Heart Failure Reviews最新文献_第10页

Mineralocorticoid receptor antagonists and heart failure with preserved ejection fraction: current understanding and future prospects. 矿物皮质激素受体拮抗剂与射血分数保留型心力衰竭：当前认识与未来展望。

IF 4.5 2区医学

Heart Failure Reviews Pub Date : 2025-01-01 Epub Date: 2024-10-17 DOI: 10.1007/s10741-024-10455-1

Xi Chen, Meinv Huang, Yi Chen, Haishan Xu, Meifang Wu

{"title":"Mineralocorticoid receptor antagonists and heart failure with preserved ejection fraction: current understanding and future prospects.","authors":"Xi Chen, Meinv Huang, Yi Chen, Haishan Xu, Meifang Wu","doi":"10.1007/s10741-024-10455-1","DOIUrl":"10.1007/s10741-024-10455-1","url":null,"abstract":"The mineralocorticoid receptor (MR), part of the steroid hormone receptor subfamily within nuclear hormone receptors, is found in the kidney and various non-epithelial tissues, including the heart and blood vessels. When improperly activated, it can contribute to heart failure processes such as cardiac hypertrophy, fibrosis, stiffening of arteries, inflammation, and oxidative stress. MR antagonists (MRAs) have shown clear clinical benefits in patients with heart failure with reduced ejection fraction (HFrEF). However, in cases of heart failure with preserved ejection fraction (HFpEF), there is considerable diversity due to its complex underlying mechanisms, resulting in conflicting findings regarding the effectiveness of MRAs in relevant studies. The concept of phenomapping presents an encouraging avenue for investigating different intervention targets and novel therapies for HFpEF. Post hoc analysis of the TOPCAT trial identified certain HFpEF phenotypes that responded favorably to spironolactone. Growing clinical and preclinical evidence suggests that non-steroidal MRAs, which exhibit greater receptor selectivity, stronger anti-fibrotic and anti-inflammatory properties, and fewer hormone-related side effects, may emerge as another promising treatment option for HFpEF alongside sodium-glucose co-transporter 2 (SGLT2) inhibitors. This review aims to outline the structural and functional characteristics of MR, discuss the physiological effects of its activation and inhibition, and delve into the potential for personalized MRA therapy based on the concept of HFpEF phenotype.","PeriodicalId":12950,"journal":{"name":"Heart Failure Reviews","volume":" ","pages":"191-208"},"PeriodicalIF":4.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142463825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The sympathetic nervous system in heart failure with preserved ejection fraction. 射血分数保留型心力衰竭的交感神经系统。

IF 4.5 2区医学

Heart Failure Reviews Pub Date : 2025-01-01 Epub Date: 2024-10-23 DOI: 10.1007/s10741-024-10456-0

Joshua W-H Chang, Rohit Ramchandra

{"title":"The sympathetic nervous system in heart failure with preserved ejection fraction.","authors":"Joshua W-H Chang, Rohit Ramchandra","doi":"10.1007/s10741-024-10456-0","DOIUrl":"10.1007/s10741-024-10456-0","url":null,"abstract":"The sympathetic nervous system (SNS) is a major mediator of cardiovascular physiology during exercise in healthy people. However, its role in heart failure with preserved ejection fraction (HFpEF), where exercise intolerance is a cardinal symptom, has remained relatively unexplored. The present review summarizes and critically explores the currently limited data on SNS changes in HFpEF patients with a particular emphasis on caveats of the data and the implications for its subsequent interpretation. While direct measurements of SNS activity in HFpEF patients is scarce, modest increases in resting levels of muscle sympathetic nerve activity are apparent, although this may be due to the co-morbidities associated with the syndrome rather than HFpEF per se. In addition, despite some evidence for dysfunctional sympathetic signaling in the heart, there is no clear evidence for elevated cardiac sympathetic nerve activity. The lack of a compelling prognostic benefit with use of β-blockers in HFpEF patients also suggests a lack of sympathetic hyperactivity to the heart. Similarly, while renal and splanchnic denervation studies have been performed in HFpEF patients, there is no concrete evidence that the sympathetic nerves innervating these organs exhibit heightened activity. Taken together, the totality of data suggests limited evidence for elevated sympathetic nerve activity in HFpEF and that any SNS perturbations that do occur are not universal to all HFpEF patients. Finally, how the SNS responds during exertion in HFpEF patients remains unknown and requires urgent investigation.","PeriodicalId":12950,"journal":{"name":"Heart Failure Reviews","volume":" ","pages":"209-218"},"PeriodicalIF":4.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11646211/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142499209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adrenal crisis-induced cardiogenic shock (ACCS): a comprehensive review. 肾上腺危象诱发的心源性休克（ACCS）：全面回顾。

