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Hans Journal of Medicinal Chemistry最新文献

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AggreWell Plate Culture of Breast Cancer Tumor Spheroids and the Impact of Matrine on the Secretion of Proteins Associated with Invasion and Migration 乳腺癌肿瘤球体的AggreWell平板培养及苦参碱对侵袭迁移相关蛋白分泌的影响
Hans Journal of Medicinal Chemistry Pub Date : 2026-01-01 DOI: 10.12677/hjmce.2026.141001
晗 王
{"title":"AggreWell Plate Culture of Breast Cancer Tumor Spheroids and the Impact of Matrine on the Secretion of Proteins Associated with Invasion and Migration","authors":"晗 王","doi":"10.12677/hjmce.2026.141001","DOIUrl":"https://doi.org/10.12677/hjmce.2026.141001","url":null,"abstract":"","PeriodicalId":12854,"journal":{"name":"Hans Journal of Medicinal Chemistry","volume":"14 01","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147891011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Establishment of Three-Dimensional Polyurethane Model of Lung Cancer and Curcumin Susceptibility Test 肺癌三维聚氨酯模型的建立及姜黄素敏感性试验
Hans Journal of Medicinal Chemistry Pub Date : 2025-01-01 DOI: 10.12677/hjmce.2025.131002
晗 王
{"title":"Establishment of Three-Dimensional Polyurethane Model of Lung Cancer and Curcumin Susceptibility Test","authors":"晗 王","doi":"10.12677/hjmce.2025.131002","DOIUrl":"https://doi.org/10.12677/hjmce.2025.131002","url":null,"abstract":"","PeriodicalId":12854,"journal":{"name":"Hans Journal of Medicinal Chemistry","volume":"13 01","pages":"11-18"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147899262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Research Progress on Virtual Screening Design Techniques for Small Molecule Inhibitors of JAK3 Kinase JAK3激酶小分子抑制剂虚拟筛选设计技术研究进展
Hans Journal of Medicinal Chemistry Pub Date : 2025-01-01 DOI: 10.12677/hjmce.2025.131011
宪昊 迟
{"title":"Research Progress on Virtual Screening Design Techniques for Small Molecule Inhibitors of JAK3 Kinase","authors":"宪昊 迟","doi":"10.12677/hjmce.2025.131011","DOIUrl":"https://doi.org/10.12677/hjmce.2025.131011","url":null,"abstract":"","PeriodicalId":12854,"journal":{"name":"Hans Journal of Medicinal Chemistry","volume":"13 01","pages":"107-117"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147898187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Deep Eutectic Solvent Can Inhibit the Proliferation of Hepatocellular Carcinoma Cells in Many Ways 深共熔溶剂可通过多种途径抑制肝癌细胞的增殖
Hans Journal of Medicinal Chemistry Pub Date : 2025-01-01 DOI: 10.12677/hjmce.2025.132014
家伟 俞
{"title":"Deep Eutectic Solvent Can Inhibit the Proliferation of Hepatocellular Carcinoma Cells in Many Ways","authors":"家伟 俞","doi":"10.12677/hjmce.2025.132014","DOIUrl":"https://doi.org/10.12677/hjmce.2025.132014","url":null,"abstract":"研究目的：研究以氯化胆碱(CHCL)和维生素C(VITC)为组成成分所形成的深共熔溶剂(DES)对肿瘤细胞增殖能力的影响研究。方法：用DES混合液处理细胞24 h后，采用MTT实验检测细胞的增殖能力；采用凋亡坏死试剂盒检测细胞中的凋亡水平；采用Western blot检测细胞相关蛋白的表达水平；采用透射电镜观察DES对细胞的细胞膜及细胞器等各方面的影响。研究结果：DES对细胞具有毒性作用；DES促进肝癌细胞的凋亡坏死进而抑制细胞增殖；DES通过抑制PI3K-AKT通路进而抑制细胞的增殖。研究结论：深共熔溶剂可以从多种途径抑制肿瘤细胞的增殖。