Hematological Oncology最新文献

{"title":"Correction to Staging FDG-avidity in extranodal marginal zone lymphoma (EMZL) by disease location","authors":"","doi":"10.1002/hon.3223","DOIUrl":"https://doi.org/10.1002/hon.3223","url":null,"abstract":"<p>Alderuccio, J.P., Saul, E.E., Stanchina, Polar, M.K, M., Sassi, R.H., Zhao, W., Moskowitz, C.H., Reis, I., Kuker, R.A., Lossos, I.S. (2023), Staging FDG-avidity in extranodal marginal zone lymphoma (EMZL) by disease location. Hematological Oncology, 41: 103–104. https://doi.org/10.1002/hon.3163_64</p><p>In the author byline, the middle initials of the authors are missing, and the sequence is incorrect.</p><p>The incorrect author byline is:</p><p>J. P. Alderuccio, E. Edelman Saul, M. Stanchina, R. Hennemann Sassi, W. Zhao, C. Moskowitz, I. Reis, R. Kuker, I. Lossos, M. Polar</p><p>The correct author byline should be:</p><p>J.P. Alderuccio, E. Edelman Saul, M.D. Stanchina, M.K. Polar, R. Henneman Sassi, W. Zhao, C.H. Moskowitz, I. Reis, R.A. Kuker, I.S. Lossos</p>","PeriodicalId":12882,"journal":{"name":"Hematological Oncology","volume":"42 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hon.3223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141439542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Outcomes of therapeutic plasma exchange for the treatment of patients with multiple myeloma cast nephropathy","authors":"Danai Dima,&nbsp;Utkarsh Goel,&nbsp;Aishwarya Sannareddy,&nbsp;Nnaemeka Ibeh,&nbsp;Fauzia Ullah,&nbsp;Aimaz Afrough,&nbsp;Sandra Mazzoni,&nbsp;Ali Mehdi,&nbsp;Joslyn Rudoni,&nbsp;Shahzad Raza,&nbsp;Nicole De Simone,&nbsp;Louis Williams,&nbsp;Adeel Khan,&nbsp;Aliya Rashid,&nbsp;Mikhaila Rice,&nbsp;Kristin Ricci,&nbsp;Christy Samaras,&nbsp;Jason Valent,&nbsp;Larry D. Anderson,&nbsp;Faiz Anwer,&nbsp;Gurbakhash Kaur,&nbsp;Jack Khouri","doi":"10.1002/hon.3293","DOIUrl":"10.1002/hon.3293","url":null,"abstract":"<p>Current treatment guidelines of myeloma cast nephropathy (MCN) recommend the institution of plasma cell-directed therapy and consideration of therapeutic plasma exchange (TPE), with the goal of rapid reduction of the serum free light chain (sFLC). However, the role of TPE continues to remain a subject of debate. The goal of this retrospective bi-institutional study was to evaluate the clinical outcomes of TPE in combination with systemic therapy. Eighty patients were included in this analysis, of whom 72.5% had ≥50% drop in their initial involved sFLC. At 3 months from TPE initiation, the overall hematologic response rate (ORR) was 67.5% with a very good partial response or better (≥VGPR) rate of 40%. At 6 months, ORR was 57.5%, with ≥VGPR rate of 49%. The renal response rate at 3 and 6 months was 47.5% and 43.75%, respectively; the overall renal response rate was 48.75%. On multivariable analysis, every one unit increase in baseline creatinine (odds ratio [OR] 0.76, <i>p</i> = 0.006), and achievement of ≥VGPR (OR 21.7 <i>p</i> &lt; 0.0001) were significantly associated with renal response. Also, a ≥50% drop in sFLC was favorably associated with renal response (OR 3.39, <i>p</i> = 0.09). With a median follow-up of 36.4 months, the median overall survival (OS) was 11 months. On multivariable analysis, achievement of renal response (hazard ratio [HR] 0.3, <i>p</i> &lt; 0.0001) and newly diagnosed disease (NDMM; HR 0.43, <i>p</i> = 0.0055) were associated with improved OS. Among NDMM patients, those treated with daratumumab-based regimens had a trend for better OS (<i>p</i> = 0.15), compared to other regimens, but the difference was not significant. At the end of follow-up, an estimated 40.4% of patients who were on dialysis were able to become dialysis independent. In conclusion, our study highlights the poor survival of patients with MCN. Achievement of early renal response is crucial for prolonged OS, with daratumumab-based therapies showing promise.