IF 4.5 2区医学

Heart Failure Reviews Pub Date : 2025-01-01 Epub Date: 2024-11-06 DOI: 10.1007/s10741-024-10458-y

Maryam Heidarpour, Davood Shafie, Reza Eshraghi, Seyed Reza Mirjalili, Ashkan Bahrami, Mohammad Reza Movahed

引用次数: 0

Machine learning in the prevention of heart failure. 预防心力衰竭的机器学习

IF 4.5 2区医学

Heart Failure Reviews Pub Date : 2025-01-01 Epub Date: 2024-10-07 DOI: 10.1007/s10741-024-10448-0

Arsalan Hamid, Matthew W Segar, Biykem Bozkurt, Carlos Santos-Gallego, Vijay Nambi, Javed Butler, Michael E Hall, Marat Fudim

{"title":"Machine learning in the prevention of heart failure.","authors":"Arsalan Hamid, Matthew W Segar, Biykem Bozkurt, Carlos Santos-Gallego, Vijay Nambi, Javed Butler, Michael E Hall, Marat Fudim","doi":"10.1007/s10741-024-10448-0","DOIUrl":"10.1007/s10741-024-10448-0","url":null,"abstract":"Heart failure (HF) is a global pandemic with a growing prevalence and is a growing burden on the healthcare system. Machine learning (ML) has the potential to revolutionize medicine and can be applied in many different forms to aid in the prevention of symptomatic HF (stage C). HF prevention currently has several challenges, specifically in the detection of pre-HF (stage B). HF events are missed in contemporary models, limited therapeutic options are proven to prevent HF, and the prevention of HF with preserved ejection is particularly lacking. ML has the potential to overcome these challenges through existing and future models. ML has limitations, but the many benefits of ML outweigh these limitations and risks in most scenarios. ML can be applied in HF prevention through various strategies such as refinement of incident HF risk prediction models, capturing diagnostic signs from available tests such as electrocardiograms, chest x-rays, or echocardiograms to identify structural/functional cardiac abnormalities suggestive of pre-HF (stage B HF), and interpretation of biomarkers and epigenetic data. Altogether, ML is able to expand the screening of individuals at risk for HF (stage A HF), identify populations with pre-HF (stage B HF), predict the risk of incident stage C HF events, and offer the ability to intervene early to prevent progression to or decline in stage C HF. In this narrative review, we discuss the methods by which ML is utilized in HF prevention, the benefits and pitfalls of ML in HF risk prediction, and the future directions.","PeriodicalId":12950,"journal":{"name":"Heart Failure Reviews","volume":" ","pages":"117-129"},"PeriodicalIF":4.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart failure with reduced ejection fraction and chronic kidney disease: a focus on therapies and interventions. 射血分数降低型心力衰竭与慢性肾脏病：重点关注疗法和干预措施。

IF 4.5 2区医学

Heart Failure Reviews Pub Date : 2025-01-01 Epub Date: 2024-10-18 DOI: 10.1007/s10741-024-10453-3

Hesham Salah Eldin Taha, Mohamed Momtaz, Ahmed Adel Elamragy, Omar Younis, Mera Alfred Sabet Fahim