Objective: To investigate the effect of deep eutectic solvent (DES) formed with choline chloride (CHCL) and vitamin C (VITC) as components on the proliferation ability of tumor cells. Methods: After treating the cells with DES mixture for 24 h, the proliferation ability of the cells was detected by MTT assay. Apoptosis level was detected by apoptotic necrosis kit. The expression levels of related proteins were detected by Western blot. The effects of DES on cell membranes and organelles were observed by transmission electron microscopy. The results showed that DES had toxic effect on cells. DES promoted apoptosis and necrosis of hepatocellular carcinoma cells and inhibited cell proliferation. DES inhibits cell proliferation by inhibiting PI3K-AKT pathway. Conclusion: Deep eutectic solvent can inhibit the proliferation of tumor cells in many ways.","PeriodicalId":12854,"journal":{"name":"Hans Journal of Medicinal Chemistry","volume":"13 02","pages":"136-144"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pdf.hanspub.org/hjmce_3070264.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147886591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Based on Network Pharmacology and Experimental Validation, to Investigate the Mechanism of Action of Miao Medicine and Crossbow in the Treatment of Knee Osteoarthritis 基于网络药理学和实验验证，探讨苗药与弓弩治疗膝关节骨性关节炎的作用机制
Hans Journal of Medicinal Chemistry Pub Date : 2024-01-01 DOI: 10.12677/hjmce.2024.121004
欢 谢
{"title":"Based on Network Pharmacology and Experimental Validation, to Investigate the Mechanism of Action of Miao Medicine and Crossbow in the Treatment of Knee Osteoarthritis","authors":"欢 谢","doi":"10.12677/hjmce.2024.121004","DOIUrl":"https://doi.org/10.12677/hjmce.2024.121004","url":null,"abstract":"","PeriodicalId":12854,"journal":{"name":"Hans Journal of Medicinal Chemistry","volume":"12 01","pages":"20-26"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147882322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Resource, Chemical Structure and Immunomodulatory Activity of Natural Polysaccharides 天然多糖的来源、化学结构及免疫调节活性
Hans Journal of Medicinal Chemistry Pub Date : 2024-01-01 DOI: 10.12677/hjmce.2024.123026
虎 张
{"title":"Resource, Chemical Structure and Immunomodulatory Activity of Natural Polysaccharides","authors":"虎 张","doi":"10.12677/hjmce.2024.123026","DOIUrl":"https://doi.org/10.12677/hjmce.2024.123026","url":null,"abstract":"","PeriodicalId":12854,"journal":{"name":"Hans Journal of Medicinal Chemistry","volume":"12 03","pages":"227-238"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147919832","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Construction and Performance Evaluation of Juglone Nano Drug Delivery System Based on Chitosan 壳聚糖基核桃苷纳米给药体系的构建及性能评价
Hans Journal of Medicinal Chemistry Pub Date : 2024-01-01 DOI: 10.12677/hjmce.2024.124032
伟 周
{"title":"Construction and Performance Evaluation of Juglone Nano Drug Delivery System Based on Chitosan","authors":"伟 周","doi":"10.12677/hjmce.2024.124032","DOIUrl":"https://doi.org/10.12677/hjmce.2024.124032","url":null,"abstract":"","PeriodicalId":12854,"journal":{"name":"Hans Journal of Medicinal Chemistry","volume":"12 04","pages":"284-296"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147890554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Protective Effect Analysis of AGGF1 Primed EPCs on Acute Kidney Injury in Mice AGGF1诱导EPCs对小鼠急性肾损伤的保护作用分析
Hans Journal of Medicinal Chemistry Pub Date : 2024-01-01 DOI: 10.12677/hjmce.2024.123025
夏 李
{"title":"The Protective Effect Analysis of AGGF1 Primed EPCs on Acute Kidney Injury in Mice","authors":"夏 李","doi":"10.12677/hjmce.2024.123025","DOIUrl":"https://doi.org/10.12677/hjmce.2024.123025","url":null,"abstract":"","PeriodicalId":12854,"journal":{"name":"Hans Journal of Medicinal Chemistry","volume":"12 03","pages":"220-226"},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147898006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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