</p>","PeriodicalId":12882,"journal":{"name":"Hematological Oncology","volume":"42 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hon.3293","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141317044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to Real-life study on the use of response adapted therapy in patients with Hodgkin Lymphoma: Results from a multicenter experience","authors":"","doi":"10.1002/hon.3291","DOIUrl":"10.1002/hon.3291","url":null,"abstract":"<p>Vittorio Ruggero Zilioli, Emanuele Cencini, Sonya De Lorenzo, Luca Pezzullo, Michele Merli, Flavia Rivellini, Cristina Muzi, Barbieri Emiliano, Luigi Marcheselli, Stefano Luminari. Real-life study on the use of response adapted therapy in patients with Hodgkin Lymphoma: Results from a multicenter experience. Hematol Oncol. 2023;42(3):e3273. https://doi.org/10.1002/hon.3273.</p><p>In the article, affiliation 9 is not correct. The correct affiliation is “Hematology, Azienda Unità Sanitaria Locale - IRCCS of Reggio Emilia, Reggio Emilia, Italy”.</p><p>We apologize for this error.</p>","PeriodicalId":12882,"journal":{"name":"Hematological Oncology","volume":"42 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hon.3291","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clonal dynamics of Richter transformation in chronic lymphocytic leukemia","authors":"Hanyin Wang,&nbsp;Shulan Tian,&nbsp;Charla R. Secreto,&nbsp;Sutapa Sinha,&nbsp;Min Shi,&nbsp;Timothy Call,&nbsp;Yucai Wang,&nbsp;Sameer A. Parikh,&nbsp;Saad S. Kenderian,&nbsp;Rong He,&nbsp;Jose F. Leis,&nbsp;Daniel L. VanDyke,&nbsp;Eric W. Klee,&nbsp;Susan L. Slager,&nbsp;Esteban Braggio,&nbsp;Huihuang Yan,&nbsp;Wei Ding","doi":"10.1002/hon.3282","DOIUrl":"10.1002/hon.3282","url":null,"abstract":"","PeriodicalId":12882,"journal":{"name":"Hematological Oncology","volume":"42 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141293340","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and effectiveness of mogamulizumab in relapsed or refractory CC chemokine receptor 4-positive peripheral T-cell lymphoma and relapsed or refractory cutaneous T-cell lymphoma: A post-marketing surveillance in Japan","authors":"Kenji Ishitsuka,&nbsp;Tomoharu Yasukawa,&nbsp;Yukie Tsuji","doi":"10.1002/hon.3292","DOIUrl":"10.1002/hon.3292","url":null,"abstract":"<p>Mogamulizumab is a humanized antibody targeting CC chemokine receptor 4 (CCR4). This post-marketing surveillance was conducted in Japan as a regulatory requirement from 2014 to 2020 to ensure the safety and effectiveness of mogamulizumab in patients with relapsed or refractory (r/r) CCR4-positive peripheral T-cell lymphoma (PTCL) or r/r cutaneous T-cell lymphoma (CTCL). Safety and effectiveness data were collected for up to 31 weeks after treatment initiation. A total of 142 patients were registered; safety was evaluated in 136 patients. The median number of doses was 8.0 (range, 1–18). The main reasons for treatment termination were insufficient response (22.1%) and adverse events (13.2%). The frequency of any grade adverse drug reaction was 57.4%, including skin disorders (26.5%), infections and immune system disorders (16.2%), and infusion-related reactions (13.2%). Graft-versus-host disease, grade 2, developed in one of two patients who underwent allogeneic-hematopoietic stem cell transplantation after receiving mogamulizumab. Effectiveness was evaluated in 131 patients (103 with PTCL; 28 with CTCL). The best overall response rate was 45.8% (PTCL, 47.6%; CTCL, 39.3%). At week 31, the survival rate was 69.0% (95% confidence interval, 59.8%–76.5%) [PTCL, 64.4% (54.0%–73.0%); CTCL, 90.5% (67.0%–97.5%)]. Safety and effectiveness were comparable between patients &lt;70 and ≥ 70 years old and between those with relapsed and refractory disease. The safety and effectiveness of mogamulizumab for PTCL and CTCL in the real world were comparable with the data reported in previous clinical trials.