Acute Stroke in COVID-19 Patients

Mohsen Alshamam, M. Saliaj, N. Nso, P. Moondra, Umair Ali
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引用次数: 1

Abstract

The novel Coronavirus-19 (COVID-19) outbreak has brought unprecedented implications globally for the medical community and continues to present challenges when delivering neurological care and intervention. Here we describe six patients with acute cerebrovascular symptoms and concurrent COVID-19 infection who presented to our hospital. This is a retrospective case series study of six patients presenting with neurological, either with or without respiratory symptoms. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was suspected in the patients. Testing was conducted by BioReference Lab with the reverse-transcriptase polymerase chain reaction (RT-PCR) assay for most patients. Brain imaging revealed evidence of acute cerebral infarction. Ethical approval and informed consent waivers when appropriate were granted by the Mount Sinai Institutional Review Board. The study was conducted at NYC Health + Hospitals-Queens in Jamaica, New York. All patients were men, ages 39 to 69 years, four of whom were found to have associated risk factors for stroke. Inflammatory markers were elevated in most patients and brain imaging revealed ischemic infarcts. With the exception of one patient who expired, five patients made a significant recovery. Ischemic stroke was one of many newfound complications related to the COVID-19 infection. In our case reports, many patients did not present with respiratory symptoms, however, all tested positive for COVID-19. Neurological sequelae related to COVID-19 apart from cerebrovascular disease continue to be discovered. With growing evidence that the central nervous system is vulnerable to the devastating effects of COVID-19, testing should be expedited in all patients presenting with neurological symptoms during the COVID-19 pandemic.
COVID-19患者的急性卒中
新型冠状病毒-19 (COVID-19)疫情给全球医学界带来了前所未有的影响,并在提供神经护理和干预方面继续带来挑战。本文描述了6例急性脑血管症状并并发COVID-19感染的患者。这是一个回顾性的病例系列研究,6例患者表现为神经系统,或有或无呼吸道症状。患者疑似感染严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)。对大多数患者采用逆转录聚合酶链反应(RT-PCR)检测,由bireference实验室进行检测。脑成像显示急性脑梗死的证据。伦理批准和知情同意豁免在适当的时候由西奈山机构审查委员会批准。这项研究是在纽约牙买加皇后区的纽约健康医院进行的。所有患者均为男性,年龄在39至69岁之间,其中4人被发现有卒中相关危险因素。大多数患者炎症标志物升高,脑成像显示缺血性梗死。除1名患者死亡外,其余5名患者均明显康复。缺血性中风是与COVID-19感染相关的许多新发现的并发症之一。在我们的病例报告中,许多患者没有出现呼吸道症状,但所有患者的COVID-19检测均呈阳性。除脑血管疾病外,与新冠肺炎相关的神经系统后遗症不断发现。随着越来越多的证据表明,中枢神经系统容易受到COVID-19的破坏性影响,应加快对COVID-19大流行期间出现神经系统症状的所有患者进行检测。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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