{"title":"Heart failure with reduced ejection fraction and chronic kidney disease: a focus on therapies and interventions.","authors":"Hesham Salah Eldin Taha, Mohamed Momtaz, Ahmed Adel Elamragy, Omar Younis, Mera Alfred Sabet Fahim","doi":"10.1007/s10741-024-10453-3","DOIUrl":"10.1007/s10741-024-10453-3","url":null,"abstract":"In heart failure with reduced ejection fraction (HFrEF), the presence of concomitant chronic kidney disease (CKD) predicts poorer cardiovascular outcomes, more aggravated heart failure (HF) status, and higher mortality. Physicians might be reluctant to initiate life-saving anti-HF medications out of fear of worsening renal function and a higher incidence of adverse events. Moreover, international guidelines do not give clear recommendations on managing this subgroup of patients as well as advanced CKD was always an exclusion criterion in most major HF trials. Nevertheless, in this review, we will highlight several recent clinical trials and post-hoc analyses of major trials that showed the safety and efficacy of the different therapies in HFrEF patients with CKD, besides several small-scale cohorts that tested guideline-directed medical therapies in End Stage Kidney Disease (ESKD). Regarding interventions in this subgroup of patients, we will provide up-to-date data on implantable cardioverter defibrillators, cardiac resynchronization therapy, and coronary revascularization, in addition to mitral valve transcatheter edge-to-edge repair and implantable pulmonary artery pressure sensors.","PeriodicalId":12950,"journal":{"name":"Heart Failure Reviews","volume":" ","pages":"159-175"},"PeriodicalIF":4.5,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142463823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The many faces of SCN5A pathogenic variants: from channelopathy to cardiomyopathy. SCN5A 致病变体的多面性：从通道病到心肌病。

IF 4.5 2区医学

Heart Failure Reviews Pub Date : 2025-01-01 Epub Date: 2024-10-28 DOI: 10.1007/s10741-024-10459-x

Ioannis Vouloagkas, Andrea Agbariah, Thomas Zegkos, Thomas D Gossios, Georgios Tziomalos, Despoina Parcharidou, Matthaios Didagelos, Vasileios Kamperidis, Antonios Ziakas, Georgios K Efthimiadis

引用次数: 0

Digital health as a tool for patient activation and improving quality of care for heart failure. 将数字医疗作为激活患者和提高心力衰竭护理质量的工具。

IF 4.5 2区医学

Heart Failure Reviews Pub Date : 2024-11-01 Epub Date: 2024-09-06 DOI: 10.1007/s10741-024-10433-7

Aradhana Verma, Zahra Azizi, Alexander T Sandhu

{"title":"Digital health as a tool for patient activation and improving quality of care for heart failure.","authors":"Aradhana Verma, Zahra Azizi, Alexander T Sandhu","doi":"10.1007/s10741-024-10433-7","DOIUrl":"10.1007/s10741-024-10433-7","url":null,"abstract":"The clinical and economic impact of heart failure (HF) is immense and will continue to rise due to the increasing prevalence of the disease. Despite the availability of guideline-recommended medications that improve mortality, reduce hospitalizations, and enhance quality of life, there are major gaps in the implementation of such care. Quality improvement interventions have generally focused on clinicians. While certain interventions have had modest success in improving the use of heart failure medications, they remain insufficient in optimizing HF care. Here, we discuss how patient-facing interventions can add value and supplement clinician-centered interventions. We discuss how digital health can be leveraged to create patient activation tools that create a larger, sustainable impact. Small studies have suggested the promise of digital tools for patient engagement and self-care, but there are also important barriers to the adoption of such interventions that we describe. We share key principles and strategies around the design and implementation of digital health innovations to maximize patient participation and engagement. By uniquely activating patients in their own care, digital health can unlock the full potential of both existing and new quality improvement initiatives to drive forward high-quality and equitable heart failure care.","PeriodicalId":12950,"journal":{"name":"Heart Failure Reviews","volume":" ","pages":"1239-1245"},"PeriodicalIF":4.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142139885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Artificial intelligence and myocarditis-a systematic review of current applications. 人工智能与心肌炎--当前应用的系统回顾。

IF 4.5 2区医学

Heart Failure Reviews Pub Date : 2024-11-01 Epub Date: 2024-08-14 DOI: 10.1007/s10741-024-10431-9