</p><p>Clinical Trial Registration</p>","PeriodicalId":12882,"journal":{"name":"Hematological Oncology","volume":"42 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hon.3292","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141283539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Strategies for overcoming resistance to Bruton's tyrosine kinase inhibitor zanubrutinib","authors":"Hana Dostálová,&nbsp;Vladimír Kryštof","doi":"10.1002/hon.3294","DOIUrl":"10.1002/hon.3294","url":null,"abstract":"<p>Bruton's tyrosine kinase (BTK) inhibitors have revolutionized the treatment of B-cell malignancies. They target BTK, a key effector in the B-cell receptor (BCR) signaling pathway, crucial for B-cell survival and proliferation. The first-in-class irreversible BTK inhibitor, ibrutinib, was approved for various B-cell malignancies but has limitations due to off-target effects. Second-generation inhibitors, such as acalabrutinib and zanubrutinib, offer improved selectivity and reduced side effects. However, resistance to BTK inhibitors, driven by BTK mutations, remains a challenge. Combinatorial therapies with PI3K inhibitors, immune checkpoint inhibitors, BH3 mimetics, and anti-CD20 antibodies show promise in overcoming resistance. Noncovalent BTK inhibitors and proteolysis-targeting chimeras (PROTACs) are emerging strategies with potential to combat resistance. Overall, advancements in BTK-targeted therapies provide hope for improved outcomes in patients with B-cell malignancies and a promising avenue to address drug resistance. Further research is needed to optimize combination therapies and identify optimal treatment regimens.</p>","PeriodicalId":12882,"journal":{"name":"Hematological Oncology","volume":"42 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hon.3294","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141283540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A real-life study of daratumumab combinations in newly diagnosed patients with light chain (AL) amyloidosis","authors":"Claudia Bellofiore,&nbsp;Pietro Benvenuti,&nbsp;Roberto Mina,&nbsp;Marco Basset,&nbsp;Andrea Foli,&nbsp;Martina Nanci,&nbsp;Mario Nuvolone,&nbsp;Gianluigi Guida,&nbsp;Andrea Attanasio,&nbsp;Roberta Mussinelli,&nbsp;Silvia Mangiacavalli,&nbsp;Claudio Salvatore Cartia,&nbsp;Valeria Masoni,&nbsp;Michele Palumbo,&nbsp;Lorenzo Cani,&nbsp;Stefania Oliva,&nbsp;Ugo Consoli,&nbsp;Concetta Conticello,&nbsp;Francesco Di Raimondo,&nbsp;Luca Arcaini,&nbsp;Sara Bringhen,&nbsp;Giampaolo Merlini,&nbsp;Giovanni Palladini,&nbsp;Paolo Milani","doi":"10.1002/hon.3289","DOIUrl":"10.1002/hon.3289","url":null,"abstract":"<p>Daratumumab-based regimens are the new standard of care for newly diagnosed patients with AL amyloidosis based on the results of the ANDROMEDA study. However, real-world data on daratumumab efficacy in upfront therapy in unselected patients are scanty. In the framework of a prospective observational study, we investigated the efficacy and safety of daratumumab in 88 newly diagnosed patients, including subjects with IIIb cardiac stage (26%) or myeloma defining events (29%). Daratumumab was administered with bortezomib in 50 (56%) patients, lenalidomide in 31 (35%), and monotherapy in 7 (8%). The rate of serious adverse events was low (16%). The overall hematologic response rate was 75% with 52 (59%) patients attaining at least a very good partial response (VGPR) at six months. Amongst patients evaluable for organ response, the rate of cardiac and renal responses at 6 months was 31% and 21%, respectively. Comparing stage IIIb patients with the remaining ones, the rate of profound hematologic response was not significantly different (≥VGPR 57% vs. 59%, <i>p</i> 0.955) likewise the rate of cardiac (33% vs. 30%, <i>p</i> 0.340) and renal (40% vs. 16%, <i>p</i> 0.908) responses. Daratumumab-based regimens demonstrated to be safe and effective in treatment-naïve AL amyloidosis even in advanced stage disease.