conclusion: </strong>This meta-analysis indicates a statistically significant reduction in spontaneous PTB rates associated with LDA administration only in spontaneous PTB pregnancies before 34 weeks (not any spontaneous PTB) and for LDA administration starting before 16 weeks. Although LDA can potentially prevent any spontaneous PTB, further well-conducted trials focussing specifically on this subgroup are warranted to provide robust evidence of its efficacy.</p>","PeriodicalId":12952,"journal":{"name":"Gynecologic and Obstetric Investigation","volume":" ","pages":"274-282"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144690043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Blastocyst-To-Oocyte Ratio Predict Live Birth When Only One Blastocyst Is Available For Transfer?","authors":"Gurkan Bozdag, Fazilet Kubra Boynukalin, Sinan Ozkavukcu, Meral Gultomruk, Mustafa Bahceci","doi":"10.1159/000548078","DOIUrl":"10.1159/000548078","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate whether having only one blastocyst-stage embryo on Day 5/6 rectify the live birth rate (LBR) when various number of oocytes had been collected.</p><p><strong>Design: </strong>A retrospective cohort study from two in vitro fertilization (IVF) centers has been conducted. Participants/Materials: The study included women undergoing IVF treatment whose cycles resulted in only one blastocyst-stage embryo available for frozen transfer on Day 5/6. Cases with no oocyte retrieval, no blastocyst development, or missing clinical data were excluded. There were no restrictions based on female age or BMI to reflect real-world clinical conditions.</p><p><strong>Setting: </strong>A multi-center study was conducted.</p><p><strong>Methods: </strong>This retrospective cohort study included 2,125 single blastocyst frozen embryo transfer cycles performed between November 2018 and February 2023. All patients had only one blastocyst-stage embryo available for transfer on Day 5/6, regardless of the number of oocytes retrieved during controlled ovarian stimulation. Patients were stratified into quartiles based on their blastocyst-to-oocyte ratio. Baseline demographic, ovarian stimulation, and embryological parameters were compared across quartiles. The primary outcome was the LBR. Binary logistic regression was used to identify independent predictors of the LBR, including female age, embryo quality, BMI, and blastocyst-to-oocyte ratio.</p><p><strong>Results: </strong>The mean blastocyst-to-oocyte ratio was 18.6%. Patients in the lowest quartile had significantly younger mean age and higher AMH levels compared to the highest quartile. Although blastocyst development rates increased across quartiles, the LBR was lower in the highest quartile from all other groups (24.5% vs. 31.9 to 29.9%). When the LBR was analyzed as dependent variable, binary logistic regression identified female age (β = 0.93, 95% CI: 0.92-0.95, p < 0.001) and embryo quality (β = 2.35, 95% CI: 1.62-3.39, p < 0.001, compared with moderate-quality embryos; β = 4.22, 95% CI: 2.91-6.11, p < 0.001, compared with poor-quality embryos) as independent predictors. However, the blastocyst-to-oocyte ratio did not demonstrate a significant association with the LBR.</p><p><strong>Limitations: </strong>The retrospective design and absence of genetic testing for embryo ploidy might limit the ability to establish causality. Variability in laboratory conditions and stimulation protocols may also have introduced confounding factors.</p><p><strong>Conclusions: </strong>The blastocyst-to-oocyte ratio does not significantly impact the LBR when only one blastocyst is available for transfer. Instead, female age and embryo quality remain the most critical factors in determining the LBR. These findings emphasize the importance of embryo selection over numerical ovarian response parameters in clinical decision-making to obtain live birth.</p>","PeriodicalId":12952,"journal":{"name":"Gynecologic and Obstetric Investigation","volume":" ","pages":"298-304"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144951828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Random-Start Approach in Breast Cancer Patients: Are All Menstrual Cycle Phases the Same?","authors":"Alessandro Conforti, Giuseppe Gabriele Iorio, Marika Ylenia Rovetto, Luigi Carbone, Raffaella Di Girolamo, Federica Cariati, Francesca Marino, Maurizio Guida, Alberto Vaiarelli, Filippo Maria Ubaldi, Laura Rienzi, Danilo Cimadomo, Sandro C Esteves, Carlo Alviggi","doi":"10.1159/000547459","DOIUrl":"10.1159/000547459","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to investigate the ovarian response in different phases of the menstrual cycle in breast cancer women candidates for fertility preservation.</p><p><strong>Design: </strong>A retrospective study was carried out, including women with breast cancer undergoing oocyte cryopreservation at the Fertility Preservation Unit of the University of Naples Federico II between 2017 and 2023.</p><p><strong>Participants/materials, setting, methods: </strong>Women who started ovarian stimulation (OS) during the follicular phase (FP) were compared with those who started during the luteal phase (LP). The two study groups were further stratified according to the phase of the menstrual cycle at OS initiation: early (day 1-5, EFP) or late follicular phase (day 6-14, LFP), early (day 15-21, ELP) or late luteal phase (day 22-32, LLP). The primary outcome was oocyte recovery.</p><p><strong>Results: </strong>A total of 113 women who underwent fertility preservation for breast cancer were included. No differences in oocytes retrieved and ovarian sensitivity were observed when comparing follicular and luteal phases. No differences were observed regarding oocytes retrieved and ovarian sensitivity among the four groups divided according to the menstrual cycle phase. OS was significantly shorter in the early follicular phase (9 days; 8-10) than in the other menstrual phases (LFP: 10 days, 9-11, p < 0.04; ELP: 11, 9-11, p < 0.004; and LLP: 11 days, 10-12, p < 0.001).</p><p><strong>Limitations: </strong>Our study's limitations are its small sample size and retrospective design.</p><p><strong>Conclusions: </strong>The phases of the menstrual cycle at which OS was started did not affect oocyte yield and ovarian sensitivity in women with breast cancer undergoing a random-start protocol with letrozole.</p>","PeriodicalId":12952,"journal":{"name":"Gynecologic and Obstetric Investigation","volume":" ","pages":"433-440"},"PeriodicalIF":2.7,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145668248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction Statement.","authors":"","doi":"10.1159/000549496","DOIUrl":"10.1159/000549496","url":null,"abstract":"<p><p>The article \"A Prospective Comparative Study on IVF Outcomes with Either Purified FSH or Human Menopausal Gonadotrophin in Downregulated Normogonadotrophic Women\" [Gynecol Obstet Invest. 2002;53:220-223; https://doi.org/10.1159/000064568] by Aboul Foutouh Ismail, Al-Inany Hesham, Zaki Salah, M. Khaled, Nahas Fouad, Nasr Ashraf, Shawky Hatem and Badrawi Hamdi has been retracted by the Publisher and the Editor. Following publication, concerns were raised regarding a significant difference between intervention groups in the average number of embryos transferred. When asked to comment, the corresponding author stated that they believed the value of transferred embryos in the Menogon group in the article is likely to be incorrect and that the data underlying the study are no longer available due to the time elapsed since the study was conducted. As the concerns raised cannot be addressed or resolved, and due to the relevance of this difference for the conclusions of the study, the reliability of the findings presented in the article cannot be guaranteed and the article is being retracted. Hesham Al-Inany disagrees with the retraction. The remaining authors could not be reached for comment regarding this retraction.</p>","PeriodicalId":12952,"journal":{"name":"Gynecologic and Obstetric Investigation","volume":" ","pages":"148"},"PeriodicalIF":2.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145781147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}