International Journal of Clinical and Experimental Neurology最新文献

Improvement in Heart Rate Variability Without Treatment: A Case Study 无需治疗即可改善心率变异性：病例研究

International Journal of Clinical and Experimental Neurology Pub Date : 2024-04-09 DOI: 10.12691/ijcen-10-1-1

John Hart DC MHSc

引用次数: 0

Stiff Person Syndrome Overlapping with Multiple Sclerosis 与多发性硬化症重叠的僵硬人综合症

International Journal of Clinical and Experimental Neurology Pub Date : 2022-05-16 DOI: 10.12691/ijcen-9-1-1

H. AlHussein, Syed Ali Raza, Roger E. Kelley

引用次数: 0

Acute Stroke in COVID-19 Patients COVID-19患者的急性卒中

International Journal of Clinical and Experimental Neurology Pub Date : 2020-12-23 DOI: 10.12691/ijcen-8-1-4

Mohsen Alshamam, M. Saliaj, N. Nso, P. Moondra, Umair Ali

{"title":"Acute Stroke in COVID-19 Patients","authors":"Mohsen Alshamam, M. Saliaj, N. Nso, P. Moondra, Umair Ali","doi":"10.12691/ijcen-8-1-4","DOIUrl":"https://doi.org/10.12691/ijcen-8-1-4","url":null,"abstract":"The novel Coronavirus-19 (COVID-19) outbreak has brought unprecedented implications globally for the medical community and continues to present challenges when delivering neurological care and intervention. Here we describe six patients with acute cerebrovascular symptoms and concurrent COVID-19 infection who presented to our hospital. This is a retrospective case series study of six patients presenting with neurological, either with or without respiratory symptoms. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was suspected in the patients. Testing was conducted by BioReference Lab with the reverse-transcriptase polymerase chain reaction (RT-PCR) assay for most patients. Brain imaging revealed evidence of acute cerebral infarction. Ethical approval and informed consent waivers when appropriate were granted by the Mount Sinai Institutional Review Board. The study was conducted at NYC Health + Hospitals-Queens in Jamaica, New York. All patients were men, ages 39 to 69 years, four of whom were found to have associated risk factors for stroke. Inflammatory markers were elevated in most patients and brain imaging revealed ischemic infarcts. With the exception of one patient who expired, five patients made a significant recovery. Ischemic stroke was one of many newfound complications related to the COVID-19 infection. In our case reports, many patients did not present with respiratory symptoms, however, all tested positive for COVID-19. Neurological sequelae related to COVID-19 apart from cerebrovascular disease continue to be discovered. With growing evidence that the central nervous system is vulnerable to the devastating effects of COVID-19, testing should be expedited in all patients presenting with neurological symptoms during the COVID-19 pandemic.","PeriodicalId":128994,"journal":{"name":"International Journal of Clinical and Experimental Neurology","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124062375","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Association between Adenosine Triphosphate Binding Cassette B1 Cytosine 3435 Thymine Polymorphism and Pharmacoresistant Idiopathic Epilepsy: An Egyptian Study 三磷酸腺苷结合盒B1胞嘧啶3435胸腺嘧啶多态性与耐药性特发性癫痫的关系:一项埃及研究

International Journal of Clinical and Experimental Neurology Pub Date : 2019-05-23 DOI: 10.12691/IJCEN-7-1-2

Y. Altaweel, A. Kamel, Karam S. Amin, S. H. Abd-Allah, Shaimaa A. Elaidy

{"title":"The Association between Adenosine Triphosphate Binding Cassette B1 Cytosine 3435 Thymine Polymorphism and Pharmacoresistant Idiopathic Epilepsy: An Egyptian Study","authors":"Y. Altaweel, A. Kamel, Karam S. Amin, S. H. Abd-Allah, Shaimaa A. Elaidy","doi":"10.12691/IJCEN-7-1-2","DOIUrl":"https://doi.org/10.12691/IJCEN-7-1-2","url":null,"abstract":"Background: P-glycoprotein (P-gp) is a drug efflux transporter present in the blood brain barrier whose function was suggested to be modified by a genetic polymorphism affecting ABCB1 C3435T gene at exon 26. Overexpression was related to homozygous C allele in some studies, however other studies in different ethnic populations showed relation to homozygous T allele, furthermore others failed to confirm any relation to resistance to therapeutic effects of AEDs. Aim of the study: Our aim is to find out the association between C3435T polymorphism and pharmacoresistance in idiopathic epilepsy in order to identify early the pharmacoresistant patients so we can select the proper AED and other proper therapeutic modalities. Patients and methods: Our case-control study was conducted on 44 idiopathic epileptic patients (22 drug-resistant and 22 drug-responsive epilepsy) and 44 healthy controls of comparable age and sex. Blood samples were obtained. Allele and genotype frequencies were evaluated between our study groups and their association with pharmacoresistance, some historical and semiology of epilepsy. Results: Our work revealed a lower risk of drug resistance in patients with the genotype CT (OR: 0.8) in comparison to genotypes CC and TT (OR: 1.2, 1 respectively) but the results were not statistically significant. However, significant association regarding daytime seizures was found with genotype CC in comparison to genotypes CT and TT. Conclusion: Daytime seizures were found to be more prevalent among those with CC genotype and this association was significant. The risk of drug resistant epilepsy was lower in patients with CT than those with CC and TT genotypes, but this association was not statistically significant in our study.","PeriodicalId":128994,"journal":{"name":"International Journal of Clinical and Experimental Neurology","volume":"14 7-8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115727882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0