</p>","PeriodicalId":12882,"journal":{"name":"Hematological Oncology","volume":"42 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-06-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141185878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elotuzumab plus pomalidomide and dexamethasone in relapsed/refractory multiple myeloma: Extended follow-up of a multicenter, retrospective real-world experience with 321 cases outside of controlled clinical trials","authors":"Enrica Antonia Martino,&nbsp;Salvatore Palmieri,&nbsp;Monica Galli,&nbsp;Daniele Derudas,&nbsp;Roberto Mina,&nbsp;Roberta Della Pepa,&nbsp;Renato Zambello,&nbsp;Ernesto Vigna,&nbsp;Antonella Bruzzese,&nbsp;Silvia Mangiacavalli,&nbsp;Elena Zamagni,&nbsp;Catello Califano,&nbsp;Maurizio Musso,&nbsp;Concetta Conticello,&nbsp;Claudio Cerchione,&nbsp;Giuseppe Mele,&nbsp;Nicola Di Renzo,&nbsp;Massimo Offidani,&nbsp;Giuseppe Tarantini,&nbsp;Gloria Margiotta Casaluci,&nbsp;Angela Rago,&nbsp;Roberto Ria,&nbsp;Giuseppina Uccello,&nbsp;Gregorio Barilà,&nbsp;Gaetano Palumbo,&nbsp;Loredana Pettine,&nbsp;Iolanda Donatella Vincelli,&nbsp;Marino Brunori,&nbsp;Fabrizio Accardi,&nbsp;Valeria Amico,&nbsp;Angela Amendola,&nbsp;Raffaele Fontana,&nbsp;Velia Bongarzoni,&nbsp;Bernardo Rossini,&nbsp;Emilia Cotzia,&nbsp;Alessandro Gozzetti,&nbsp;Rita Rizzi,&nbsp;Nicola Sgherza,&nbsp;Giovanni Reddiconto,&nbsp;Antonio Maroccia,&nbsp;Luca Franceschini,&nbsp;Giuseppe Bertuglia,&nbsp;Davide Nappi,&nbsp;Emiliano Barbieri,&nbsp;Barbara Gamberi,&nbsp;Maria Teresa Petrucci,&nbsp;Francesco Di Raimondo,&nbsp;Antonino Neri,&nbsp;Fortunato Morabito,&nbsp;Pellegrino Musto,&nbsp;Massimo Gentile","doi":"10.1002/hon.3290","DOIUrl":"10.1002/hon.3290","url":null,"abstract":"<p>The ELOQUENT-3 trial demonstrated the superiority of the combination of elotuzumab, pomalidomide, and dexamethasone (EloPd) in terms of efficacy and safety, compared to Pd in relapsed/refractory multiple myeloma (RRMM), who had received at least two prior therapies, including lenalidomide and a proteasome inhibitor. The present study is an 18-month follow-up update of a previously published Italian real-life RRMM cohort of patients treated with EloPd. This revised analysis entered 319 RRMM patients accrued in 41 Italian centers. After a median follow-up of 17.7 months, 213 patients (66.4%) experienced disease progression or died. Median progression-free survival (PFS) and overall survival (OS) were 7.5 and 19.2 months, respectively. The updated multivariate analysis showed a significant reduction of PFS benefit magnitude both in advanced International Staging System (ISS) (II and III) stages and previous exposure to daratumumab cases. Instead, advanced ISS (II and III) stages and more than 2 previous lines of therapy maintained an independent prognostic impact on OS. Major adverse events included grade three-fourths neutropenia (24.9%), anemia (13.4%), lymphocytopenia (15.5%), and thrombocytopenia (10.7%), while infection rates and pneumonia were 19.3% and 8.7%, respectively. A slight increase in the incidence of neutropenia and lymphocytopenia was registered with longer follow-up. In conclusion, our real-world study still confirms that EloPd is a safe and possible therapeutic choice for RRMM. Nevertheless, novel strategies are desirable for those patients exposed to daratumumab.