Paweł Marek Łajczak, Kamil Jóźwik

{"title":"Artificial intelligence and myocarditis-a systematic review of current applications.","authors":"Paweł Marek Łajczak, Kamil Jóźwik","doi":"10.1007/s10741-024-10431-9","DOIUrl":"10.1007/s10741-024-10431-9","url":null,"abstract":"Myocarditis, marked by heart muscle inflammation, poses significant clinical challenges. This study, guided by PRISMA guidelines, explores the expanding role of artificial intelligence (AI) in myocarditis, aiming to consolidate current knowledge and guide future research. Following PRISMA guidelines, a systematic review was conducted across PubMed, Cochrane Reviews, Scopus, Embase, and Web of Science databases. MeSH terms including artificial intelligence, deep learning, machine learning, myocarditis, and inflammatory cardiomyopathy were used. Inclusion criteria involved original articles utilizing AI for myocarditis, while exclusion criteria eliminated reviews, editorials, and non-AI-focused studies. The search yielded 616 articles, with 42 meeting inclusion criteria after screening. The identified articles, spanning diagnostic, survival prediction, and molecular analysis aspects, were analyzed in each subsection. Diagnostic studies showcased the versatility of AI algorithms, achieving high accuracies in myocarditis detection. Survival prediction models exhibited robust discriminatory power, particularly in emergency settings and pediatric populations. Molecular analyses demonstrated AI's potential in deciphering complex immune interactions. This systematic review provides a comprehensive overview of AI applications in myocarditis, highlighting transformative potential in diagnostics, survival prediction, and molecular understanding. Collaborative efforts are crucial for overcoming limitations and realizing AI's full potential in improving myocarditis care.","PeriodicalId":12950,"journal":{"name":"Heart Failure Reviews","volume":" ","pages":"1217-1234"},"PeriodicalIF":4.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11455665/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141975591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Embracing an era of targeted combination therapy for heart failure with preserved ejection fraction. 迎接射血分数保留型心力衰竭靶向综合疗法时代的到来。

IF 4.5 2区医学

Heart Failure Reviews Pub Date : 2024-11-01 Epub Date: 2024-08-27 DOI: 10.1007/s10741-024-10432-8

Satoshi Shoji, Stephen J Greene, Robert J Mentz

{"title":"Embracing an era of targeted combination therapy for heart failure with preserved ejection fraction.","authors":"Satoshi Shoji, Stephen J Greene, Robert J Mentz","doi":"10.1007/s10741-024-10432-8","DOIUrl":"10.1007/s10741-024-10432-8","url":null,"abstract":"The concept of quadruple therapy as a \"one-size-fit-all\" approach is effective among all eligible patients with heart failure with reduced ejection fraction, with consistent and significant clinical benefits including reduced mortality across various subgroups. However, with exception of sodium-glucose cotransporter 2 inhibitors, the consistency of benefit with therapies does not extend to patients with heart failure with preserved ejection fraction. The clinical benefits of other promising medical therapies, such as angiotensin receptor-neprilysin inhibitors, mineralocorticoid receptor antagonists, and glucagon-like peptide-1 receptor agonists, have been demonstrated only in certain phenotypes of the highly heterogenous heart failure with preserved ejection fraction population. This variability can confuse frontline practicing cardiologists, potentially leading to the under-implementation of these medications. Therefore, we propose a simple approach: \"targeted\" combination therapy. This strategy aims to optimize evidence-based medications in heart failure with preserved ejection fraction by tailoring treatments to specific subgroups within the heart failure with preserved ejection fraction population where significant benefits are most evident.","PeriodicalId":12950,"journal":{"name":"Heart Failure Reviews","volume":" ","pages":"1235-1238"},"PeriodicalIF":4.5,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142072634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treating heart failure by targeting the vagus nerve. 通过迷走神经治疗心力衰竭。

IF 4.5 2区医学

Heart Failure Reviews Pub Date : 2024-11-01 Epub Date: 2024-08-09 DOI: 10.1007/s10741-024-10430-w

Francesco Gentile, Giulia Orlando, Sabrina Montuoro, Yu Fu Ferrari Chen, Vaughan Macefield, Claudio Passino, Alberto Giannoni, Michele Emdin

引用次数: 0