Haemostasis最新文献_第3页

Heparins in diabetic microangiopathy: rationale and preliminary clinical results. 肝素治疗糖尿病微血管病变:基本原理和初步临床结果。

Haemostasis Pub Date : 1999-12-01 DOI: 10.1159/000054113

F J van Der Woude

引用次数: 5

Use of glycoprotein IIb/IIIa inhibitors in patients with acute coronary syndromes undergoing coronary revascularization. 糖蛋白IIb/IIIa抑制剂在接受冠状动脉血管重建术的急性冠状动脉综合征患者中的应用

Haemostasis Pub Date : 1999-12-01 DOI: 10.1159/000054115

J J Popma

引用次数: 0

Should patients with venous thromboembolism and cancer be treated differently? 静脉血栓栓塞和癌症患者应该区别对待吗?

Haemostasis Pub Date : 1999-12-01 DOI: 10.1159/000054122

S M Smorenburg, B A Hutten, M H Prins

引用次数: 20

Modern approach to diagnosis in patients with suspected deep vein thrombosis. 疑似深静脉血栓形成的现代诊断方法。

Haemostasis Pub Date : 1999-12-01 DOI: 10.1159/000054107

P S Wells, D R Anderson

{"title":"Modern approach to diagnosis in patients with suspected deep vein thrombosis.","authors":"P S Wells, D R Anderson","doi":"10.1159/000054107","DOIUrl":"https://doi.org/10.1159/000054107","url":null,"abstract":"Deep vein thrombosis is a relatively common disease, amenable to therapy but with a potentially fatal outcome if untreated. The diagnosis can be made in most patients with the non-invasive imaging procedure ultrasonography, but limitations exist. As with all tests, there is a potential for false-positive and false-negative results. The latter are especially an issue for calf vein thrombi, and this in part has led to the concept of serial testing of the proximal venous system rather than imaging the calf. The premise of the repeat (serial) test is that only thrombi that extend to the proximal system are clinically relevant and such thrombi will be detected on the repeat test. However, despite the safety of the serial-testing concept, it is inconvenient and expensive. In the last few years, the diagnostic process has been improved by the validation of a clinical model that accurately categorizes patients as having low, moderate or high probability of deep vein thrombosis. Among the improvements this provides is the elimination of serial testing if the ultrasound is normal and the clinical probability low. The fibrin degradation product D-dimer has been demonstrated to have a high negative predictive value and has also proven useful in diagnostic algorithms. The combination of the D-dimer with clinical model assessment will enable diagnostic-testing strategies that are more safe, effective and convenient for patients.","PeriodicalId":12910,"journal":{"name":"Haemostasis","volume":"29 Suppl S1 ","pages":"10-20"},"PeriodicalIF":0.0,"publicationDate":"1999-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000054107","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21485666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Low-molecular-weight heparins in acute unstable coronary artery disease - an update. 低分子肝素在急性不稳定冠状动脉疾病中的作用

Haemostasis Pub Date : 1999-12-01 DOI: 10.1159/000054116

A G Turpie

引用次数: 5

Venous thrombosis: prevalence and interaction of risk factors. 静脉血栓形成:患病率和危险因素的相互作用。

Haemostasis Pub Date : 1999-12-01 DOI: 10.1159/000054106

F R Rosendaal

引用次数: 46

For how long should the treatment with vitamin K antagonists be maintained? 维生素K拮抗剂治疗应该维持多久?

Haemostasis Pub Date : 1999-12-01 DOI: 10.1159/000054121

S Schulman

引用次数: 2

Modern strategy for diagnosis and treatment of pulmonary embolism. 肺栓塞诊断与治疗的现代策略。

Haemostasis Pub Date : 1999-12-01 DOI: 10.1159/000054108

J P Laaban

引用次数: 1

Extended prophylaxis against venous thromboembolism following total hip and knee replacement. 全髋关节和膝关节置换术后静脉血栓栓塞的扩展预防。

Haemostasis Pub Date : 1999-12-01 DOI: 10.1159/000054109

R D Hull, G F Pineo

引用次数: 21

Comparative inhibition of LPS-activated human monocyte-induced thrombin generation by unfractionated heparin and low molecular weight heparins. 未分离肝素和低分子量肝素对lps激活的人单核细胞诱导凝血酶生成的比较抑制作用。

Haemostasis Pub Date : 1999-11-01 DOI: 10.1159/000022517

P Nguyên, M G Rémy, G Potron

{"title":"Comparative inhibition of LPS-activated human monocyte-induced thrombin generation by unfractionated heparin and low molecular weight heparins.","authors":"P Nguyên, M G Rémy, G Potron","doi":"10.1159/000022517","DOIUrl":"https://doi.org/10.1159/000022517","url":null,"abstract":"Monocyte tissue factor may play a role in the physiological or pathological triggering of blood coagulation. It is well known that unfractionated heparin and low molecular weight heparins inhibit extrinsic thrombin generation. However, this notion has never been confirmed in a physiological model using tissue factor obtained from stimulated human monocytes. This is the purpose of this study. It was important to obtain a pure preparation of monocytes with no platelet contamination. This was possible by leukapheresis and elutriation. Under sterile and endotoxin-free conditions, the process does not activate tissue factor expression by monocytes. We adapted the technique of thrombin generation on an automatic analyzer and used human monocyte tissue factor to trigger thrombin generation. Our results show that unfractionated and low molecular weight heparins potently inhibit monocytic tissue factor induced thrombin generation. The comparison of low molecular weight heparins suggests that molecules with higher anti-IIa/anti-Xa ratios exert a stronger inhibitory effect. These data may be relevant to explain the therapeutic effects of unfractionated and low molecular weight heparins in cardiovascular disorders such as unstable angina.","PeriodicalId":12910,"journal":{"name":"Haemostasis","volume":"29 6","pages":"301-9"},"PeriodicalIF":0.0,"publicationDate":"1999-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000022517","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"21688850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2