</p>","PeriodicalId":12882,"journal":{"name":"Hematological Oncology","volume":"42 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic pathway-based subtyping reveals distinct microenvironmental states associated with diffuse large B-cell lymphoma outcomes","authors":"Xiaohui Wang,&nbsp;Hengqi Liu,&nbsp;Yue Fei,&nbsp;Zheng Song,&nbsp;Xiangrui Meng,&nbsp;Jingwei Yu,&nbsp;Xia Liu,&nbsp;Lanfang Li,&nbsp;Lihua Qiu,&nbsp;Zhengzi Qian,&nbsp;Shiyong Zhou,&nbsp;Xianhuo Wang,&nbsp;Huilai Zhang","doi":"10.1002/hon.3279","DOIUrl":"10.1002/hon.3279","url":null,"abstract":"<p>Diffuse large B-cell lymphoma (DLBCL) is a biologically and clinically heterogeneous disease that requires personalized clinical treatment. Assigning patients to different risk categories and cytogenetic abnormality and genetic mutation groups has been widely applied for prognostic stratification of DLBCL. Increasing evidence has demonstrated that dysregulated metabolic processes contribute to the initiation and progression of DLBCL. Metabolic competition within the tumor microenvironment is also known to influence immune cell metabolism. However, metabolism- and immune-related stratification has not been established. Here, 1660 genes involved in 84 metabolic pathways were selected and tested to establish metabolic clusters (MECs) of DLBCL. MECs established based on independent lymphoma datasets distinguished different survival outcomes. The CIBERSORT algorithm and EcoTyper were applied to quantify the relative abundance of immune cell types and identify variation in cell states for 13 lineages comprising the tumor micro environment among different MECs, respectively. Functional characterization showed that MECs were an indicator of the immune microenvironment and correlated with distinctive mutational characteristics and oncogenic signaling pathways. The novel immune-related MECs exhibited promising clinical prognostic value and potential for informing DLBCL treatment decisions.</p>","PeriodicalId":12882,"journal":{"name":"Hematological Oncology","volume":"42 4","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141179607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FLT3-ITD regulation of the endoplasmic reticulum functions in acute myeloid leukemia","authors":"María Turos-Cabal,&nbsp;Ana M. Sánchez-Sánchez,&nbsp;Noelia Puente-Moncada,&nbsp;Federico Herrera,&nbsp;Isaac Antolin,&nbsp;Carmen Rodríguez,&nbsp;Vanesa Martín","doi":"10.1002/hon.3281","DOIUrl":"10.1002/hon.3281","url":null,"abstract":"<p>The FLT3-ITD mutation represents the most frequent genetic alteration in newly diagnosed acute myeloid leukemia (AML) patient and is associated with poor prognosis. Mutation result in the retention of a constitutively active form of this receptor in the endoplasmic reticulum (ER) and the subsequent modification of its downstream effectors. Here, we assessed the impact of such retention on ER homeostasis and found that mutant cells present lower levels of ER stress due to the overexpression of ERO1α, one of the main proteins of the protein folding machinery at the ER. Overexpression of ERO1α resulted essential for ITD mutant cells survival and chemoresistance and also played a crucial role in shaping the type of glucose metabolism in AML cells, being the mitochondrial pathway the predominant one in those with a higher ER stress (non-mutated cells) and the glycolytic pathway the predominant one in those with lower ER stress (mutated cells). Our data indicate that FLT3 mutational status dictates the route for glucose metabolism in an ERO1α depending on manner and this provides a survival advantage to tumors carrying these ITD mutations.</p>","PeriodicalId":12882,"journal":{"name":"Hematological Oncology","volume":"42 3","pages":""},"PeriodicalIF":3.3,"publicationDate":"2024-05-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/hon.3281","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141075637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}